Internal Medicine
Meta-Analysis: Opioids for Chronic Noncancer Pain
10 Jan, 2019 | 21:44h | UTCOpioids for Chronic Noncancer Pain: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)
Video Summary: How Effective are Opioids for Chronic Noncancer Pain? (free)
Commentaries: Opioids unlikely to provide clinically meaningful reduction in chronic non-cancer pain – 2 Minute Medicine (free) AND Opioids offer little chronic pain benefit and wane over time, study says – CNN (free)
Related: Opioid vs Nonopioid Medications in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain (free study, guideline and commentaries)
HIV Viral Load and Transmissibility of HIV Infection: Undetectable Equals Untransmittable
10 Jan, 2019 | 21:47h | UTCHIV Viral Load and Transmissibility of HIV Infection: Undetectable Equals Untransmittable – JAMA (free for a limited period)
Related: Negligible Risk of Transmitting HIV During Sex When Viral Load is Suppressed (free study and commentary) AND UNAIDS Explainer: UNDETECTABLE = UNTRANSMITTABLE (free report and commentaries)
Meta-Analysis: Catheter Ablation of Atrial Fibrillation in Patients With Heart Failure
10 Jan, 2019 | 21:26h | UTCCatheter Ablation of Atrial Fibrillation in Patients With Heart Failure: A Meta-analysis of Randomized Controlled Trials – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Catheter ablation better than drug therapy for a-fib, heart failure – UPI (free) AND Catheter Ablation Boosts Outcomes in Patients With A-fib and Heart Failure: Meta-analysis – TCTMD (free)
ACC/AHA/SCAI/SIR/SVM 2018 Appropriate Use Criteria for Peripheral Artery Intervention
10 Jan, 2019 | 21:23h | UTCCommentary: New Appropriate Use Criteria for Peripheral Artery Interventions: A Multisociety Collaboration – TCTMD (free) AND 2018 Appropriate Use Criteria for Peripheral Artery Intervention – American College of Cardiology (free)
AHA Statement: Optimal Exercise Programs for Patients with Peripheral Artery Disease
10 Jan, 2019 | 21:21h | UTCTop Ten Things to Know: Optimal Exercise Programs for Patients With Peripheral Artery Disease (free)
Commentaries: AHA Scientific Statement: Get PAD Patients Moving to Improve Symptoms and QoL – TCTMD (free) AND Promoting Exercise Therapy in Peripheral Artery Disease: Time to Get Moving – AHA News (free)
Monoclonal Gammopathy of Undetermined Significance: A Primary Care Guide
10 Jan, 2019 | 21:03h | UTC
Hypertension Guidelines: Treat Patients, Not Numbers
10 Jan, 2019 | 20:46h | UTCHypertension guidelines: Treat patients, not numbers – Cleveland Clinic Journal of Medicine (free)
Meta-Analysis: Pharmacological Treatments and Pain Control in Patients with Knee Osteoarthritis
10 Jan, 2019 | 19:50h | UTCAssociation of Pharmacological Treatments With Long-term Pain Control in Patients With Knee Osteoarthritis: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)
Commentaries: Medications may not heal long-term knee pain, study says – UPI (free) AND Knee osteoarthritis: 31 medications provide only uncertain pain control in large meta-analysis – Univadis (free registration required)
Randomized Trial: Intensive Blood Pressure Treatment for Resistant Hypertension
10 Jan, 2019 | 20:31h | UTCCommentary: Resistant hypertension: intensive treatment reduces MACE – Univadis (free registration required)
Study: Association of Prescribed Opioids With Increased Risk of Community-Acquired Pneumonia
10 Jan, 2019 | 17:43h | UTCAssociation of Prescribed Opioids With Increased Risk of Community-Acquired Pneumonia Among Patients With and Without HIV – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentary: Prescribed opioids raise risk of pneumonia in patients with and without HIV – Yale University (free)
Consensus: Management of Skin and Soft-tissue Infections
10 Jan, 2019 | 00:18h | UTC
Study: The Best Dose of Aspirin for Cardiovascular protection may Depend on Body Weight
10 Jan, 2019 | 00:14h | UTCThe best dose of aspirin for cardiovascular protection may depend on body weight – NIHR Signal (free)
Original Article: Effects of Aspirin for CV Disease Prevention According to Bodyweight and Dose (free study and commentaries)
Meta-Analysis: Corticosteroids Associated with Reduced Mortality in Patients with Sepsis
10 Jan, 2019 | 00:11h | UTCAssociation of Corticosteroid Treatment With Outcomes in Adult Patients With Sepsis: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentary: Steroids Associated With Reduced Mortality in Adults with Sepsis – MedicalResearch.com (free)
