Oncology (all articles)
Randomized Trial: Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma
13 Jul, 2018 | 02:33h | UTCCabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Cabozantinib in Hepatocellular Carcinoma – NEJM Resident 360 (free)
Median overall survival was 10.2 months with cabozantinib and 8.0 months with placebo, but the rate of high-grade adverse events in the cabozantinib group was approximately twice that observed in the placebo group.
Randomized Trial: Cervical Cancer Screening with Cervical HPV Testing vs Cytology Testing
13 Jul, 2018 | 02:26h | UTCEffect of Screening With Primary Cervical HPV Testing vs Cytology Testing on High-grade Cervical Intraepithelial Neoplasia at 48 Months: The HPV FOCAL Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: For Women Over 30, There May Be A Better Choice Than The Pap Smear – NPR (free) AND Study Suggests HPV Test More Accurate Than Pap Smear for Cervical Cancer Screening – AJMC (free) AND HPV testing could be more accurate than smear tests for initial screening of cervical cancer – NHS Choices (free)
Cohort Study: Dietary Insulin Load and Cancer Recurrence and Survival in Patients With Stage III Colon Cancer
13 Jul, 2018 | 01:46h | UTCDietary Insulin Load and Cancer Recurrence and Survival in Patients With Stage III Colon Cancer: Findings From CALGB 89803 (Alliance) – JNCI: Journal of the National Cancer Institute (link to abstract – $ for full-text)
Commentary: Dietary Insulin Load and Risk of Disease Recurrence in Stage III Colon Cancer – The ASCO Post (free)
Guideline: Primary Imaging Test and Appropriate Biopsy Methods for Thyroid Nodules
13 Jul, 2018 | 01:36h | UTC
Study: Cancer Prevalence Among Flight Attendants Compared to the General Population
13 Jul, 2018 | 01:30h | UTCCancer prevalence among flight attendants compared to the general population – Environmental Health (free)
Commentaries: Flight attendants show higher cancer risks – UPI (free) AND Flight crew have higher rates of some cancers, study finds – The Guardian (free)
Liquid Biopsy: Still Early Days for Early Detection
13 Jul, 2018 | 01:31h | UTCLiquid biopsy: still early days for early detection – The Lancet (free registration required)
Statement Paper: Liquid Biopsy for Advanced Non-Small Cell Lung Cancer
13 Jul, 2018 | 01:12h | UTCCommentary: IASLC Issues Statement Paper on Liquid Biopsy for Lung Cancer – The ASCO Post (free)
Guideline: Endocrine Disorders in Survivors of Childhood Cancer
6 Jul, 2018 | 09:56h | UTCCommentaries: Up to half of childhood cancer survivors will develop hormone disorders – The Endocrine Society, via ScienceDaily (free) AND Guideline Addresses Endocrine Effects After Childhood Cancer – Medscape (free registration required)
Study: Risk-Stratified Screening for Breast Cancer
6 Jul, 2018 | 09:55h | UTCEditorial: Implementation Challenges for Risk-Stratified Screening in the Era of Precision Medicine (free)
Author Interview: Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Breast Cancer Screening (free)
Commentaries: New approach to breast cancer screening — tailoring guidelines for each patient — may save lives and money, study says – STAT (free) AND No screening is better for women with low breast cancer risk, finds study – Guardian (free) AND Breast Cancer Screening Only for Women at Higher Risk – Medscape (free registration required)
Randomized Trial: Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer
6 Jul, 2018 | 09:34h | UTCEnzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Related Perspective: Metastasis-free Survival — A New End Point in Prostate Cancer Trials – New England Journal of Medicine (free)
Commentaries: Enzalutamide: Now Also for Earlier Use in Prostate Cancer? – Medscape (free registration required) AND Enzalutamide Improves Outcomes for Aggressive Prostate Cancer – MPR (free) AND Enzalutamide Postpones Metastasis for a Subset of High-Risk Patients With Prostate Cancer – Cancer Therapy Advisor (free)
Guideline: Fertility Preservation for Patients with Malignant Disease
6 Jul, 2018 | 09:31h | UTCRelated guidelines: Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free) AND Fertility preservation for patients with gynecologic malignancies: The Korean Society for Fertility Preservation clinical guidelines – Clinical and Experimental Reproductive Medicine (free) AND Fertility preservation for medical reasons in girls and women: British fertility society policy and practice guideline – Human Fertility (free)
Immunotherapy: Hype and Hope
6 Jul, 2018 | 09:32h | UTCEditorial: Immunotherapy: hype and hope – The Lancet Oncology (free) (via @OphiraG)
Related: What Precisely Is Precision Oncology—and Will It Work? – The ASCO Post (free) AND Hope and hype around cancer immunotherapy – CNN (free)
Cohort Study: Endocrine Late Effects in Survivors of Cancer in Adolescence and Young Adulthood
6 Jul, 2018 | 03:21h | UTCInvited Commentary: Unmet Survivorship Care Needs of Adolescent and Young Adult Cancer Survivors (free)
Related Reviews: Endocrine late-effects of childhood cancer and its treatments – European Journal of Endocrinology (free) AND Metabolic syndrome induced by anticancer treatment in childhood cancer survivors – Annals of Pediatric Endocrinology & Metabolism (free) AND Screening and management of adverse endocrine outcomes in adult survivors of childhood and adolescent cancer – The Lancet Diabetes & Endocrinology (free)
