Internal Medicine
Diabetes – Injection and Infusion Technique Recommendations
1 Jun, 2017 | 18:31h | UTCCommentary: New Guidance Focuses on Best Injection Practices for Diabetes – Medscape (free registration required)
Related guideline: New Insulin Delivery Recommendations – Mayo Clinic Proceedings (free)
Recommendations for the Use of Mechanical Circulatory Support
31 May, 2017 | 16:37h | UTCSee also: News release (free) AND Top Ten Things to Know (free PDF)
Related: Cardiopulmonary Resuscitation in Adults and Children With Mechanical Circulatory Support: A Scientific Statement From the American Heart Association (free PDF) AND CPR in Patients With Mechanical Circulatory Support – American College of Cardiology, Latest in Cardiology(free)
Maternal and Fetal Outcomes of Anticoagulation in Pregnant Women With Mechanical Heart Valves
1 Jun, 2017 | 18:25h | UTCCommentaries: Warfarin OK in Expectant Moms with Mechanical Heart Valve – MedPage Today (free registration required) AND Anticoagulation in Pregnant Women With Mechanical Valves – American College of Cardiology, Latest in Cardiology (free) (RT @keaglemd see Tweet)
In this meta-analysis, warfarin was associated with lower risk of adverse maternal outcomes, whereas LMWH was associated with lower risk of adverse fetal outcomes.
Current guidelines on prevention with a focus on dyslipidemias
30 May, 2017 | 15:33h | UTCReview: Current guidelines on prevention with a focus on dyslipidemias – Cardiovascular Diagnosis & Therapy (free)
Review comparing current recommendations for the treatment of dyslipidemia.
The British Society for Rheumatology Guideline for the Management of Gout
31 May, 2017 | 16:40h | UTCThe British Society for Rheumatology Guideline for the Management of Gout – Rheumatology (free)
Source: BSR guideline: Urate-lowering drugs should be offered early in gout – Healio Rheumatology (free)
Management of pericardial disease
30 May, 2017 | 15:34h | UTCA New Renaissance in Pericardial Diseases – Progress in Cardiovascular Diseases (special issue with series of review articles on the management of pericardial disease).
Source: Hospital Medicine Virtual Journal Club
1 – Introduction: A New Renaissance in Pericardial Diseases (free)
2 – Structure and Anatomy of the Human Pericardium (free)
3 – Pathophysiology of the Pericardium (free)
4 – Acute Pericarditis (free)
5 – Recurrent Pericarditis (free)
6 – Constrictive Pericarditis: A Practical Clinical Approach (free)
7 – Pericardial Effusions: Causes, Diagnosis, and Management (free)
8 – Pericardial Masses, Cysts and Diverticula: A Comprehensive Review Using Multimodality Imaging (free)
9 – Congenital Absence of the Pericardium (free)
10 – Surgical Management of Pericardial Diseases (free)
Healthcare Providers Shouldn’t Come to Work While Sick, but They Do — Here’s Why
31 May, 2017 | 16:35h | UTC
B-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction
30 May, 2017 | 15:35h | UTCCommentary: Some heart attack patients may not benefit from beta blockers – University of Leads, via Science Daily (free)
Large cohort suggests there may be no benefit in continuing B-Blockers in patients who do not develop heart failure or ventricular dysfunction after myocardial infarction.
Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk
30 May, 2017 | 15:27h | UTCComparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe – British Journal of Cancer (free)
Commentaries: Why your waist measurement can predict cancer risk – The Guardian (free) AND Large Waist Raises Cancer Risk – Medscape (free registration required)
The Weight Loss Trap: Why Your Diet Isn’t Working
29 May, 2017 | 15:23h | UTCThe Weight Loss Trap: Why Your Diet Isn’t Working – Time (cover story) (free)
“The challenges of weight loss and obesity – really well addressed” (RT @EricTopol see Tweet)
Type 2 diabetes in adults: management – NICE Guideline
29 May, 2017 | 15:24h | UTCType 2 diabetes in adults: management – NICE Guideline (free)
See also: Algorithm for blood glucose lowering therapy in adults with type 2 diabetes (free PDF)
Source: UK NICE Elevates SGLT2 Inhibitors in Diabetes Guidance – Medscape (free registration required)
Cancer Pain – Updated PDQ Cancer Information Summary
29 May, 2017 | 15:17h | UTCCancer Pain – Updated PDQ Cancer Information Summary, National Cancer Institute (US) (free)
Exercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment
29 May, 2017 | 15:21h | UTCCommentary: Several non-drug options help with fatigue during, after cancer treatment – Reuters Health News (free)
Cardiovascular Toxicity of Illicit Anabolic-Androgenic Steroid Use
26 May, 2017 | 15:11h | UTCCardiovascular Toxicity of Illicit Anabolic-Androgenic Steroid Use – Circulation (link to abstract – $ for full-text)
Commentaries: Anabolic Steroid Use Linked With Myocardial Dysfunction and Accelerated Atherosclerosis – TCTMD (free) AND Chronic anabolic steroid use may damage heart – American Heart Association News (free)
“The findings are a public health concern, given that as many as 1% of young men, not all of them athletes, may use these agents” (from TCTMD above).
