Internal Medicine

Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease

25 May, 2017 | 14:46h | UTC

Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease – Cochrane Library (link to abstract – $ for full-text) (RT @Gas_Craic see Tweet)

“Compared with culprit-only intervention, the complete revascularisation strategy may be superior due to lower proportions of long-term cardiovascular mortality, long-term revascularisation, and long-term non-fatal myocardial infarction, but these findings are based on evidence of very low quality”

Angioedema in the emergency department

25 May, 2017 | 14:46h | UTC

Angioedema in the emergency department: a practical guide to differential diagnosis and management – International Journal of Emergency Medicine (free) (RT @Gas_Craic see Tweet)

Perioperative management of patients on direct oral anticoagulants

24 May, 2017 | 14:42h | UTC

Review: Perioperative management of patients on direct oral anticoagulants – Thrombosis Journal (free)

Cardiopulmonary Resuscitation in Adults and Children With Mechanical Circulatory Support

24 May, 2017 | 14:40h | UTC

Cardiopulmonary Resuscitation in Adults and Children With Mechanical Circulatory Support: A Scientific Statement From the American Heart Association (free PDF)

See also: News release (free) AND Top Ten Things to Know (free PDF)

Trans-fat – The Worst Fat in the Food Supply

24 May, 2017 | 14:36h | UTC

The Worst Fat in the Food Supply – The New York Times (10 articles per month are free)

Trans-fat bans seem to be reducing cardiovascular deaths.

Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults

23 May, 2017 | 14:32h | UTC

Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults: The ALLHAT-LLT Randomized Clinical Trial – JAMA Internal Medicine (free) (RT @EricTopol see Tweet)

Editorial: Risks of Statin Therapy in Older Adults (free)

Commentaries: Older adults may not benefit from taking statins to prevent heart disease – Medical News Today (free) AND Pravastatin Doesn’t Improve Clinical Outcomes in Seniors – Physician’s First Watch (free)

Patients > 65 years with moderate hyperlipidemia and hypertension had no benefit from pravastatin for primary prevention. “A nonsignificant direction toward increased all-cause mortality with pravastatin was observed among adults 75 years and older” (HR 1.34; 95% CI, 0.98-1.84; P = .07).

Lack of Evidence for Benefit From Long-term Use of Opioid Analgesics for Patients With Neuropathy

24 May, 2017 | 14:35h | UTC

Association of Long-term Opioid Therapy With Functional Status, Adverse Outcomes, and Mortality Among Patients With Polyneuropathy – JAMA Neurology (free)

Editorial: Lack of Evidence for Benefit From Long-term Use of Opioid Analgesics for Patients With Neuropathy (free)

Commentaries: Long-Term Opioid Treatment Seems Only to Add Complications to Polyneuropathy – Physician’s First Watch (free) AND Long-Term Opioids May Not Help in Polyneuropathy – MedPage Today (free registration required)

“Patients had worse functional outcomes than controls; some became dependent” (from MedPage Today)

Cancer screening in the United States, 2017

23 May, 2017 | 14:27h | UTC

Cancer screening in the United States, 2017: A review of current American Cancer Society guidelines and current issues in cancer screening – CA: A Cancer Journal for Clinicians (free)

Home Noninvasive Ventilation to Reduce Readmissions for COPD

23 May, 2017 | 14:30h | UTC

#ATS2017 – Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial – JAMA (free)

Editorial: Home Noninvasive Ventilation to Reduce Readmissions for Chronic Obstructive Pulmonary Disease (free)

Commentary: Addition of Home Noninvasive Ventilation Tied to Fewer Readmissions After COPD Exacerbation – Physician’s First Watch (free)

American Urological Assn. Adds 5 More Unnecessary Practices to Choosing Wisely

23 May, 2017 | 14:24h | UTC

American Urological Assn. Adds 5 More Unnecessary Practices to Choosing Wisely – Physician’s First Watch (free)

Directly Observed Therapy for Multidrug-Resistant TB Decreases Mortality

23 May, 2017 | 14:29h | UTC

#ATS2017 – Directly Observed Therapy for Multidrug-Resistant TB Decreases Mortality – ATS 2017 Conference (free summary)

Directly Observed Therapy (DOT) for multidrug-resistant tuberculosis (MDR TB) was associated with a 77 percent decrease in mortality in observational study.

