Nephrology
UK Guidelines for Living Donor Kidney Transplantation
27 Apr, 2018 | 01:11h | UTC
Guideline: Diagnosis and Management of Primary Aldosteronism
23 Apr, 2018 | 21:17h | UTCDiagnosis and Management of Primary Aldosteronism: the Endocrine Society guideline 2016 revisited – European Journal of Endocrinology (free)
Hypokalemia: A Clinical Update
23 Apr, 2018 | 21:16h | UTCHypokalemia: a clinical update – Endocrine Connections (free)
Cohort Study: Relationship between Clinic and Ambulatory Blood-Pressure Measurements and Mortality
20 Apr, 2018 | 02:02h | UTCEditorial: The Value in an Ambulatory Blood-Pressure Registry (free)
Commentaries: Value of Ambulatory BP Monitoring Bolstered by Large Study – TCTMD (free) AND 24-hour ambulatory BP measurements strongly predict mortality – The Hospitalist (free) AND Expert reaction to study looking at blood pressure measurement method and predicting risk of heart disease – Science Media Centre (free)
Research: Association of Repeated Measurements With Blood Pressure Control in Primary Care
20 Apr, 2018 | 01:43h | UTCAssociation of Repeated Measurements With Blood Pressure Control in Primary Care – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Repeat BP Measurements in the Office Are Key, Study Highlights – TCTMD (free) AND Should Blood Pressure Measurement Be Repeated During Primary Care Visit? – MedicalResearch.com (free) AND Second BP Measurement Often Brings Better News – MedPage Today (free registration required) AND Repeated BP Measures Linked to Drop in Initially Elevated BP – Physician’s Weekly (free)
Systematic Review: First-line Drugs for Hypertension
20 Apr, 2018 | 01:34h | UTCFirst-line drugs for hypertension – Cochrane Library (free)
Summary: Thiazides best first choice for hypertension – Cochrane Library (free)
“First-line low-dose thiazides reduced all morbidity and mortality outcomes in adult patients with moderate to severe primary hypertension. First-line ACE inhibitors and calcium channel blockers may be similarly effective, but the evidence was of lower quality”.
Perspective: Incremental Benefits and Harms of the 2017 ACC/AHA High Blood Pressure Guideline
18 Apr, 2018 | 01:03h | UTCIncremental Benefits and Harms of the 2017 American College of Cardiology/American Heart Association High Blood Pressure Guideline – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: New blood pressure guidelines may make millions anxious that they’re at risk of heart disease – The Conversation (free) AND New blood pressure guidelines could put lives at risk – The University of Sydney (free)
Related: AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free) AND The Hypertension Guideline War Is Not A Fake War – Cardiobrief (free) AND Redefining Hypertension: Assessing the New Blood-Pressure Guidelines – New England Journal of Medicine (free)
Meta-Analysis of Observational Studies: Proton Pump Inhibitors are Associated with Increased Risk of Kidney Disease
16 Apr, 2018 | 16:54h | UTCAcid‐suppressive drugs and risk of kidney disease: A systematic review and meta‐analysis – Journal of Gastroenterology and Hepatology (link to abstract – $ for full-text)
Source: Hospital Medicine Virtual Journal Club
Proton pump inhibitors were associated with higher risks of acute interstitial nephritis (HR, 2.78; 95% CI, 1.25‐6.17), acute kidney injury (HR, 1.85; 95% CI, 1.33‐2.59), chronic kidney disease (HR, 1.47; 95% CI, 1.03‐2.09), and end‐stage renal disease (HR, 1.61; 95% CI, 1.26‐2.04) than non‐PPI therapy. Similar risks were not identified for H2RA therapy.
