Internal Medicine
Guideline: Induction therapy of ANCA-associated vasculitis
9 Aug, 2017 | 15:47h | UTC
Richard Lehman’s journal review, 7 August 2017
7 Aug, 2017 | 22:00h | UTCRichard Lehman’s journal review, 7 August 2017 – The BMJ Blogs (free)
Richard Lehman reviews the latest research in the top medical journals.
Subclinical thyrotoxicosis: prevalence, causes and choice of therapy
7 Aug, 2017 | 22:01h | UTC10 – Review: Subclinical thyrotoxicosis: prevalence, causes and choice of therapy – European Journal of Endocrinology (free)
Raw milk and cheese cause 840 times more illnesses than pasteurized products
7 Aug, 2017 | 21:56h | UTCCommentaries: Raw milk: a superfood or super risky? – The Guardian (free) AND Raw milk and cheese cause 840 times more illnesses than pasteurized products – STAT News (free)
Long-term follow-up of patients with pulmonary thromboembolism
7 Aug, 2017 | 01:11h | UTC
Optimal timing of an invasive strategy in patients with non-ST-elevation acute coronary syndrome
7 Aug, 2017 | 21:55h | UTCOptimal timing of an invasive strategy in patients with non-ST-elevation acute coronary syndrome: a meta-analysis of randomised trials – The Lancet (link to abstract – $ for full-text)
Commentary: Optimal Timing of an Invasive Strategy in NSTE-ACS Patients – American College of Cardiology, Latest in Cardiology (free)
An early invasive strategy does not reduce mortality compared with a delayed invasive strategy in most patients with NSTE-ACS, but seems to reduce mortality in high-risk patients.
Guideline: stroke prevention in atrial fibrillation
7 Aug, 2017 | 01:10h | UTC
Modifiable Risk Factors for Incident Heart Failure in Atrial Fibrillation
5 Aug, 2017 | 19:50h | UTCModifiable Risk Factors for Incident Heart Failure in Atrial Fibrillation – Journal of The American College of Cardiology (link to abstract – $ for full-text)
Commentary: Risk for Incident Heart Failure in Atrial Fibrillation – American College of Cardiology, Latest in Cardiology (free)
“Lose weight, treat hypertension & diabetes, stop smoking: That’s how we might prevent heart failure” (RT @JACCJournals see Tweet)
Too Many Meds?
5 Aug, 2017 | 20:02h | UTCToo Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free)
See more on “Deprescribing” in our May 8th issue (see #7), May 9th issue (see #4) and May 15th issue (see #2), and also a related article on Current and future perspectives on the management of polypharmacy
“Yes. Way Too Many Meds. Think De-prescribe”. (RT @EricTopol see Tweet)
Factors Associated With Achieving a Body Mass Index of Less Than 30 After Bariatric Surgery
5 Aug, 2017 | 19:05h | UTCFactors Associated With Achieving a Body Mass Index of Less Than 30 After Bariatric Surgery – JAMA Surgery (link to abstract – $ for full-text)
Commentaries: Opting for Weight-Loss Surgery at Lower BMIs May Be Best for Patients’ Health, Study Suggests – University of Michigan, via NewsWise (free) AND Delayed Weight Loss Surgery Tied to Worse Outcomes – MedPage Today (free registration required) AND Weight-loss surgery may work better when patients aren’t too obese – Reuters (free) AND With bariatric surgery, a patient’s starting weight makes a difference, study finds – STAT (free)
Association of Resistance Exercise With the Incidence of Metabolic Syndrome
5 Aug, 2017 | 19:15h | UTCCommentaries: Metabolic syndrome: An hour of resistance training per week may cut risk – Medical News Today (free) AND Resistance Training Tied to Lower Risk for Metabolic Syndrome – Physician’s First Watch (free)
Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes
5 Aug, 2017 | 18:11h | UTCReview: Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes – BMC Medicine (free)
Nutrition support for adults: oral nutrition support, enteral tube feeding and parenteral nutrition
5 Aug, 2017 | 18:57h | UTCGuideline: Nutrition support for adults: oral nutrition support, enteral tube feeding and parenteral nutrition – National Institute for Health and Care Excellence (NICE)
Frailty and cancer: Implications for oncology surgery, medical oncology, and radiation oncology
5 Aug, 2017 | 17:43h | UTCReview: Frailty and cancer: Implications for oncology surgery, medical oncology, and radiation oncology – CA: A Cancer Journal for Clinicians (free)
Bronchoscopy and bleeding risk
5 Aug, 2017 | 18:05h | UTCEditorial: Bronchoscopy and bleeding risk – European Respiratory Review (free)
