Internal Medicine
Guideline Synopsis: Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease–Mineral and Bone Disorder
23 Feb, 2018 | 01:05h | UTC
Research: Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults
23 Feb, 2018 | 01:03h | UTCCommentaries: Low-Carb And Low-Fat Diets Battle To A Draw – Cardiobrief (free) AND Matching DNA to a diet doesn’t work: ‘We didn’t even come close,’ researcher says – STAT (free) AND Counting Calories Is Not the Key to Weight Loss, New Study Finds – The New York Times (10 articles per month are free) AND Debating low-fat vs low-carb diets? New study found a draw – Scope (free)
Review: Adverse pregnancy outcomes and future maternal cardiovascular disease
23 Feb, 2018 | 01:01h | UTCReview: Adverse pregnancy outcomes and future maternal cardiovascular disease – Clinical Cardiology (free)
Sex Differences in Ischemic Heart Disease: Advances, Obstacles, and Next Steps
23 Feb, 2018 | 00:56h | UTCSex Differences in Ischemic Heart Disease: Advances, Obstacles, and Next Steps – Circulation: Cardiovascular Quality and Outcomes (free for a limited period)
Related AHA Scientific Statement: Preventing and Experiencing Ischemic Heart Disease as a Woman: State of the Science (free)
Research: Contribution of alcohol use disorders to the burden of dementia
23 Feb, 2018 | 01:00h | UTCCommentaries: Alcohol and dementia: a complex relationship with potential for dementia prevention – The Lancet Public Health (free) AND Expert reaction to study looking at alcohol use disorders and dementia risk – Science Media Centre (free) AND Heavy Drinking Tied to Early-Onset Dementia in French Study – MedPage Today (free registration required)
“Of 57,000 people diagnosed before age 65 with early-onset dementia, 39% had alcohol-related dementia by definition, and 18% had an additional diagnosis of alcohol use disorders” (via @medpagetoday see Tweet)
Current Concepts of Fluid Management in Enhanced Recovery Pathways
23 Feb, 2018 | 00:56h | UTCCurrent concepts of fluid management in enhanced recovery pathways – British Journal of Anaesthesia (free)
See other Enhanced Recovery After Surgery Guidelines and Reviews
Research: Cleaning at Home and at Work in Relation to Lung Function Decline and Airway Obstruction
23 Feb, 2018 | 00:54h | UTCCleaning at Home and at Work in Relation to Lung Function Decline and Airway Obstruction – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)
Commentaries: Women Who Clean at Home or Work Face Increased Lung Function Decline – American Thoracic Society, via NewsWise (free) AND Cleaning Chemicals ‘Likely Cause Substantial Damage To Women’s Lungs’, Study Finds – Huffpost (free) AND Cleaning at home or work linked to faster lung function decline in women – Univadis (free registration required)
Guideline: Diagnosis and Treatment of Neurocysticercosis
22 Feb, 2018 | 23:39h | UTC
Guideline: Spontaneous Coronary Artery Dissection
22 Feb, 2018 | 23:39h | UTCSee also: Commentary: Spontaneous Coronary Artery Dissection: Making strides, long journey ahead! (free) AND Top Ten Things to Know (free PDF)
Research: Association of Cigarette, Cigar, and Pipe Use With Mortality Risk
22 Feb, 2018 | 23:34h | UTCAssociation of Cigarette, Cigar, and Pipe Use With Mortality Risk in the US Population – JAMA Internal Medicine (free for a limited period)
Commentaries: Cigars and pipes tied to same risks as cigarettes – Reuters (free) AND Cigars and pipes raise mortality risk independent of cigarettes – OnMedica (free)
Benzodiazepines: Our Other Prescription Drug Epidemic
22 Feb, 2018 | 23:37h | UTCPerspective: Our Other Prescription Drug Problem – New England Journal of Medicine (free)
Related opinion: Benzodiazepines: our other prescription drug epidemic – STAT (free)
Research: Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation
22 Feb, 2018 | 23:35h | UTCCommentaries: Anticoagulants Tied With Stroke, Hemorrhage in CKD – Renal & Urology News (free) AND Could a Blood Thinner Actually Raise Stroke Risk for Some? – HealthDay (free) AND Anticoagulants for Patients with Afib and Kidney Disease? Study Yields Mixed Findings – Physician’s First Watch (free) AND Blood-thinning drugs designed to cut stroke risk may actually increase it – The Guardian (free)
“Given the lack of guidelines, the decision to start anticoagulant treatment in patients with chronic kidney disease and new onset atrial fibrillation should be made on an individual basis, concludes research” (via @bmj_latest see Tweet)
Meta-analysis: Outcomes of non-invasive diagnostic modalities for the detection of coronary artery disease
22 Feb, 2018 | 23:33h | UTCAmong patients with low risk acute coronary syndrome, stress echocardiography, cardiovascular magnetic resonance, and exercise electrocardiograms resulted in fewer invasive referrals for coronary angiography than coronary computed tomographic angiography, without apparent impact on the future risk of myocardial infarction. Similarly, for outpatients with suspected stable angina, an initial strategy based on functional testing might be preferable, resulting in fewer referrals for invasive coronary angiography and revascularization, without a statistically significant difference in the future risk of MI.
