Nephrology
[Abstracts Only] Randomized Trials: Evaluation of New Treatment for Anemia of Chronic Kidney
27 Jul, 2019 | 13:55h | UTCRoxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis – New England Journal of Medicine (link to abstract – $ for full-text)
Related Study: Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis- New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Roxadustat Effective in Correcting Anemia in Nondialysis CKD and Dialysis – Renal & Urology News (free) AND New Oral Agent for Anemia in CKD Encouraging but Questions Remain – Medscape (free registration required)
Meta-Analysis: Impact of Furosemide on Mortality and the Requirement for Renal Replacement Therapy in Acute Kidney Injury
26 Jul, 2019 | 00:45h | UTC
Review: Renal Replacement Therapy in the Critical Care Setting
25 Jul, 2019 | 01:51h | UTCRenal Replacement Therapy in the Critical Care Setting – Critical Care Research and Practice (free)
Related Meta-Analysis: Early Initiation of Renal Replacement Therapy in Critically Ill Patients (free)
Related Randomized Trial: Early vs. Delayed Dialysis in Acute Kidney Injury (link to abstract and commentaries)
Source: Critical Care Reviews Newsletter
Guideline on Peri- and Postoperative Care of Arteriovenous Fistulas and Grafts for Hemodialysis in Adults
23 Jul, 2019 | 01:58h | UTC
[Abstract Only] Pilot Study Suggests High-dose Spironolactone May Be Effective in Diuretic-Resistant Heart Failure
21 Jul, 2019 | 20:47h | UTCHigh-Dose Spironolactone When Patients With Acute Decompensated Heart Failure Are Resistant to Loop Diuretics: A Pilot Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: High-Dose Spironolactone Effective in Diuretic-Resistant Heart Failure – NEJM Journal Watch (free)
Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline
20 Jul, 2019 | 18:35h | UTCBuffered solutions versus 0.9% saline for resuscitation in critically ill adults and children – Cochrane Library (free)
Summary: Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children – Cochrane Library (free)
Related Meta-Analysis: Choice of Intravenous Crystalloid Fluid and Mortality in Critically Ill Adult Patients – Southern Medical Journal (link to abstract – $ for full-text)
Related Randomized Trials: Balanced Crystalloids vs Saline in Hospitalized Patients (free studies and commentary)
“The three ongoing studies once published and assessed may alter the conclusions of the review.”
[Abstract Only] Meta-Analysis: Benefits and Harms of Oral Anticoagulant Therapy in Chronic Kidney Disease
16 Jul, 2019 | 09:43h | UTCBenefits and Harms of Oral Anticoagulant Therapy in Chronic Kidney Disease: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Non-vitamin K oral anticoagulants appear superior to vitamin K antagonists in early-stage CKD – ACP Internist (free) AND Evidence Favors NOACs for Anticoagulation in Early Chronic Kidney Disease – NEJM Journal Watch (free)
Meta-analysis: Hemodynamic Goal-directed Therapy and Postoperative Kidney Injury
16 Jul, 2019 | 09:21h | UTC
[Abstract Only] Meta-Analysis: Balanced Crystalloids Do Not Improve Outcomes When Compared with Normal Saline in Critically Ill Patients
14 Jul, 2019 | 19:13h | UTCChoice of Intravenous Crystalloid Fluid and Mortality in Critically Ill Adult Patients – Southern Medical Journal (link to abstract – $ for full-text)
Related Randomized Trials: Balanced Crystalloids vs Saline in Hospitalized Patients (free studies and commentary)
Source: Hospital Medicine Virtual Journal Club
Consensus Statement on Renal Denervation
14 Jul, 2019 | 19:00h | UTCJoint UK societies’ 2019 consensus statement on renal denervation – Heart (free)
Quality Improvement Goals for Acute Kidney Injury
11 Jul, 2019 | 10:15h | UTC
Related Commentary on Twitter
Quality Improvement Goals for Acute Kidney Injury: "The AKI care process starts with the community, continues in the hospital, and ends in community, and each of these phases requires specific intervention." https://t.co/V4nkKQLZuL #FridayReads #ICYMI #AKI
— Crit Care Nephrology (@CCCNPitt) May 24, 2019
[Abstract Only] Study: Directly Observed Therapy May Identify Nonadherence in Patients with Apparent Treatment-Resistant Hypertension
8 Jul, 2019 | 10:03h | UTCUse of Directly Observed Therapy to Assess Treatment Adherence in Patients With Apparent Treatment-Resistant Hypertension – JAMA Internal Medicine (free link for a limited period)
Commentaries: Directly Observed Therapy Effective for Treatment-Resistant Hypertension – Clinical Advisor (free) AND Think it’s treatment-resistant hypertension? Your eyes need to DOT (directly observe therapy) – Univadis (free registration required)
Related Commentary on Twitter
Nonadherence to BP-lowering drug regimens is high among referred patients with apparent treatment-resistant hypertension https://t.co/BTzKLTuYwi
