Internal Medicine
Review | Clinical significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in acute exacerbations of COPD.
7 Nov, 2022 | 12:11h | UTC
Review | Non-Aspergillus mold lung infections.
7 Nov, 2022 | 11:51h | UTCNon-Aspergillus mould lung infections – European Respiratory Review
Review | Respiratory viruses: their importance and lessons learned from COVID-19.
7 Nov, 2022 | 11:54h | UTC
RCT | Once-weekly Semaglutide effective for weight loss in adolescents with obesity.
4 Nov, 2022 | 13:59h | UTCOnce-Weekly Semaglutide in Adolescents with Obesity – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
STEP TEENS: High-dose semaglutide weight loss benefits shown in adolescents – medwire News
Trial Shows Weight-Loss Drug Works in Teens – HealthDay
Commentary on Twitter
In this trial, adolescents with obesity assigned to weekly subcutaneous semaglutide plus lifestyle intervention had a greater reduction in BMI than those who received lifestyle intervention alone. https://t.co/yiFseP38xa pic.twitter.com/uRqkFfon1s
— NEJM (@NEJM) November 2, 2022
RCT | Discontinuing RAS inhibitors in patients with advanced CKD did not result in a slower decline in eGFR.
4 Nov, 2022 | 13:55h | UTCRenin–Angiotensin System Inhibition in Advanced Chronic Kidney Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
In this randomized trial, the discontinuation of renin–angiotensin system inhibitors in patients with advanced chronic kidney disease did not lead to a significant between-group difference in the long-term rate of decline in the eGFR. #KidneyWk https://t.co/81EIwG5FQ0 pic.twitter.com/nHNmzlPbHV
— NEJM (@NEJM) November 3, 2022
M-A | Blood pressure lowering and prevention of dementia.
4 Nov, 2022 | 13:46h | UTCNews Release: Best evidence yet that lowering blood pressure can prevent dementia – George Institute for Global Health
Commentary: Meta-Analysis Shows Decrease in Dementia Risk With HTN Treatment – HealthDay
RCT | Clinical and cost-effectiveness of single stage compared vs. two-stage revision for hip prosthetic joint infection.
4 Nov, 2022 | 13:49h | UTC
Consensus Paper | Atypical hemolytic uremic syndrome.
4 Nov, 2022 | 13:40h | UTC
Brief Review | The prediction of fluid responsiveness.
4 Nov, 2022 | 13:39h | UTCThe prediction of fluid responsiveness – Intensive Care Medicine
Commentary on Twitter
Predicting fluid responsiveness in #ICU to avoid administration to patients who do not need & give when needed, allowing for truly personalized treatment
💧fluids could be harmful
💧fluids could be inconstantly effective#FOAMcc free to read on @yourICM
🖇️ https://t.co/os6seDVna2 pic.twitter.com/wy2wDVzfEA— Intensive Care Medicine (@yourICM) November 3, 2022
Cohort Study | Moderate to heavy drinking is linked to an increased risk of hemorrhagic stroke in young adults.
4 Nov, 2022 | 13:36h | UTCCumulative Alcohol Consumption Burden and the Risk of Stroke in Young Adults: A Nationwide Population-Based Study – Neurology (link to abstract – $ for full-text)
Commentaries:
Moderate-to-Heavy Drinking Linked to Stroke Risk in Young Adults – HealthDay
Moderate to heavy drinking could increase the risk of stroke in young adults – News Medical
Heat-related illness in emergency and critical care: recognition and management with medico-legal considerations.
4 Nov, 2022 | 13:24h | UTCRelated:
Treatment and Prevention of Heat-Related Illness – New England Journal of Medicine
RCT | Post-operative electrical muscle stimulation may attenuate loss of muscle mass after abdominal surgery in older adults.
4 Nov, 2022 | 13:19h | UTC
Review | Determining prognosis of alcoholic liver disease and alcoholic hepatitis.
4 Nov, 2022 | 13:17h | UTC
M-A | Risk of major adverse events associated with gabapentinoid and opioid combination therapy.
4 Nov, 2022 | 13:13h | UTC
2022 ACC/AHA Guideline for the diagnosis and management of aortic disease.
3 Nov, 2022 | 14:21h | UTCNews Release: ACC, AHA Issue Aortic Disease Guideline – American Heart Association
USPSTF Statement | Hormone therapy is not recommended for the prevention of chronic conditions in postmenopausal women.