Avoid common mistakes when treating hyponatremia
22 Feb, 2018 | 23:30h | UTCAvoid common mistakes when treating hyponatremia – ACP Hospitalist (free)
Research: Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium
22 Feb, 2018 | 23:31h | UTCProphylactic haloperidol in this population with elevated risk of delirium did not reduce mortality or any of the 15 prespecified secondary outcomes, including delirium incidence, 28-day delirium-free and coma-free days, duration of mechanical ventilation, and ICU and hospital length of stay.
Research: Continuous Glucose Monitoring in Adults with Type 1 Diabetes
22 Feb, 2018 | 23:29h | UTCReal-time continuous glucose monitoring in adults with type 1 diabetes and impaired hypoglycaemia awareness or severe hypoglycaemia treated with multiple daily insulin injections (HypoDE): a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
The mean number of hypoglycemic events per 28 days was reduced from 10.8 to 3.5 among patients in the continuous glucose monitoring group and from 14.4 to 13.7 among control group participants.
Research: Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis
22 Feb, 2018 | 23:28h | UTCHydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis: A Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Hydroxychloroquine no more effective than placebo for relieving osteoarthritis hand pain – American College of Physicians, via EurekAlert (free)
Meta-Analysis: Short-Term Versus Long-Term Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation in Elderly Patients
22 Feb, 2018 | 23:27h | UTCShort-Term Versus Long-Term Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation in Elderly Patients: A Meta-Analysis of Individual Participant Data From 6 Randomized Trials – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)
Commentary: Dual Antiplatelet Therapy Duration in Elderly Patients – American College of Cardiology, Latest in Cardiology (free)
Short-term Dual Antiplatelet Therapy was not associated with increased risk of ischemic events in elderly patients and was associated with a significant reduction in major bleeding.
Research: Risk of Recurrent Disease and Surgery Following an Admission for Acute Diverticulitis
22 Feb, 2018 | 23:25h | UTCRisk of Recurrent Disease and Surgery Following an Admission for Acute Diverticulitis – Diseases of the Colon and Rectum (link to abstract – $ for full-text)
Commentary: Which Patients with Diverticulitis Require Surgery? – Diseases of the Colon & Rectum, via NewsWise (free)
In this large cohort of 65,162 patients identified with a first episode of acute diverticulitis, younger patients, women, smokers, obese individuals, and those who had diverticulitis with perforation and/or abscess were more likely to develop recurrent diverticulitis.
Review: Anaphylaxis
22 Feb, 2018 | 23:24h | UTCReview: Anaphylaxis – Chest (free)
Source: Critical Care Reviews Newsletter
Opinion: Stories about tragic flu deaths wrongly portray Tamiflu as a panacea
22 Feb, 2018 | 23:25h | UTCOpinion: Stories about tragic flu deaths wrongly portray Tamiflu as a panacea – HealthNewsReview (free)
Related: Tamiflu and Relenza: getting the full evidence picture – Cochrane Library (free)
“The review confirms small benefits on symptom relief, namely shortening duration of symptoms by half a day on average. However, there is little evidence to support any belief that use of NIs reduces hospital admission or the risk of developing confirmed pneumonia”. (from Cochrane)
Richard Lehman’s journal reviews – 19 February 2018
22 Feb, 2018 | 23:24h | UTCRichard Lehman’s journal reviews, 19 February 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Guideline for Prescribing Medical Cannabinoids in Primary Care
22 Feb, 2018 | 23:22h | UTCCommentary: New guideline warns pain benefits of medical cannabis overstated – University of Alberta Faculty of Medicine & Dentistry, via ScienceDaily (free)
Research: Incidence, Etiology, and Outcomes of Community-Acquired Pneumonia
22 Feb, 2018 | 23:23h | UTC“Aside from the rare extra-pulmonary manifestations of mycoplasma (e.g., rashes, hemolysis, neurologic complications), do any of the many causes of pneumonia have distinctive clinical presentations? Probably not”. (via @PaulSaxMD see Tweet)
Research: Systolic Blood Pressure and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction
22 Feb, 2018 | 23:21h | UTCSystolic Blood Pressure and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction – JAMA Cardiology (link to abstract – $ for full-text)
Commentaries: Aggressive Systolic Blood Pressure Control In Older Patients With HFpEF Should Be Avoided – MedicalResearch.com (free) AND Low blood pressure linked to worse outcomes in HFpEF patients – Cardiovascular Business (free)
“A systolic blood pressure level of less than 120 mm Hg identifies patients with heart failure with preserved ejection fraction at higher risk for short- and long-term mortality and emphasizes the need for future prospective studies to evaluate optimal systolic blood pressure treatment goals in this patient population”.