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Oncology – Breast

M-A | Treatment-related adverse events associated with HER2-Targeted antibody-drug conjugates in clinical trials

9 Feb, 2023 | 13:37h | UTC

Treatment-related adverse events associated with HER2-Targeted antibody-drug conjugates in clinical trials: A systematic review and meta-analysis – eClinicalMedicine

 


Cohort Study | Risk of primary hematologic cancers following incident non-metastatic breast cancer

8 Feb, 2023 | 12:11h | UTC

Risk of primary haematologic cancers following incident non-metastatic breast cancer: A Danish population-based cohort study – Cancer Epidemiology

 


M-A | Risk of second primary cancer among breast cancer patients

6 Feb, 2023 | 13:10h | UTC

Risk of second primary cancer among breast cancer patients: A systematic review and meta-analysis – Frontiers in Oncology

 


SR | Partial breast irradiation for breast cancer

3 Feb, 2023 | 14:06h | UTC

Partial Breast Irradiation for Breast Cancer – Agency for Healthcare Research and Quality

 


SR | Immediate breast reconstruction uptake in older women with primary breast cancer

1 Feb, 2023 | 13:04h | UTC

Immediate breast reconstruction uptake in older women with primary breast cancer: systematic review – British Journal of Surgery

 


Perspective | Endocrine treatment for 5 years or radiation for 5 days for patients with early breast cancer older than 65 years

26 Jan, 2023 | 12:04h | UTC

Endocrine Treatment for 5 Years or Radiation for 5 Days for Patients With Early Breast Cancer Older Than 65 Years: Can We Do It Right? – Journal of Clinical Oncology

 

Commentary from the author on Twitter

 


RCT | Breast-cancer–related lymphedema after reverse lymphatic mapping and selective axillary dissection vs. standard surgical treatment of axilla

24 Jan, 2023 | 14:15h | UTC

Occurrence of breast-cancer–related lymphedema after reverse lymphatic mapping and selective axillary dissection versus standard surgical treatment of axilla: A two-arm randomized clinical trial – Cancer

 

Commentary on Twitter

 


RCT | Abemaciclib plus endocrine therapy for hormone receptor-positive, HER2-negative, node-positive, high-risk early breast cancer

20 Jan, 2023 | 14:20h | UTC

Abemaciclib plus endocrine therapy for hormone receptor-positive, HER2-negative, node-positive, high-risk early breast cancer (monarchE): results from a preplanned interim analysis of a randomised, open-label, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentaries:

Interim Analysis of Overall Survival in the monarchE Trial – The ASCO Post

 

Commentary on Twitter

 


Review | Role of immunotherapy in breast cancer

18 Jan, 2023 | 14:03h | UTC

Role of Immunotherapy in Breast Cancer – JCO Oncology Practice

 


RCT | Cosmetic results and side effects of accelerated partial-breast irradiation vs. whole-breast irradiation for low-risk invasive carcinoma of the breast

15 Jan, 2023 | 19:53h | UTC

Cosmetic Results and Side Effects of Accelerated Partial-Breast Irradiation Versus Whole-Breast Irradiation for Low-Risk Invasive Carcinoma of the Breast: The Randomized Phase III IRMA Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)

 

Commentary from the author on Twitter

 


ASCO Guideline Update | Chemotherapy and targeted therapy for endocrine-pretreated or hormone receptor–negative metastatic breast cancer

13 Jan, 2023 | 13:28h | UTC

Chemotherapy and Targeted Therapy for Endocrine-Pretreated or Hormone Receptor–Negative Metastatic Breast Cancer: ASCO Guideline Rapid Recommendation Update – Journal of Clinical Oncology

 


Cohort Study | Contralateral breast cancer risk among carriers of germline pathogenic variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2

13 Jan, 2023 | 13:14h | UTC

Contralateral Breast Cancer Risk Among Carriers of Germline Pathogenic Variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2 – Journal of Clinical Oncology

Commentary: Incidence of Contralateral Breast Cancers Among Pathogenic Variant Carriers Could Guide Management Decisions – ASCO Daily News

 


Post-trial follow-up | Fluorouracil and dose-dense adjuvant chemotherapy in patients with early-stage breast cancer.

15 Dec, 2022 | 13:29h | UTC

Fluorouracil and dose-dense adjuvant chemotherapy in patients with early-stage breast cancer (GIM2): end-of-study results from a randomised, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Dose-Dense Adjuvant Chemotherapy “Optimal” for High-Risk Early Breast Cancer – Cancer Therapy Advisor

Original Study: Fluorouracil and dose-dense chemotherapy in adjuvant treatment of patients with early-stage breast cancer: an open-label, 2 × 2 factorial, randomised phase 3 trial – The Lancet

 

Commentary on Twitter

 


Post-trial follow-up | Radiotherapy vs. surgery of the axilla after a positive sentinel node in breast cancer.

