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Internal Medicine

Perspective | Climbing melatonin use for insomnia raises safety concerns.

28 Jul, 2022 | 13:24h | UTC

Climbing Melatonin Use for Insomnia Raises Safety Concerns – JAMA (free for a limited period)

 

Cohort Study | Physical and mental activity, disease susceptibility, and risk of dementia.

28 Jul, 2022 | 13:22h | UTC

Physical and Mental Activity, Disease Susceptibility, and Risk of Dementia: A Prospective Cohort Study Based on UK Biobank – Neurology

News Release: Study: Chores, exercise, and social visits linked to lower risk of dementia – American Academy of Neurology

 

Cohort Study | Predictive utility of a validated polygenic risk score for long-term risk of coronary heart disease in young and middle-aged adults.

28 Jul, 2022 | 13:15h | UTC

Predictive Utility of a Validated Polygenic Risk Score for Long-Term Risk of Coronary Heart Disease in Young and Middle-Aged Adults – Circulation (free for a limited period)

News Release: Old-School Health Assessment Beats Genetic Test for Predicting Heart Disease – Nuke University

 

Cohort Study | Association of ultraprocessed food consumption with risk of dementia.

28 Jul, 2022 | 13:10h | UTC

Association of Ultraprocessed Food Consumption With Risk of Dementia: A Prospective Cohort – Neurology (link to abstract – $ for full-text)

Commentary: Dementia Risk Climbs With Intake of Ultra-Processed Foods — Swapping out ultra-processed for unprocessed or minimally processed foods can lower risk sharply – MedPage Today (link to abstract – $ for full-text)

 

USPSTF Recommendations | Behavioral counseling interventions to promote a healthy diet and physical activity in adults without cardiovascular disease risk factors.

27 Jul, 2022 | 12:26h | UTC

Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Cardiovascular Disease Risk Factors: US Preventive Services Task Force Recommendation Statement – JAMA

Editorials:

Implications of the New Recommendation on Behavioral Counseling Interventions to Promote Healthy Eating and Physical Activity – JAMA

Updated USPSTF Recommendations for Behavioral Counseling Interventions: Gaps, Challenges, and Opportunities – JAMA Internal Medicine

Improving Behavioral Counseling for Primary Cardiovascular Disease Prevention – JAMA Cardiology

Evidence Report: Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Known Cardiovascular Disease Risk Factors: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Author Interview: USPSTF Recommendation: Behavioral Counseling Interventions to Promote Healthy Behaviors for CVD Prevention – JAMA

Patient Page: Behavioral Counseling Interventions to Promote a Healthy Diet and Physical Activity to Prevent CVD in Adults Without Risk Factors – JAMA

 

RCT | Vitamin B6 supplements could reduce anxiety and depression.

27 Jul, 2022 | 12:19h | UTC

News Release: Vitamin B6 supplements could reduce anxiety and depression – University of Reading

Original Study: High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression – Human Psychopharmacology: Clinical and Experimental

Commentary: B6 a New Approach for Depression, Anxiety? – Medscape (free registration required)

 

RCT | Short vs. extended treatment with a carbapenem in patients with high-risk fever of unknown origin during neutropenia.

27 Jul, 2022 | 12:17h | UTC

Short versus extended treatment with a carbapenem in patients with high-risk fever of unknown origin during neutropenia: a non-inferiority, open-label, multicentre, randomised trial – The Lancet Haematology (link to abstract – $ for full-text)

Commentary: Short-Course or Extended Antibiotics in Febrile Neutropenia? – Medscape (free registration required)

 

Commentary on Twitter

 

Practical Guide | Antihypertensive deprescribing in older adults.

27 Jul, 2022 | 12:23h | UTC

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

 

Cross-Sectional Study | Association of registered nurse staffing with mortality risk in hospitalized patients with sepsis.

27 Jul, 2022 | 12:16h | UTC

Association of Registered Nurse Staffing With Mortality Risk of Medicare Beneficiaries Hospitalized With Sepsis – JAMA Health Forum

Commentaries:

Greater Nurse Staffing Tied to Better Sepsis Outcomes – HealthDay

Reduced Sepsis Mortality Risk Seen With High Nurse Staffing – AJMC

 

M-A | Antiviral drug treatment for nonsevere COVID-19.

27 Jul, 2022 | 12:14h | UTC

Antiviral drug treatment for nonsevere COVID-19: a systematic review and network meta-analysis – Canadian Medical Association Journal

News Release: Some antivirals used in nonsevere COVID-19 may reduce hospitalizations and deaths – Canadian Medical Association Journal

Commentary: COVID-19 antivirals may cut risk of hospitalization, death – CIDRAP

 

M-A | Beneficial and harmful effects of monoclonal antibodies for the treatment and prophylaxis of COVID-19.

27 Jul, 2022 | 12:12h | UTC

Beneficial and harmful effects of monoclonal antibodies for the treatment and prophylaxis of COVID-19: a systematic review and meta-analysis of randomized controlled trials – American Journal of Medicine

 

AGA Clinical Practice Update | Diagnosis and management of nonalcoholic fatty liver disease in lean individuals.

27 Jul, 2022 | 12:11h | UTC

AGA Clinical Practice Update: Diagnosis and Management of Nonalcoholic Fatty Liver Disease in Lean Individuals: Expert Review – Gastroenterology

Commentaries:

Best practice advice for diagnosing, managing NAFLD in lean individuals – Boston University School of Medicine

New Guidelines Focus on NAFLD in Lean People – Medscape (free registration required)

 

M-A | Treating eosinophilic esophagitis with budesonide.