Thrombocytosis and cancer
29 May, 2017 | 15:18h | UTCClinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data – British Journal of General Practice (link to abstract – $ for full-text)
Commentaries: Cautions and caveats help buoy Guardian story on using high platelet count for cancer detection – HealthNewsReview (free) High blood platelet count ‘as good a cancer predictor as a lump in the breast’ – The Guardian (free)
Thrombocytosis seems to be a risk marker of cancer in adults, but questions remain about the clinical usefulness of these findings.
Antibiotic therapy for nearly one in four adults with pneumonia does not work
29 May, 2017 | 15:20h | UTC#ATS2017 – Antibiotic therapy for nearly one in four adults with pneumonia does not work – American Thoracic Society, via Science Daily (free) (RT @IDSAInfo see Tweet)
See also: Pneumonia Treatment Failure Rates High – Medscape (free registration required) AND Adults With Pneumonia Often Fail First Antibiotic – MedPage Today (free registration required)
Thrombolysis may reduce complications of deep vein thrombosis
26 May, 2017 | 15:09h | UTCThrombolysis may reduce complications of deep vein thrombosis – NIHR Signal (free)
Original article: Thrombolysis for acute deep vein thrombosis – Cochrane Library (Link to abstract – $ for full-text)
Thrombolysis reduced post-thrombotic syndrome, but lead to more bleeding complications than standard anticoagulation. “Individuals with clots in the pelvis and thigh, which carry higher risk of complications, may be likely to gain most benefit”.
Guidelines on the Management of Intra-Abdominal Infection
26 May, 2017 | 15:10h | UTCRelated: Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference – World Journal of Emergency Surgery (free)
Idiopathic pulmonary fibrosis in adults: diagnosis and management
26 May, 2017 | 15:04h | UTCIdiopathic pulmonary fibrosis in adults: diagnosis and management – NICE Guideline (free)
Diagnostic accuracy of post-mortem CT
26 May, 2017 | 15:07h | UTCEditorial: Targeted coronary post-mortem CT angiography, straight to the heart (free)
Commentary: Digital autopsies should be standard for probable natural deaths, says study – The Guardian (free)
Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease
25 May, 2017 | 14:55h | UTCRecommended: New QRISK-3 2017 Calculator (free)
QRISK-3 risk prediction model was developed with data from 7.89 million patients in the derivation cohort and 2.67 million patients in the validation cohort. QRISK-3 includes more factors than QRISK2 to help enable doctors to identify those at most risk of heart disease and stroke. New risk factors include: 1) Chronic kidney disease, which now includes stage 3 CKD; 2) Migraine; 3) Use of corticosteroids; 4) Systemic lupus erythematosus (SLE); 5) Use of atypical antipsychotics; 6) Severe mental illness; 7) Erectile dysfunction; 8) and Systolic blood pressure variability.
Eating disorders: recognition and treatment
26 May, 2017 | 15:03h | UTCEating disorders: recognition and treatment – NICE Guideline (free)
Effect of Cephalexin Plus Trimethoprim-Sulfamethoxazole vs Cephalexin Alone on Clinical Cure of Uncomplicated Cellulitis
25 May, 2017 | 14:53h | UTCEffect of Cephalexin Plus Trimethoprim-Sulfamethoxazole vs Cephalexin Alone on Clinical Cure of Uncomplicated Cellulitis: A Randomized Clinical Trial – JAMA (Link to abstract – $ for full-text)
Commentaries: Adding Anti-MRSA to Cephalexin No Better for Simple Cellulitis – Medscape (free registration required) AND Adding TMP/SMX to Cephalexin May Not Boost Cure Rate in Uncomplicated Cellulitis – Physician’s First Watch (free)
The lap band for weight loss is a tale of medicine gone wrong
25 May, 2017 | 15:02h | UTCThe lap band for weight loss is a tale of medicine gone wrong – VOX (free)
See also a recent study showing high complication rates of laparoscopic gastric band surgeries in our May 23rd issue (see #7)
Effect of a Modified Hospital Elder Life Program on Delirium and Length of Hospital Stay in Patients Undergoing Abdominal Surgery
25 May, 2017 | 14:50h | UTCEffect of a Modified Hospital Elder Life Program on Delirium and Length of Hospital Stay in Patients Undergoing Abdominal Surgery: A Cluster Randomized Clinical Trial – JAMA Surgery (free) (RT @PreetiNMalani see Tweet)
Commentary: Anti-delirium strategy reduces after-surgery confusion in elderly – Reuters Health (free)
Multicomponent nonpharmacologic interventions, including orienting communications, oral and nutritional assistance, and early mobilization reduced postoperative delirium by 56% and length of stay by 2 days.