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Oncology (all articles)

Addressing palliative care and end-of-life issues in patients with advanced cancer: a systematic review of communication interventions for physicians not specialized in palliative care.

20 Jul, 2022 | 11:40h | UTC

Addressing palliative care and end-of-life issues in patients with advanced cancer: a systematic review of communication interventions for physicians not specialised in palliative care – BMJ Open

 


RCT | Doxorubicin alone vs. doxorubicin with trabectedin followed by trabectedin alone as first-line therapy for metastatic or unresectable leiomyosarcoma.

20 Jul, 2022 | 11:36h | UTC

Doxorubicin alone versus doxorubicin with trabectedin followed by trabectedin alone as first-line therapy for metastatic or unresectable leiomyosarcoma (LMS-04): a randomised, multicentre, open-label phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)

 


Phase 2 RCT | Deintensified chemoradiotherapy for pretreatment Epstein-Barr Virus DNA-selected low-risk locoregionally advanced nasopharyngeal carcinoma.

19 Jul, 2022 | 12:58h | UTC

Deintensified Chemoradiotherapy for Pretreatment Epstein-Barr Virus DNA-Selected Low-Risk Locoregionally Advanced Nasopharyngeal Carcinoma: A Phase II Randomized Noninferiority Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentaries:

#VisualAbstract: Pretreatment with radiotherapy and two cycles of concurrent cisplatin may reduce toxicity in locally advanced nasopharyngeal carcinoma – Physician’s Weekly

Intensity-Modulated Radiotherapy Plus 2 Cycles of Concurrent Cisplatin Improved Low-Risk LA-NPC Outcomes – Cancer Network

 

Commentary on Twitter

 


Network M-A | Comparative effectiveness and risk of preterm birth of local treatments for cervical intraepithelial neoplasia and stage IA1 cervical cancer.

18 Jul, 2022 | 11:27h | UTC

Comparative effectiveness and risk of preterm birth of local treatments for cervical intraepithelial neoplasia and stage IA1 cervical cancer: a systematic review and network meta-analysis – The Lancet Oncology

 

Commentary on Twitter

 


Using circulating tumor DNA in colorectal cancer: current and evolving practices.

18 Jul, 2022 | 10:51h | UTC

Using Circulating Tumor DNA in Colorectal Cancer: Current and Evolving Practices – Journal of Clinical Oncology

 


A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation.

15 Jul, 2022 | 12:55h | UTC

A guide for managing patients with stage I NSCLC: deciding between lobectomy, segmentectomy, wedge, SBRT and ablation – Journal of Thoracic Disease

Part 1 – A guide to decision-making

Part 2 – Systematic review of evidence regarding resection extent in generally healthy patients

Part 3 – Systematic review of evidence regarding surgery in compromised patients or specific tumors

Part 4 – Systematic review of evidence involving SBRT and ablation

 


Guidelines on germline testing for urologic tumor syndromes.

15 Jul, 2022 | 12:49h | UTC

Guidelines on Germline Testing for Urologic Tumor Syndromes – European Urology Focus

 


Phase 2 RCT | Efficacy of preoperative mFOLFIRINOX vs. mFOLFIRINOX plus hypofractionated radiotherapy for borderline resectable adenocarcinoma of the pancreas.

15 Jul, 2022 | 12:29h | UTC

Efficacy of Preoperative mFOLFIRINOX vs mFOLFIRINOX Plus Hypofractionated Radiotherapy for Borderline Resectable Adenocarcinoma of the PancreasThe A021501 Phase 2 Randomized Clinical Trial – JAMA Oncology (free for a limited period)

Editorial: The Continued Struggle for Defining a Role for Radiotherapy in Pancreas Cancer – JAMA (free for a limited period)

News Release: Preoperative combination chemotherapy improved survival in patients with pancreatic cancer – The University of Texas MD Anderson Cancer Center

 

Commentary on Twitter

 


M-A of RCTs | Megestrol Acetate not beneficial for cancer-related anorexia/cachexia.

14 Jul, 2022 | 12:50h | UTC

A Systematic Review and Meta-Analysis of the Clinical Use of Megestrol Acetate for Cancer-Related Anorexia/Cachexia – Journal of Clinical Medicine

 


The EBMT nursing guidelines on CAR-T Therapy | A framework for patient care and managing common toxicities.

14 Jul, 2022 | 12:45h | UTC

The EBMT Immune Effector Cell Nursing Guidelines on CAR-T Therapy: A Framework for Patient Care and Managing Common Toxicities – Clinical Hematology International

 


How to treat renal cell carcinoma: the current treatment landscape and cardiovascular toxicities.

14 Jul, 2022 | 12:35h | UTC

How to Treat Renal Cell Carcinoma: The Current Treatment Landscape and Cardiovascular Toxicities – JACC: CardioOncology

Related: Clinical Outcomes and Adverse Events after First-Line Treatment in Metastatic Renal Cell Carcinoma: A Systematic Review and Network Meta-Analysis – The Journal of Urology

 


Randomized crossover trial | AI reduces miss rate of precancerous polyps in colorectal cancer screening.

