Internal Medicine
Overtesting and undertesting in primary care: a systematic review and meta-analysis
16 Feb, 2018 | 02:22h | UTCOvertesting and undertesting in primary care: a systematic review and meta-analysis – BMJ Open (free) (via @JackOSullivan3 and @KariTikkinen)
Guideline: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy
16 Feb, 2018 | 02:17h | UTCCommentary: New Guidelines for Treating Checkpoint Inhibitor Toxicities – Medscape (free registration required)
Relate guideline: Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free) AND Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)
Screening for Ovarian Cancer: US Preventive Services Task Force Recommendation Statement
16 Feb, 2018 | 02:18h | UTCScreening for Ovarian Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)
Editorials: Screening for Ovarian Cancer in Asymptomatic Women (free) AND The Yet Unrealized Promise of Ovarian Cancer Screening (free) AND Is There a Future for Ovarian Cancer Screening? (free)
Author interview: USPSTF Recommendation: Screening for Ovarian Cancer (free audio)
“The USPSTF recommends against screening for ovarian cancer in asymptomatic women. (D recommendation) This recommendation applies to asymptomatic women who are not known to have a high-risk hereditary cancer syndrome”.
Review: Physical Activity in the Prevention and Treatment of Coronary Artery Disease
16 Feb, 2018 | 02:14h | UTCReview: Physical Activity in the Prevention and Treatment of Coronary Artery Disease – Journal of the American Heart Association (free for a limited period)
Do All Patients Need β-Blockers After a Heart Attack?
16 Feb, 2018 | 02:12h | UTCMedical News & Perspectives: Do All Patients Need β-Blockers After a Heart Attack? – JAMA (free for a limited period)
Research: Opioid Analgesic Use and Risk for Invasive Pneumococcal Diseases
16 Feb, 2018 | 02:09h | UTCOpioid Analgesic Use and Risk for Invasive Pneumococcal Diseases: A Nested Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Opioids may be associated with increased risk for serious invasive pneumococcal infections – ACP Internist (free) AND Opioids For Pain Can Exacerbate Pneumococcal Infections – MedicalResearch.com (free) AND Prescription Opioid Use Tied to Higher Pneumonia Risk – MedPage Today (free registration required)
Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism
16 Feb, 2018 | 01:39h | UTCEdoxaban for the Treatment of Cancer-Associated Venous Thromboembolism – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Edoxaban for Cancer-Associated Venous Thromboembolism (free)
Commentaries: Edoxaban Noninferior to Dalteparin for Cancer-Associated VTE – Physician’s First Watch (free) AND Oral Edoxaban Noninferior to Dalteparin for Cancer-Related Venous Thromboembolism – Cardiology Advisor (free)
Systematic Review: Comprehensive Geriatric Assessment for Older People Admitted to a Surgical Service
16 Feb, 2018 | 01:32h | UTCComprehensive geriatric assessment for older people admitted to a surgical service – Cochrane Library (free)
Summary: Does special assessment of older people getting surgery improve their recovery after surgery? – Cochrane Library (free)
Opinion: Heart Stents Are Useless for Most Stable Patients
16 Feb, 2018 | 01:28h | UTCOpinion: Heart Stents Are Useless for Most Stable Patients. They’re Still Widely Used – The New York Times (10 articles per month are free)
Richard Lehman’s journal reviews – 12 February 2018
16 Feb, 2018 | 01:27h | UTCRichard Lehman’s journal reviews, 12 February 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Research: Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients
16 Feb, 2018 | 01:26h | UTC“Trimethoprim is associated with a greater risk of acute kidney injury and hyperkalaemia compared with other antibiotics used to treat UTIs, but not a greater risk of death”
Review compares effectiveness, cost, and safety of second-line drugs for diabetes
16 Feb, 2018 | 01:22h | UTCOriginal Report: New Drugs for Type 2 Diabetes: Second-Line Therapy – Canadian Agency for Drugs and Technologies in Health (free)
