Oncology (all articles)
M-A of randomized controlled trials: Intrathoracic vs. cervical anastomosis in esophagectomy for esophageal cancer.
12 Apr, 2022 | 08:47h | UTC
Drug-induced interstitial lung disease during cancer therapies: expert opinion on diagnosis and treatment.
12 Apr, 2022 | 08:27h | UTC
RCT: Selinexor in advanced, metastatic dedifferentiated liposarcoma.
12 Apr, 2022 | 08:24h | UTC
NCCN Guidelines: CAR T-cell–related toxicities in patients with cancer.
11 Apr, 2022 | 01:32h | UTCRelated:
Reviews: CAR T-Cell Therapy Toxicities and Side Effects
Reviews: CAR T-Cell Therapy Toxicities and Side Effects
Critical Care Management of Chimeric Antigen Receptor T Cell–related Toxicity. Be Aware and Prepared
Reviews: CAR T-Cell Therapy Toxicities and Side Effects
RCT: Effects of abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer.
11 Apr, 2022 | 01:23h | UTCAbiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design – The Lancet (link to abstract – $ for full-text)
M-A: Sentinel lymph node biopsy in patients with ductal carcinoma in situ.
11 Apr, 2022 | 00:46h | UTC
Commentary on Twitter
What is the role of #slnb in #dcis?
This #systematicreview included 16 studies/4388 patients.#DCIS associated with v. low rates of axillary + disease.
Palpable disease, tumour necrosis, g3 DCIS may predict +ve SLNB.#some4surgery #breastcancer https://t.co/oNR25Nu9KN pic.twitter.com/orlMF73300— BJS Open (@BjsOpen) April 8, 2022
Internal mammary node irradiation in patients with node-positive early breast cancer: fifteen-year results from the Danish breast cancer group internal mammary node study.
11 Apr, 2022 | 00:41h | UTCInternal Mammary Node Irradiation in Patients With Node-Positive Early Breast Cancer: Fifteen-Year Results From the Danish Breast Cancer Group Internal Mammary Node Study – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentary from the author on Twitter (thread – click for more)
Internal Mammary Node Irradiation in Patients With Node-Positive Early Breast Cancer: Fifteen-Year Results From the Danish Breast Cancer Group Internal Mammary Node Study https://t.co/fwtVF5Z6g7
— Lise Bech Jellesmark Thorsen (@Lise_BJT) April 9, 2022
Risk factors and prognostic implications of diagnosis of cancer within 30 days after an emergency hospital admission (emergency presentation).
8 Apr, 2022 | 10:52h | UTCCommentary: Emergency presentations: what are they, and what do they mean for cancer survival? – Cancer Research UK
Commentary on Twitter (thread – click for more) – text and images under a Creative Commons Attribution (CC BY 4.0) licence
1/12 With colleagues in 14 jurisdictions in 6 countries we have just published a study on the predictors and consequences of cancer diagnosis within 30 days after an emergency hospital admission (=emergency presentation) in @TheLancetOncol https://t.co/Hv9XWZDpuy A🧵:
— YoryosLyratzopoulos (@GLyratzopoulos) April 7, 2022
Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019.
8 Apr, 2022 | 10:58h | UTCInvited Commentary: Global epidemiology and prevention of colorectal cancer – The Lancet Gastroenterology & Hepatology (free registration required)
RCT: Laparoscopic sentinel node navigation surgery for stomach preservation in patients with early gastric cancer.
8 Apr, 2022 | 09:59h | UTC
Commentary on Twitter
In a phase III noninferiority trial of laparoscopic sentinel node navigation surgery vs standard gastrectomy for gastric cancer, 3-year DFS was 91.8% vs 95.5%, but with fewer complications, better physical function, improved nutrition & similar DSS/OS: https://t.co/A7Z8tejiIA
— NatureRevClinOncol (@NatRevClinOncol) March 30, 2022
Oncoplastic breast consortium recommendations for mastectomy and whole breast reconstruction in the setting of post-mastectomy radiation therapy.
8 Apr, 2022 | 09:43h | UTC
Systematic Review: Diagnostic and prognostic factors in patients with prostate cancer.
7 Apr, 2022 | 08:16h | UTCDiagnostic and prognostic factors in patients with prostate cancer: a systematic review – BMJ Open
Case-cohort study: The relative and attributable risks of cardia and non-cardia gastric cancer associated with Helicobacter pylori infection in China.