Review: Cardiovascular Toxicity in Cancer Survivors
6 Jul, 2018 | 03:20h | UTCRelated Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations – Revista Espanola de Cardiologia (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)
Cohort Study: In Patients with Rectal Cancer, Restriction of Neoadjuvant Chemoradiotherapy to High‐Risk Patients Achieved Good Results
29 Jun, 2018 | 03:10h | UTCOncological outcome after MRI‐based selection for neoadjuvant chemoradiotherapy in the OCUM Rectal Cancer Trial – British Journal of Surgery (link to abstract – $ for full-text)
Commentaries: Many patients with rectal cancer may not need chemoradiotherapy – eCancer News (free) AND Limiting Chemo to High-Risk Rectal Cancer Called Feasible – MedPage Today (free registration required) AND OCUM Trial: Some Rectal Cancers Need Only Surgery – Medscape (free registration required)
ASCO Guideline: Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases
29 Jun, 2018 | 02:55h | UTC
ASCO Guideline: Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer
29 Jun, 2018 | 02:56h | UTC
Case Series: Recurrent Glioblastoma Treated with Recombinant Poliovirus
29 Jun, 2018 | 02:50h | UTCRecurrent Glioblastoma Treated with Recombinant Poliovirus – New England Journal of Medicine (free for a limited period)
Editorial: Exploiting Viruses to Treat Diseases (free for a limited period)
Commentaries: Doctors Try Genetically Modified Poliovirus As Experimental Brain Cancer Treatment – NPR (free) AND Poliovirus therapy shows early promise in patients with aggressive brain cancer but questions linger – STAT (free)
Cohort Study: Percutaneous Ablation Versus Partial and Radical Nephrectomy for T1a Renal Cancer
29 Jun, 2018 | 02:34h | UTCPercutaneous Ablation Versus Partial and Radical Nephrectomy for T1a Renal Cancer: A Population-Based Analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Percutaneous ablation may be preferred to nephrectomy for selected patients with early-stage renal cancer – ACP Internist (free) AND New Findings Support Ablation for Small Renal Tumors – Renal & Urology News (free)
Related Meta-Analysis: Radiofrequency ablation versus partial nephrectomy for treatment of renal masses: A systematic review and meta-analysis – The Kaohsiung Journal of Medical Sciences (free) AND Radiofrequency Ablation Versus Partial Nephrectomy in Treating Small Renal Tumors: A Systematic Review and Meta-Analysis – Medicine (free)
“Percutaneous ablation for T1a renal cancer has similar 5-year survival rates to radical nephrectomy but with far fewer 30-day complications and less kidney failure (via @AnnalsofIM see Tweet)
Randomized Trial: Robot-Assisted Radical Cystectomy No Better Than Open Radical Cystectomy in Patients with Bladder Cancer
29 Jun, 2018 | 02:18h | UTCRobot-assisted radical cystectomy versus open radical cystectomy in patients with bladder cancer (RAZOR): an open-label, randomised, phase 3, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Robotic, Open Cystectomy Offer Comparable Bladder Cancer Outcomes – Renal & Urology News (free) AND RAZOR study: No differences in robotic vs open surgery for bladder cancer – Coloproctology News (free) AND Robotic surgery is no better than traditional surgery, bladder cancer study finds – The Washington Post (free)
Guideline: Management of Patients with Cervical Cancer
29 Jun, 2018 | 02:04h | UTC
ESMO Guideline: Diarrhea in Adult Cancer Patients
24 Jun, 2018 | 19:34h | UTCDiarrhoea in adult cancer patients: ESMO Clinical Practice Guidelines – Annals of Oncology (free)
Randomized Trial: Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss
22 Jun, 2018 | 02:49h | UTCSodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Sodium Thiosulfate for Cisplatin-Induced Hearing Loss (free)
Commentaries: New drug halves hearing loss in children following cancer treatment – Cancer Research UK, via ScienceDaily (free) AND Otoprotectant Guards Against Cisplatin-Induced Hearing Loss – Medscape (free registration required) AND Antioxidant Cuts Hearing Loss in Cisplatin-Treated Kids – MedPage Today (free registration required)
Cohort Study: The Association of Lifetime Alcohol use with Mortality and Cancer Risk
22 Jun, 2018 | 02:33h | UTCCommentaries: Risks of cancer and mortality by average lifetime alcohol intake – PLOS, via ScienceDaily (free) AND Drinking Alcohol Can Raise Cancer Risk. How Much Is Too Much? – NPR (free) AND Light drinkers at a lower combined risk of earlier death or developing cancer – The Conversation (free) AND Expert reaction to the association between lifetime drinking and mortality and cancer risk – Science Media Centre (free)
Related Meta-analysis: Risk Thresholds for Alcohol Consumption (free study, editorial and commentaries)
Cohort Study: Pancreatic Cancer Following Incident Diabetes
22 Jun, 2018 | 02:31h | UTCPancreatic Cancer Following Incident Diabetes in African Americans and Latinos: The Multiethnic Cohort – Journal of the National Cancer Institute (link to abstract – $ for full-text)
Commentaries: Diabetes may be an early manifestation of pancreatic cancer – eCancer News (free) AND Recent-onset diabetes linked to pancreatic cancer for some minorities – UPI (free) AND Diabetes after 50 could be early sign of pancreatic cancer, study says – CNN (free)