Internal Medicine
Guideline: Antibiotic Use in Adults with Acute Upper Respiratory Tract Infections
8 Jan, 2018 | 00:50h | UTC
Guidelines: Treatment of Community-Acquired Skin and Soft Tissue Infection
8 Jan, 2018 | 00:48h | UTC
Systematic Review: Modifiable Risk Factors for Cognitive Impairment After Critical Illness
4 Jan, 2018 | 19:51h | UTC
Meta-Analysis: Effect of PCSK9 Inhibitors on Clinical Outcomes in Patients With Hypercholesterolemia
4 Jan, 2018 | 18:59h | UTCPCSK9 inhibitors were associated with reduced incidence of myocardial infarction (2.3% vs 3,6%), stroke (1.0% vs 1.4%) and coronary revascularization (4,2% vs 5,8%). Overall, no significant change was observed in cardiovascular or all-cause mortality.
Practice Guideline: Mild Cognitive Impairment
4 Jan, 2018 | 17:28h | UTCPractice guideline update summary: Mild cognitive impairment – American Academy of Neurology (free PDF)
Commentary: Mild cognitive impairment: a practice guideline update – Clinical Advisor (free)
“For patients diagnosed with MCI, clinicians may choose NOT to offer cholinesterase inhibitors”.
“If clinicians choose to offer cholinesterase inhibitors, they must first discuss with patients the fact that this is an off-label prescription not currently backed by empirical evidence”.
Delayed Antibiotic Prescribing’ for Respiratory Infections may Reduce Antibiotic Use
4 Jan, 2018 | 17:25h | UTCA strategy of ‘delayed antibiotic prescribing’ for respiratory infections may reduce antibiotic use – NIHR Signal (free)
Original article: Delayed antibiotic prescriptions for respiratory infections – Cochrane Library (free) AND Summary: Delayed antibiotic prescriptions for respiratory tract infections – Cochrane Library (free)
Research: Myeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma
4 Jan, 2018 | 17:13h | UTCMyeloablative Autologous Stem-Cell Transplantation for Severe Scleroderma – The New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Stem Cell Transplant for Severe Scleroderma Improves Survival, Quality of Life – NIH (free) AND Stem Cell Transplantation Offers Hope For Severe Scleroderma – MedicalResearch (free)
Research: Increased Cardiovascular Risk After Initiation of Inhaled Long-Acting Bronchodilators in Patients With COPD
4 Jan, 2018 | 17:16h | UTCAssociation of Cardiovascular Risk With Inhaled Long-Acting Bronchodilators in Patients With Chronic Obstructive Pulmonary Disease: A Nested Case-Control Study – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Starting new COPD inhaler tied to heart attack risk – Reuters (free) AND New Use of Long-Acting Bronchodilators in COPD Tied to Increased Cardiovascular Risk – Physician’s First Watch (free) AND COPD patients beginning inhaler therapy at greater short-term risk for CVD – Cardiovascular Business (free)
Systematic Review: Sugar-Sweetened Beverages and Weight Gain in Children and Adults
4 Jan, 2018 | 17:11h | UTCCommentary: New review confirms link between consumption of sugar-sweetened beverages and overweight, obesity – The Medical News (free) AND Review confirms link between sugary drinks and obesity – Medical News Today (free)
Thyroid Storm: A Japanese Perspective
4 Jan, 2018 | 17:08h | UTCThyroid Storm: A Japanese Perspective – Thyroid (free)
Commentary: New diagnostic criteria and treatment guidelines proposed for thyroid storm – EurekAlert (free)
Meta-Analysis: Carfilzomib-Associated Cardiovascular Adverse Events
4 Jan, 2018 | 17:01h | UTCCarfilzomib-Associated Cardiovascular Adverse Events: A Systematic Review and Meta-analysis – JAMA Oncology (link to abstract – $ for full-text)
Commentaries: Carfilzomib can lead to cardiovascular toxicity in multiple myeloma patients – eCancer News (free) AND Higher Rates of Cardiovascular Adverse Events in Patients with MM Treated With Carfilzomib – AJMC (free) AND Important CV Risk Seen With Carfilzomib in Multiple Myeloma – Medscape (free registration required)
Research: Socioeconomic Position, Alcohol Drinking Patterns, and Cardiovascular Mortality
4 Jan, 2018 | 16:56h | UTCLife course socioeconomic position, alcohol drinking patterns in midlife, and cardiovascular mortality: Analysis of Norwegian population-based health surveys – PLOS Medicine (free) (via @EricTopol see Tweet)
Commentary: Heart benefit of moderate drinking greater in wealthy people – Reuters (free)
