Internal Medicine
M-A of RCTs | Efficacy of corticosteroids for hand osteoarthritis.
18 Jul, 2022 | 11:07h | UTC
Recent advances in the management of pulmonary hypertension with interstitial lung disease.
18 Jul, 2022 | 11:01h | UTC
Targeted cancer therapies: clinical pearls for primary care.
18 Jul, 2022 | 10:56h | UTCTargeted cancer therapies: Clinical pearls for primary care – Canadian Family Physicians
Cohort Study | Risks of stroke and heart disease following hysterectomy and oophorectomy in premenopausal women.
15 Jul, 2022 | 13:07h | UTCCommentary: Removal of Uterus, Ovaries Poses Extra Cardiovascular Risk for Younger Women – MedPage Today (free registration required)
Review | Invasive respiratory fungal infections in COVID-19 critically ill patients.
15 Jul, 2022 | 12:58h | UTCInvasive Respiratory Fungal Infections in COVID-19 Critically Ill Patients – Journal of Fungi
7 of your most pressing monkeypox vaccine questions, answered – “We have safe, effective options — but in short supply”.
15 Jul, 2022 | 13:00h | UTC7 of your most pressing monkeypox vaccine questions, answered – Vox
Related:
How contagious is monkeypox—and should you get a vaccine? Here’s the latest. – National Geographic
Prevention and Treatment of Monkeypox – Drugs
Monkeypox soars in Europe, with more than 4,000 cases – CIDRAP
No room for complacency – World Health Organization
Multi-country monkeypox outbreak: situation update – World Health Organization
Monkeypox Genital Lesions – New England Journal of Medicine
Monkeypox vaccination begins — can the global outbreaks be contained? – Nature
Incubation period for monkeypox: Estimates from the Netherlands.
‘Discriminatory and stigmatizing’: Scientists push to rename monkeypox viruses – STAT
Rename monkeypox strains to remove geographic stigma, researchers say – Science
2022 Monkeypox and Orthopoxvirus Outbreak Global Map – Centers for Disease Control and Prevention
As monkeypox threat grows, scientists debate best vaccine strategy – Science
Monkeypox is a new global threat. African scientists know what the world is up against – Science
Experts highlight sexual aspect of monkeypox spread – CIDRAP
What to Know About Monkeypox – JAMA
Multi-country monkeypox outbreak in non-endemic countries: Update – World Health Organization
Monkeypox outbreaks: 4 key questions researchers have – Nature
Study reports first use of antivirals in monkeypox patients – Lancet
Surveillance, case investigation and contact tracing for Monkeypox – World Health Organization
Laboratory testing for the monkeypox virus: Interim guidance – World Health Organization
A Novel International Monkeypox Outbreak – Annals of Internal Medicine
EU health agency warns monkeypox could become endemic in Europe if outbreak continues – STAT
Monkeypox cases increase across Europe, North America – CIDRAP
Multi-country monkeypox outbreak in non-endemic countries – World Health Organization
Monkeypox goes global: why scientists are on alert – Nature
Monkeypox: What do we know about the outbreaks in Europe and North America? – The BMJ
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – STAT
Monkeypox: Time to worry or one to ignore? – BBC
UK, Spain, Portugal report more monkeypox cases – CIDRAP
U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak – STAT
Monkeypox – United Kingdom of Great Britain and Northern Ireland – World Health Organization
Monkeypox cases confirmed in England – latest updates – UK Health Security Agency
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – Health Policy Watch
European outbreak of monkeypox: what you need to know – The Conversation
Rare monkeypox outbreak in U.K., Europe and U.S.: What is it and should we worry – NPR
Monkeypox cases under investigation in Canada as outbreak spreads in Europe, U.S. – CBC News
Position Paper | Diagnostic reasoning in rehabilitation nutrition.
15 Jul, 2022 | 12:53h | UTC
Guideline on prevention of foot ulceration in diabetic patients.
15 Jul, 2022 | 12:51h | UTCRelated:
Guideline: ADA 2022 Standards of Medical Care in Diabetes.
NICE Updated Guidance: Management of Type 2 Diabetes.
Recent updates to clinical practice guidelines for diabetes mellitus.
Systematic Review | Antithrombotic therapy to prevent cognitive decline in people with small vessel disease on neuroimaging but without dementia.
15 Jul, 2022 | 12:47h | UTC
Commentary on Twitter
BREAKING: Our new Cochrane review: no evidence of clinically relevant cognitive benefit of antithrombotic therapy on top of usual Rx for cerebral small vessel disease but without dementia (but may ⬆️ bleed risk) @DrTerryQuinn @StrokeImperial @CochraneDCIG https://t.co/WaaydHdBqq pic.twitter.com/qpL9TooQNa
— Joseph Kwan, MD 🇬🇧 (@drjkwan) July 13, 2022
RCT | Efficacy and safety of ciprofloxacin plus fluocinolone acetonide among patients with acute otitis externa.
15 Jul, 2022 | 12:43h | UTC
Commentary on Twitter
In this randomized clinical trial, ciprofloxacin 0.3% plus fluocinolone acetonide 0.025% otic solution was efficacious and safe in treating acute otitis externa. https://t.co/VRf1vEojY1
— JAMA Network Open (@JAMANetworkOpen) July 14, 2022
Registry-based cohort study | Modifiable and non-modifiable risk factors in hip fracture mortality in Norway, 2014 to 2018.
