Internal Medicine

Brief Review | Mpox — A rapidly evolving disease

10 Feb, 2023 | 13:56h | UTC

Mpox—A Rapidly Evolving Disease – JAMA Dermatology

Related:

Surveillance, case investigation and contact tracing for mpox (monkeypox): interim guidance, 22 December 2022 – World Health Organization

Rapid review on monkeypox policies among the G20 nations: relevance to policy and practitioner – F1000 Research

Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study – The Lancet Infectious Diseases

Monkeypox (hMPXV infection): A practical review – American Journal of Medicine

Monkeypox in pregnancy: virology, clinical presentation, and obstetric management – American Journal of Obstetrics & Gynecology

WHO renames “monkeypox” as “mpox” to help destigmatize the disease.

Monkeypox – The Lancet

Study shows there is substantial monkeypox transmission before symptoms appear.

Global monkeypox case hospitalisation rates: A rapid systematic review and meta-analysis – eClinicalMedicine

Human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks: a global case series – The Lancet

Monkeypox — A Sobering Sentinel for Pandemic Preparedness and Sexual Health System Capacity – New England Journal of Medicine

CDC study shows healthcare workers have a low risk of infection after exposure to patients with monkeypox.

Monkeypox – New England Journal of Medicine

Diagnosis and Management of Monkeypox: A Review for the Emergency Clinician – Annals of Emergency Medicine

Monkeypox: disease epidemiology, host immunity and clinical interventions.

Monkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health

Cohort Study | Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain.

CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.

Update on the Monkeypox Outbreak – JAMA

Antivirals with Activity Against Monkeypox: A Clinically Oriented Review – Clinical Infectious Diseases

Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series – The BMJ

WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 – New England Journal of Medicine

Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases

 

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Opinion | Interpreting the results from the first randomized controlled trial of colonoscopy: does it save lives?

10 Feb, 2023 | 13:54h | UTC

Interpreting the results from the first randomised controlled trial of colonoscopy: does it save lives? – BMJ Evidence Based Medicine

Original Study: RCT | Effect of colonoscopy screening on risks of colorectal cancer and related death.

 

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Consensus Statement | Evaluation and management of patients with diabetes and heart failure

10 Feb, 2023 | 13:51h | UTC

Evaluation and Management of Patients with Diabetes and Heart Failure: A Korean Diabetes Association and Korean Society of Heart Failure Consensus Statement – Diabetes & Metabolism Journal

Related:

ACC/AHA/HFSA 2022 and ESC 2021 guidelines on heart failure comparison – ESC Heart Failure

#ACC22 – 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure.

#ESCCongress – 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure – SGLT2 inhibitors are now recommended for patients with heart failure with reduced ejection fraction regardless of the presence of diabetes.

 

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Consensus Paper | Use of cerebral CT angiography to support a clinical diagnosis of death using neurological criteria

10 Feb, 2023 | 13:48h | UTC

The use of cerebral computed tomographic angiography as an ancillary investigation to support a clinical diagnosis of death using neurological criteria: a consensus guideline – Anaesthesia

 

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Review | Management of adult patients with hematological malignancies in critical care

10 Feb, 2023 | 13:45h | UTC

Management of adult patients with haematological malignancies in critical care – Anaesthesia

 

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Cohort Study | Fecal hemoglobin concentrations are associated with all-cause mortality in colorectal cancer screening

10 Feb, 2023 | 13:41h | UTC

Faecal haemoglobin concentrations are associated with all-cause mortality and cause of death in colorectal cancer screening – BMC Medicine

Commentary: Faecal haemoglobin concentrations associated with mortality and cause of death in colorectal cancer screening – Physician’s Weekly

 

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RCT | Consumption of 2 green kiwifruits daily improves constipation and abdominal comfort

10 Feb, 2023 | 13:39h | UTC

Consumption of 2 Green Kiwifruits Daily Improves Constipation and Abdominal Comfort—Results of an International Multicenter Randomized Controlled Trial – The American Journal of Gastroenterology

 

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M-A | Effect of SGLT-2 inhibitors on body composition in patients with type 2 diabetes mellitus

10 Feb, 2023 | 13:38h | UTC

Effect of SGLT-2 inhibitors on body composition in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials – PLOS One

 

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Sex differences in clinical features, treatment, and lifestyle factors in patients with cluster headache

10 Feb, 2023 | 13:33h | UTC

Sex Differences in Clinical Features, Treatment, and Lifestyle Factors in Patients With Cluster Headache – Neurology

Commentaries:

