Pediatrics (all articles)
A case series of children with acute hepatitis and human Adenovirus infection.
14 Jul, 2022 | 12:56h | UTCA Case Series of Children with Acute Hepatitis and Human Adenovirus Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Related Study: Clinical Spectrum of Children with Acute Hepatitis of Unknown Cause – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Unexplained Acute Hepatitis in Children: More Evidence for Adenovirus 41 — Two studies point to a suspiciously high prevalence – MedPage Today (free registration required)
Commentaries on Twitter
A majority of children admitted to a single hospital in late 2021–early 2022 with acute hepatitis of unknown cause tested positive for adenovirus. This report describes the children’s illnesses and outcomes. https://t.co/QYvi6U1jUN pic.twitter.com/auPRq1duQm
— NEJM (@NEJM) July 13, 2022
From January–April 2022, 44 children with acute hepatitis of unknown cause were referred to a liver-transplantation center in the U.K. Six underwent liver transplantation. https://t.co/CMI4KCqdxM pic.twitter.com/og72u58L5R
— NEJM (@NEJM) July 13, 2022
Systematic Review | Anti‐IL‐5 therapies for asthma.
14 Jul, 2022 | 12:40h | UTCAnti‐IL‐5 therapies for asthma – Cochrane Library
RCT | Erythropoietin not beneficial for hypoxic-ischemic encephalopathy in newborns.
14 Jul, 2022 | 12:42h | UTCTrial of Erythropoietin for Hypoxic–Ischemic Encephalopathy in Newborns – New England Journal of Medicine (link to abstract – $ for full-text)
Cohort Study | Prediction models for celiac disease development in children from high-risk families.
14 Jul, 2022 | 12:31h | UTC
Review | Neonatal acute kidney injury.
14 Jul, 2022 | 12:21h | UTCNeonatal Acute Kidney Injury – Frontiers in Pediatrics
M-A | Risk factors of delirium in pediatric intensive care units.
13 Jul, 2022 | 11:35h | UTCRisk factors of delirium in paediatric intensive care units: A meta-analysis – PLOS One
RCT | Efficacy and safety of Elexacaftor/Tezacaftor/Ivacaftor in children 6 through 11 years of age with cystic fibrosis heterozygous for F508del and a minimal function mutation.
13 Jul, 2022 | 11:07h | UTCEfficacy and Safety of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 Through 11 Years of Age with Cystic Fibrosis Heterozygous for F508del and a Minimal Function Mutation: A Phase 3B, Randomized, Placebo-Controlled Study – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)
M-A | Global changes in child and adolescent physical activity during the COVID-19 pandemic.
12 Jul, 2022 | 12:53h | UTCGlobal Changes in Child and Adolescent Physical Activity During the COVID-19 Pandemic: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a limited period)
Consensus on the management of complications of cirrhosis of the liver in pediatrics.
11 Jul, 2022 | 12:24h | UTC
Study finds childhood obesity occurring at greater frequency, with more severity and at younger ages.
11 Jul, 2022 | 12:10h | UTCNews Release: Study finds childhood obesity occurring at greater frequency, with more severity and at younger ages – Emory University
Original Study: Changes in the Incidence of Childhood Obesity – Pediatrics
RCT | Balovaptan no better than placebo for social communication in childhood autism spectrum disorder.
8 Jul, 2022 | 11:38h | UTC
Commentary on Twitter
In this RCT, balovaptan did not demonstrate efficacy in improvement of socialization and communication in pediatric autism spectrum disorder (ASD), highlighting challenges faced in #ASD trial design, such as outcome measure sensitivity & placebo response. https://t.co/FFAJeu5xv0
— JAMA Psychiatry (@JAMAPsych) July 6, 2022
Podcast | BRUE’s Clues: understanding brief resolved unexplained events.
8 Jul, 2022 | 11:34h | UTC#54: BRUE’s Clues: Understanding Brief Resolved Unexplained Events with Dr. Tieder – The Cribsiders
M-A | Antithyroid drug therapy in pregnancy and risk of congenital anomalies.
8 Jul, 2022 | 11:36h | UTC
Evaluation of the molecular landscape of pediatric thyroid nodules and use of a multigene genomic classifier in children.
