Internal Medicine
Randomized Controled Trial: Continuous glucose monitoring in pregnant women with type 1 diabetes
25 Sep, 2017 | 22:23h | UTCContinuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentaries: In Pregnant Women with Type 1 Diabetes, Continuous Glucose Monitoring Linked to Better Outcomes – Physician’s First Watch (free) AND All pregnant women with type 1 diabetes should be offered continuous glucose monitoring – OnMedica (free)
Richard Lehman’s journal review – 25 September 2017
25 Sep, 2017 | 22:22h | UTCRichard Lehman’s journal review, 25 September 2017 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Interventions to Reduce Suicide Risk Among Hospital Emergency Department Patients
25 Sep, 2017 | 22:20h | UTCModeling the Cost-Effectiveness of Interventions to Reduce Suicide Risk Among Hospital Emergency Department Patients – Psychiatric Services (link to abstract – $ for full-text)
Commentary: Life-Saving Post-ER Suicide Prevention Strategies are Cost Effective – National Institute of Mental Health (free)
See also related meta-analysis and studies on strategies to prevent suicide in our August 11th issue (see #6 and #7)
Adherence Tradeoff to Multiple Preventive Therapies and All-Cause Mortality After Acute Myocardial Infarction
24 Sep, 2017 | 21:37h | UTCAdherence Tradeoff to Multiple Preventive Therapies and All-Cause Mortality After Acute Myocardial Infarction – Journal of The American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Study Questions Incremental Benefit of Beta-Blockers After Acute MI – TCTMD (free) AND Beta blockers not needed after heart attack if other medications taken – University of North Carolina at Chapel Hill, via Eurekalert (free) AND Adherence to medications post-MI is below 50%; beta-blockers offer little incremental benefit – Cardiovascular Business (free)
Related study published recently: β-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction – Journal of The American College of Cardiology (free)
The effect of physical activity on mortality and cardiovascular disease
24 Sep, 2017 | 21:40h | UTCThe effect of physical activity on mortality and cardiovascular disease in 130 000 people from 17 high-income, middle-income, and low-income countries: the PURE study – The Lancet (link to abstract – $ for full-text)
Commentaries: Any type of physical exercise is good for the heart – NHS Choices (free) AND Physical Activity of Any Ilk Cuts CVD, Deaths in Global Study: PURE – TCTMD (free) AND Being active saves lives whether a gym workout, walking to work or washing the floor – McMaster University, via ScienceDaily (free) AND Don’t overthink your exercise: just 2.5 hours per week of any kind could help you live longer – VOX (free) AND A daily half hour’s exercise could prevent 1 in 12 early deaths, study shows – Reuters (free)
Adverse drug reactions of montelukast in children and adults
24 Sep, 2017 | 21:34h | UTCAdverse drug reactions of montelukast in children and adults – Pharmacology Research & Perspectives (free)
Commentaries: Montelukast Tied to Psychiatric Adverse Events in Kids, Adults – Medscape (free registration required) AND Asthma Drug, Montelukast, Tied to Nightmares, Depression – Drugs.com (free)
Cardiomyopathy Compendium
24 Sep, 2017 | 21:35h | UTCHomepage: Cardiomyopathy Compendium – Circulation Research
– Cardiomyopathies: An Overview, by Eugene Brawnwald (free)
– Classification, Epidemiology, and Global Burden of Cardiomyopathies (free)
– Dilated Cardiomyopathy: Genetic Determinants and Mechanisms (free)
– Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy (free)
– Hypertrophic Obstructive Cardiomyopathy: Surgical Myectomy and Septal Ablation (free)
– Arrhythmogenic Cardiomyopathy (free)
– Inflammatory Cardiomyopathic Syndromes (free)
– Restrictive Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy (free)
– Pediatric Cardiomyopathies (free)
– Modern Imaging Techniques in Cardiomyopathies (free)
Source: Critical Care Reviews Newsletter
Blood test and ECG may safely rule out heart attack
24 Sep, 2017 | 21:31h | UTCBlood test and ECG may safely rule out heart attack – NIHR Signal (free)
Original article: Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text) and Commentary: High-sensitivity troponin T result may help rule out of myocardial infarction – 2 Minute Medicine (free)
Meta-analysis: Antidepressants linked to increased risk of death
24 Sep, 2017 | 21:39h | UTCThe Mortality and Myocardial Effects of Antidepressants Are Moderated by Preexisting Cardiovascular Disease: A Meta-Analysis – Psychotherapy and Psychosomatics (link to abstract – $ for full-text)
Commentaries: Antidepressant use associated with higher risk of death – OnMedica (free) AND Antidepressants may raise death risk by a third – Medical News Today (free) AND Antidepressants Tied to a Significantly Increased Risk for Death – Medscape (free registration required) AND Antidepressants Associated with Significantly Elevated Risk of Death, Researchers Find – McMaster University, via NewsWise (free)
Systematic Review: Interventions for treating tuberculous pericarditis
24 Sep, 2017 | 21:32h | UTCInterventions for treating tuberculous pericarditis – Cochrane Library (free)
News release: Treatment for tuberculosis infection of the membrane around the heart (free)
“For HIV-negative patients, corticosteroids may reduce death. For HIV-positive patients not on antiretroviral drugs, corticosteroids may reduce constriction. For HIV-positive patients with good antiretroviral drug viral suppression, clinicians may consider the results from HIV-negative patients more relevant”.