Reoperation and Medicare Expenditures After Laparoscopic Gastric Band Surgery

23 May, 2017 | 14:25h | UTC

Reoperation and Medicare Expenditures After Laparoscopic Gastric Band Surgery – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Following gastric band surgery, device-related reoperation common, costly – Science Daily (free) AND Safety, Effectiveness of Gastric Banding Called Into Question – Medscape (free registration required) AND 1 In 5 Gastric Band Surgeries Require Corrective Operations – American Council on Science and Health (free)

Science Has Begun Taking Gluten Seriously

19 May, 2017 | 18:06h | UTC

Science Has Begun Taking Gluten Seriously – The Atlantic (free)

Original article: Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study – The BMJ (free)

“New research from Harvard and Columbia says gluten does not cause heart disease. Why is that even a question?”

Reducing Recurrent Stroke With PFO Closure

19 May, 2017 | 18:00h | UTC

Finally, Success Reducing Recurrent Stroke With PFO Closure – Medscape (free registration required)

Two randomized trials presented at the 3rd European Stroke Organization Conference (ESOC) 2017 showed that in carefully selected stroke patients in whom Patent Foramen Oval (PFO) was suspected to be a cause of their strokes, a reduction in recurrent stroke was observed with PFO closure.

Guidelines on eosinophilic esophagitis

23 May, 2017 | 14:26h | UTC

Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults – United European Gastroenterology Journals (free)

Time to Treatment and Mortality during Mandated Emergency Care for Sepsis

19 May, 2017 | 18:08h | UTC

Time to Treatment and Mortality during Mandated Emergency Care for Sepsis – New England Journal of Medicine (free)

Commentary: Doctors have resisted guidelines to treat sepsis. New study suggests those guidelines save lives – STAT News (free)

“For every hour you delay antibiotics in sepsis, mortality goes up” (RT @CMichaelGibson see Tweet)

“Trauma: Golden Hour

Cardiology: Time is muscle

Neurology: Time is brain

Sepsis: Early antibiotics to survive”

(interesting remark by @CMichaelGibson see Tweet)

Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults

19 May, 2017 | 17:52h | UTC

Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Exercise and Dieting in Obese Older Adults (free)

Commentary: Aerobic Plus Resistance Exercise Best for Obese Older Adults – MedPage Today (free)

Position Paper – Prevention and Treatment of Substance Use Disorders

19 May, 2017 | 17:56h | UTC

Health and Public Policy to Facilitate Effective Prevention and Treatment of Substance Use Disorders Involving Illicit and Prescription Drugs: An American College of Physicians Position Paper – Annals of Internal Medicine (free)

News release: ACP issues recommendations to prevent and treat substance use disorders (free)

Commentary: Treat Addiction Like a Chronic Disease, ACP Recommends – AJMC (free)

Pressure ulcer prevention and treatment

19 May, 2017 | 17:53h | UTC

Pressure ulcer prevention and treatment. Is ‘best practice’ evidence-based? – Cochrane Blogs: Evidence for Everyday Nursing (free) (RT @CochraneUK see Tweet)

Evidence for the treatment of pressure ulcers reviewed.

Long-term oxygen therapy shows no benefit for moderate lung disease

18 May, 2017 | 17:51h | UTC

Long-term oxygen therapy shows no benefit for moderate lung disease – NIHR Signal: Dissemination Centre Discover Portal (free)

Original article: A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation – New England Journal of Medicine (free)

Patients with stable COPD and moderate resting desaturation (Spo₂, 89 to 93%) or moderate exercise-induced desaturation (during the 6-minute walk test, Spo₂ ≥80% for ≥5 minutes and <90% for ≥10 seconds) don’t seem to benefit from supplemental oxygen therapy.