Internal Medicine
RCT | Heterogeneity in blood pressure response to 4 antihypertensive drugs
17 Apr, 2023 | 13:14h | UTCHeterogeneity in Blood Pressure Response to 4 Antihypertensive Drugs: A Randomized Clinical Trial – JAMA (free for a limited period)
News Release: Personalized blood pressure treatment more effective – Uppsala University
Phase 2 RCT | High-dose VE303 reduces recurrent Clostridioides difficile infection rates
17 Apr, 2023 | 13:12h | UTCVE303, a Defined Bacterial Consortium, for Prevention of Recurrent Clostridioides difficile Infection: A Randomized Clinical Trial – JAMA (free for a limited period)
See also: Visual Abstract
Cohort Study | Association between hearing aid use and all-cause and cause-specific dementia
17 Apr, 2023 | 13:07h | UTCCommentaries: Preventing dementia through correcting hearing: huge progress but more to do – The Lancet Public Health
News Release: Hearing aids may protect against a higher risk of dementia associated with hearing loss, study suggests – Lancet
Related:
M-A | Association of hearing aids and cochlear implants with cognitive decline and dementia
Dementia and hearing-aid use: a two-way street – Age and Ageing
Association of Hearing Loss With Dementia – JAMA Network Open
Commentary on Twitter
NEW—Hearing aids may protect against a higher risk of #dementia associated with hearing loss, a @TheLancetPH study suggests.https://t.co/Yliq2wT7SR pic.twitter.com/v3iuTuHYVI
— The Lancet (@TheLancet) April 13, 2023
RCT | Exercise and protein intervention may improve resilience and reduce frailty in seniors
17 Apr, 2023 | 13:04h | UTC
SR | Oral direct thrombin inhibitors vs. conventional anticoagulants for the treatment of pulmonary embolism
17 Apr, 2023 | 13:02h | UTC
RCT | Methylprednisolone pulse followed by oral prednisone vs. oral prednisone alone in sarcoidosis tubulointerstitial nephritis
17 Apr, 2023 | 12:58h | UTCEfficacy and safety of methylprednisolone pulse followed by oral prednisone vs. oral prednisone alone in sarcoidosis tubulointerstitial nephritis: a randomized, open-label, controlled clinical trial – Nephrology Dialysis Transplantation (free for a limited period)
RCT | Safety of Fezolinetant for vasomotor symptoms associated with menopause
17 Apr, 2023 | 12:54h | UTCRelated:
RCT | Fezolinetant for treatment of moderate-to-severe vasomotor symptoms associated with menopause
RCT | Efficacy of Fezolinetant in moderate-to-severe vasomotor symptoms associated with menopause
SR | Exercise‐based rehabilitation programs for pulmonary hypertension
17 Apr, 2023 | 12:44h | UTCExercise‐based rehabilitation programmes for pulmonary hypertension – Cochrane Library
Summary: Exercise-based rehabilitation in pulmonary hypertension – Cochrane Library
SR | Inhaled corticosteroids versus placebo for stable chronic obstructive pulmonary disease
17 Apr, 2023 | 12:40h | UTC
Review | Diagnosis and management of prediabetes
12 Apr, 2023 | 13:28h | UTCDiagnosis and Management of Prediabetes: A Review – JAMA (free for a limited period)
Editorial: Prediabetes Diagnosis and Management – JAMA (free for a limited period)
Video: Screening for Prediabetes – JAMA
Audio Clinical Review: Diagnosis and Management of Patients With Prediabetes – JAMA
RCT | Doxycycline postexposure prophylaxis effective in preventing gonorrhea, chlamydia, and syphilis in MSM
12 Apr, 2023 | 13:30h | UTCSummary: In this open-label, randomized study involving 501 men who have sex with men (MSM) and transgender women, researchers investigated the effectiveness of postexposure doxycycline in preventing bacterial sexually transmitted infections (STIs), specifically gonorrhea, chlamydia, and syphilis. Participants with a previous STI in the past year, either taking preexposure prophylaxis (PrEP) against HIV or living with HIV, were randomly assigned to receive 200 mg of doxycycline within 72 hours after condomless sex or standard care without doxycycline. STI testing was performed quarterly, with the primary end point being the incidence of at least one STI per follow-up quarter.
Results demonstrated a significant reduction in STI incidence in both the PrEP and persons living with HIV cohorts who received doxycycline. Overall, the combined incidence of these three STIs was lower by two thirds with doxycycline postexposure prophylaxis compared to standard care. The study also reported five grade 3 adverse events but no serious adverse events attributed to doxycycline. This finding supports the use of doxycycline postexposure prophylaxis among MSM with recent bacterial STIs.
