Internal Medicine
Meta-Analysis: Conventional and Biologic Disease-Modifying Anti-Rheumatic Drugs for Osteoarthritis
18 Nov, 2018 | 00:49h | UTC
Meta-Analysis: Efficacy and Safety of Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation and Coronary Artery Disease
18 Nov, 2018 | 00:16h | UTC
Overview of Drug Allergy: From Immunogenetic Basis to Practice
18 Nov, 2018 | 00:07h | UTCOverview of Drug Allergy: From Immunogenetic Basis to Practice – Acta Médica Portuguesa (free PDF)
Expert Consensus: Diagnosis and Treatment of Patient with Hyperuricemia and High Cardiovascular Risk
17 Nov, 2018 | 23:37h | UTC
Systematic Review: Clinical Outcomes Associated With Sickle Cell Trait
17 Nov, 2018 | 23:39h | UTCClinical Outcomes Associated With Sickle Cell Trait: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Links between SCT and adverse outcomes – HematologyTimes (free)
Cohort Study: SGLT2 and Risk of Serious Adverse Events
16 Nov, 2018 | 03:30h | UTCCommentaries: New diabetes drug may increase the risk of serious adverse events – Karolinska Institutet (free) AND SGLT2 Inhibitors Tied to Increased Risk for Amputation, Diabetic Ketoacidosis – NEJM Journal Watch (free) AND SGLT2 Inhibitor Amputation Risk Seen in Real-World Diabetes Study – Medscape (free registration required)
Review: Interruption and Reversal of Direct Oral Anticoagulants in Preprocedural and Acute Settings
16 Nov, 2018 | 03:28h | UTCSource: Medscape
Randomized Trial: Prednisone for the Prevention of Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome
16 Nov, 2018 | 03:00h | UTC“Prednisone treatment during the first 4 weeks after the initiation of ART for HIV infection resulted in a lower incidence of tuberculosis-associated immune reconstitution inflammatory syndrome than placebo, without evidence of an increased risk of severe infections or cancers.”
Randomized Trial: Prophylactic Intravenous Hydration to Protect Renal Function From Intravascular Iodinated Contrast Material
16 Nov, 2018 | 03:23h | UTCRelated: Post-Contrast Acute Kidney Injury (free reviews) AND Does contrast cause kidney injury? The evidence (free) AND Meta-Analysis: Acute Kidney Injury After Computed Tomography (link to abstract and commentaries)
Study: Safe Outpatient Management of Emergency Department Patients With Pulmonary Embolism
16 Nov, 2018 | 02:57h | UTCIncreasing Safe Outpatient Management of Emergency Department Patients With Pulmonary Embolism: A Controlled Pragmatic Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Electronic Decision Support Facilitates Home Discharge of Some PE Patients From ER – MedicalResearch.com (free) AND EMR-Integrated Tool Lets More PE Patients Be Discharged from the ED – NEJM Journal Watch (free)
Review: Neuroinfections Caused by Fungi
16 Nov, 2018 | 02:51h | UTCNeuroinfections caused by fungi – Infection (free)
USPSTF Statement: Screening and Behavioral Counseling to Reduce Unhealthy Alcohol Use
16 Nov, 2018 | 02:26h | UTCEditorials: Screening for Unhealthy Alcohol Use (free) AND Unhealthy Alcohol Use in Primary Care—The Elephant in the Examination Room (free)
Author Interview: USPSTF Recommendation: Screening and Interventions for Unhealthy Alcohol Use (free audio)
JAMA Patient Page: Screening and Counseling to Reduce Unhealthy Alcohol Use (free)
Meta-Analysis: Antipsychotic Drug Use and Pneumonia
16 Nov, 2018 | 02:49h | UTCAntipsychotic drug use and pneumonia: Systematic review and meta-analysis – Journal of Psychopharmacology (link to abstract – $ for full-text)
Commentary: Antipsychotics May Increase Risk of Pneumonia, Meta-Analysis Suggests – Psychiatric News Alert (free)
“Although antipsychotic use was associated with a higher risk of pneumonia, the researchers stopped short of claiming causality, citing a lack of data from randomized, controlled trials and a failure of observational studies to control for relevant confounders like tobacco use and weight.” (from Psychiatric News Alert)
Randomized Trial: Effect of a Pharmacist-Led Educational Intervention on Inappropriate Medication Prescriptions in Older Adults