Differences ID’d Between Men, Women With Cluster Headache – HealthDay

Cluster Headaches Affect Men More Often, But It’s Women Who Are Hit Hardest – Science Alert

 

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Cohort Study | Adverse pregnancy outcomes and long-term risk of ischemic heart disease in mothers

9 Feb, 2023 | 14:02h | UTC

Adverse pregnancy outcomes and long term risk of ischemic heart disease in mothers: national cohort and co-sibling study – The BMJ

News Release: Five major adverse pregnancy outcomes associated with long term risks of ischemic heart disease – News Medical/BMJ

Commentary: Complications during pregnancy linked to a higher risk of heart disease, study finds – CNN

Related:

Risk and trajectory of premature ischemic CVD in women with a history of pre-eclampsia: a nationwide register-based study

Cohort Study | Pre-eclampsia is associated with increased risk of premature-onset obstructive coronary artery stenosis.

Primary Care–Based Cardiovascular Disease Risk Management After Adverse Pregnancy Outcomes: a Narrative Review – Journal of General Internal Medicine

Pregnancy Complications and Risk of Cardiovascular Disease Later in Life: A Nationwide Cohort Study – Journal of the American Heart Association

AHA Scientific Statement | Adverse Pregnancy Outcomes and Cardiovascular Disease Risk

Consensus statement: Cardiovascular health after menopause transition, pregnancy disorders, and other gynecologic conditions

Cohort Study: Preeclampsia and Cardiovascular Disease

Cohort Study: Cardiovascular Disease After Hypertensive Disorders of Pregnancy Largely Explained by Conventional Cardiovascular Risk Factors

All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease

Gestational Hypertension and Future Risk of Cardiovascular Disease

Research: Conjoint Associations of Gestational Diabetes and Hypertension With Diabetes, Hypertension, and Cardiovascular Disease in Parents

 

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RCT | Pegylated Interferon Lambda reduces hospitalizations in predominantly vaccinated outpatients with Covid-19

9 Feb, 2023 | 14:03h | UTC

Early Treatment with Pegylated Interferon Lambda for Covid-19 – New England Journal of Medicine

News Release: Single-dose treatment reduces risk of COVID-19 hospitalization by half for high-risk patients in a largely vaccinated population – University Health Network

 

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[Not published yet] Dual blood thinners under prescribed after minor or warning stroke, especially in women

9 Feb, 2023 | 14:01h | UTC

Dual blood thinners under prescribed after minor or warning stroke, especially in women – American Heart Association

Related:

Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ

Dual Antiplatelet Therapy Versus Aspirin in Patients With Stroke or Transient Ischemic Attack: Meta-Analysis of Randomized Controlled Trials – Stroke

Efficacy and Safety of Using Dual Versus Monotherapy Antiplatelet Agents in Secondary Stroke Prevention: Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials – Circulation

Multiple versus fewer antiplatelet agents for preventing early recurrence after ischaemic stroke or transient ischaemic attack – Cochrane Library

 

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Cohort Study | Middle-age high normal serum sodium as a risk factor for chronic diseases and premature mortality

9 Feb, 2023 | 13:38h | UTC

Middle-age high normal serum sodium as a risk factor for accelerated biological aging, chronic diseases, and premature mortality – eBioMedicine

News Release: Good hydration linked to healthy aging – National Institutes of Health

Related: Cohort study: Increased middle age serum sodium levels (may correlate with low water ingestion) are linked to increased risk of left ventricular hypertrophy and heart failure after 25 years of follow up.

 

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How to use biomarkers of infection or sepsis at the bedside: guide to clinicians

9 Feb, 2023 | 13:26h | UTC

How to use biomarkers of infection or sepsis at the bedside: guide to clinicians – Intensive Care Medicine

 

Commentary on Twitter

Infection or #sepsis at bedside:
🧫 how to use biomarkers? Serial determinations & never as stand-alone test: do not miss clinical evaluation
🧫 pathogen‑specific & host‑response biomarkers? useful to provide additional data to optimize care
🧫 future
🖇️ https://t.co/Z3Hgb2I6o1 pic.twitter.com/bX4PanG2Et

— Intensive Care Medicine (@yourICM) January 2, 2023

 

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Cohort Study | The impact of population-level HbA1c screening on reducing diabetes diagnostic delay in middle-aged adults

9 Feb, 2023 | 13:28h | UTC

The impact of population-level HbA_1c screening on reducing diabetes diagnostic delay in middle-aged adults: a UK Biobank analysis – Diabetologia

 

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Brief Review | Acute kidney injury

