Internal Medicine
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological DMARDs.
15 Nov, 2022 | 12:53h | UTCCommentary: Updated EULAR recommendations on the use of DMARDs for people with RA – News Medical
RCT | Genicular nerve block offers short-term pain relief in patients with knee osteoarthritis.
15 Nov, 2022 | 12:50h | UTCCommentary: Genicular nerve block may provide short-term pain relief for knee osteoarthritis – medwire News
M-A | SGLT2 inhibitors reduce the risk of kidney disease progression and AKI, irrespective of diabetes status.
11 Nov, 2022 | 14:04h | UTCCommentaries:
Meta-analysis backs SGLT2 inhibitors for kidney disease – medwire News
EMPA-KIDNEY: Empagliflozin a ‘Win’ for Patients With CKD – TCTMD
Commentary on Twitter
Our SGLT2 Trialists Consortium meta-analysis *the largest ever* in @TheLancet https://t.co/YlWkRQTDAW
Definitive evidence that SGLT2i ⬇️:
– Kidney failure
– AKI
– CV death
– All-cause deathRegardless of diabetes
Led by @NatalieStaplin @RichardHaynes3 @willkidney #AHA22 pic.twitter.com/uAX15mD9XY
— Brendon Neuen (@brendonneuen) November 6, 2022
Under a Creative Commons Attribution (CC BY 4.0) License
RCT | Indobufen vs. aspirin on top of clopidogrel after coronary drug-eluting stent implantation.
11 Nov, 2022 | 14:03h | UTC
Commentary on Twitter
#OriginalResearch simpub #AHA2022 #CIRCAHA22: In this #RCT, indobufen + clopidogrel DAPT compared with aspirin + clopidogrel DAPT significantly reduced the risk of 1-year net clinical outcomes, mainly driven by a reduction in bleeding events without an ….https://t.co/ctk1fwhXt2 pic.twitter.com/vFPS6gvpjN
— Circulation (@CircAHA) November 6, 2022
RCT | Helicobacter pylori eradication may prevent peptic ulcer bleeding in older patients prescribed aspirin in primary care.
11 Nov, 2022 | 14:00h | UTCNews Release: Cutting the risk of stomach bleeding, occasionally caused by regular aspirin use – University of Nottingham
Commentary on Twitter
New @TheLancet – the HEAT trial of H pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (1/4)https://t.co/9SlP3y6DGf #gitwitter #medtwitter
— Rob Brierley (@Rob__Brierley) November 4, 2022
RCT | Dual endothelin antagonist Aprocitentan is effective for resistant hypertension.
11 Nov, 2022 | 13:59h | UTCDual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentaries:
Endothelin Receptor Antagonist Effective in Resistant Hypertension: PRECISION – TCTMD
Phase 2RCT | Baxdrostat reduces BP in patients with treatment-resistant hypertension.
11 Nov, 2022 | 13:57h | UTCPhase 2 Trial of Baxdrostat for Treatment-Resistant Hypertension – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Big Drops in Blood Pressure With Baxdrostat: BrigHTN Phase II Study – TCTMD
New Drug Helps Tame Uncontrolled High Blood Pressure – HealthDay
RCT | A small study tested Apixaban’s efficacy and safety versus a Vitamin K-antagonist in patients on chronic hemodialysis.
11 Nov, 2022 | 13:52h | UTCRelated Study: Apixaban for Patients with Atrial Fibrillation on Hemodialysis: A Multicenter Randomized Controlled Trial – Circulation
SR | Biomarkers as point‐of‐care tests to guide use of antibiotics in people with acute respiratory infections in primary care.
11 Nov, 2022 | 13:47h | UTC
M-A | Cardiovascular safety of febuxostat and allopurinol in patients with gout.
11 Nov, 2022 | 13:41h | UTC
M-A | Head-to-head trials comparing sulfonylureas and low hypoglycemic risk antidiabetic drugs.
11 Nov, 2022 | 13:38h | UTC
M-A | Medication reviews and deprescribing as a single intervention in falls prevention.
11 Nov, 2022 | 12:53h | UTC
NICE Guideline Update | Colonoscopic surveillance in adults with inflammatory bowel disease or adenomas.
10 Nov, 2022 | 14:16h | UTCRelated:
USPSTF Statement: Start colorectal cancer screening at 45 years for most patients.
ACG Clinical Guidelines: Start colorectal cancer screening at 45
RCT | Mindfulness-based stress reduction vs. escitalopram for the treatment of adults with anxiety disorders.
