Pain Medicine
RCT | Efficacy and safety of intravenous acetaminophen (2 g/day) for reducing opioid consumption in Chinese adults after elective orthopedic surgery.
9 Aug, 2022 | 12:39h | UTC
Cohort Study | The risk of opioid overdose is increased with concomitant use of oxycodone and selective serotonin reuptake inhibitors that are inhibitors of oxycodone metabolism.
4 Aug, 2022 | 14:27h | UTCCommentary from the author: Taking certain opioids while on commonly prescribed antidepressants may increase the risk of overdose – The Conversation
Commentary on Twitter
This cohort study found that concomitant use of oxycodone with potent CYP2D6-inhibiting serotonin reuptake inhibitors (SSRIs, eg. fluoxetine or paroxetine) is associated with an increased risk of overdose. https://t.co/Eol89RHWAu
— JAMA Network Open (@JAMANetworkOpen) February 24, 2022
RCT | Effect of graded sensorimotor retraining on pain intensity in patients with chronic low back pain.
3 Aug, 2022 | 14:08h | UTCEffect of Graded Sensorimotor Retraining on Pain Intensity in Patients With Chronic Low Back Pain: A Randomized Clinical Trial – JAMA (free for a limited period)
News release: An effective new treatment for chronic back pain targets the nervous system – University of New South Wales
Commentary on Twitter
A graded sensorimotor retraining intervention, compared with a sham procedure and attention control, resulted in a statistically significant improvement in pain intensity at 18 weeks. https://t.co/MXO89JeOSe pic.twitter.com/0A865RWW85
— JAMA (@JAMA_current) August 2, 2022
Brief Review | Monitoring pain in the intensive care unit.
1 Aug, 2022 | 12:30h | UTCMonitoring pain in the intensive care unit (ICU) – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Monitoring pain in #ICU
➡️ self‐assessment tools in pts able to self‐report
➡️ observational behavioural scales in pts unable to self‐report
➡️ physiologic parameters in pts unable to self‐report nor express behaviours (deep sedaution, NMBAs)#FOAMcc
? https://t.co/SaD1BBxSNw pic.twitter.com/81tNNvnTDe— Intensive Care Medicine (@yourICM) July 30, 2022
RCT | Effects of walking exercise at a pace with vs. without ischemic leg symptoms on functional performance measures in people with lower extremity peripheral artery disease.
28 Jul, 2022 | 13:27h | UTCNews Release: ‘No pain, no gain’ approach improves walking ability with peripheral artery disease – American Heart Association
RCT | Intra-articular botulinum toxin A injection for painful base-of-thumb osteoarthritis.
27 Jul, 2022 | 11:56h | UTCIntra-articular botulinum toxin A injection for painful base-of-thumb osteoarthritis: a double-blind, randomised, controlled, phase 3 trial (RHIBOT) – The Lancet Rheumatology (link to abstract – $ for full-text)
Commentaries:
Botulinum toxin A injection may ease base-of-thumb osteoarthritis pain – medwire News
Commentary on Twitter
NEW RESEARCH—Intra-articular botulinum toxin A injection for painful base-of-thumb #osteoarthritis: a double-blind, randomised, controlled, phase 3 trial (RHIBOT) https://t.co/pY4ZQdW6p9 @cchnguyen pic.twitter.com/KT4XLzhIlb
— The Lancet Rheumatology (@TheLancetRheum) June 24, 2022
Review | Opioid sparing strategies for perioperative pain management other than regional anesthesia.
20 Jul, 2022 | 11:47h | UTC
M-A of RCTs | Efficacy of corticosteroids for hand osteoarthritis.
18 Jul, 2022 | 11:07h | UTC
Review | The current role and future directions of imaging in failed back surgery syndrome patients.
18 Jul, 2022 | 10:46h | UTC
Review | Regional anesthesia and acute perioperative pain management in thoracic surgery.
15 Jul, 2022 | 12:33h | UTC
M-A | Little benefit from viscosupplementation in knee osteoarthritis.
11 Jul, 2022 | 12:39h | UTCViscosupplementation for knee osteoarthritis: systematic review and meta-analysis – The BMJ
News Release: Scant evidence to recommend use of hyaluronic acid injections for knee osteoarthritis – BMJ Newsroom
Commentary: Common injections don’t help knee osteoarthritis more than placebo, large data review finds – STAT
Commentary on Twitter
New research finds that injections of hyaluronic acid to treat knee osteoarthritis make almost no difference to pain and might raise risk of adverse events https://t.co/G80BHoOgl3
— The BMJ (@bmj_latest) July 7, 2022
RCT | Acupuncture for patients with chronic tension-type headache.
11 Jul, 2022 | 12:12h | UTCAcupuncture for Patients With Chronic Tension-Type Headache: A Randomized Controlled Trial – Neurology (link to abstract – $ for full-text)
News Release: Can acupuncture reduce headaches? – American Academy of Neurology
Commentary:
New Evidence on the Efficacy of Acupuncture for Chronic Tension-type Headache – NeurologyToday
An ancient practice may offer relief from chronic tension headaches – CNN
Related: Acupuncture for the prevention of tension‐type headache – Cochrane Library
RCT | Effect of electroacupuncture on insomnia in patients with depression.
