Internal Medicine
Meta-Analysis: Beta-Blockers for Heart Failure with Reduced, Mid-Range, and Preserved Ejection Fraction
9 Feb, 2018 | 11:34h | UTC
Research: Catheter Ablation for Atrial Fibrillation with Heart Failure
5 Feb, 2018 | 16:51h | UTCCatheter Ablation for Atrial Fibrillation with Heart Failure – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Catheter ablation better than pharmacological atrial fibrillation therapies – University of Utah Health, via EurekAlert (free)
“In patients w/heart failure & atrial fibrillation, catheter ablation lowers rate of death and hospitalization for worsening HF vs. medical therapy”. (via @NEJM see Tweet)
Early use of tranexamic acid reduces bleeding more effectively
5 Feb, 2018 | 16:51h | UTCEarly use of tranexamic acid reduces bleeding more effectively – NIHR Signal (free)
Original article: Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients – The Lancet (free) AND Invited Commentary: Tranexamic acid: is it about time? (free)
“It is now clearer that every 15-minute delay after the first hour can reduce survival by about 10%”.
Guideline: Gastrointestinal Complications in Adult Cancer Patients
5 Feb, 2018 | 16:53h | UTCGuideline: Diagnosis and management of gastrointestinal complications in adult cancer patients – German Society of Hematology and Medical Oncology (free)
AHA Scientific Statement: Cardiovascular Disease and Breast Cancer
5 Feb, 2018 | 16:49h | UTCCommentaries: Breast cancer treatments may increase the risk of heart disease – AHA / ASA Newsroom (free) AND Heart group warns of cardiovascular risks after treatment for breast cancer – STAT (free)
Intravenous antibiotics, administered over 3 hours, are linked to lower death rates in sepsis
5 Feb, 2018 | 16:50h | UTCIntravenous antibiotics, administered over 3 hours, are linked to lower death rates in sepsis – NIHR Signal (free)
Original article: Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Research: Migraine Associated with Increased Risk of Cardiovascular Diseases
5 Feb, 2018 | 16:47h | UTCMigraine and risk of cardiovascular diseases: Danish population based matched cohort study – The BMJ (free)
Editorial: Migraine and risk of cardiovascular disease (free)
Commentaries: Migraine Associated With Broad Range of CVD Diagnoses in Nationwide Study – TCTMD (free) AND Migraine Linked To Increased Risk of Stroke, AFib, PE and Cardiovascular Disease – MedicalResearch.com (free)
Research: Prevalence of Pulmonary Embolism in Patients With Syncope
5 Feb, 2018 | 16:46h | UTCPrevalence of Pulmonary Embolism in Patients With Syncope – JAMA Internal Medicine (free for a period)
Author Interview: Prevalence of Pulmonary Embolism in Patients With Syncope (free)
Commentaries: Prevalence of PE Low for Patients Presenting to ER With Syncope – Physician’s Weekly (free) AND Study Finds Pulmonary Embolus Rarely the Cause of Syncope – MedicalResearch.com (free)
Proton Pump Inhibitors: Review of Emerging Concerns
5 Feb, 2018 | 16:23h | UTCProton Pump Inhibitors: Review of Emerging Concerns – Mayo Clinic Proceedings (free)
Related reviews: Complications of Proton Pump Inhibitor Therapy – Gastroenterology (free) AND Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence – Therapeutic Advances in Drug Safety (free)
Related guideline: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free)
New Document for Patients: Advanced Health Directive for Dementia
5 Feb, 2018 | 16:26h | UTCOne Day Your Mind May Fade. At Least You’ll Have a Plan – The New York Times (10 articles per month are free)
Free download: Health Directive for Dementia (free PDF) from Advanced Directive for Dementia
Source: New document allows advance planning for dementia – Univadis (free registration required)
“A Simple Way to Document the Medical Care You Would Want If You Had Dementia”
Research: D-dimer Predicts Long-Term Cause-Specific Mortality, Cardiovascular Events and Cancer
5 Feb, 2018 | 16:22h | UTCD-dimer Predicts Long-Term Cause-Specific Mortality, Cardiovascular Events and Cancer in Stable Coronary Heart Disease Patients: The LIPID Study – Circulation (link to abstract – $ for full-text)
Commentary: D-dimer Predicts Long-Term Mortality, Vascular Events, Cancer – American College of Cardiology, Latest in Cardiology (free) AND D-Dimer Predicts CV, Cancer Mortality Over 16 Years in Patients With Stable CHD – Medscape (free registration required)
Meta-analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk
5 Feb, 2018 | 16:18h | UTCCommentary: Omega-3 Supplements Don’t Protect Against Heart Disease – The New York Times (10 articles per month are free)
Omega-3 fatty acids did not prevent fatal or nonfatal coronary heart disease or any major vascular events.