Lung Cancer Mortality Associated With Smoking and Smoking Cessation Among People Living With HIV
24 Sep, 2017 | 21:23h | UTCEditorial: If We Are Smart Enough to Stop HIV From Replicating, Why Can’t We Help People to Stop Smoking? (free)
Commentaries: People with HIV who smoke are more likely to die from lung cancer than from HIV itself – eCancer (free) AND Smoking cuts life expectancy in HIV more than AIDS does – OnMedica (free)
Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis
24 Sep, 2017 | 21:24h | UTCRandomized clinical trial of antibiotic therapy for uncomplicated appendicitis – British Journal of Surgery (link to abstract – $ for full-text)
See also a related meta-analysis suggesting the safety of nonoperative treatment for uncomplicated cases (free) and a recent guideline that incorporates the possibility of non-operative treatment for uncomplicated disease (free)
“1st RCT to show uncomplicated appendicitis resolve even without antibiotics (let alone surgery)” (RT @villesallinen see Tweet)
Weight and Metabolic Outcomes 12 Years after Gastric Bypass
24 Sep, 2017 | 21:21h | UTCWeight and Metabolic Outcomes 12 Years after Gastric Bypass – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Benefits of gastric bypass persist for 12 years – Reuters (free) AND Gastric bypass surgery benefits continue for 12 years – Diabetes.co.uk (free) AND Bariatric Surgery’s Benefits Last Over a Decade – Physician’s First Watch (free)
All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease
24 Sep, 2017 | 21:26h | UTCAll Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease – Hypertension (link to abstract – free PDF via @unpaywall)
Commentaries: Hypertensive disorders of pregnancy increase future risk of heart disease – Cardiovascular Business (free) AND A type of hypertension during pregnancy more dangerous than thought – AHA News (free)
See related articles and commentaries in our August 22nd issue (see #3)
Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis
24 Sep, 2017 | 20:18h | UTCEditorial: Romosozumab — Promising or Practice Changing? (free)
Review: Advents in the Diagnosis and Management of Ischemic Colitis
24 Sep, 2017 | 20:18h | UTCAdvents in the Diagnosis and Management of Ischemic Colitis – Frontiers in Surgery (free)
Source: Critical Care Reviews Newsletter
Prevention and Control of Seasonal Influenza with Vaccines
24 Sep, 2017 | 20:10h | UTCCommentary: CDC: Updated Influenza Immunization Recommendations for 2017-2018 – MPR (free)
Position paper: testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis
24 Sep, 2017 | 20:12h | UTCPosition paper: Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis – Nature Reviews Rheumatology (free) (RT @Abraham_RMI)
Review: Whooping Cough (Pertussis)
24 Sep, 2017 | 20:06h | UTCWhooping Cough (Pertussis) – U.S. Pharmacists (free)
Source: Medscape
Artificial sweeteners raise risk of type 2 diabetes, study suggests
24 Sep, 2017 | 20:07h | UTCArtificial sweeteners raise risk of type 2 diabetes, study suggests – The Guardian (free)
52-week programme leads to more weight loss than 12-week
24 Sep, 2017 | 00:25h | UTC52-week programme leads to more weight loss than 12-week – NIHR Signal (free)
Original article: Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP): a randomised controlled trial – The Lancet (free) AND Commentary: Weight management programmes of extended duration (free)
“Although short-term costs higher, referring people to a 52-week programme is probably more cost-effective long-term” (RT @NIHR_DC see Tweet)
Why Do People Stop Taking Their Meds?
24 Sep, 2017 | 00:24h | UTCWhy Do People Stop Taking Their Meds? Cost Is Just One Reason – NPR (free)
Systematic Review: Comprehensive geriatric assessment for older adults admitted to hospital
20 Sep, 2017 | 22:26h | UTCComprehensive geriatric assessment for older adults admitted to hospital – Cochrane Library (free)
Original article: Comprehensive geriatric assessment for older adults admitted to hospital – Cochrane Library (link to abstract – $ for full-text)
Related: Comprehensive assessment may reduce risk of delirium after hip fracture – NIHR Signal (free)
“Older patients are more likely to be alive and in their own homes at follow-up if they received comprehensive geriatric assessment on admission to hospital”.
Guideline: Corticosteroids for sore throat
20 Sep, 2017 | 22:28h | UTCRapid Recommendations: Corticosteroids for sore throat: a clinical practice guideline – The BMJ (free text and infographic)
See also other Rapid Recommendations from The BMJ (all free)
Association of spontaneous abortion with influenza vaccine
20 Sep, 2017 | 22:24h | UTCAssociation of spontaneous abortion with receipt of inactivated influenza vaccine containing H1N1pdm09 in 2010–11 and 2011–12 – Vaccine (link to abstract – $ for full-text)
Commentaries: Study signals association between flu vaccine, miscarriage – CIDRAP (free) AND New study finds link between flu vaccine and miscarriage. But is it real? – Science (free) AND Study shows miscarriage risk may have increased after flu shots, puzzling researchers – STAT (free) AND A new finding of a possible flu shot-miscarriage link shows science prioritizes vaccine safety – STAT (free)
“This study does not and cannot establish a causal relationship between repeated influenza vaccination and SAB, but further research is warranted”.