— JAMA Internal Medicine (@JAMAInternalMed) June 22, 2019
Hypertension in CKD: Core Curriculum 2019
5 Jul, 2019 | 02:38h | UTCHypertension in CKD: Core Curriculum 2019 – American Journal of Kidney Diseases (free) (via @Abraham_RMI)
Related: KDOQI US Commentary on the 2017 ACC/AHA Hypertension Guideline – American Journal of Kidney Diseases (free)
[Abstract Only] Randomized Trial: Treatments for Membranous Nephropathy Compared
4 Jul, 2019 | 11:09h | UTCRituximab or Cyclosporine in the Treatment of Membranous Nephropathy – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Study Finds Rituximab Noninferior to Cyclosporine for Membranous Nephropathy – Center for Biosimilars (free)
Cohort Study: Association of Initiation of Maintenance Dialysis with Functional Status and Caregiver Burden
4 Jul, 2019 | 10:40h | UTCCommentaries: Functional Decline Seen in Many Older Adults Initiating Dialysis – Renal & Urology News (free) AND Many Older Patients Initiating Dialysis Experience Functional Decline – American Society of Nephrology (free) AND Starting Dialysis Worse Than ‘Being Hit by a Silent Freight Train’ – Medscape (free registration required)
Portuguese Guidelines in Peritoneal Dialysis
3 Jul, 2019 | 06:01h | UTCCurrent guidelines in peritoneal dialysis – Part I – Portuguese Journal of Nephrology & Hypertension (free PDF)
Part II: Current guidelines in peritoneal dialysis (free PDF)
Estimation of Kidney Function in Oncology
30 Jun, 2019 | 17:47h | UTC“In one retrospective study, approximately one half of kidney function–impaired patients with solid tumors who were receiving a drug that necessitated dose adjustments for kidney function received almost 50% of their prescriptions at standard doses”.
[Abstract Only] Cohort Study: Kidney Donors with Hypertension Have a Higher Risk of Kidney Failure
26 Jun, 2019 | 00:39h | UTCRisk of ESKD in Older Live Kidney Donors with Hypertension – Clinical Journal of the American Society of Nephrology (link to abstract – $ for full-text)
Commentary: Higher Risk of Kidney Failure in Older Donors With Hypertension – Medscape (free registration required)
Related Commentary on Twitter
#Hypertension linked to a 3-6X higher risk of older living #kidneydonors developing #kidneyfailure. New study in @CJASN by @fawazalammary et al. https://t.co/zuzQJKY0Fi https://t.co/RG2yMP0bqS@HopkinsMedicine @ASNKidney pic.twitter.com/oCm0C9S6B5
— Hopkins Med News (@HopkinsMedNews) June 25, 2019
Physiology and Pathophysiology of Potassium Homeostasis
25 Jun, 2019 | 06:31h | UTC
Meta-analysis: Effects of Treatment of Metabolic Acidosis in CKD
24 Jun, 2019 | 01:06h | UTCRelated: Sodium Bicarbonate for Metabolic Acidosis Slows CKD Progression – Renal & Urology News (free)
Metabolic Acidosis in CKD: Core Curriculum 2019
24 Jun, 2019 | 01:05h | UTCMetabolic Acidosis in CKD: Core Curriculum 2019 – American Journal of Kidney Diseases (free)
[Abstract Only] Randomized Trial: In Patients Undergoing Cardiac Surgery, A Restrictive Transfusion Approach Does Not Increase the Risk of Acute Kidney Injury
21 Jun, 2019 | 08:15h | UTCSafety of a Restrictive versus Liberal Approach to Red Blood Cell Transfusion on the Outcome of AKI in Patients Undergoing Cardiac Surgery: A Randomized Clinical Trial – Journal of the American Society of Nephrology (link to abstract – $ for full-text)
Commentary: Restrictive Approach to Blood Cell Transfusions Safe for Heart Surgery Patients – American Society of Nephrology (free)
Related: Effects of restrictive red blood cell transfusion on the prognoses of adult patients undergoing cardiac surgery: a meta-analysis of randomized controlled trials – Critical Care (free) AND Research: Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery (free study and commentaries) AND Transfusion Requirements After Cardiac Surgery: The TRACS Randomized Controlled Trial – JAMA (free)
Blood Pressure in Chronic Kidney Disease: Conclusions from a KDIGO Controversies Conference
17 Jun, 2019 | 01:50h | UTC
[Abstract Only] Randomized Trial: SGLT2 Inhibitor Reduces Adverse Renal Events in Patients with Type 2 Diabetes and Nephropathy
14 Jun, 2019 | 06:49h | UTCCanagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation – CREDENCE – American College of Cardiology (free)
[Abstract Only] Meta-analysis: Cardiovascular Events and Mortality in White Coat Hypertension
11 Jun, 2019 | 03:33h | UTCCardiovascular Events and Mortality in White Coat Hypertension: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: People with Untreated “White Coat Hypertension” Twice as Likely to Die from Heart Disease – Penn Medicine (free) AND Untreated white-coat hypertension associated with increased cardiovascular and mortality risk – ACP Internist (free) AND Patients whose blood pressure only spikes at the doctor’s office are twice as likely to die of a heart attack or other cardiac event – STAT (free)