7 Apr, 2022 | 08:22h | UTCCommentary: Helicobacter pylori infection and risk of gastric cancer – The Lancet Public Health
Cohort study: Prognostic value of stromal tumor-infiltrating lymphocytes in young, node-negative, triple-negative breast cancer patients who did not receive (neo)adjuvant systemic therapy.
7 Apr, 2022 | 08:09h | UTC
Commentary on Twitter
Out now @JCO_ASCO huge effort of our team and @TILsWorkGroup: Excellent prognosis of TNBC pts with high TILs even without chemo! Chemo de-escalation trials urgently needed! # bcsm https://t.co/42eUZaA2vo
— MarleenKokLab (@lab_kok) March 31, 2022
Guideline: Revision of pharmacological treatment recommendations for cancer pain.
6 Apr, 2022 | 09:49h | UTC
Canadian recommendations on prostate cancer screening and early diagnosis.
6 Apr, 2022 | 09:47h | UTCSee also: Summary of changes
Cohort Study: Recipient and donor outcomes after living-donor liver transplant for unresectable colorectal liver metastases.
6 Apr, 2022 | 10:23h | UTCCommentaries:
Living-Donor Liver Transplant Promising for CRC With Liver Mets – HealthDay
Commentary on Twitter
Study suggests living-donor liver transplant is a promising option for meticulously selected patients with unresectable colorectal cancer liver metastases. https://t.co/p6Jbzb73DL
— JAMA Surgery (@JAMASurgery) March 30, 2022
Review: Translational advances in pancreatic ductal adenocarcinoma therapy.
6 Apr, 2022 | 10:05h | UTCTranslational advances in pancreatic ductal adenocarcinoma therapy – Nature Cancer (if the link is paywalled, try this one)
Commentary on Twitter
🔥Don't miss this beautiful review @NatureCancer on translational advances in pancreatic ductal adenocarcinoma by #AbdelNasserHosein, #StephanieKDougan, #AndrewJAguirre & @Aiims1742
Read it here🔥👇https://t.co/t6CWD0KCoxhttps://t.co/6RjCQ5NqNo
— Nature Cancer (@NatureCancer) March 29, 2022
Review: Atrial fibrillation in older adults with cancer.
6 Apr, 2022 | 09:53h | UTCAtrial fibrillation in older adults with cancer – Journal of Geriatric Cardiology
Cohort Study: The five major autoimmune diseases are associated with increased risk of cancer.
6 Apr, 2022 | 09:52h | UTCCommentary: Increased Cancer Risk with Autoimmune Disorders – RheumNow
RCT: Rucaparib vs. standard-of-care chemotherapy in patients with relapsed ovarian cancer and a deleterious BRCA1 or BRCA2 mutation.
6 Apr, 2022 | 09:45h | UTCRucaparib versus standard-of-care chemotherapy in patients with relapsed ovarian cancer and a deleterious BRCA1 or BRCA2 mutation (ARIEL4): an international, open-label, randomised, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary on Twitter
In ARIEL4 phase III trial, pts with BRCA1/2-mut ovarian cancer who received ≥2 chemo regimens received rucaparib or chemo. In the ITT, mPFS was 7.4 mo vs 5.7 mo (HR 0.67, 95% CI 0.52–0.86; P = 0.0017). Three treatment-related deaths occurred w rucaparib https://t.co/G7j7djp6kV
— NatureRevClinOncol (@NatRevClinOncol) March 22, 2022
M-A of randomized trials: Effects of capecitabine as part of neo-/adjuvant chemotherapy in patients with breast cancer.
5 Apr, 2022 | 08:06h | UTCEffects of capecitabine as part of neo-/adjuvant chemotherapy – A meta-analysis of individual breast cancer patient data from 13 randomised trials including 15,993 patients – European Journal of Cancer (link to abstract – $ for full-text)
ACG Guideline: Diagnosis and management of Barrett’s esophagus.
4 Apr, 2022 | 01:07h | UTC
RCT: Pembrolizumab vs. placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma.
4 Apr, 2022 | 00:56h | UTCPembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Before-and-after study: Antimicrobial stewardship in high-risk febrile neutropenia patients reduced carbapenem and glycopeptide use and was associated with improved clinical outcomes.
4 Apr, 2022 | 00:49h | UTCRelated:
Management of febrile neutropaenia: ESMO Clinical Practice Guidelines – Annals of Oncology
Commentary from the author on Twitter (thread – click for more)
https://twitter.com/AdrienContejean/status/1508792991917432838