9 Feb, 2023 | 13:25h | UTC

Acute kidney injury – Intensive Care Medicine

 

Commentary on Twitter

Acute kidney injury
🫘 contributing mechanisms
🫘 emerging trends
Deeper understanding of complex pathophysiology offers opportunities for new therapies & reno-protective strategies, supported by tools to accurately measure kidney function in real time.
🗞️ https://t.co/9RdU5AFD68 pic.twitter.com/LYgt9d21EQ

— Intensive Care Medicine (@yourICM) January 3, 2023

 

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M-A | Prevalence of polypharmacy and potentially inappropriate medication use in older lung cancer patients

9 Feb, 2023 | 13:24h | UTC

Prevalence of polypharmacy and potentially inappropriate medication use in older lung cancer patients: A systematic review and meta-analysis – Frontiers in Pharmacology

 

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Retrospective Cohort | Survivors of sepsis are at increased risk of late cardiovascular events

8 Feb, 2023 | 12:46h | UTC

Cardiovascular Events Among Survivors of Sepsis Hospitalization: A Retrospective Cohort Analysis – Journal of the American Heart Association

Editorial: Describing Sepsis as a Risk Factor for Cardiovascular Disease – Journal of the American Heart Association

News Release: Sepsis increased risk of heart failure and rehospitalization after hospital discharge – American Heart Association

Commentaries:

Sepsis Emerges as Powerful CVD Risk Factor in Large US Analysis – TCTMD

Cardiovascular Hospitalization Increased After Sepsis Hospitalization – HealthDay

 

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Review | Management of menopausal symptoms

8 Feb, 2023 | 12:44h | UTC

Management of Menopausal Symptoms: A Review – JAMA (free for a limited period)

Audio Clinical Review: Treatment of Menopausal Symptoms – JAMA

 

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Review | Autonomic dysfunction and postural orthostatic tachycardia syndrome in post-acute COVID-19 syndrome

8 Feb, 2023 | 12:38h | UTC

Autonomic dysfunction and postural orthostatic tachycardia syndrome in post-acute COVID-19 syndrome – Nature Reviews Cardiology

 

Commentary on Twitter

In our latest Comment, Fedorowski & Sutton discuss the role of autonomic dysfunction and postural orthostatic tachycardia syndrome (POTS) in post-acute #COVID19 syndrome: https://t.co/gJ08XxnfQ6 pic.twitter.com/FmC9JwDs4C

— Nature Reviews Cardiology (@NatRevCardiol) February 2, 2023

 

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Crossover RCT | Effects of SGLT2 inhibition on sodium in patients with chronic syndrome of inappropriate antidiuresis

8 Feb, 2023 | 12:34h | UTC

Treatment Effect of the SGLT2 Inhibitor Empagliflozin on Chronic Syndrome of Inappropriate Antidiuresis: Results of a Randomized, Double-Blind, Placebo-Controlled, Crossover Trial – Journal of the American Society of Nephrology

 

Commentary on Twitter

The syndrome of inappropriate antidiuresis (SIAD) is a major cause of hypotonic hyponatremia. This study shows the SGLT2 inhibitor empagliflozin is a promising new treatment for chronic SIAD-induced hyponatremia, possibly improving neurocognitive function https://t.co/U26RNmVM9j pic.twitter.com/8pH6xqSs7D

— JASN_News (@JASN_News) December 12, 2022

 

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Review | Pyoderma gangrenosum: Established and emerging pharmacological treatments

8 Feb, 2023 | 12:27h | UTC

Pyoderma Gangrenosum: An Updated Literature Review on Established and Emerging Pharmacological Treatments – American Journal of Clinical Dermatology

 

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Guideline | Delirium: prevention, diagnosis and management in hospital and long-term care

7 Feb, 2023 | 14:21h | UTC

Delirium: prevention, diagnosis and management in hospital and long-term care – National Institute for Health and Care Excellence

 

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SR | Calcium and vitamin D supplements do not increase bone mineral density or prevent fractures in premenopausal women

7 Feb, 2023 | 14:18h | UTC

Calcium and vitamin D for increasing bone mineral density in premenopausal women – Cochrane Library

Summary: Calcium and vitamin D for improving bone health in healthy premenopausal women – Cochrane Library

 

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SR | The current evidence does not support a role for Vitamin D in the management of asthma

7 Feb, 2023 | 14:16h | UTC

Vitamin D for the management of asthma – Cochrane Library

Commentary: Vitamin D for asthma: new evidence, new message – Evidently Cochrane

 

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