10 Nov, 2022 | 14:09h | UTCMindfulness-Based Stress Reduction vs Escitalopram for the Treatment of Adults With Anxiety Disorders: A Randomized Clinical Trial – JAMA Psychiatry (free for a limited period)
Commentaries:
Mindfulness worked as well for anxiety as drug in study – Associated Press
Meditation works as well as a popular drug to reduce anxiety, study finds – NPR
Commentary on Twitter
This randomized, controlled #anxiety disorder treatment trial comparing a standardized, evidence-based mindfulness-based intervention with pharmacotherapy and found that mindfulness based stress reduction was non-inferior to escitalopram https://t.co/P7KJQlT03g
— JAMA Psychiatry (@JAMAPsych) November 9, 2022
Cohort Study | Study shows subclinical Hyperthyroidism is linked to an increased risk of fractures.
10 Nov, 2022 | 14:08h | UTCAssociation Between Subclinical Thyroid Dysfunction and Fracture Risk – JAMA Network Open
Commentary: Does Subclinical Hyperthyroidism Raise Fracture Risk? – Medscape (free registration required)
Commentary on Twitter
Subclinical hyperthyroidism may be an independent risk factor associated with fracture, highlighting a potential role for more aggressive screening and monitoring to prevent bone mineral disease. #OAReasearch https://t.co/LQVjaNU1zM
— JAMA Network Open (@JAMANetworkOpen) November 8, 2022
Review | New horizons in the ageing autonomic nervous system: orthostatic hypotension and supine hypertension.
10 Nov, 2022 | 13:37h | UTC
RCT | Using an algorithm to stratify the risk of patients with acute heart failure may improve outcomes.
9 Nov, 2022 | 12:30h | UTCTrial of an Intervention to Improve Acute Heart Failure Outcomes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: New Tool Assesses Risk in Acute HF Then Suggests Next Steps, Cutting Later Events – TCTMD
Commentary on Twitter
The use of a validated tool for risk assessment, combined with rapid follow-up, led to a lower risk of death or hospitalization for cardiovascular causes at 30 days among patients with acute heart failure. #AHA22 https://t.co/0cbvcHl3US pic.twitter.com/kpWbRGpOJX
— NEJM (@NEJM) November 5, 2022
Study Commentary | Radial artery beats both right internal thoracic artery and vein grafting at 15 years.
9 Nov, 2022 | 12:28h | UTC(Not published yet, presented at the American Heart Association Scientific Sessions, November 6, 2022)
RAPCO: Radial Artery Beats Both RITA and Vein Grafting at 15 Years – TCTMD
See also:
Related:
Meta-Analysis: Radial-Artery vs Saphenous-Vein Grafts in CABG
M-A | DOACs increase the risk of arterial thrombosis vs. Vitamin-K antagonists in antiphospholipid syndrome.
9 Nov, 2022 | 12:28h | UTCDirect Oral Anticoagulants vs Vitamin-K Antagonists in Thrombotic Antiphospholipid Syndrome: Meta-analysis of Randomized Controlled Trials – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Guidelines | Managing functional dyspepsia overlapping with other gastrointestinal symptoms.
9 Nov, 2022 | 12:26h | UTC
Cohort Study | Population-based estimates of 1-year mortality after major surgery among community-living older adults.
9 Nov, 2022 | 12:23h | UTCPopulation-Based Estimates of 1-Year Mortality After Major Surgery Among Community-Living Older US Adults – JAMA Surgery (link to abstract – $ for full-text)
Commentaries:
One in Seven Older Adults Die Within a Year After Surgery – Medscape (free registration required)
Surgery Holds Danger for Seniors. Who’s Most at Risk? – HealthDay
Commentary on Twitter
In a nationally representative sample of community-living Americans aged ≥65 years, nearly 1 out of every 7 persons died in the year after major surgery, including more than 1 of 4 who were frail and nearly 1 of 3 who had probable #dementia. https://t.co/nf8W4oLOLd @NHATS_NSOC
— JAMA Surgery (@JAMASurgery) October 19, 2022
Defining the optimum strategy for identifying adults and children with celiac disease: systematic review and economic modeling.
9 Nov, 2022 | 12:16h | UTC
Review | Direct oral anticoagulants for the prevention and acute treatment of cancer-associated thrombosis.
9 Nov, 2022 | 12:13h | UTC
Canadian guideline for the prevention and management of cardiovascular disease in primary care.
8 Nov, 2022 | 12:37h | UTCNews Release: New one-stop guideline for cardiovascular health in Canada – Canadian Medical Association Journal
NICE Guideline | Obesity: identification, assessment and management.
8 Nov, 2022 | 12:35h | UTCRelated:
ASMBS Guidelines | Indications for metabolic and bariatric surgery.
AGA clinical practice guideline on pharmacological interventions for adults with obesity.
Guideline | Preventing obesity in midlife women.