Reviews: CAR T-Cell Therapy Toxicities and Side Effects
5 Feb, 2018 | 16:13h | UTCCAR T-Cell Therapy – What do you need to know for the ED? – emDocs (free)
Related reviews: Toxicities of chimeric antigen receptor T cells: recognition and management – Blood (free) AND Toxicity and management in CAR T-cell therapy – Molecular Therapy Oncolytics (free) AND New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)
CHEST Guideline: Screening for Lung Cancer
5 Feb, 2018 | 16:11h | UTCScreening for Lung Cancer: CHEST Guideline and Expert Panel Report (free PDF)
Summary and commentary: New guideline released on lung cancer screening – ACP Internist (free)
Research: HbA1c, Diabetes and Cognitive Decline
5 Feb, 2018 | 16:10h | UTCHbA1c, diabetes and cognitive decline: the English Longitudinal Study of Ageing – Diabetologia (free)
Commentaries: The Startling Link Between Sugar and Alzheimer’s – The Atlantic (free) And Study Shows Long-Term Effects Of Diabetes And Prediabetes On The Brain – Forbes (free) AND New research shows diabetes and worse blood sugar control are associated with long-term cognitive decline – MedicalXpress (free) AND HbA1c Levels in Diabetes Linked to Cognitive Decline – Medscape (free registration required)
Research: Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease
4 Feb, 2018 | 18:36h | UTCMetformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or 4 – Diabetes Care (link to abstract – $ for full-text)
Commentaries: How I learned to stop worrying and love metformin – NephJC (free) AND Adjusted-Dose Metformin Appears Safe in Patients With Type 2 Diabetes and Chronic Kidney Disease Stage 3 or 4 – PracticeUpdate (free registration required)
Research: History of Childhood Kidney Disease and Risk of Adult End-Stage Renal Disease
4 Feb, 2018 | 18:34h | UTCHistory of Childhood Kidney Disease and Risk of Adult End-Stage Renal Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Childhood Kidney Disease and Adult ESRD (free)
Commentaries: History of Childhood Kidney Disease Linked to Risk of ESRD – Physician’s Weekly (free) AND Childhood Kidney Disease Predicts Adult ESRD – MedPage Today (free registration required)
Clinical Practice Guidelines: Hypertension
4 Feb, 2018 | 18:28h | UTCMinistry of Health Clinical Practice Guidelines: Hypertension – Singapore Medical Journal (free PDF)
Research: Periodontal Disease May Increase Cancer Risk
4 Feb, 2018 | 18:30h | UTCCommentaries: More evidence of link between severe gum disease and cancer risk – eCancer News (free) AND Evidence mounts of link between severe gum disease and various cancers – eCancer News (free) AND Severe Gum Disease Increases Both Cancer Risk and Mortality – Medscape (free registration required)
Recommendations on the Use of Ultrasound Guidance for Adult Thoracentesis
4 Feb, 2018 | 18:27h | UTC
Laxatives Naturally Occurring in Plants Such as Aloe or Senna May Increase Cancer Risk
4 Feb, 2018 | 18:26h | UTCSafety of hydroxyanthracene derivatives for use in food – EFSA Journal (free)
Press release: EFSA confirms health concerns for hydroxyanthracene derivatives in food – European Food Safety Agency (free)
Commentary: Europe’s safety watchdog says laxatives may increase cancer risk – Reuters (free)
“This group of substances naturally occurs in plants such as aloe or senna species. Extracts containing them are used in food supplements for their laxative effect”. (from Press Release)
Review: Coronary Artery Calcium and Cardiovascular Disease Risk
4 Feb, 2018 | 18:02h | UTCThe evolving view of coronary artery calcium and cardiovascular disease risk – Clinical Cardiology (free)
Review: Postural Tachycardia Syndrome
4 Feb, 2018 | 17:49h | UTCPostural tachycardia syndrome: current perspectives – Vascular Health and Risk Management (free)
Blood Test Reduces Mortality and Shortens Antibiotic use Among Adults with Chest Infection
4 Feb, 2018 | 17:17h | UTCBlood test reduces mortality and shortens antibiotic use among adults with chest infection – NIHR Signal (free)
Original article: Effect of procalcitonin-guided antibiotic treatment on mortality in acute respiratory infections: a patient level meta-analysis – The Lancet (free)
Guideline: Management of Patients on Antithrombotic Agents Undergoing Endoscopy
4 Feb, 2018 | 17:34h | UTC