14 Jul, 2022 | 12:29h | UTC

News Release: AI reduces miss rate of precancerous polyps in colorectal cancer screening – Mayo Clinic

Original Study: Impact of Artificial Intelligence on Miss Rate of Colorectal Neoplasia – Gastroenterology

 


Prevalence of cardiovascular disease in patients with potentially curable malignancies: a national registry dataset analysis.

14 Jul, 2022 | 12:33h | UTC

Prevalence of Cardiovascular Disease in Patients With Potentially Curable Malignancies: A National Registry Dataset Analysis – JACC: CardioOncology

Editorial: How Common Is Pre-Existing Cardiovascular Disease in Cancer Patients: What Do We Know? Does It Matter? – JACC: CardioOncology

 


The Global Retinoblastoma Outcome Study | A prospective, cluster-based analysis of 4,064 patients from 149 countries.

14 Jul, 2022 | 12:16h | UTC

The Global Retinoblastoma Outcome Study: a prospective, cluster-based analysis of 4064 patients from 149 countries – The Lancet Global Health

Invited Commentary: Retinoblastoma as a lens for correctable disparities worldwide – The Lancet Global Health

News Release: Children in low-income countries 16 times more likely to die from most common eye cancer – London School of Hygiene & Tropical Medicine

 


M-A | Risk of developing gallbladder cancer in patients with gallbladder polyps detected on Trans-Abdominal ultrasound.

14 Jul, 2022 | 12:14h | UTC

Risk of developing gallbladder cancer in patients with gallbladder polyps detected on Trans-Abdominal ultrasound: a systematic review and Meta-Analysis – British Journal of Radiology (link to abstract – $ for full-text)

Related:

Critical Analysis of the Updated Guidelines for Management of Gallbladder Polyps – Annals of Surgical Oncology (if the link is paywalled, try this one)

Guideline: Management and follow-up of gallbladder polyps – “If the patient has no risk factors for malignancy, and a gallbladder polypoid lesion of 5 mm or less, follow-up is not required”.

 


RCT | Gemcitabine vs. Nab-paclitaxel combined with cisPlatin as first-line treatment in patients with metastatic triple-negative breast cancer.

14 Jul, 2022 | 12:10h | UTC

A randomized phase 3 trial of Gemcitabine or Nab-paclitaxel combined with cisPlatin as first-line treatment in patients with metastatic triple-negative breast cancer – Nature Communications

 

Commentary on Twitter

 


ESMO recommendations on the use of circulating tumor DNA assays for patients with cancer.

13 Jul, 2022 | 11:38h | UTC

ESMO recommendations on the use of circulating tumour DNA assays for patients with cancer: a report from the ESMO Precision Medicine Working Group – Annals of Oncology

 


Genetic testing in prostate cancer management: considerations informing primary care.

13 Jul, 2022 | 11:25h | UTC

Genetic testing in prostate cancer management: Considerations informing primary care – CA: A Cancer Journal for Clinicians

 


Female erectile tissues and sexual dysfunction after pelvic radiotherapy: a scoping review.

13 Jul, 2022 | 11:23h | UTC

Female erectile tissues and sexual dysfunction after pelvic radiotherapy: A scoping review – CA: A Cancer Journal for Clinicians

 


Modern developments in germline pharmacogenomics for oncology prescribing.

13 Jul, 2022 | 11:21h | UTC

Modern developments in germline pharmacogenomics for oncology prescribing – CA: A Cancer Journal for Clinicians

 


Phase II RCT | Proton craniospinal irradiation vs. photon involved-field radiotherapy for patients with solid tumor leptomeningeal metastasis.

13 Jul, 2022 | 11:09h | UTC

Randomized Phase II Trial of Proton Craniospinal Irradiation Versus Photon Involved-Field Radiotherapy for Patients With Solid Tumor Leptomeningeal Metastasis – Journal of Clinical Oncology (link to abstract – $ for full-text)

 


ASCO Living Guideline | Therapy for stage IV non–small-cell lung cancer with driver alterations.

12 Jul, 2022 | 12:46h | UTC

Therapy for Stage IV Non–Small-Cell Lung Cancer With Driver Alterations: ASCO Living Guideline – Journal of Clinical Oncology

 

Commentary on Twitter

 


ASCO Living Guideline | Therapy for stage IV non–small-cell lung cancer without driver alterations.

12 Jul, 2022 | 12:44h | UTC

Therapy for Stage IV Non–Small-Cell Lung Cancer Without Driver Alterations: ASCO Living Guideline – Journal of Clinical Oncology

 

Commentary on Twitter

 


M-A | Does it really pay-off? Comparison of lymphadenectomy versus observational approach in skin melanoma with positive sentinel node biopsy.

12 Jul, 2022 | 12:37h | UTC

Does It Really Pay-Off? Comparison of Lymphadenectomy versus Observational Approach in Skin Melanoma with Positive Sentinel Node Biopsy: Systematic Review and Meta-Analysis – Journal of Clinical Medicine

 


RCT | Weekly dose-dense chemotherapy in first-line epithelial ovarian, fallopian tube, or primary peritoneal cancer treatment.

12 Jul, 2022 | 11:51h | UTC

Weekly dose-dense chemotherapy in first-line epithelial ovarian, fallopian tube, or primary peritoneal cancer treatment (ICON8): overall survival results from an open-label, randomised, controlled, phase 3 trial – The Lancet Oncology

 

Commentary on Twitter

 


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