15 Jul, 2022 | 12:31h | UTC
Review | Strongyloides stercoralis.
15 Jul, 2022 | 12:23h | UTCStrongyloides stercoralis – Lung (if the link is paywalled, try this one)
Pressure ulcers (pressure injuries) | Cochrane Library evidence and resources.
14 Jul, 2022 | 13:03h | UTCPressure ulcers (pressure injuries): evidence and resources – Evidently Cochrane
RCT | Pharmacogenomic testing for drug-gene interactions provides little benefit for the remission of symptoms in major depressive disorder.
14 Jul, 2022 | 13:05h | UTCEffect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Pharmacogenomic Testing for Next-Step Antidepressant Selection: Still a Work in Progress – JAMA (free for a limited period)
Commentary: Does Pharmacogenomic Testing Improve Outcomes in Major Depressive Disorder? — The evidence is unclear – MedPage Today (free registration required)
Commentary on Twitter
In this randomized clinical trial, pharmacogenomic testing for drug-gene interactions in major depressive disorder reduced prescription of medications with predicted drug-gene interactions but had small and nonpersistent effects on symptom remission. https://t.co/Z2OIK3h1Bo pic.twitter.com/8eKSipfBFN
— JAMA (@JAMA_current) July 12, 2022
Consensus Statement | Clinical indications and triaging for adult transthoracic echocardiography.
14 Jul, 2022 | 12:47h | UTC
Systematic Review | Anti‐IL‐5 therapies for asthma.
14 Jul, 2022 | 12:40h | UTCAnti‐IL‐5 therapies for asthma – Cochrane Library
Prevalence of cardiovascular disease in patients with potentially curable malignancies: a national registry dataset analysis.
14 Jul, 2022 | 12:33h | UTC
M-A | Risk of developing gallbladder cancer in patients with gallbladder polyps detected on Trans-Abdominal ultrasound.
14 Jul, 2022 | 12:14h | UTCRisk of developing gallbladder cancer in patients with gallbladder polyps detected on Trans-Abdominal ultrasound: a systematic review and Meta-Analysis – British Journal of Radiology (link to abstract – $ for full-text)
Related:
Critical Analysis of the Updated Guidelines for Management of Gallbladder Polyps – Annals of Surgical Oncology (if the link is paywalled, try this one)
RCT | Endovascular thrombectomy NOT noninferior to standard bridging thrombolytic with endovascular thrombectomy within 4.5 h of stroke onset.
13 Jul, 2022 | 11:57h | UTCEndovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Related Study: Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
Two new RCTs show we shouldn't skip bridging intravenous thrombolysis in eligible thrombectomy patients: DIRECT-SAFE (n=293) & SWIFT DIRECT (n=408) @TheLancet @SNISinfo@cvsection https://t.co/Tks14TlaVFhttps://t.co/WaTPn34diy pic.twitter.com/Gcddws8oDf
— Babak Jahromi MD PhD FRCSC (@babaksjahromi) July 9, 2022
RCT | Thrombectomy alone NOT noninferior to intravenous alteplase plus thrombectomy in patients with stroke.
13 Jul, 2022 | 11:55h | UTCThrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Related Study: Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
Two new RCTs show we shouldn't skip bridging intravenous thrombolysis in eligible thrombectomy patients: DIRECT-SAFE (n=293) & SWIFT DIRECT (n=408) @TheLancet @SNISinfo@cvsection https://t.co/Tks14TlaVFhttps://t.co/WaTPn34diy pic.twitter.com/Gcddws8oDf
— Babak Jahromi MD PhD FRCSC (@babaksjahromi) July 9, 2022
RCT | Myosin inhibition in patients with obstructive hypertrophic cardiomyopathy referred for septal reduction therapy.
13 Jul, 2022 | 11:52h | UTC
Fever therapy in febrile adults: systematic review with meta-analyses and trial sequential analyses.
13 Jul, 2022 | 11:51h | UTC
M-A | Home oxygen for moderate hypoxemia in chronic obstructive pulmonary disease.
13 Jul, 2022 | 11:47h | UTCHome oxygen for moderate hypoxaemia in chronic obstructive pulmonary disease: a systematic review and meta-analysis – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Home oxygen probably makes little or no difference to 3-year mortality in pts with #COPD and moderate hypoxaemia
Systematic review & meta-analysis from Yves Lacasse & colleagues https://t.co/8wDrkEd1LH pic.twitter.com/UoOqW7hngT
— The Lancet Respiratory Medicine (@LancetRespirMed) July 11, 2022
Cohort Study | Risk and timing of noncardiac surgery after transcatheter aortic valve implantation.
13 Jul, 2022 | 11:43h | UTCCommentaries:
Surgery After TAVR: Waiting a Month or More Not Really Better— Prosthesis-patient mismatch, paravalvular regurgitation the bigger issues for surgical candidates – MedPage Today (free registration required)
Commentaries on Twitter
https://twitter.com/JAMANetworkOpen/status/1545120466326749186
https://twitter.com/preopconsult/status/1546167570771894272
ESC Consensus Statement | Digital health in older adults for the prevention and management of cardiovascular diseases and frailty.
13 Jul, 2022 | 11:42h | UTC