Research: Co-administration of Vancomycin and Piperacillin-Tazobactam and Renal Dysfunction
4 Jan, 2018 | 16:55h | UTCSee also related meta-analysis: Vancomycin Plus Piperacillin-Tazobactam and Acute Kidney Injury in Adults
Research: Screening in the Community to Reduce Fractures in Older Women
4 Jan, 2018 | 16:54h | UTCScreening in the community to reduce fractures in older women (SCOOP): a randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Screening could catch a quarter of hip fractures before they happen – University of Manchester (free) AND FRAX Screening Reduces Hip Fractures in Healthy Older Women – Medscape (free registration required)
Systematic Review: Calcium Channel Blockers for Raynaud’s Phenomenon
3 Jan, 2018 | 14:21h | UTCCalcium channel blockers for primary and secondary Raynaud’s phenomenon – Cochrane Library (link to abstract – $ for full-text)
Commentary: Cochrane Review: Calcium Channel Blocker Efficacy in Raynaud’s – RheumNow (free)
Draft Recommendation Statement: No Screening With Electrocardiography
3 Jan, 2018 | 13:29h | UTCDraft Recommendation Statement: Cardiovascular Disease Risk: Screening With Electrocardiography – U.S. Preventive Services Task Force (free)
Commentaries: USPSTF Examines ECG Screening to Prevent CVD Events, AFib – AAFP (free) AND USPSTF Doesn’t Endorse Routine ECG for Atrial Fibrillation Detection or CVD Prevention – Physician’s First Watch (free) AND USPSTF Releases Draft Recommendations on ECG Screening for CVD, A-fib – TCTMD (free)
Scientific Statement: Childhood and Adolescent Adversity and Cardiometabolic Outcomes
3 Jan, 2018 | 13:26h | UTCNews release: Abuse and adversity in childhood linked to more cardiovascular risk in adulthood (free)
Commentaries: Distressing experiences as a kid impact cardiovascular health later in life – AHA News (free) AND Adversity In Childhood and Adolescence Sets Stage for Cardiometabolic Outcomes – AHA Centers for Health Metrics and Evaluation (free)
Debate: Is “Precision Medicine” Ready To Use In Primary Care Practice?
3 Jan, 2018 | 13:25h | UTCControversies in Family Medicine: Is “Precision Medicine” Ready To Use In Primary Care Practice?
No: It Is Barely Ready for Testing – American Family Physician (free)
ECG Pointers: AV Blocks
3 Jan, 2018 | 13:16h | UTCECG Pointers: AV Blocks – Part I – emDocs (free) AND ECG Pointers: AV blocks – Part II – emDocs (free)
Systematic Review: Probiotics to Prevent Clostridium Difficile Diarrhea Associated with Antibiotic Use
2 Jan, 2018 | 16:33h | UTCSee related meta-analysis: Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection
“Based on this systematic review and meta-analysis of 31 randomized controlled trials including 8672 patients, moderate certainty evidence suggests that probiotics are effective for preventing C. difficile-associated diarrhea”
Richard Lehman’s journal review – 2 January 2018
2 Jan, 2018 | 16:32h | UTCRichard Lehman’s journal review, 2 January 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Meta-Analysis: Antimicrobials for the Treatment of Drug-Resistant A. Baumannii Pneumonia in Critically Ill Patients
2 Jan, 2018 | 16:29h | UTC
Research: Topiramate Use Early in Pregnancy and the Risk of Oral Clefts
2 Jan, 2018 | 16:27h | UTCTopiramate use early in pregnancy and the risk of oral clefts: A pregnancy cohort study – Neurology (link to abstract – $ for full-text)
Commentaries: Topiramate in early pregnancy increases risk of oral clefts – OnMedica (free) AND Risk of Oral Clefts with Topiramate May Be Dose-Dependent – MedPage Today (free) AND Epilepsy Drug Could Raise Birth Defect Risks – MedlinePlus (free)
Review: Treatment of Recurrent Clostridium Difficile Colitis
2 Jan, 2018 | 16:23h | UTCTreatment of recurrent Clostridium difficile colitis: a narrative review – Gastroenterology Report (free)
Opinion: Too Much Screening Has Misled Us About Real Cancer Risk Factors
2 Jan, 2018 | 16:19h | UTCToo much screening has misled us about real cancer risk factors, experts say – STAT (free) AND Overscreening for Cancer Yields Misleading Results – MedPage Today (free) AND Could finding more cancer lead us to understand risk factors less? – HealthNewsReview (free)
Original article: Scrutiny-Dependent Cancer and Self-fulfilling Risk Factors – Annals of Internal Medicine (link to abstract – $ for full-text)