Oncology (all articles)
Fears over a medical gold rush in cancer drug race
4 Jul, 2017 | 21:19h | UTCFears over a medical gold rush in cancer drug race – Financial Times (a few articles per month are free)
Source: Nature Newsletter
“With almost 800 trials under way observers warn scientific rigour is being compromised”
Benchmarking life expectancy and cancer mortality: global comparison with cardiovascular disease 1981-2010
3 Jul, 2017 | 17:58h | UTCEditorial: Cancer and the limits of longevity – The BMJ (free)
“Declining mortality from CVD was responsible for about half of the life expectancy gains in ages 40-84 in 1981-2010, whereas the contribution from cancer is smaller (up to one fifth) and varied depending on a country’s level of development”
Checkpoint inhibitor-related pneumonitis
3 Jul, 2017 | 17:40h | UTC
Hematopoietic cell transplantation for acute lymphoblastic leukemia in adult patients
3 Jul, 2017 | 17:41h | UTC
Long-term complications after hematopoietic cell transplantation
3 Jul, 2017 | 17:35h | UTC
Potential Drug-Drug and Herb-Drug Interactions in Patients With Cancer
3 Jul, 2017 | 17:25h | UTCPotential Drug-Drug and Herb-Drug Interactions in Patients With Cancer: A Prospective Study of Medication Surveillance – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentaries: Cancer patients should check drug list with pharmacist – Reuters Health (free) AND Cancer Patients’ Drug-to-Drug Interactions Have Consequences – Medscape (free registration required) AND Research Warns Patients of Drug-Drug and Herb-Drug Interactions – AJMC (free)
Waiting and watching with ‘Stage 0’ breast cancer put to nationwide test
3 Jul, 2017 | 15:38h | UTCWaiting and watching with ‘Stage 0’ breast cancer put to nationwide test – The Washington Post (a few articles per month are free)
“Treatment of early-stage breast cancer: is no treatment an option?” (RT @GemmaJacklyn see Tweet)
Last Month in Oncology with Dr. Bishal Gyawali
30 Jun, 2017 | 15:08h | UTCLast Month in Oncology with Dr. Bishal Gyawali: June 2017 – ecancer News (free)
“New edition of my blogs @ecancer is out focusing on studies presented at #ASCO17 (RT @oncology_bg see Tweet)
Precision Medicine: the Promise vs. the Reality
29 Jun, 2017 | 15:36h | UTCPrecision Medicine: the Promise vs. the Reality – Michigan University Health Lab (free) (RT @pash22 see Tweet)
“Scientists find great potential in using genetic sequencing to help direct targeted cancer therapy, but practicing oncologists see some important limitations”.
Variability in the diagnosis of invasive melanoma
29 Jun, 2017 | 12:38h | UTCThe BMJ Opinion: Joann Elmore: When diagnostic uncertainty hits home (free)
Commentaries: Concern over huge diagnostic variability for melanoma – OnMedica (free) Pathologists Often Misclassify Melanoma – Physician’s First Watch (free)
The ABCs and Ds of Whether to Get Prostate Cancer Screening
28 Jun, 2017 | 22:43h | UTCThe ABCs and Ds of Whether to Get Prostate Cancer Screening – The New York Times (10 articles per month are free)
See also the new USPSTF guidelines on prostate cancer screening and related commentaries in our April 12 issue (see #1) and in our April 13 issue (see #4)
Balanced point of view regarding prostate cancer screening.
A Reality Check for IBM’s AI Ambitions
28 Jun, 2017 | 17:27h | UTCA Reality Check for IBM’s AI Ambitions – MIT Technology Review (free) (RT @EricTopol see Tweet)
“IBM overhyped its Watson machine-learning system, but the company still could have the best access to the kind of data needed to make medicine much smarter”.
