Open access
Open access
Powered by Google Translator Translator

Nephrology

RCT: Efficacy and safety of Difelikefalin in patients with moderate to severe pruritus receiving hemodialysis.

9 May, 2022 | 01:21h | UTC

Efficacy and Safety of Difelikefalin in Japanese Patients With Moderate to Severe Pruritus Receiving Hemodialysis: A Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 

Guideline: Management of hypertension in patients with diabetic kidney disease.

5 May, 2022 | 10:18h | UTC

Management of Hypertension in Patients With Diabetic Kidney Disease: Summary of the Joint Association of British Clinical Diabetologists and UK Kidney Association (ABCD-UKKA) Guideline 2021 – Kidney International Reports

 

Systematic Review: Immunosuppressive treatment for focal segmental glomerulosclerosis in adults.

5 May, 2022 | 10:03h | UTC

Summary: Immunosuppressive treatment for focal segmental glomerulosclerosis in adults – Cochrane Library

Original Study: Interventions for focal segmental glomerulosclerosis in adults – Cochrane Library

 

Review: Epidemiology of hemodialysis outcomes.

5 May, 2022 | 10:00h | UTC

Epidemiology of haemodialysis outcomes – Nature Reviews Nephrology (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Bring it on: Top five antimicrobial stewardship challenges in transplant infectious diseases and practical strategies to address them.

29 Apr, 2022 | 10:51h | UTC

Bring it on: Top five antimicrobial stewardship challenges in transplant infectious diseases and practical strategies to address them – Antimicrobial Stewardship & Healthcare Epidemiology

 

Commentary on Twitter

Under a http://creativecommons.org/licenses/by/4.0/ license

 

Study Commentary | People of all ages benefit from drugs to lower blood pressure.

29 Apr, 2022 | 08:18h | UTC

People of all ages benefit from drugs to lower blood pressure – National Institute for Health and Care Research

Original Study: Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis – The Lancet

 

Guideline: Management of small renal masses.

28 Apr, 2022 | 10:36h | UTC

Canadian Urological Association guideline: Management of small renal masses – Canadian Urological Association Journal

See also: Summary of Recommendations

 

International guidelines for hypertension: resemblance, divergence and inconsistencies.

27 Apr, 2022 | 07:41h | UTC

International Guidelines for Hypertension: Resemblance, Divergence and Inconsistencies – Journal of Clinical Medicine

 

Conclusions from a controversies conference: genetics in chronic kidney disease.

26 Apr, 2022 | 07:53h | UTC

Genetics in chronic kidney disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference – Kidney International

 

An observational study in patients with chronic kidney disease suggests the optimum range of water intake is around 1–2 L/day.

18 Apr, 2022 | 10:12h | UTC

Water intake and progression of chronic kidney disease: the CKD-REIN cohort study – Nephrology Dialysis Transplantation

 

M-A: Symptom burden and health-related quality of life in chronic kidney disease.

14 Apr, 2022 | 08:22h | UTC

Symptom burden and health-related quality of life in chronic kidney disease: A global systematic review and meta-analysis – PLOS Medicine

 

M-A: Sodium-glucose Cotransporter 2 inhibitors are associated with reduced risk of hyperkalemia in people with type 2 diabetes.

13 Apr, 2022 | 10:52h | UTC

Sodium-glucose Cotransporter 2 Inhibitors and Risk of Hyperkalemia in People with Type 2 diabetes: A Meta-analysis of Individual Participant Data from Randomized Controlled Trials – Circulation

 

Review | Less is more: deprescribing medications in older adults with kidney disease.

13 Apr, 2022 | 10:44h | UTC

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Related:

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review.

AGA clinical practice update on de-prescribing of proton pump inhibitors.

Development of a metric to detect and decrease low-value prescribing in older adults.

Cluster Randomized Clinical Trial: An electronic decision support system for deprescribing in hospitalized older adults was safe and led to improvements in deprescribing but did not reduce adverse drug events.

Systematic Review: Quantifying anticholinergic burden and sedative load in older adults with polypharmacy.

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines.

Systematic review: Prescribing practices, patterns, and potential harms in patients receiving palliative care – “many patients receiving palliative care receive multiple medications closer to the time of death”.

A narrative review of evidence to guide deprescribing among older adults.

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens.

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt internationa

Eliminating Medication Overload: A National Action Plan

Deprescribing in Older Adults With Cardiovascular Disease – Journal of the American College of Cardiology

Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)

 

Cluster RCT: A multifaceted intervention did not reduce catheter related bloodstream infections in patients on hemodialysis.

13 Apr, 2022 | 10:29h | UTC

Multifaceted intervention to reduce haemodialysis catheter related bloodstream infections: REDUCCTION stepped wedge, cluster randomised trial – The BMJ

 

Overview of diagnostic criteria and epidemiology of acute kidney injury and acute kidney disease in the critically ill patient.

12 Apr, 2022 | 08:30h | UTC

Overview of Diagnostic Criteria and Epidemiology of Acute Kidney Injury and Acute Kidney Disease in the Critically Ill Patient – Clinical Journal of the American Society of Nephrology

 

Interventions for treating catheter‐related bloodstream infections in people receiving maintenance hemodialysis.

8 Apr, 2022 | 10:18h | UTC

Interventions for treating catheter‐related bloodstream infections in people receiving maintenance haemodialysis – Cochrane Library

Summary: Interventions for treating catheter-related bloodstream infections in people receiving maintenance haemodialysis – Cochrane Library

 

Study Commentary | Back to BaSICS (study that compared balanced solution vs. 0.9% saline solution in critically ill patients).