Related Guideline: Corticosteroid Therapy for Sepsis – The BMJ (free)
Related Meta-Analysis: Corticosteroids in Sepsis (link to abstract) AND Corticosteroids for Patients with Septic Shock (free)
Randomized Trial: Home Modifications to Reduce Disability in Older Adults with Functional Disability
10 Jan, 2019 | 00:13h | UTCEffect of a Biobehavioral Environmental Approach on Disability Among Low-Income Older Adults: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Commentaries: Home Modifications to Reduce Disability in Older Adults With Functional Disability – JAMA Internal Medicine (free for a limited period)
Related Commentary on Twitter
Novel RCT shows that practical home based intervention that modifies environment in order to help older persons adapt to disability significantly improves independence and well being #geriatrics #hpm @JamaInternalMed https://t.co/Y802BEZC5i
— Ken Covinsky (@geri_doc) January 7, 2019
Review: Sepsis Associated Acute Kidney Injury
10 Jan, 2019 | 00:09h | UTCSepsis associated acute kidney injury – The BMJ (free)
Related Commentary on Twitter
https://twitter.com/bmj_latest/status/1083030914656018432
Study: Repeat Thyroid Function Tests for Healthy Older People are Not Needed
9 Jan, 2019 | 23:35h | UTCRepeat thyroid function tests for healthy older people are not needed – NIHR Signal (free)
Original Research: Stability of thyroid function in older adults: the Birmingham Elderly Thyroid Study – British Journal of General Practice (link to abstract – $ for full-text)
Study: Prognosis in Patients With Cardiac Troponin Elevation Without a Specific Diagnosis
10 Jan, 2019 | 00:05h | UTCCardiac Troponin Elevation in Patients Without a Specific Diagnosis – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Non-ACS Troponin Elevation and Outcomes – American College of Cardiology (free) AND Don’t Dismiss High Troponin Without Classical MI – MedPage Today (free registration required) AND Cardiac troponin elevation without definitive diagnosis associated with higher mortality – 2 Minute Medicine (free)
Updated Guidelines on Complex Regional Pain Syndrome in Adults
9 Jan, 2019 | 23:16h | UTCSummary: Updated guidelines on complex regional pain syndrome in adults – JPRAS (free)
Original Guideline: Complex regional pain syndrome in adults (2nd edition) – UK guidelines for diagnosis, referral and management in primary and secondary care 2018 – Royal College of Physicians (free PDF)
Systematic Review: Short-acting Insulins vs. Regular Insulin for Type 2 Diabetes
9 Jan, 2019 | 22:54h | UTCShort‐acting insulin analogues versus regular human insulin for adult, non‐pregnant persons with type 2 diabetes mellitus – Cochrane Library (free)
Summary: Short-acting insulin analogues versus regular human insulin for type 2 diabetes mellitus – Cochrane Library (free)
“The current evidence from clinical trials suggests neither clear benefits nor clear harms from the use of short‐acting insulin analogues over regular human insulin.”
Proton Pump Inhibitors: Review of Reported Risks and Controversies
9 Jan, 2019 | 16:40h | UTCRelated: Proton Pump Inhibitors: Review of Emerging Concerns (free reviews) AND Deprescribing Proton Pump Inhibitors (free guidelines and reviews)
Systematic Review: Iron for the Treatment of Restless Legs Syndrome
9 Jan, 2019 | 16:19h | UTCIron for the treatment of restless legs syndrome – Cochrane Library (free)
Summary: Iron for the treatment of restless legs syndrome – Cochrane Library (free)
Position Statement: Clinical Use of a Home Sleep Apnea Test
8 Jan, 2019 | 22:23h | UTC
10 of the Best Articles in Emergency Medicine from 2018
9 Jan, 2019 | 06:12h | UTC10 of the Best Medical Journal Articles from 2018 – ACEP Now (free)
Guideline: Diagnosis of Cough at Primary Care Setting
8 Jan, 2019 | 21:20h | UTCIndian Consensus on Diagnosis of Cough at Primary Care Setting – Journal of The Association of Physicians of India (free PDF)
The Year in Cardiology 2018
8 Jan, 2019 | 21:08h | UTCThe Year in Cardiology 2018 – European Heart Journal (free articles)
– Arrhythmias and Cardiac Devices
– Aorta and Peripheral Circulation
– Imaging
Related: AHA names top heart disease and stroke research advances of 2018 – American Heart Association (free) AND 2018 Top Clinical Trials and Journal Scans – American College of Cardiology (free)