Internal Medicine
“Just because we can, doesn’t mean we should” – supporting informed decision-making
27 Apr, 2018 | 02:56h | UTC
Guideline: Pharmacologic Glycemic Management of Type 2 Diabetes in Adults
27 Apr, 2018 | 02:59h | UTCGuideline: Pharmacologic Glycemic Management of Type 2 Diabetes in Adults – Canadian Journal of Diabetes (free)
Related Guidelines: ADA 2018 Standards of Medical Care in Diabetes (free) AND ACP Guideline: Hemoglobin A1c Targets for Glycemic Control in Type 2 Diabetes (free)
In this new guideline Hemoglobin A1c Targets are similar from ADA 2018 Standards.
Randomized Controlled Trial: BNP Guided Therapy in Acute Decompensated Heart Failure
27 Apr, 2018 | 02:40h | UTCNT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide)-Guided Therapy in Acute Decompensated Heart Failure – Circulation (link to abstract – $ for full-text)
Related Systematic Review: Effectiveness and cost-effectiveness of serum B-type natriuretic peptide testing and monitoring in patients with heart failure in primary and secondary care: an evidence synthesis, cohort study and cost-effectiveness model – Health Technology Assessment (free) AND Commentary: Uncertain benefits of BNP blood tests to monitor heart failure treatment – NIHR Signal (free)
Related AHA Scientific Statement: Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure (free)
Source: EvidenceAlerts
“NT Pro BNP guided heart failure treatment no better than usual care”. (via @doctorvec)
Review: Optimised Care of Elderly Patients with Acute Coronary Syndrome
27 Apr, 2018 | 02:39h | UTCOptimised care of elderly patients with acute coronary syndrome – European Heart Journal: Acute Cardiovascular Care (free) (via @krychtiukmd see Tweet)
Case-control Study: Anticholinergic Drugs and Risk of Dementia
27 Apr, 2018 | 02:38h | UTCAnticholinergic drugs and risk of dementia: case-control study – The BMJ (free)
Editorial: Anticholinergic drugs and dementia in older adults (free)
Commentaries: Expert reaction to study investigating the association between different types of anticholinergic drugs and risk of dementia – Science Media Centre (free) AND Anticholinergic drugs may be linked to increased risk of dementia – OnMedica (free)
“The effect of anticholinergic therapy is relatively small (odds ratio 1.1 – 1.2) and establishing an association does not prove a causal link. Nevertheless, the paper may act as a useful guide for future research and clinical practice”. (by Prof Les Iversen, in Science Media Centre)
Meta-Analysis: Probiotics for the Prevention of Clostridium difficile
27 Apr, 2018 | 02:36h | UTCCommentary: Probiotics may be safe, low-cost prevention tool for Clostridium difficile infections – News Medical (free)
Related Articles: The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use – Cochrane Library (free) AND Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis – Antibiotics (free) AND Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis – Gastroenterology (free)
Clinical Guideline: HIV Pre-exposure Prophylaxis
27 Apr, 2018 | 02:32h | UTCRelated guidelines: WHO implementation tool for pre-exposure prophylaxis of HIV infection – World Health Organization (free) AND Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis – Canadian Medical Association Journal (free) AND Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update: a Clinical Practice Guideline (free)
NICE Guideline Update: Neuropathic pain in adults
27 Apr, 2018 | 02:29h | UTCGuideline Update: Neuropathic pain in adults: pharmacological management in non-specialist settings – National Institute for Health and Care Excellence (free)
Research: Avoid Piperacillin-tazobactam When Treating BSI Caused by Ceftriaxone-resistant Pathogens
27 Apr, 2018 | 02:25h | UTC28th ECCMID: The MERINO Trial: piperacillin-tazobactam versus meropenem for the definitive treatment of bloodstream infections caused by third-generation cephalosporin nonsusceptible Escherichia coli or Klebsiella spp.: an international multi-centre openlabel non-inferiority randomised controlled trial (free abstract)
Commentaries: Avoid piperacillin-tazobactam when treating BSI cause by ceftriaxone-resistant pathogens – European Society of Clinical Microbiology and Infectious Diseases, via EurekAlert (free) AND Combo antibiotic found inferior for MDR bloodstream infections – CIDRAP (free)
Debate: Should we Recommend e-Cigarettes to Help Smokers Quit?