Cohort study: time for chronic dialysis initiation and mortality
12 Apr, 2018 | 02:11h | UTCDialysis Initiation and Mortality Among Older Veterans With Kidney Failure Treated in Medicare vs the Department of Veterans Affairs – JAMA Internal Medicine (free for a limited period)
Invited commentary: Appropriate Time for Chronic Dialysis Initiation: A Cause for Humility (free for a limited period)
Related articles: Treatment decisions for older adults with advanced chronic kidney disease – BMC Nephrology (free) AND Timing of Dialysis Initiation – What Has Changed Since IDEAL? – Seminars in Nephrology (free)
Review: hyperchloraemia in sepsis
5 Apr, 2018 | 18:32h | UTCHyperchloraemia in sepsis – Annals of Intensive Care (free)
Source: Critical Care Reviews Newsletter
Meta-Analysis: Blood pressure-lowering treatment strategies based on cardiovascular risk versus blood pressure
23 Mar, 2018 | 01:57h | UTCRelated study with similar conclusions: Impact of Cardiovascular Risk on the Relative Benefit and Harm of Intensive Treatment of Hypertension – Journal of the American College of Cardiology (link to abstract – $ for full-text)
“An intelligent approach towards blood pressure management: by the individual’s risk instead of just their measurements” (via @EricTopol see Tweet)
Research: Direct-Acting Antiviral Prophylaxis in Kidney Transplantation From Hepatitis C Virus–Infected Donors to Noninfected Recipients
23 Mar, 2018 | 01:52h | UTCCommentaries: HCV Prophylaxis Could Expand Kidney Availability – Renal & Urology News (free) AND HCV-infected kidney donors could save lives – 2 Minute Medicine (free) AND One year posttransplant, recipients of hepatitis C kidneys disease-free – Johns Hopkins Medicine, ScienceDaily (free)
Research: Cardiovascular and renal burdens of prediabetes
22 Mar, 2018 | 23:58h | UTCCardiovascular and renal burdens of prediabetes in the USA: analysis of data from serial cross-sectional surveys, 1988–2014 – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries: Slightly elevated blood sugar tied to heart and kidney problems – Reuters (free) AND Study finds prediabetes patients at heightened risk for cardiovascular and chronic kidney diseases – MedicalXpress (free)
Viewpoint: Individualizing Blood Pressure Targets for People With Diabetes and Hypertension
22 Mar, 2018 | 23:43h | UTCViewpoint: Individualizing Blood Pressure Targets for People With Diabetes and Hypertension: Comparing the ADA and the ACC/AHA Recommendations – JAMA (free for a limited period)
Research: Low-Dose ‘Triple Pill’ Lowers Blood Pressure More Than Usual Care
16 Mar, 2018 | 03:36h | UTC#ACC18 – Low-Dose ‘Triple Pill’ Lowers Blood Pressure More Than Usual Care – American College of Cardiology (free) AND Low-Dose, Three-Drug Polypill TRIUMPHs for Blood Pressure – TCTMD (free)
Meta-Analysis: Dialysis Modality Survival Comparison
16 Mar, 2018 | 02:40h | UTCEditorial: Dialysis Modality Survival Comparison: Time to End the Debate, It’s a Tie – American Journal of Kidney Diseases (free)
Related commentary: PD or HD: Which Road Do We Take? – AJKD Blog (free)
Original article: Comparison of Patient Survival Between Hemodialysis and Peritoneal Dialysis Among Patients Eligible for Both Modalities – American Journal of Kidney Diseases (link to abstract – $ for full-text)
Source: Hemodialysis vs. Peritoneal Dialysis for End-Stage Renal Disease – NEJM Journal Watch ($)
Chronic kidney disease and arrhythmias
16 Mar, 2018 | 02:27h | UTC
Predicting acute kidney injury: current status and future challenges
16 Mar, 2018 | 01:04h | UTCPredicting acute kidney injury: current status and future challenges – Journal of Nephrology (free)
Source: Critical Care Reviews Newsletter
Research: Healthy diet may not offset high salt intake
8 Mar, 2018 | 21:33h | UTCRelation of Dietary Sodium (Salt) to Blood Pressure and Its Possible Modulation by Other Dietary Factors: The INTERMAP Study – Hypertension (link to abstract – $ for full-text)
Commentaries: Healthy diet may not offset high salt intake – Imperial College London (free) AND Dietary sodium’s impact may not be offset by other aspects of a diet – AHA / ASA Newsroom (free)
Research: Comparative cardiovascular safety of non-steroidal anti-inflammatory drugs in patients with hypertension
8 Mar, 2018 | 20:44h | UTCComparative cardiovascular safety of non-steroidal anti-inflammatory drugs in patients with hypertension: a population-based cohort study – British Journal of Clinical Pharmacology (link to abstract – $ for full-text)
Commentary: Cardiovascular Risk Compared Among COX-2 Selective, Nonselective NSAIDs – MPR (free)
Points of Concern in Post Acute Kidney Injury Management
8 Mar, 2018 | 20:21h | UTCPoints of Concern in Post Acute Kidney Injury Management – Nephron (free)
Source: Critical Care Reviews Newsletter
Reviews: Post-Contrast Acute Kidney Injury
8 Mar, 2018 | 20:18h | UTCSource: Critical Care Reviews Newsletter
Balanced Crystalloids vs Saline in Hospitalized Patients
2 Mar, 2018 | 02:10h | UTCBalanced Crystalloids versus Saline in Critically Ill Adults – New England Journal of Medicine (free)
Related article: Balanced Crystalloids versus Saline in Noncritically Ill Adults – New England Journal of Medicine (free)
Commentary: Balanced Crystalloids May Be Better Than Saline for Critically Ill Patients – NEJM Physician’s First Watch (free)
“Balanced crystalloids may be superior to saline in critically ill patients — but not in patients hospitalized outside an ICU” (from Physician’s First Watch)
Research: Efficacy of self-monitored blood pressure for titration of antihypertensive medication
2 Mar, 2018 | 01:53h | UTCCommentaries: Hypertension: time for doctors to switch the driver’s seat? (free) AND Should home-based blood pressure monitoring be commonplace in NHS? – University of Oxford News & Events (free)
“Self-monitoring, with or without telemonitoring, when used by general practitioners to titrate antihypertensive medication in individuals with poorly controlled blood pressure, leads to significantly lower blood pressure than titration guided by clinic readings”.
Research: Spironolactone Vs Clonidine for Resistant Hypertension
2 Mar, 2018 | 00:54h | UTCCommentary: Spironolactone bests clonidine as fourth drug for resistant hypertension – Univadis (free registration required)