14 Dec, 2022 | 14:42h | UTC

Radiotherapy or Surgery of the Axilla After a Positive Sentinel Node in Breast Cancer: 10-Year Results of the Randomized Controlled EORTC 10981-22023 AMAROS Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentary: ART Preferred Over ALND in Sentinel Node-Positive Early Breast Cancer – Cancer Therapy Advisor

 


RCT | Mepitel film for the prevention of acute radiation dermatitis in breast cancer.

12 Dec, 2022 | 12:40h | UTC

Mepitel Film for the Prevention of Acute Radiation Dermatitis in Breast Cancer: A Randomized Multicenter Open-Label Phase III Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)


RCT | Trastuzumab deruxtecan vs. trastuzumab emtansine in patients with HER2-positive metastatic breast cancer.

8 Dec, 2022 | 12:49h | UTC

Trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer: updated results from DESTINY-Breast03, a randomised, open-label, phase 3 trial – The Lancet

 


Post-trial follow-up | Long-term outcomes of adjuvant denosumab in breast cancer.

22 Nov, 2022 | 13:14h | UTC

Long-Term Outcomes of Adjuvant Denosumab in Breast Cancer – NEJM Evidence 

Original Study: Adjuvant denosumab in breast cancer (ABCSG-18): a multicentre, randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text) 

 


18F-sodium fluoride PET–CT vs. 99mTc bone scintigraphy with SPECT in patients with prostate cancer or breast cancer.

22 Nov, 2022 | 13:09h | UTC

Intra-individual comparison of 18F-sodium fluoride PET–CT and 99mTc bone scintigraphy with SPECT in patients with prostate cancer or breast cancer at high risk for skeletal metastases (MITNEC-A1): a multicentre, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text) 

Commentary: 18F-NaF PET-CT More Accurate Than 99mTc-MDP SPECT for Detecting Bone Metastasis – Cancer Therapy Advisor 

 


Cohort Study | Use of breast cancer risk factors may identify risk-adapted starting age of screening.

18 Nov, 2022 | 13:16h | UTC

Use of Breast Cancer Risk Factors to Identify Risk-Adapted Starting Age of Screening in China – JAMA Network Open

Invited Commentary: Risk-Based Approaches to Breast Cancer Screening in China – JAMA Network Open

 

Commentary on Twitter

https://twitter.com/JAMANetworkOpen/status/1590766235989708801

 


Phase 2 RCT | Non-hormonal drug reduces vasomotor symptoms in women taking oral adjuvant endocrine therapy after breast cancer.

15 Nov, 2022 | 12:58h | UTC

Q-122 as a novel, non-hormonal, oral treatment for vasomotor symptoms in women taking tamoxifen or an aromatase inhibitor after breast cancer: a phase 2, randomised, double-blind, placebo-controlled trial – The Lancet

Commentary: Non-hormonal therapy reduces hot flashes and night sweats in women who have been diagnosed with breast cancer – Monash University 

 


RCT | Comparison of acupuncture vs. sham acupuncture in the treatment of aromatase inhibitor–related joint pain.

15 Nov, 2022 | 12:47h | UTC

Comparison of Acupuncture vs Sham Acupuncture or Waiting List Control in the Treatment of Aromatase Inhibitor–Related Joint Pain: A Randomized Clinical Trial – JAMA Network Open

Commentary: Aromatase inhibitors and acupuncture in breast cancer: Spinning a negative study, four years later – Science-based Medicine

 

Commentary on Twitter

https://twitter.com/JAMANetworkOpen/status/1591113526222913538

 


Cohort Study | Association of Taxane type with chemotherapy-induced peripheral neuropathy in patients with breast cancer.

4 Nov, 2022 | 13:15h | UTC

Association of Taxane Type With Patient-Reported Chemotherapy-Induced Peripheral Neuropathy Among Patients With Breast Cancer – JAMA Network Open 

 


Single-arm P2 study | Eliminating breast surgery for invasive breast cancer in exceptional responders to neoadjuvant systemic therapy.

2 Nov, 2022 | 14:23h | UTC

Eliminating breast surgery for invasive breast cancer in exceptional responders to neoadjuvant systemic therapy: a multicentre, single-arm, phase 2 trial – The Lancet Oncology (link to abstract – $ for full-text)

News Release: Some breast cancer patients with high responses to chemotherapy may not need surgery: Biopsy protocol identifies patients at low risk of recurrence – University of Texas M. D. Anderson Cancer Center

Commentary: Elimination of Surgery Explored for Selected Breast Cancer Patients – HealthDay

 

Commentary on Twitter

 


Risk reduction and screening of cancer in hereditary breast-ovarian cancer syndromes: ESMO Clinical Practice Guideline.

31 Oct, 2022 | 13:50h | UTC

Risk reduction and screening of cancer in hereditary breast-ovarian cancer syndromes: ESMO Clinical Practice Guideline – Annals of Oncology

 


Nonsurgical options for risk reduction of contralateral breast cancer in BRCA mutation carriers with early breast cancer.

31 Oct, 2022 | 13:41h | UTC

Nonsurgical Options for Risk Reduction of Contralateral Breast Cancer in BRCA Mutation Carriers With Early-Stage Breast Cancer – Journal of Clinical Oncology (free for a limited period)

 


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