8 Apr, 2022 | 10:09h | UTC

Back to BaSICS – Annals of Emergency Medicine

Original Studies:

BaSICS RCT: Among critically ill patients requiring fluid therapy, treatment with a balanced solution did not lead to reduced mortality compared to a 0.9% saline solution.

BaSICS RCT: Among critically ill patients requiring fluid therapy, there was no difference in mortality with slower (333 mL/h) vs. faster (999 mL/h) intravenous fluid bolus rates.

Related:

Perspective: The ongoing saga of normal saline vs. balanced fluids.

RCT: In critically ill adults, using a balanced multielectrolyte solution did not lower the risk of death or acute kidney injury compared to standard saline.

Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis – NEJM Evidence

Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline

 

Current applications and limitations of European guidelines on blood pressure measurement: implications for clinical practice.

8 Apr, 2022 | 09:56h | UTC

Current applications and limitations of European guidelines on blood pressure measurement: implications for clinical practice – Internal and Emergency Medicine

Related:

Randomized Diagnostic Study: home blood pressure measurements correlate better with 24-h ambulatory monitoring measurements compared to clinic, and kiosk measurements.

Practice guidelines for office and out-of-office blood pressure measurement.

Study suggests a 30-second interval between automated office blood pressure measurements is as accurate and reliable as a 60-second interval.

USPSTF Statement recommends screening for hypertension in adults 18 years or older with office blood pressure measurement – diagnostic confirmation with blood pressure measurements outside of the clinical setting is advised before starting treatment

Study suggests that 7 days of home blood pressure monitoring is likely better than 24h ambulatory monitoring or 3 office measurements

 

Randomized, sham-controlled trial: Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs.

7 Apr, 2022 | 09:49h | UTC

Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary: Three-year trial of SPYRAL HTN-ON MED shows blood pressure reductions – MedicalXpress

Related:

Systematic Review: Renal denervation may have a modest effect in improving 24h ambulatory blood pressure monitoring (reduction in SBP by 5.29 mmHg and DBP by 3.75 mmHg) but does not improve major cardiovascular outcomes and renal function.

M-A: Renal denervation for hypertension is associated with a modest reduction in ambulatory blood pressure control (3.61 mm Hg reduction in ambulatory systolic BP and 1.85 mm Hg reduction in ambulatory diastolic BP).

#ACC21 – RCT: Among patients with resistant hypertension, ultrasound renal denervation resulted in a modest improvement in systolic BP (–4.5 mm Hg) vs. sham procedure.

Meta-Analysis: Sham-Controlled Randomized Trials of Catheter-Based Renal Denervation in Patients with Hypertension

 

Commentary on Twitter

 

RCT: Oral Roxadustat vs. Epoetin Alfa for treating anemia in patients with chronic kidney disease on dialysis.

6 Apr, 2022 | 10:45h | UTC

Roxadustat Versus Epoetin Alfa for Treating Anemia in Patients with Chronic Kidney Disease on Dialysis: Results from the Randomized Phase 3 ROCKIES Study – Journal of the American Society of Nephrology

Related:

Randomized Trials: Evaluation of New Treatment for Anemia of Chronic Kidney

RCT: Efficacy and safety of Daprodustat (oral drug) for treating anemia of chronic kidney disease in incident dialysis patients.

RCT: In patients with chronic kidney diseases and anemia undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa to increase hemoglobin levels and regarding cardiovascular outcomes.

RCT: In patients with chronic kidney diseases and anemia not undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa in increasing hemoglobin levels and regarding cardiovascular outcomes.

 

RCT: Erythropoietin not beneficial for patients with acute kidney injury.

6 Apr, 2022 | 10:02h | UTC

Erythropoietin in Acute Kidney Injury (EAKI): a pragmatic randomized clinical trial – BMC Nephrology

 

Opinion: Moving xenotransplantation research into human trials will require adjusting our expectations, researchers say.

6 Apr, 2022 | 09:59h | UTC

Moving xenotransplantation research into human trials will require adjusting our expectations, researchers say – STAT

Related:

After a flurry of firsts, xenotransplantation is suddenly back in the spotlight.

In 1st, US surgeons transplant pig heart into human patient.

 

RCT: Efficacy and safety of Daprodustat (oral drug) for treating anemia of chronic kidney disease in incident dialysis patients.

5 Apr, 2022 | 08:34h | UTC

Efficacy and Safety of Daprodustat for Treatment of Anemia of Chronic Kidney Disease in Incident Dialysis Patients: A Randomized Clinical Trial – JAMA Internal Medicine

Related:

RCT: In patients with chronic kidney diseases and anemia undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa to increase hemoglobin levels and regarding cardiovascular outcomes.

RCT: In patients with chronic kidney diseases and anemia not undergoing dialysis, Daprodustat (oral drug) was noninferior to darbepoetin alfa in increasing hemoglobin levels and regarding cardiovascular outcomes.

 

Commentary on Twitter

 

Review: The intensivist’s perspective of shock, volume management, and hemodynamic monitoring.

5 Apr, 2022 | 08:20h | UTC

The Intensivist’s Perspective of Shock, Volume Management, and Hemodynamic Monitoring – Clinical Journal of the American Society of Nephrology

 

Commentary on Twitter

https://twitter.com/CJASN/status/1511025812283092992

 

Review: Patient-centered approaches for the management of unpleasant symptoms in kidney disease.

5 Apr, 2022 | 08:16h | UTC

Patient-centred approaches for the management of unpleasant symptoms in kidney disease – Nature Reviews Nephrology

 

Commentary on Twitter

 

Stay Updated in Your Specialty

Telegram Channels
Free

WhatsApp alerts 10-day free trial

No spam, just news.