Oncology (all articles)
Phase 1b/2 RCT | Niraparib plus nivolumab vs. niraparib plus ipilimumab in patients with platinum-sensitive advanced pancreatic cancer.
20 Jul, 2022 | 11:39h | UTCNiraparib plus nivolumab or niraparib plus ipilimumab in patients with platinum-sensitive advanced pancreatic cancer: a randomised, phase 1b/2 trial – The Lancet Oncology (link to abstract – $ for full-text)
Commentary on Twitter
https://twitter.com/TheLancetOncol/status/1545362068026556418
Addressing palliative care and end-of-life issues in patients with advanced cancer: a systematic review of communication interventions for physicians not specialized in palliative care.
20 Jul, 2022 | 11:40h | UTC
RCT | Doxorubicin alone vs. doxorubicin with trabectedin followed by trabectedin alone as first-line therapy for metastatic or unresectable leiomyosarcoma.
20 Jul, 2022 | 11:36h | UTCDoxorubicin alone versus doxorubicin with trabectedin followed by trabectedin alone as first-line therapy for metastatic or unresectable leiomyosarcoma (LMS-04): a randomised, multicentre, open-label phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
Phase 2 RCT | Deintensified chemoradiotherapy for pretreatment Epstein-Barr Virus DNA-selected low-risk locoregionally advanced nasopharyngeal carcinoma.
19 Jul, 2022 | 12:58h | UTCDeintensified Chemoradiotherapy for Pretreatment Epstein-Barr Virus DNA-Selected Low-Risk Locoregionally Advanced Nasopharyngeal Carcinoma: A Phase II Randomized Noninferiority Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentaries:
Commentary on Twitter
Less is more? 🤔 2-cycle cisplatin concurrent chemoradiotherapy is not inferior to 3-cycles based on 3-yr PFS in treating locoregionally advanced nasopharyngeal ca w/preRX EBV DNA levels < 4000.QOL & toxicity improved w/ less chemo https://t.co/XovHi2P06W pic.twitter.com/JJqiC8wnWW
— Journal of Clinical Oncology (@JCO_ASCO) January 25, 2022
Network M-A | Comparative effectiveness and risk of preterm birth of local treatments for cervical intraepithelial neoplasia and stage IA1 cervical cancer.
18 Jul, 2022 | 11:27h | UTC
Commentary on Twitter
Online first: Comparative effectiveness and risk of #preterm #birth of local #treatments for #cervicalintraepithelialneoplasia and stage IA1 #cervicalcancer: a systematic review and network meta-analysis https://t.co/APwtqyXJKO pic.twitter.com/GYuoroxRmw
— The Lancet Oncology (@TheLancetOncol) July 12, 2022
Using circulating tumor DNA in colorectal cancer: current and evolving practices.
18 Jul, 2022 | 10:51h | UTC
A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation.
15 Jul, 2022 | 12:55h | UTCA guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation – Journal of Thoracic Disease
Part 1 – A guide to decision-making
Part 2 – Systematic review of evidence regarding resection extent in generally healthy patients
Part 3 – Systematic review of evidence regarding surgery in compromised patients or specific tumors
Part 4 – Systematic review of evidence involving SBRT and ablation
Guidelines on germline testing for urologic tumor syndromes.
15 Jul, 2022 | 12:49h | UTCGuidelines on Germline Testing for Urologic Tumor Syndromes – European Urology Focus
Phase 2 RCT | Efficacy of preoperative mFOLFIRINOX vs. mFOLFIRINOX plus hypofractionated radiotherapy for borderline resectable adenocarcinoma of the pancreas.
15 Jul, 2022 | 12:29h | UTCEfficacy of Preoperative mFOLFIRINOX vs mFOLFIRINOX Plus Hypofractionated Radiotherapy for Borderline Resectable Adenocarcinoma of the PancreasThe A021501 Phase 2 Randomized Clinical Trial – JAMA Oncology (free for a limited period)
Editorial: The Continued Struggle for Defining a Role for Radiotherapy in Pancreas Cancer – JAMA (free for a limited period)
Commentary on Twitter
Ph 2 trial of 126 pts w/borderline resectable pancreatic ductal adenoCa shows 18 mo OS after neoadjuvant mFOLFIRINOX of 66.7%, favorable vs. historical data; 18m OS if mFOLFORINOX then hypofract RT is 47.3%, if chemo then pancreatectomy is 87.5%. https://t.co/wOMNrTOAzm
— JAMA Oncology (@JAMAOnc) July 14, 2022
M-A of RCTs | Megestrol Acetate not beneficial for cancer-related anorexia/cachexia.
