Internal Medicine
An emergency department protocol to restore circulation doesn’t improve outcomes in septic shock
21 Jul, 2017 | 17:38h | UTCAn emergency department protocol to restore circulation doesn’t improve outcomes in septic shock – NIHR Signal (free)
Original article: Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis – New England Journal of Medicine (link to abstract – $ for full-text)
Community-associated methicillin-resistant Staphylococcus aureus infection
21 Jul, 2017 | 00:24h | UTCClinical Review: Community-associated methicillin-resistant Staphylococcus aureus infection: Literature review and clinical update – Canadian Family Physician (free)
Efficacy and Safety of Spironolactone in Acute Heart Failure
21 Jul, 2017 | 00:21h | UTCEfficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial – JAMA Cardiology (link to abstract – $ for full-text)
Commentaries: High-dose spironolactone didn’t affect acute heart failure outcomes – ACP Hospitalist (free) AND High-Dose Spironolactone in Acute Heart Failure – American College of Cardiology, Latest in Cardiology (free)
Use of antibiotics during pregnancy and the risk of major congenital malformations
21 Jul, 2017 | 00:22h | UTCUse of antibiotics during pregnancy and the risk of major congenital malformations: A population based cohort study – British Journal of Pharmacology (link to abstract – $ for full-text)
Commentary: New study finds link between certain antibiotics during pregnancy and risk for birth defects – News Medical (free)
Related article: Use of antibiotics during pregnancy and risk of spontaneous abortion – Canadian Medical Association Journal (free)
In this large cohort clindamycin, doxycycline, quinolones, macrolides, and phenoxymethylpenicillin were associated with congenital malformations. Amoxicillin, cephalosporins, and nitrofurantoin were not associated with birth defects.
Healthful and Unhealthful Plant-Based Diets and the Risk of Coronary Heart Disease
20 Jul, 2017 | 00:13h | UTCHealthful and Unhealthful Plant-Based Diets and the Risk of Coronary Heart Disease in U.S. Adults – Journal of The American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Some Plant-Based Diets May Increase Heart Disease Risk –American College of Cardiology, Latest in Cardiology (free) AND Not All Vegetarian, Plant-Based Diets Equal for CHD Risk – Medscape (free registration required) AND Not all plant-based diets are created equal – American College of Cardiology, via ScienceDaily (free)
USPSTF Draft Recommendation Statement on Ovarian Cancer Screening
20 Jul, 2017 | 00:10h | UTCDraft Recommendation Statement: Ovarian Cancer: Screening – U.S. Preventive Services Task Force (free)
Commentaries: USPSTF Again Recommends Against Screening General Population for Ovarian Cancer – Physician’s First Watch (free) AND USPSTF Stays Course on Ovarian Cancer Screening: No screening for asymptomatic women – MedPage Today (free registration required)
Oral antifungal medication for toenail onychomycosis
20 Jul, 2017 | 00:08h | UTCCochrane What is the best medication for a fungal infection of the toenail? – Cochrane Library (free)
Full review: Oral antifungal medication for toenail onychomycosis – Cochrane Library (link to abstract – $ for full-text)
Terbinafine probably leads to better cure rates than azoles, with the same risk of adverse events. Griseofulvin is no better and has more adverse effects than azoles.
Rhabdomyolysis & Exertional Heat Stroke
20 Jul, 2017 | 00:03h | UTCAs Workouts Intensify, a Harmful Side Effect Grows More Common – New York Times (10 articles per month are free)
Related practical review: Exercise-Induced Emergencies in the Heat: Rhabdomyolysis & Exertional Heat Stroke – emDocs (free)
Comprehensive geriatric assessment and optimization in vascular surgery
20 Jul, 2017 | 00:02h | UTCRandomized clinical trial of comprehensive geriatric assessment and optimization in vascular surgery – British Journal of Surgery (link to abstract – $ for full-text)
Source: ACP Journal Club ($ resource to find articles of interest)
In this RCT, a comprehensive preoperative geriatric assessment and optimization before vascular surgery was associated with shorter length of hospital stay, lower incidence of complications, and patients were less likely to be discharged to a higher level of dependency.
Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy
20 Jul, 2017 | 00:04h | UTCPatient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Tapering long-term opioid therapy may improve outcomes in chronic pain, review finds – ACP Internist (free) AND Opioid Reduction Therapy Offers Some Benefits to Patients with Chronic Pain – Physician’s First Watch (free) AND How tapering off opioids can help people with chronic pain – CNN (free)
“Opioid tapering:
– less pain: 8 of 8 studies
– Improved function: 5 of 5 studies
– Improved QOL: 3 of 3 studies” (RT @DavidJuurlink see Tweet)
Guideline: Asymptomatic Microscopic Hematuria in Women
18 Jul, 2017 | 23:08h | UTCGuideline: Asymptomatic Microscopic Hematuria in Women – American College of Obstetricians and Gynecologists Recommendations and Conclusions (free)
Concise review: Irritable Bowel Syndrome
18 Jul, 2017 | 22:59h | UTCConcise review: Irritable Bowel Syndrome – NEJM Resident 360 clinical pearls (free)
Iron substitution in the treatment of chronic heart failure
18 Jul, 2017 | 22:57h | UTCClinical Review: Iron substitution in the treatment of chronic heart failure – Swiss Medical Weekly (free)
Rehabilitation in patients with pulmonary arterial hypertension
18 Jul, 2017 | 22:58h | UTCClinical Review: Rehabilitation in patients with pulmonary arterial hypertension – Swiss Medical Weekly (free)
Treatment and outcomes: medical and surgical treatment for intestinal Behçet’s disease
18 Jul, 2017 | 22:44h | UTCClinical Review: Treatment and outcomes: medical and surgical treatment for intestinal Behçet’s disease (free)
Concise review: Amyotrophic Lateral Sclerosis
18 Jul, 2017 | 22:59h | UTCConcise review: Amyotrophic Lateral Sclerosis – NEJM Resident 360 clinical pearls (free)
Optimal diagnosis and disease activity monitoring of intestinal Behçet’s disease
18 Jul, 2017 | 22:45h | UTCClinical Review: Optimal diagnosis and disease activity monitoring of intestinal Behçet’s disease (free)
Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis
18 Jul, 2017 | 22:42h | UTCClinical Review: Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis – Gut and Liver (free PDF)
Hypersensitivity to antipyretics: pathogenesis, diagnosis, and management
18 Jul, 2017 | 22:41h | UTCClinical Review: Hypersensitivity to antipyretics: pathogenesis, diagnosis, and management – Hong Kong Medical Journal (free)
Evidence-based guidelines for fall prevention
18 Jul, 2017 | 00:01h | UTC
Meta-analysis: Artificial sweeteners do not help with weight loss
18 Jul, 2017 | 00:10h | UTCCommentaries: Artificial Sweeteners Not Tied to Lower BMI and May Even Increase It – Physician’s First Watch (free) AND Artificial Sweeteners Don’t Help People Lose Weight, Review Finds – NPR (free) AND The Irony Of Artificial Sweeteners – Forbes (free) AND Low-calorie sweeteners don’t help with weight loss — and may lead to gained pounds – STAT News (free)
Richard Lehman’s weekly review
18 Jul, 2017 | 00:03h | UTCRichard Lehman’s journal review, 17 July 2017 – The BMJ Blogs (free)
Richard Lehman reviews the latest research in the top medical journals.
High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy
17 Jul, 2017 | 01:36h | UTCSource: Hospital Medicine Virtual Journal Club (free resource to find articles of interest)
Hypertensive disorders of pregnancy
17 Jul, 2017 | 01:34h | UTCRelated article: Lifestyle in progression from hypertensive disorders of pregnancy to chronic hypertension in Nurses’ Health Study II: observational cohort study – The BMJ (free)
Editorial: Hypertensive disorders of pregnancy – The BMJ (free)
Commentaries: Hypertensive Disorders of Pregnancy Tied to Increased Hypertension Risk Decades Later – Physician’s First Watch (free)
Studies suggest apneic oxygenation reduces hypoxemia during emergency intubation
17 Jul, 2017 | 01:34h | UTCStudies suggest apneic oxygenation reduces hypoxemia during emergency intubation:
Meta-analysis 1: Apneic oxygenation during intubation in the emergency department and during retrieval: A systematic review and meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full-text)
Meta-analysis 2: Apneic oxygenation reduces the incidence of hypoxemia during emergency intubation: A systematic review and meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full text)
Source: Apneic Oxygenation Prevents Desaturation During Intubation – Journal Watch ($ resource to find articles of interest)