27 Jul, 2022 | 12:06h | UTC

A meta-analysis on randomized controlled trials of treating eosinophilic esophagitis with budesonide – Annals of Medicine

 

NICE Guideline | Pneumonia in adults: diagnosis and management.

26 Jul, 2022 | 13:37h | UTC

Pneumonia in adults: diagnosis and management – National Institute for Health and Care Excellence

Related Guidelines:

Pneumonia (community-acquired): antimicrobial prescribing

Pneumonia (hospital-acquired): antimicrobial prescribing

Diagnosis and Treatment of Adults with Community-acquired Pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America – American Journal of Respiratory and Critical Care Medicine

 

20-year follow-up of a RCT trial | Immunosuppressive therapy in virus-negative inflammatory cardiomyopathy.

26 Jul, 2022 | 13:33h | UTC

Immunosuppressive therapy in virus-negative inflammatory cardiomyopathy: 20-year follow-up of the TIMIC trial – European Heart Journal

Commentary: Immunosuppression may benefit long term in virus-negative inflammatory cardiomyopathy – Healio (free registration required)

 

Commentary on Twitter

Under a https://creativecommons.org/licenses/by/4.0/ license

 

Cohort Study | Cardiometabolic outcomes up to 12 months after COVID-19 infection.

26 Jul, 2022 | 13:30h | UTC

Cardiometabolic outcomes up to 12 months after COVID-19 infection. A matched cohort study in the UK – PLOS Medicine

News Release: COVID-19 patients more likely to develop cardiovascular diseases and diabetes soon after infection – PLOS

Commentaries:

COVID: risk of diabetes and heart disease is higher after infection – but maybe only temporarily – The Conversation

COVID-19 tied to new-onset, short-term heart disease, diabetes – CIDRAP

CVD, Diabetes Spike in Acute Phase of COVID-19 – TCTMD

Covid-19: Infection raises risk of diabetes and heart disease diagnoses in following weeks, study finds – The BMJ

 

M-A | Effectiveness of wearable activity trackers to increase physical activity and improve health.

26 Jul, 2022 | 13:27h | UTC

Effectiveness of wearable activity trackers to increase physical activity and improve health: a systematic review of systematic reviews and meta-analyses – The Lancet Digital Health

Commentary: Wearable activity trackers encourage us to walk up to 40 minutes more each day – University of South Australia

 

Commentary on Twitter

Under a CC BY-NC-ND 4.0 license

 

Cohort Study | Laparoscopically confirmed endometriosis and risk of incident stroke.

26 Jul, 2022 | 13:25h | UTC

Laparoscopically Confirmed Endometriosis and Risk of Incident Stroke: A Prospective Cohort Study – Stroke (free for a limited period)

News Release: Women with endometriosis may have higher risk of stroke – American Heart Association

Commentary: Endometriosis Linked to Greater Risk for Stroke – HealthDay

 

Commentary on Twitter

 

Systematic Review | Antiplatelet agents for the treatment of deep venous thrombosis.

26 Jul, 2022 | 12:44h | UTC

Antiplatelet agents for the treatment of deep venous thrombosis – Cochrane Library

Summary: Aspirin and similar drugs for the treatment of deep vein thrombosis (DVT) – Cochrane Library

 

Central venous catheter (CVC) management: evidence round-up.

26 Jul, 2022 | 12:41h | UTC

Central venous catheter (CVC) management: evidence round-up – Cochrane Library

Related: Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults – Cochrane Library

Summary: Does heparin locking prevent blocking of central venous catheters in adults when compared to locking with normal saline? – Cochrane Library

 

Systematic Review | Heparin vs. 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults.

26 Jul, 2022 | 12:43h | UTC

Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults – Cochrane Library

Summary: Does heparin locking prevent blocking of central venous catheters in adults when compared to locking with normal saline? – Cochrane Library

Related: Central venous catheter (CVC) management: evidence round-up – Cochrane Library

 

Non-alcoholic fatty liver disease and risk of new-onset heart failure: an updated meta-analysis of about 11 million individuals.

26 Jul, 2022 | 12:36h | UTC

Non-alcoholic fatty liver disease and risk of new-onset heart failure: an updated meta-analysis of about 11 million individuals – Gut

News Release: Fat build-up in liver (NAFLD) linked to heightened heart failure risk over next decade – BMJ

Commentary: NAFLD Tied to Higher Risk of Heart Failure — Meta-analysis showed a modest risk independent of key risk factors – MedPage Today (free registration required)

 

Cohort Study | Polygenic risk, midlife life’s simple 7, and lifetime risk of stroke.

26 Jul, 2022 | 12:38h | UTC

Polygenic Risk, Midlife Life’s Simple 7, and Lifetime Risk of Stroke – Journal of the American Heart Association

News Release: A healthy lifestyle can offset a high genetic risk for stroke – University of Texas Health Science Center at Houston

Commentary: Lifetime Risk for Stroke Varies With Genetic Risk, Cardiovascular Health – HealthDay

 

RCT | Effect of canagliflozin on the decline of estimated glomerular filtration rate in chronic kidney disease patients with type 2 diabetes mellitus.

26 Jul, 2022 | 11:53h | UTC

Effect of canagliflozin on the decline of estimated glomerular filtration rate in chronic kidney disease patients with type 2 diabetes mellitus: A multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 study in Japan – Journal of Diabetes Investigation

 

Brief Review | Contraception in women with cardiovascular disease.

25 Jul, 2022 | 13:05h | UTC

Contraception in Women With Cardiovascular Disease – JAMA (free for a limited period)

 

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