Article: Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Doxycycline after sex found to reduce STI incidence in gay men, transgender women – CIDRAP
Commentary on Twitter
In an open-label, randomized study involving men who have sex with men, doxycycline use after high-risk sexual exposure reduced the incidence of sexually transmitted infections (chlamydia, gonorrhea, and syphilis). https://t.co/tYOj8FLEy2 pic.twitter.com/bzNyvwzYS7
— NEJM (@NEJM) April 5, 2023
M-A | Association of inhaled corticosteroids with all-cause mortality risk in patients with COPD
12 Apr, 2023 | 13:25h | UTCAssociation of Inhaled Corticosteroids With All-Cause Mortality Risk in Patients With COPD: A Meta-analysis of 60 Randomized Controlled Trials – Chest (link to abstract – $ for full-text)
Commentary on Twitter
ICS-based inhaled therapy of longer than 6 months associated with reduction in all-cause mortality risk in patients with #COPD in a meta-analysis of 60 RCTs. Read the full original research in the January issue: https://t.co/p2CwSu8aqb#journalCHEST #MedEd pic.twitter.com/0j24enQmX3
— CHEST® Journal (@journal_CHEST) January 20, 2023
Review | Revised definition of pulmonary hypertension and approach to management
12 Apr, 2023 | 13:22h | UTCRelated:
#ESCCongress | 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension.
Pulmonary hypertension: An update of Dx and Tx guidelines – Journal of Family Practice
The physiological basis of pulmonary arterial hypertension – European Respiratory Journal
Topic-Based, Recent Literature Review on Pulmonary Hypertension – Mayo Clinic Proceedings
Twenty‐four-hour ambulatory blood pressure profile in patients with reflex syncope vs. matched controls
12 Apr, 2023 | 13:21h | UTC
Cohort Study | Association of the AHA’s new “Life’s Essential 8” with all-cause and cardiovascular disease-specific mortality
12 Apr, 2023 | 13:20h | UTCCommentaries:
Related: Life’s Essential 8: Updating and enhancing the AHA construct of cardiovascular health.
Guideline | Management of systemic lupus erythematosus
12 Apr, 2023 | 13:16h | UTC
Review | Inappropriate prescriptions of direct oral anticoagulants (DOACs) in hospitalized patients
12 Apr, 2023 | 13:14h | UTC
Perspective | Proposal of a model of care for outpatient antimicrobial therapy for infective endocarditis
12 Apr, 2023 | 13:08h | UTCOutpatient Parenteral Antimicrobial Therapy for Infective Endocarditis—Model of Care – Antibiotics
Commentary on Twitter
🆕️⚡️ @antibioticsmdpi
Outpatient Parenteral Antimicrobial Therapy for Infective Endocarditis—Model of Care#IDTwitter #IEWikiguidelines https://t.co/uI88p1l7nR pic.twitter.com/2JiFTKR5fr— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) February 10, 2023
Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews
11 Apr, 2023 | 14:39h | UTCRelated:
SR | Nonopioid pharmacological management of acute low back pain
M-A | Limited evidence for analgesic effectiveness in acute low back pain treatment
M-A: Effectiveness of treatments for acute and subacute mechanical non-specific low back pain
Guideline Interventions for the management of acute and chronic low back pain.
M-A: Little benefit from muscle relaxants for adults with non-specific low back pain.
Screening colonoscopy in seniors: common in patients with limited life expectancy and associated with higher complication risks
11 Apr, 2023 | 14:30h | UTCFrequency of Use and Outcomes of Colonoscopy in Individuals Older Than 75 Years – JAMA Internal Medicine (link to abstract – $ for full-text)
Related: Study reveals overuse of surveillance colonoscopy in older adults with limited life expectancy
Commentary:
In older adults >75 years of age, most screening colonoscopies were in patients in patients with limited life expectancy (defined as <10 years) and associated with increased risk of adverse events. https://t.co/XOsy2UKNRx @Jessica_Halabi @MRothbergMD @burkegastrodoc
— JAMA Internal Medicine (@JAMAInternalMed) April 4, 2023
Review | Anticoagulation in patients with liver cirrhosis: friend or foe?
11 Apr, 2023 | 14:17h | UTCAnticoagulation in Patients with Liver Cirrhosis: Friend or Foe? – Digestive Diseases and Sciences
Late mortality in childhood cancer survivors: causes & modifiable risk factors
11 Apr, 2023 | 14:16h | UTCSpecific causes of excess late mortality and association with modifiable risk factors among survivors of childhood cancer: a report from the Childhood Cancer Survivor Study cohort – The Lancet (link to abstract – $ for full-text)
News Release: Healthy lifestyle associated with reduced mortality risk in childhood cancer survivors – St. Jude Children’s Research Hospital
Review | Evaluation and management of chronic thromboembolic pulmonary hypertension
11 Apr, 2023 | 14:00h | UTCEvaluation and Management of Chronic Thromboembolic Pulmonary Hypertension – Chest
M-A | The risk of long-term cardiometabolic disease in women with premature or early menopause
11 Apr, 2023 | 13:59h | UTC
WHO Report | Dengue & Chikungunya cases spreading beyond known transmission zones in the Americas
10 Apr, 2023 | 14:04h | UTCCommentary: WHO: Concerning Spread of Dengue, Chikungunya in Latin America – JAMA