14 Jul, 2022 | 12:50h | UTC
The EBMT nursing guidelines on CAR-T Therapy | A framework for patient care and managing common toxicities.
14 Jul, 2022 | 12:45h | UTC
How to treat renal cell carcinoma: the current treatment landscape and cardiovascular toxicities.
14 Jul, 2022 | 12:35h | UTC
Randomized crossover trial | AI reduces miss rate of precancerous polyps in colorectal cancer screening.
14 Jul, 2022 | 12:29h | UTCNews Release: AI reduces miss rate of precancerous polyps in colorectal cancer screening – Mayo Clinic
Original Study: Impact of Artificial Intelligence on Miss Rate of Colorectal Neoplasia – Gastroenterology
Prevalence of cardiovascular disease in patients with potentially curable malignancies: a national registry dataset analysis.
14 Jul, 2022 | 12:33h | UTC
The Global Retinoblastoma Outcome Study | A prospective, cluster-based analysis of 4,064 patients from 149 countries.
14 Jul, 2022 | 12:16h | UTCInvited Commentary: Retinoblastoma as a lens for correctable disparities worldwide – The Lancet Global Health
M-A | Risk of developing gallbladder cancer in patients with gallbladder polyps detected on Trans-Abdominal ultrasound.
14 Jul, 2022 | 12:14h | UTCRisk of developing gallbladder cancer in patients with gallbladder polyps detected on Trans-Abdominal ultrasound: a systematic review and Meta-Analysis – British Journal of Radiology (link to abstract – $ for full-text)
Related:
Critical Analysis of the Updated Guidelines for Management of Gallbladder Polyps – Annals of Surgical Oncology (if the link is paywalled, try this one)
RCT | Gemcitabine vs. Nab-paclitaxel combined with cisPlatin as first-line treatment in patients with metastatic triple-negative breast cancer.
14 Jul, 2022 | 12:10h | UTC
Commentary on Twitter
Gemcitabine or nab-paclitaxel in combination with cisplatin as first-line treatment in patients with metastatic triple-negative breast cancer: results of a randomized phase 3 trial.https://t.co/RKZYdLRbHq#CancerResearch @natrescancer pic.twitter.com/CrCOCJ2HMu
— Nature Communications (@NatureComms) July 13, 2022
ESMO recommendations on the use of circulating tumor DNA assays for patients with cancer.
13 Jul, 2022 | 11:38h | UTC
Genetic testing in prostate cancer management: considerations informing primary care.
13 Jul, 2022 | 11:25h | UTC
Female erectile tissues and sexual dysfunction after pelvic radiotherapy: a scoping review.
13 Jul, 2022 | 11:23h | UTC
Modern developments in germline pharmacogenomics for oncology prescribing.
13 Jul, 2022 | 11:21h | UTC
Phase II RCT | Proton craniospinal irradiation vs. photon involved-field radiotherapy for patients with solid tumor leptomeningeal metastasis.
13 Jul, 2022 | 11:09h | UTCRandomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis – Journal of Clinical Oncology (link to abstract – $ for full-text)
ASCO Living Guideline | Therapy for stage IV non–small-cell lung cancer with driver alterations.
12 Jul, 2022 | 12:46h | UTC
Commentary on Twitter
Just published in #JCO: 🫁 Updated recommendations on therapy for stage IV #NSCLC with driver alterations by @ns_chd et al 👉 https://t.co/JzrxEey4Si #lungcancer #lcsm pic.twitter.com/CFPTJIkrhK
— Journal of Clinical Oncology (@JCO_ASCO) July 11, 2022
ASCO Living Guideline | Therapy for stage IV non–small-cell lung cancer without driver alterations.
12 Jul, 2022 | 12:44h | UTC
Commentary on Twitter
Now available in #JCO: Key updated first-line recommendations on therapy for stage IV #NSCLC 🫁 without driver alterations by @ns_chd et al. ➡️ https://t.co/KovrwEtYGz #lungcancer #lcsm pic.twitter.com/iQONRkgxsj
— Journal of Clinical Oncology (@JCO_ASCO) July 11, 2022
M-A | Does it really pay-off? Comparison of lymphadenectomy versus observational approach in skin melanoma with positive sentinel node biopsy.
12 Jul, 2022 | 12:37h | UTC