Internal Medicine
Study: Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding
22 Aug, 2017 | 15:19h | UTCGastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial – The Lancet (link to abstract – $ for full-text)
Source: ACP Journal Club
In this study, patients at high risk of both cardiovascular and gastrointestinal events who required concomitant aspirin and NSAID, celecoxib associated with a proton pump inhibitor led to less recurrent gastrointestinal bleeding when compared to naproxen associated with a proton pump inhibitor (5.6% vs 12.3%).
Systematic Review: Benefits and Harms of Osteoporosis Medications in Patients With Chronic Kidney Disease
22 Aug, 2017 | 15:32h | UTCBenefits and Harms of Osteoporosis Medications in Patients With Chronic Kidney Disease: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Benefits and harms of osteoporosis medications unclear for patients with CKD – Medical News Today (free) AND Benefits and harms of osteoporosis medications unclear for patients with CKD – 2 Minute Medicine (free)
Source: ACP Journal Club ($)
Study: Risk of Arterial Thromboembolism in Patients With Cancer
22 Aug, 2017 | 14:44h | UTCRisk of Arterial Thromboembolism in Patients With Cancer – Journal of The American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Cancer Patients at Heightened Risk for Arterial Thromboembolism – American College of Cardiology, Latest in Cardiology (free) AND Thromboembolism Risk Doubled in Cancer Patients – Medscape (free registration required) AND Cancer patients carry double the short-term risk of arterial thromboembolism – Cardiovascular Business (free) AND Short-Term Risk of Arterial Thromboembolism in Newly Diagnosed Patients With Cancer – ASCO Post (free)
Study: Hypertensive Disorders in Pregnancy and the Risk of Subsequent Cardiovascular Disease
22 Aug, 2017 | 13:07h | UTCCommentaries: Study: Hypertension in pregnancy may affect long-term heart health – UPI (free) AND Hypertension during pregnancy may affect women’s long-term cardiovascular health – Wiley, via EurekAlert (free)
Related: Women with High-Risk Pregnancies Are More Likely To Develop Heart Disease – NPR (free) AND Adverse Pregnancy Conditions, Infertility, and Future Cardiovascular Risk: Implications for Mother and Child – Cardiovascular Drugs and Therapy (free)
Study: Smoking Cessation Pharmacotherapy Among Smokers Hospitalized for Coronary Heart Disease
22 Aug, 2017 | 13:02h | UTCCommentaries: Smokers hospitalized for heart attacks often don’t get cessation drugs – Reuters (free) AND Smokers Hospitalized for CHD Rarely Receive Cessation Pharmacotherapy During Hospitalization – American College of Cardiology, Latest in Cardiology (free)
Re-analysis of the USPSTF 2016 Evidence Report on Colorectal Cancer Screening
22 Aug, 2017 | 13:01h | UTCRe-analysis of All-Cause Mortality in the U.S. Preventive Services Task Force 2016 Evidence Report on Colorectal Cancer Screening – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Flexible Sigmoidoscopy Tied to Lower Mortality Risk – Physician’s First Watch (free) AND Flexible Sigmoidoscopy Reduces All-Cause Mortality – Medscape (free registration required)
Review: Oncological patients in the intensive care unit
22 Aug, 2017 | 00:53h | UTCSource: Critical Care Review Newsletter
Free Online Course: Bacteria and Chronic Infections
21 Aug, 2017 | 01:51h | UTCStarts Today! Free Online Course: Bacteria and Chronic Infections – University of Copenhagen and Coursera
Guideline: Safe Medication Use in the ICU
21 Aug, 2017 | 01:44h | UTCClinical Practice Guideline: Safe Medication Use in the ICU – Critical Care Medicine (free)
See also: Executive Summary (free)
Meta-analysis: Acute Kidney Injury After Computed Tomography
21 Aug, 2017 | 01:41h | UTCAcute Kidney Injury After Computed Tomography: A Meta-analysis – Annals of Emergency Medicine (link to abstract – $ for full-text)
Commentary: When kidneys are injured, CT contrast isn’t the culprit – Health Imaging (free)
Related article: Risk of Acute Kidney Injury After Intravenous Contrast Media Administration – Annals of Emergency Medicine (free)
Source: Hospital Medicine Virtual Journal Club
Compared with noncontrast CT, contrast-enhanced CT was not significantly associated with either acute kidney injury, need for renal replacement therapy, or all-cause mortality.