16 Nov, 2018 | 02:24h | UTCEffect of a Pharmacist-Led Educational Intervention on Inappropriate Medication Prescriptions in Older Adults: The D-PRESCRIBE Randomized Clinical Trial – JAMA (free for a limited period)
Video Summary: Effect of a Pharmacist-Led Intervention on Inappropriate Prescriptions in Older Adults (free)
Randomized Trial: Effect of Exercise Intervention on Functional Decline in Very Elderly Patients During Acute Hospitalization
16 Nov, 2018 | 02:21h | UTCEffect of Exercise Intervention on Functional Decline in Very Elderly Patients During Acute Hospitalization: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Commentaries: A Novel Exercise Intervention and Functional Status in Very Elderly Patients During Acute Hospitalization – JAMA Internal Medicine (free for a limited period) AND Exercise intervention benefits elderly in hospital – OnMedica (free)
Author Interview: Effect of Exercise Intervention on Functional Decline in Very Elderly Patients (free audio)
Videos: Morning Exercise Session (free) AND Evening Exercise Session (free) AND Balance and Gait Retraining Exercises (free)
Review: Treatment and Prevention of Recurrent Lower Urinary Tract Infections in Women
16 Nov, 2018 | 02:17h | UTC
Supraventricular Arrhythmias: Clinical Framework and Common Scenarios for the Internist
16 Nov, 2018 | 02:18h | UTCSource: Hospital Medicine Virtual Journal Club
New Physical Activity Guidelines for Americans
16 Nov, 2018 | 01:43h | UTCThe Physical Activity Guidelines for Americans – JAMA (free)
Editorial: New Physical Activity Guidelines: A Call to Activity for Clinicians and Patients (free)
Video Summary: Physical Activity Guidelines for Americans, 2nd Edition (free)
Commentaries: New Physical Activity Guidelines Urge Americans: Move More, Sit Less – NPR (free) AND HHS Releases Physical Activity Guidelines for Americans, 2nd edition – U.S. Department of Health & Human Services (free)
Randomized Trial: Withdrawal of Pharmacological Treatment for Heart Failure in Patients with Recovered Dilated Cardiomyopathy
16 Nov, 2018 | 01:42h | UTCCommentaries: Stopping medication for heart failure with improved ejection fraction – The Lancet (free) AND Remission, Not Cure: No Weaning Off Meds for Dilated Cardiomyopathy Patients, Says TRED-HF – TCTMD (free) AND Drug Withdrawal Inadvisable in ‘Recovered’ Dilated Cardiomyopathy – Medscape (free registration required)
Alex Nowbar’s Research Reviews – 12 November 2018
16 Nov, 2018 | 01:39h | UTCAlex Nowbar’s research reviews, 12 November 2018 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
Review: The Misunderstood Coagulopathy of Liver Disease
16 Nov, 2018 | 01:38h | UTC
Meta-Analysis: SGLT2 Inhibitors for Prevention of Cardiovascular and Renal Outcomes in Type 2 Diabetes
16 Nov, 2018 | 01:35h | UTCSGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials – The Lancet (link to abstract – $ for full-text)
Commentary: SGLT2 Inhibitors and CV and Renal Outcomes in Type 2 Diabetes – American College of Cardiology (free)
Study: Less Surveillance Needed for Simple Ovarian Cysts
16 Nov, 2018 | 01:34h | UTCRisk of Malignant Ovarian Cancer Based on Ultrasonography Findings in a Large Unselected Population – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Most simple ovarian cysts require no treatment, surveillance – UPI (free) AND Less surveillance needed for simple ovarian cysts – University of California, San Francisco (free)
“New study finds that simple cysts should be considered normal and ignored” (from The University of California)
Guideline: Use of Risk Assessment Tools to Guide Decision-Making in the Primary Prevention of Atherosclerotic Cardiovascular Disease
16 Nov, 2018 | 01:08h | UTCSummary: Use of Risk Assessment Tools to Guide Decision-Making in ASCVD Prevention – American College of Cardiology (free)
New AHA/ACC Guideline on the Management of Blood Cholesterol
16 Nov, 2018 | 01:09h | UTCSummary: 2018 ACC/AHA Multisociety Guideline on the Management of Blood Cholesterol – American College of Cardiology (free)
See also: Cholesterol Guideline Hub (free resources)