27 Apr, 2018 | 01:36h | UTCShould we recommend e-cigarettes to help smokers quit? – The BMJ (free)
See also: related guidelines, reports and commentaries on e-cigarettes
“Experts debate: Should doctors recommend e-cigarettes to help smokers quit? Revelation in harm reduction or a way to keep people addicted and gateway to youth smoking?” (via @rich_hurley see Tweet)
NICE Guideline Update: Diagnosis and Management of Epilepsies
27 Apr, 2018 | 01:34h | UTCGuideline Update: Epilepsies: diagnosis and management – National Institute for Health and Care Excellence (free)
NICE Guideline Update: Depression in adults
27 Apr, 2018 | 01:26h | UTCGuideline Update: Depression in adults: recognition and management – National Institute for Health and Care Excellence (free)
USPSTF Draft Recommendation: Screening for Intimate Partner Violence, Elder Abuse, and Abuse of Vulnerable Adults
27 Apr, 2018 | 01:31h | UTCUSPSTF Draft Recommendation Statement: Intimate Partner Violence, Elder Abuse, and Abuse of Vulnerable Adults: Screening (free)
Commentaries: USPSTF urges abuse screening for reproductive-aged women – MedicalXpress (free) AND USPSTF Recommends Screening for Partner Violence in Reproductive-Aged Women – Clinical Advisor (free)
“The USPSTF recommends that clinicians screen for intimate partner violence (IPV) in women of reproductive age and provide or refer women who screen positive to ongoing support services.”
Things We Do For No Reason: Periprocedural Bridging Anticoagulation
27 Apr, 2018 | 01:25h | UTCThings We Do For No Reason: Periprocedural Bridging Anticoagulation – Journal of Hospital Medicine (free)
Perspective: Improving Emergency Department Care for Low-Risk Chest Pain
27 Apr, 2018 | 01:28h | UTCImproving Emergency Department Care for Low-Risk Chest Pain – NEJM Catalyst (free)
Meta-Analysis: Case Managers Improve Outcomes for People with Dementia and Their Carers
27 Apr, 2018 | 01:23h | UTCCase managers improve outcomes for people with dementia and their carers – NIHR Signal (free)
Original Article: The effectiveness of community-based coordinating interventions in dementia care: a meta-analysis and subgroup analysis of intervention components – BMC Health Services Research (free)
“The review suggests that nurses may be particularly well placed to act as case managers for people with dementia, perhaps because they have the skills to perform the broad range of tasks associated with the role.” (via @NIHR_DC see Tweet)
Meta-Analysis: Clinical Examination for Acute Aortic Dissection
27 Apr, 2018 | 01:20h | UTC
Guideline: Vaccination Strategies in Patients with Hematologic Malignancies or Solid Tumors
27 Apr, 2018 | 01:13h | UTC
Retrospective Cohort: Recent Opioid Use and Fall-related Injury Among Older Patients With Trauma
25 Apr, 2018 | 13:48h | UTCCommentary: Opioid use linked to increased risk of falls, death in older adults – CMAJ, via EurekAlert (free)
Randomized Trial: Early Endovenous Ablation in Venous Ulceration
25 Apr, 2018 | 13:38h | UTCCommentary: Early treatment for leg ulcers gets patients back on their feet – Imperial College London (free)
Viewpoint: Tube Feeding and Deteriorating Patients
25 Apr, 2018 | 12:54h | UTCDavid Oliver: Tube feeding and deteriorating patients—guidelines can take us only so far – The BMJ (free)
Related Guidelines: American Geriatrics Society Feeding Tubes in Advanced Dementia Position Statement (free) AND ESPEN guideline on ethical aspects of artificial nutrition and hydration (free)
Related Reviews: Artificial nutrition and hydration in advanced dementia – Canadian Family Physician (free) AND End-of-life issues in advanced dementia: Part 1: goals of care, decision-making process, and family education – Canadian Family Physician (free) AND End-of-life issues in advanced dementia: Part 2: management of poor nutritional intake, dehydration, and pneumonia – Canadian Family Physician (free) AND Advanced Dementia – New England Journal of Medicine (free)
Richard Lehman’s journal review – 23 April 2018
24 Apr, 2018 | 19:31h | UTCRichard Lehman’s journal review, 23 April 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Meta-Analysis: Procalcitonin-Guidance vs Usual Care for Antimicrobial Management in Critically Ill Patients
24 Apr, 2018 | 18:05h | UTCRelated Meta-Analysis: Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis – Critical Care Medicine (free)
Commentaries: Cessation, not initiation, of antibiotics is when procalcitonin guidance cuts mortality – Univadis (free registration required) AND Procalcitonin guidance reduces antibiotic duration in critically ill adults: meta-analysis – Univadis (free)
Cohort Study: Proton‐Pump Inhibitors and Risk of Pneumonia in Older Adults
24 Apr, 2018 | 19:29h | UTCCommentary: Commonly prescribed heartburn drug linked to Pneumonia in Older Adults – University of Exeter (free)
Related: Proton Pump Inhibitors: Review of Emerging Concerns – Mayo Clinic Proceedings (free) AND Complications of Proton Pump Inhibitor Therapy – Gastroenterology (free) AND Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence – Therapeutic Advances in Drug Safety (free) AND Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free)
Source: Hospital Medicine Virtual Journal Club
Review: Cardiovascular Risk in Patients with Rheumatoid Arthritis
24 Apr, 2018 | 19:31h | UTCState of the Art Review: Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications – The BMJ (free for a limited period)