8 Jul, 2022 | 11:20h | UTC
Commentaries on Twitter
A multigene classifier reveals that malignant pediatric thyroid nodules have a unique molecular landscape vs those in adults. The classifier had a sensitivity of 96% & specificity of 78% for cancer detection & might reduce the need for diagnostic surgery: https://t.co/hdsPjGe9IR
— NatureRevClinOncol (@NatRevClinOncol) June 16, 2022
Pediatric thyroid cancer is on the rise. Its genomic landscape is unique; but, this retrospective case series shows that it may still be amenable to molecular classification—potentially decreasing diagnostic surgery & opening avenues for targeted therapy. https://t.co/KiYMsB1qGM
— JAMA Oncology (@JAMAOnc) June 10, 2022
WHO Guideline | Fortification of wheat flour with vitamins and minerals as a public health strategy.
7 Jul, 2022 | 13:02h | UTC
Review | Sickle cell disease.
7 Jul, 2022 | 12:59h | UTCSickle Cell Disease: A Review – JAMA (free for a limited period)
Audio Clinical Review: Sickle Cell Disease – JAMA
Registry-based cohort study | Interventions in adults with repaired coarctation of the aorta.
7 Jul, 2022 | 12:29h | UTC
Effect of comprehensive smoke-free legislation on neonatal and infant mortality across 106 middle-income countries.
7 Jul, 2022 | 12:26h | UTC
AAP Policy Statement | Individual medical emergencies occurring at school.
6 Jul, 2022 | 11:57h | UTCIndividual Medical Emergencies Occurring at School – Pediatrics
M-A | Effectiveness of interventions to improve drinking water, sanitation, and handwashing with soap on risk of diarrheal disease in children in low-income and middle-income settings.
6 Jul, 2022 | 11:56h | UTC
Commentary on Twitter
WASH meta-analysis in @TheLancet
Effectiveness of WASH interventions on child diarrhoea in LMICshttps://t.co/yVtoyattQd
How effective are
– water supply (by level of service)
– POU water treatment (by type)
– sanitation (by LoS)
– handwashing with soapRead to find out!
— Environmental Health Group, LSHTM (@LSHTM_EHG) July 1, 2022
FDA orders Juul to remove all its e-cigarettes from US market.
6 Jul, 2022 | 11:46h | UTCFDA orders Juul to remove all its e-cigarettes from US market – The BMJ
See also:
FDA orders all Juul e-cigarettes off the market – POLITICO
The FDA orders Juul to pull all of its vaping products from the U.S. market – NPR
FDA orders Juul Labs to remove products from US market – CNN
FDA News Release: FDA Denies Authorization to Market JUUL Products – U.S. Food & Drug Administration
RCT | Odevixibat treatment in progressive familial intrahepatic cholestasis.
6 Jul, 2022 | 11:35h | UTCInvited Commentary: The first new drug for progressive familial intrahepatic cholestasis – The Lancet Gastroenterology & Hepatology (free registration required)
Commentary on Twitter
New research – Thompson et al – Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial (PEDFIC 1)https://t.co/hPLmPLMcDt#livertwitter #cholestasis #PFIC pic.twitter.com/oUMMh1H0kv
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) July 1, 2022
Position Paper | The role of surgical management in chronic pancreatitis in children.
6 Jul, 2022 | 11:37h | UTC
Commentary on Twitter
Pancreas committee of NASPGHAN published position paper on the role of surgical management in chronic pancreatitis in children: https://t.co/XnI7SCsbWQ pic.twitter.com/nBWoSd14cU
— JPGN (@JPGNonline) May 30, 2022
RCT | Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis.
6 Jul, 2022 | 11:31h | UTCCommentary: Does Azithromycin antagonize the effect of inhaled tobramycin in cystic fibrosis? – Medical Dialogues
Commentary on Twitter
Original research: Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis: a randomised, controlled clinical trialhttps://t.co/z9dGX52dAe pic.twitter.com/tpiOqIIQjb
— ThoraxBMJ (@ThoraxBMJ) May 23, 2022
Registry-based cohort study | Neonatal morbidity after fetal exposure to antipsychotics.
6 Jul, 2022 | 11:24h | UTCNeonatal morbidity after fetal exposure to antipsychotics – BMJ Open