Evidence for Dietary Fibre Modification in the Recovery and Prevention of Reoccurrence of Acute, Uncomplicated Diverticulitis
16 Feb, 2018 | 01:13h | UTC
Research: Extrafine Inhaled Triple Therapy Versus Dual Bronchodilator Therapy in COPD
16 Feb, 2018 | 01:05h | UTCExtrafine inhaled triple therapy versus dual bronchodilator therapy in chronic obstructive pulmonary disease (TRIBUTE): a double-blind, parallel group, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
“Steroid-containing fine-mist triple inhaler comp with dry powder double inhaler resulting in 0.09 fewer exacerbations per year. Yup.” (via @RichardLehman1 see Tweet) See Richard Lehman’s point of view
Uncertain benefits of BNP blood tests to monitor heart failure treatment
16 Feb, 2018 | 01:08h | UTCUncertain benefits of BNP blood tests to monitor heart failure treatment – NIHR Signal (free)
Being overweight or having diabetes are both linked to cancer
16 Feb, 2018 | 01:03h | UTCBeing overweight or having diabetes are both linked to cancer – NIHR Signal (free)
Original article: Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment – The Lancet Diabetes & Endocrinology (free) AND Commentary: Diabetes and adiposity: a heavy load for cancer (free)
Evidence Review: Pulmonary Rehabilitation for People with COPD
16 Feb, 2018 | 01:06h | UTC
Atypical Antipsychotics, Insulin Resistance and Weight; a Meta-Analysis of Healthy Volunteer Studies
16 Feb, 2018 | 01:01h | UTCAtypical antipsychotics, insulin resistance and weight; a meta-analysis of healthy volunteer studies – Progress in Neuro-Psychopharmacology and Biological Psychiatry (link to abstract – $ for full-text) (via @psychopharmacol see Tweet)
“These findings provide preliminary evidence that atypical antipsychotics cause insulin resistance and weight gain directly, independent of psychiatric disease and may be associated with length of treatment”.
Research: Prognostic Effects of Delirium Motor Subtypes in Hospitalized Older Adults
16 Feb, 2018 | 00:52h | UTCPrognostic effects of delirium motor subtypes in hospitalized older adults: A prospective cohort study – PLOS One (free) (via @DrMeganHoseyPhD)
“One in three acutely ill hospitalized older adults who suffered hypoactive or mixed delirium died in the hospital”
Risky Antipsychotic Drugs Still Overprescribed In Nursing Homes
15 Feb, 2018 | 11:26h | UTCRisky Antipsychotic Drugs Still Overprescribed In Nursing Homes – NPR (free)
Original article: How Nursing Homes in the United States Overmedicate People with Dementia – Human Rights Watch (free)
Research: Long-term Use of Inhaled Corticosteroids in COPD and the Risk of Fracture
15 Feb, 2018 | 11:18h | UTCLong-term Use of Inhaled Corticosteroids in COPD and the Risk of Fracture – CHEST (free)
Commentary: Long-term usage of inhaled corticosteroids may increase risk of bone fractures in patients with COPD – American College of Chest Physicians, via EurekAlert (free)
Review: Understanding and Management of Acquired Thrombocytopenia
15 Feb, 2018 | 11:18h | UTCRecent advances in understanding and management of acquired thrombocytopenia – F1000 Research (free)
Research: Hypertension Common After Severe Preeclampsia
15 Feb, 2018 | 10:49h | UTCBlood Pressure Profile 1 Year After Severe Preeclampsia – Hypertension (link to abstract – $ for full-text)
Commentaries: High blood pressure in pregnancy may not disappear afterward – Reuters (free) AND Ambulatory Monitoring Shows Persistent HTN Common After Severe Preeclampsia – MedPage Today (free registration required)
Review: ED Approach to Agitation
15 Feb, 2018 | 10:44h | UTCemDocs Cases: ED Approach to Agitation – emDocs (free)
Research: Blood Pressure Variability and Risk of Cardiovascular Events and Death
15 Feb, 2018 | 10:38h | UTCBlood pressure variability and risk of cardiovascular events and death in patients with hypertension and different baseline risks – European Heart Journal (link to abstract – $ for full-text)
Commentary: Blood Pressure Variability and Risk of CV Events – American College of Cardiology, Latest in Cardiology (free)