Study: association of obesity and metabolic health with coronary heart disease
21 Aug, 2017 | 01:46h | UTCSeparate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis – European Heart Journal (link to abstract – $ for full-text)
Commentaries: ‘Fat but fit’ people may still be at risk of heart disease – NHS Choices (free) AND ‘Fat but fit’ still has higher risk of heart disease, study confirms – CNN (free) AND ‘Fat but Fit’ is Myth; New UK Study Finds BMI>25 Ups MI Risk – Medscape (free registration required) AND ‘Fat but fit’ still risk heart disease – BBC (free)
Review: Postoperative pulmonary complications
21 Aug, 2017 | 01:36h | UTCPostoperative pulmonary complications – British Journal of Anaesthesia (free)
Source: Critical Care Reviews Topic of The Week
Too much medicine: Mapping the drivers of overdiagnosis to potential solutions
17 Aug, 2017 | 21:37h | UTCAnalysis – Too much medicine: Mapping the drivers of overdiagnosis to potential solutions – The BMJ (free)
Related: Overdiagnosis, ethics, and trolley problems: why factors other than outcomes matter – The BMJ (free) AND The overdiagnosis community targets solutions – The BMJ (free) AND Are expanding disease definitions unnecessarily labelling women with polycystic ovary syndrome? – The BMJ (free) AND When technology creates uncertainty: pulse oximetry and Overdiagnosis of hypoxaemia in bronchiolitis – The BMJ (free)
Standard of Care in Critically Ill Adult Patients With Atypical Hemolytic Uremic Syndrome
17 Aug, 2017 | 18:22h | UTCSource: Critical Care Reviews Newsletter
Comparison of early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients
17 Aug, 2017 | 17:55h | UTCSource: Critical Care Reviews Newsletter
Early initiation of RRT in critically ill patients did not result in reduced mortality, change in renal function recovery, dependence, duration of RRT, renal recovery time, mechanical ventilation time or complications.
Decompensated Heart Failure
17 Aug, 2017 | 18:11h | UTCSpecial issue: Topical Collection on Decompensated Heart Failure – Current Heart Failure Reports
Source: Critical Care Reviews Newsletter
– Inpatient Monitoring of Decompensated Heart Failure: What Is Needed? (free)
– Acute Heart Failure: Definition, Classification and Epidemiology (free)
– Mechanical Circulatory Support for Decompensated Heart Failure (free)
– Pharmacological and Non-pharmacological Treatment for Decompensated Heart Failure: What Is New? (free)
– Current Approach to Decongestive Therapy in Acute Heart Failure (free)
Stop Treating 70- and 90-Year-Olds the Same
17 Aug, 2017 | 16:31h | UTCOpinion: Stop Treating 70- and 90-Year-Olds the Same – New York Times (free)
The role of bariatric surgery to treat diabetes
17 Aug, 2017 | 15:45h | UTCReview: The role of bariatric surgery to treat diabetes: current challenges and perspectives – BMC Endocrine Disorders (free)
Recommendations for HIV Screening of Gay, Bisexual, and Other Men Who Have Sex with Men
17 Aug, 2017 | 16:25h | UTC“@CDC_HIVAIDS recommends men who have sex with men be tested for HIV at least annually”. (RT @CDCMMWR see Tweet)
A National Implementation Project to Prevent Catheter-Associated Urinary Tract Infection in Nursing Home Residents
17 Aug, 2017 | 15:57h | UTCA National Implementation Project to Prevent Catheter-Associated Urinary Tract Infection in Nursing Home Residents – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Study Shows 54 Percent Drop in CAUTIs Among Nursing Home Residents – Infection Control Today (free) AND AHRQ safety program helps cut catheter infections by more than 50% among nursing home patients, JAMA study shows – Healthcare Finance (free) AND Implementing technical and socioadaptive bundles may decrease catheter-associated urinary tract infections in nursing homes – 2 Minute Medicine (free) AND Nursing homes cut urinary tract infections in half through focused effort on catheter care – Michigan University, via EurekAlert (free)
Related: Toolkit for Reducing Catheter-Associated Urinary Tract Infections (CAUTI) – Agency for Healthcare Research and Quality (free resources)
Cardiac Toxicity Of Cancer Chemotherapy
17 Aug, 2017 | 16:40h | UTCReview: Cardiac Toxicity Of Cancer Chemotherapy – US Cardiology Review (free)
Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free) AND Radiation Associated Cardiac Disease – American College of Cardiology, Latest in Cardiology (free)
Five-Year Outcomes after On-Pump and Off-Pump Coronary-Artery Bypass
16 Aug, 2017 | 23:05h | UTCFive-Year Outcomes after On-Pump and Off-Pump Coronary-Artery Bypass – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Off-Pump CABG Raises Long-Term Mortality Risk – Cardiobrief (free) AND Newer method of open-heart surgery carries more risks, study finds – STAT (free)
Benefits and safety of gabapentinoids in chronic low back pain
16 Aug, 2017 | 23:04h | UTCCommentaries: Gabapentinoids Seem to Offer Little Benefit, Substantial Risks in Low Back Pain – Physician’s First Watch (free) AND Evidence does not support the use of gabapentinoids for chronic low back pain – PLOS, via Science Daily (free) AND Gabapentinoids for Chronic Low Back Pain? Not So Fast – Practical Pain Management (free)
Pregabalin and gabapentin have significant risk of adverse effects without any demonstrated benefit in chronic low back pain.
Effect of scheduled second-look endoscopy on peptic ulcer bleeding
16 Aug, 2017 | 20:43h | UTCEffect of scheduled second-look endoscopy on peptic ulcer bleeding: a prospective randomized multicenter trial – Gastrointestinal Endoscopy (link to abstract – $ for full-text)
Source: No Benefit of Second-Look Endoscopy After Endoscopic Hemostasis – Journal Watch ($)
“A single EGD with endoscopic hemostasis is not inferior to scheduled second-look endoscopy in terms of reduction in rebleeding rate of peptic ulcer bleeding. Repeat endoscopy would be helpful in the patients with unsatisfactory initial endoscopic hemostasis, use of NSAIDs, and larger amounts of transfused blood”
Role of nutrition support in adult cardiac surgery
16 Aug, 2017 | 19:48h | UTC