3 Nov, 2022 | 14:19h | UTCEditorial: Menopausal Hormone Therapy for Prevention of Chronic Conditions: When Is Enough, Enough? – JAMA
JAMA Patient Page: Menopausal Hormone Therapy for Prevention of Chronic Conditions
Author Interview: USPSTF Recommendation: Hormone Therapy for Prevention of Postmenopausal Chronic Conditions – JAMA
Commentary: USPSTF: Hormone Therapy Not Advised for Primary Prevention of Chronic Conditions – HealthDay
M-A | Effect of pulmonary rehabilitation in dyspnea, exercise capacity, fatigue, and quality of life in patients with COVID-19.
3 Nov, 2022 | 14:09h | UTC
Comparative risk of thrombosis with thrombocytopenia or thromboembolic events with different covid-19 vaccines.
3 Nov, 2022 | 14:10h | UTC
Cohort Study | Mental health morbidities and time to cancer diagnosis among adults with colon cancer in England.
3 Nov, 2022 | 13:55h | UTCInvited Commentary: The Interface Between Colon Cancer and Mental Health Morbidities – JAMA Network Open
Study suggests a personalized frequency of urinary albumin screening may be best for patients with Type 1 Diabetes.
3 Nov, 2022 | 13:46h | UTCOptimal Frequency of Urinary Albumin Screening in Type 1 Diabetes – Diabetes Care (link to abstract – $ for full-text)
Observational study suggests Apixaban for AF is associated with a lower risk of GI bleeding vs. other DOACs.
3 Nov, 2022 | 13:32h | UTCComparative Effectiveness and Safety Between Apixaban, Dabigatran, Edoxaban, and Rivaroxaban Among Patients With Atrial Fibrillation: A Multinational Population-Based Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
News Release: Best blood thinner for minimizing bleeding risk identified – University College London
Commentary: GI Bleeding Lower With Apixaban Versus Other DOACs in A-Fib – HealthDay
Phase 2 RCT | A single injection of a monoclonal antibody was 88% effective for malaria prevention over 6 months.
2 Nov, 2022 | 14:30h | UTCSafety and Efficacy of a Monoclonal Antibody against Malaria in Mali – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Monoclonal antibody prevents malaria infection in African adults – National Institutes of Health
Commentary: Monoclonal antibody infusion 88% effective against malaria – CIDRAP
Related Study: Phase 1 Study | Low-dose subcutaneous or intravenous monoclonal antibody can prevent malaria in a human challenge model.
Commentary on Twitter
In this phase 2 trial in Mali, an antimalarial monoclonal antibody (CIS43LS) at the higher dose (40 mg per kilogram) was approximately 88% effective at preventing P. falciparum infection as compared with placebo. #TropMed22 https://t.co/UGeBHOPhKY pic.twitter.com/uFX7w3qV0G
— NEJM (@NEJM) November 1, 2022
NICE Guideline | Osteoarthritis in over 16s: diagnosis and management.
2 Nov, 2022 | 14:29h | UTC
RCT | Intensive BP control after thrombectomy for ischemic stroke is associated with increased risk of poor functional outcomes.
2 Nov, 2022 | 14:26h | UTCIntensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter (thread – click for more)
1/ A #MorningPaper from @TheLancet on #Stroke. This large study randomised 821 patients into aggressive BP management (sBP <120mmHg) vs 140-180mmHg. Trial stopped early due to safety concerns. @neuro_at_ic @e1v1m1 @SomaBanerjee73 @StrokeImperialhttps://t.co/vnvnnI1KLq
— Kevin Tsang (@drtintin99) October 29, 2022
ACCP Guideline | Perioperative management of antithrombotic therapy.
1 Nov, 2022 | 12:18h | UTCExecutive Summary: Perioperative Management of Antithrombotic Therapy: An American College of Chest Physicians Clinical Practice Guideline – CHEST
Commentary on Twitter
2022 guideline for perioperative management of VKAs, heparin bridging, DOACs & antiplatelets
Pts requiring elective surgery, in general,🛑💊 before surgery
👉VKAs 3-5d
👉DOACS 1-2d
👉P2Y12 receptor inhibitors 3-7d✅drug specificshttps://t.co/RYNrEOovRe @SCCM_Surgery @SCCM_CPP— Lauren R. Sorce, PhD, RN, CPNP-AC/PC, FAAN, FCCM (@SCCMPresident) August 26, 2022