8 Jul, 2022 | 11:45h | UTCInvited Commentary: Effects of Electroacupuncture for Depression-Related Insomnia – JAMA Network Open
Commentary on Twitter
This randomized clinical trial found that an 8-weeek electroacupuncture with standard care improved sleep quality for patients with insomnia and depression, compared with sham acupuncture and/or standard care. https://t.co/nacnxEI4Ik
— JAMA Network Open (@JAMANetworkOpen) July 7, 2022
Podcast | Headache update: making migraines less painful.
7 Jul, 2022 | 12:24h | UTC#341: Headache Update: Making Migraines Less Painful with Dr. Kevin Weber – The Curbsiders
Consensus | Pediatric headache in primary care and emergency departments.
5 Jul, 2022 | 12:00h | UTCPediatric Headache in Primary Care and Emergency Departments: Consensus with RAND/UCLA Method – Life
Transcranial magnetic stimulation of the brain: What is stimulated? – A consensus and critical position paper.
27 Jun, 2022 | 11:36h | UTC
Commentary on Twitter
[Transcranial magnetic stimulation (TMS)] Siebner et al.: "Myelinated axon terminals of pyramidal cells and inhibitory interneurons in the crown of the gyri constitute low-threshold targets for TMS."https://t.co/1UfzuAHlPj@DRCMR_MRIhttps://t.co/LzHAzeGMZ5 https://t.co/n5hPOlFNlL pic.twitter.com/szdY77WieS
— IFCN and its Clinical Neurophysiology journals (@ClinicalNeuroph) May 21, 2022
M-A: Benefits and harms of interventions with surgery compared to interventions without surgery for musculoskeletal conditions.
24 Jun, 2022 | 11:04h | UTC
M-A: Effectiveness of pharmacological-based interventions, including education and prescribing strategies, to reduce subacute pain after total hip or knee arthroplasty.
23 Jun, 2022 | 10:04h | UTC
Commentary on Twitter
A systematic review of RCTs looking at effectiveness of pharmacological interventions to ⬇️ pain following total hip/knee arthroplasty. Interventions involving multimodal non-opioid analgesia & education show positive effects on ⬇️ pain intensity. https://t.co/t2majwzHPz pic.twitter.com/HoybWv2VFO
— Pain Medicine Journal (@PainMedJournal) March 31, 2022
RCT: Spinal anesthesia is associated with more pain and prescription analgesic use after hip surgery compared to general anesthesia.
22 Jun, 2022 | 12:11h | UTCStudy: Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery: A Randomized Clinical Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Original Publication: Spinal Anesthesia or General Anesthesia for Hip Surgery in Older Adults – New England Journal of Medicine
Commentary: Spinal Anesthesia Tied to More Severe Pain After Hip Fracture Surgery – HealthDay
Related:
Cohort Study: Association between short-term, chronic localized and chronic widespread pain and risk for cardiovascular disease.
22 Jun, 2022 | 11:18h | UTC
M-A: Opioid versus opioid-free analgesia after surgical discharge.
21 Jun, 2022 | 11:08h | UTCOpioid versus opioid-free analgesia after surgical discharge: a systematic review and meta-analysis of randomised trials – The Lancet (link to abstract – $ for full-text)
News Release: Taking opioids at home after surgery: More harms than benefits – McGill University Health Center
Cohort Study: Long-term risk of overdose or mental health crisis after opioid dose tapering.
14 Jun, 2022 | 10:53h | UTCLong-term Risk of Overdose or Mental Health Crisis After Opioid Dose Tapering – JAMA Network Open
Editorial: New Data on Opioid Dose Reduction—Implications for Patient Safety – JAMA Network Open
Opioid-sparing effect of cannabinoids for analgesia: an updated systematic review and meta-analysis of preclinical and clinical studies.
14 Jun, 2022 | 10:30h | UTC
Commentary on Twitter
MA of RCTs: In patients with cancer pain no effect of cannabinoid administration on opioid dose was found (MD= −3.8 mg; −10.97 to 3.37) or % change in pain scores (MD=1.84; −2.05 to 5.72) https://t.co/tTckc0z8Oz pic.twitter.com/Gh7LvYRz0n
— PfOL (@psychopharmacol) May 20, 2022
Systematic Review: Oxycodone for cancer‐related pain.
13 Jun, 2022 | 07:37h | UTCOxycodone for cancer‐related pain – Cochrane Library
Summary: Oxycodone for cancer-related pain in adults – Cochrane Library
Systematic Review: Cannabis-based products for chronic pain.
7 Jun, 2022 | 11:47h | UTCCannabis-Based Products for Chronic Pain: A Systematic Review – Annals of Internal Medicine
Annals Video Summary: Cannabis-Based Products for Chronic Pain: A Systematic Review
Summary for Patients: Cannabis-Based Products for Chronic Pain
Related:
Podcast: #338 LIVE! Medical Cannabis: Is it still dope? – The Curbsiders
M-A: Birth outcomes of neonates exposed to marijuana in utero.
Cannabis-related allergies: an international overview and consensus recommendations.
Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.
Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain.
Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.
Guideline: Medical cannabis or cannabinoids for chronic pain.
NICE Guideline: Cannabis-Based Medicinal Products
Short Review: Drug Interactions with Cannabinoids
Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain
Review: Considerations for cannabinoids in perioperative care by anesthesiologists.
Review: Cannabis-based Medicines and the Perioperative Physician
Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know