Diagnostic Accuracy of Fecal Immunochemical Test in Patients at Increased Risk for Colorectal Cancer
25 Jun, 2017 | 14:57h | UTCDiagnostic Accuracy of Fecal Immunochemical Test in Patients at Increased Risk for Colorectal Cancer: A Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Fecal immunochemical testing demonstrates good diagnostic accuracy for high-risk individuals – 2 minute medicine (free) AND Mixed Results with FIT Screen for High-Risk Colon Cancer – MedPage Today (free registration required)
Interview with the author: Fecal Testing Better At Detecting Colon Cancer Than Advanced Atypical Changes – MedicalResearch.com (free)
“FIT is the best alternative screening strategy for pts at increased risk for CRC who refuse to use colonoscopy” (RT @JAMAInternalMed see Tweet)
Personalized radiotherapy for invasive breast cancer in 2017
23 Jun, 2017 | 18:46h | UTC
Guidelines for the Management of Cancer of the Colon, Rectum and Anus
23 Jun, 2017 | 18:32h | UTCSpecial Issue – Homepage: Association of Coloproctology of Great Britain & Ireland (ACPGBI): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017)
1 – Introduction (free)
2 – Diagnosis, Investigations and Screening (free)
3 – Surgical Management (free)
4 – Multidisciplinary Management (free)
5 – Follow Up, Lifestyle and Survivorship (free)
6 – Audit and Outcome Reporting (free)
7 – Pathology Standards and Datasets (free)
8 – Anal Cancer (free)
Breast Cancer Risk Assessment and Screening in Average-Risk Women
23 Jun, 2017 | 01:44h | UTCCommentary: OB/GYN Group Revises Breast Screening Recommendations for Average-Risk Women Physician’s First Watch (free)
Related guideline with a more conservative approach: Breast Cancer: Screening – U.S.Preventive Services Task Force (free)
Why We Overrate the Lifesaving Power of Cancer Tests
23 Jun, 2017 | 01:01h | UTCWhy We Overrate the Lifesaving Power of Cancer Tests – Scientific American (free) (RT @EricTopol see Tweet)
Radiation Associated Cardiac Disease
23 Jun, 2017 | 01:03h | UTCReview: Radiation Associated Cardiac Disease – American College of Cardiology, Latest in Cardiology (free)
Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)
Landmark FDA approval bolsters personalized medicine
21 Jun, 2017 | 22:12h | UTCLandmark FDA approval bolsters personalized medicine – STAT News (free)
Related commentary: Cancer Drug Proves to Be Effective Against Multiple Tumors – The New York Times (free)
Original article: Mismatch-repair deficiency predicts response of solid tumors to PD-1 blockade – Science (link to abstract – $ for full-text)
Aspirin and other NSAIDs and colorectal cancer survival
21 Jun, 2017 | 18:01h | UTCTiming of Aspirin and Other Nonsteroidal Anti-Inflammatory Drug Use Among Patients With Colorectal Cancer in Relation to Tumor Markers and Survival – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentary: Study Informs NSAID Benefit in Colon Cancer – MedPage Today (free registration required)
Observational data suggests a benefit for individuals with KRAS wild-type tumors
Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers
21 Jun, 2017 | 02:16h | UTCRisks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers – JAMA (link to abstract – $ for full-text)
The JAMA Network – For the media: Study Estimates Age-Specific Overall Risk of Breast, Ovarian Cancer among Women with BRCA1/2 Genetic Mutations (free)
Commentary: Risk for Breast and Ovarian Cancer in BRCA1 and BRCA2 Mutation Carriers: Refining Our Estimates – Physician’s First Watch (free)
Top News From ASCO 2017: Slideshow
21 Jun, 2017 | 02:09h | UTCTop News From ASCO 2017: Slideshow – Medscape (free registration required)
Lean: Targeted Therapy for Care Delivery
21 Jun, 2017 | 02:09h | UTCLean: Targeted Therapy for Care Delivery – Journal of the National Comprehensive Cancer Network (free)
The possible benefits of applying the “Lean” approach to oncology care delivery.
Overuse of Chest CT in Patients With Stage I and II Breast Cancer
20 Jun, 2017 | 19:23h | UTCNews release: NCCN Guidelines Compliance for Chest CT Reduces False Positives and Decreases Health Care Spending in Breast Cancer, Study Finds (free)
In this cohort 11% of patients with stage I and 36% of patients with stage II breast cancer underwent chest CT, despite NCCN Guidelines against the exam. “Nearly one-third of these patients were found to have pulmonary nodules, but only 1.3% were ever diagnosed with pulmonary metastases”
New colorectal cancer screening guidelines
20 Jun, 2017 | 19:51h | UTCCommentaries: Task Force presents new ranking of colorectal cancer screening tests – American Society of Gastrointestinal Endoscopy, via EurekAlert (free) AND Latest Colorectal Cancer Screening Guidelines – Latest Colorectal Cancer Screening Guidelines – GI and Hepatology News (free)
Related: Colorectal Cancer Screening – U.S. Preventive Services Task Force (free)