Review: Management of antithrombotic agents in patients undergoing flexible bronchoscopy – European Respiratory Review (free)
A comprehensive guide to the new science of treating lower back pain
4 Aug, 2017 | 16:52h | UTCA comprehensive guide to the new science of treating lower back pain – VOX (free)
“Mainstream medicine has failed people with chronic back pain”
Mechanical clot removal for stroke reduces disability at two years
3 Aug, 2017 | 22:07h | UTCMechanical clot removal for stroke reduces disability at two years – NIHR Signal (free)
“Mechanical thrombectomy within six hours of stroke onset provides a sustained reduction of disability for patients” (RT @NIHR_DC see Tweet)
Trial of Tocilizumab in Giant-Cell Arteritis
3 Aug, 2017 | 21:39h | UTCTrial of Tocilizumab in Giant-Cell Arteritis – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: The GiACTA Trial (free)
Commentaries: Tocilizumab improves remission rates in giant-cell arteritis: The GiACTA trial – 2 Minute Medicine (free) AND Phase 3 trial confirms superiority of tocilizumab to steroids for giant cell arteritis – Massachusetts General Hospital, via EurekAlert (free) AND Tocilizumab With Steroid Taper Superior in GCA – Medscape (free registration required)
Atypical fracture with long-term bisphosphonate therapy is associated with altered cortical composition and reduced fracture resistance
3 Aug, 2017 | 20:55h | UTCCommentaries: Long-Term Bisphosphonate Use Degrades Cortical Bone – Medscape (free registration required) AND How Do Bisphosphonates Cause Atypical Femoral Fractures? – MedPage Today (free registration required) AND Study highlights underlying mechanisms of fractures associated with osteoporosis drug – Cornell University, via EurekAlert (free)
Discover and defeat your diagnostic errors
3 Aug, 2017 | 20:33h | UTCDiscover and defeat your diagnostic errors – ACP Internist (free) (RT @acpinternist see Tweet)
“Experts explain the causes and solutions for common mistakes in diagnosis”.
Oral fluoroquinolones and risk of secondary pseudotumor cerebri syndrome
3 Aug, 2017 | 20:21h | UTCOral fluoroquinolones and risk of secondary pseudotumor cerebri syndrome – Neurology (link to abstract – $ for full-text)
Commentary: Fluoroquinolones May Up Risk of PTCS, a Rare But Serious Condition – MPR (free) (RT @AmeshAA see Tweet)
Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy:
3 Aug, 2017 | 19:57h | UTCEffect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Steroid treatment for type of kidney disease associated with increased risk for serious infections – The JAMA Network (free)
Renal outcomes seemed to be less frequent in the group using methylprednisolone (5,9% vs 15,9%), but the trial was stopped early due to a significantly increased risk of serious adverse events with oral methylprednisolone vs placebo (14.7% vs 3.2%, primarily excess infections)
Tai Chi for Risk of Falls. A Meta-analysis
3 Aug, 2017 | 19:31h | UTCTai Chi for Risk of Falls. A Meta-analysis – Journal of The American Geriatrics Society (link to abstract – $ for full-text)
Commentaries: Meta-Analysis: Tai Chi Keeps Seniors from Falling – MedPage Today (free registration required) AND Tai chi may help reduce rate of falls in older and at-risk adults – News Medical (free)
‘Can reduce fall rates by almost half during the first year’ (from MedPage Today)
The global crackdown on parents who refuse vaccines for their kids has begun
3 Aug, 2017 | 19:37h | UTCThe global crackdown on parents who refuse vaccines for their kids has begun – VOX (free)
See more on mandatory vaccination in our May 29th (see #6) and July 12th (see #5) issues.
“Countries like Italy and Australia are tired of measles outbreaks — so they’re moving to fine anti-vaccine parents”.
Cancer screening: concerns, controversy and evidence
3 Aug, 2017 | 20:13h | UTCSpecial issue: Public Health Research & Practice – July 2017 Edition
– Editorial: Cancer screening: concerns, controversy and evidence (free)
– PSA testing for men at average risk of prostate cancer (free)
– What is overdiagnosis and why should we take it seriously in cancer screening? (free)
– History, development and future of cancer screening in Australia (free)
– Assessing the efficacy of cancer screening (free)
– Improving communication about cancer screening: moving towards informed decision making (free)
“A special issue to check out if you’re interested in cancer screening (including communication)” (RT @hildabast see Tweet)


