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Internal Medicine

M-A: Risk predictors of progression to severe disease during the febrile phase of dengue

28 Feb, 2021 | 20:57h | UTC

Risk predictors of progression to severe disease during the febrile phase of dengue: a systematic review and meta-analysis – The Lancet Infectious Diseases

 

Cognitive behavioral therapy for a variety of conditions: an overview of systematic reviews and panoramic meta-analysis

28 Feb, 2021 | 20:50h | UTC

Cognitive behavioural therapy for a variety of conditions: an overview of systematic reviews and panoramic meta-analysis – Health Technology Assessment

 

Bioethics | Should clinical guidelines incorporate cost pathways for persons with financial hardship?

28 Feb, 2021 | 20:54h | UTC

Should Clinical Guidelines Incorporate Cost Pathways for Persons With Financial Hardship? – AMA Journal of Ethics

 

Joint Statement: Hydroxychloroquine use with respect to retinal toxicity

28 Feb, 2021 | 20:41h | UTC

ACR, AAD, RDS, and AAO 2020 Joint Statement on Hydroxychloroquine Use with Respect to Retinal Toxicity – Arthritis & Rheumatism

Commentary: Societies Agree on Eye Safety for HCQ – MedPage Today (free registration required) AND ACR, medical societies reach consensus on hydroxychloroquine retinopathy – Healio (free registration required)

 

Commentary on Twitter

 

U.S. Guidelines panel recommendation for long-acting injectable antiretroviral regimen in adults and adolescents with HIV

28 Feb, 2021 | 20:34h | UTC

HHS Adults and Adolescents Antiretroviral Guidelines Panel Recommendation for the Long-Acting Injectable Antiretroviral Regimen of Cabotegravir and Rilpivirine – HIV.gov

What’s New in the Guidelines? Panel’s Recommendation for Long-Acting Injectable Cabotegravir and Rilpivirine in Persons with HIV

 

Conflicting results from 2 randomized trials testing Tocilizumab for Covid-19

26 Feb, 2021 | 08:48h | UTC

Study 1: Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia – New England Journal of Medicine

Study 2: Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 – New England Journal of Medicine

Editorial: Interleukin-6 Receptor Inhibition in Covid-19 — Cooling the Inflammatory Soup – New England Journal of Medicine

 

Commentary on Twitter

 

PRO-CON Debate: Are Carbapenems necessary for all infections caused by ceftriaxone-resistant Enterobacterales?

28 Feb, 2021 | 20:43h | UTC

PRO: Carbapenems should be used for ALL infections caused by ceftriaxone-resistant Enterobacterales – JAC-Antimicrobial Resistance

CON: Carbapenems are NOT necessary for all infections caused by ceftriaxone-resistant Enterobacterales – JAC-Antimicrobial Resistance

Editorial: Navigating treatment approaches for presumed ESBL-producing infections

 

Commentary on Twitter (thread – click for more)

 

WHO Report: Preparing for Long COVID 2021

26 Feb, 2021 | 08:46h | UTC

In the wake of the pandemic: preparing for Long COVID (2021) – World Health Organization

News release: New policy brief calls on decision-makers to support patients as 1 in 10 report symptoms of “long COVID” – World Health Organization

Commentaries: Long COVID sufferer still has disease’s debilitating symptoms nearly a year after first falling ill – EuroNews AND Debilitating ‘long-COVID’ may have severe health, social impacts: WHO – Reuters

Related: Dr. Fauci says new data suggests ‘long’ Covid symptoms can last up to 9 months – CNBC

 

COVID-19 hospitalizations attributable to cardiometabolic conditions

26 Feb, 2021 | 08:40h | UTC

Coronavirus Disease 2019 Hospitalizations Attributable to Cardiometabolic Conditions in the United States: A Comparative Risk Assessment Analysis – Journal of the American Heart Association

Commentary: Study estimates two-thirds of COVID-19 hospitalizations due to four conditions – Tufts University

 

Commentary on Twitter

https://twitter.com/Dmozaffarian/status/1364993823370338312

 

Cohort study: A single conventional Troponin combined with HEART score may be as good as serial measurements for safe discharge of patients with chest pain in the ED

26 Feb, 2021 | 08:32h | UTC

Single vs Serial Measurements of Cardiac Troponin Level in the Evaluation of Patients in the Emergency Department With Suspected Acute Myocardial Infarction – JAMA Network Open

Editorial: Troponin Testing in the Emergency Department—When 2 Become 1

Commentary: Single Troponin Test May Be Enough for Safe Discharge of Chest Pain Patients – TCTMD

 

Decreasing patient-reported burden of treatment: A systematic review of quantitative interventional studies

26 Feb, 2021 | 08:21h | UTC

Decreasing patient-reported burden of treatment: A systematic review of quantitative interventional studies – PLOS One

 

Myocarditis and inflammatory cardiomyopathy: current evidence and future directions

26 Feb, 2021 | 08:18h | UTC

Myocarditis and inflammatory cardiomyopathy: current evidence and future directions – Nature Reviews Cardiology (free for a limited period)

 

Drains, germs, or steel: Multidisciplinary management of acute colonic diverticulitis

26 Feb, 2021 | 08:17h | UTC

Drains, Germs, or Steel: Multidisciplinary Management of Acute Colonic Diverticulitis – Digestive Diseases and Sciences

 

Study: Unhealthy alcohol use common after bariatric surgery

26 Feb, 2021 | 08:14h | UTC

Association of Bariatric Surgical Procedures With Changes in Unhealthy Alcohol Use Among US Veterans – JAMA Network Open

Commentaries: Unhealthy Alcohol Use—A Common Iatrogenic Complication of Bariatric Surgery – JAMA Network Open AND Bariatric Surgery May Increase Risk of Unhealthy Alcohol Use – Psychiatric News Alert AND Bariatric Surgery Ups Risk of Alcohol Abuse – Physician’s Weekly

 

Commentary on Twitter

 

Guidelines for the treatment of irritable bowel syndrome

26 Feb, 2021 | 08:15h | UTC

Evidence-based clinical practice guidelines for irritable bowel syndrome 2020 – Journal of Gastroenterology

Related: ACG Clinical Guideline: Management of Irritable Bowel Syndrome – The American Journal of Gastroenterology

 

RCT: Dimenhydrinate and metoclopramide equally effective in the treatment of nausea due to vertigo

26 Feb, 2021 | 08:12h | UTC

Comparison of efficacy dimenhydrinate and metoclopramide in the treatment of nausea due to vertigo; a randomized study – The American Journal of Emergency Medicine (link to abstract – $ for full-text)

 

Series of n-of-1 trials show no difference in muscle symptoms in patients receiving placebo or statins

25 Feb, 2021 | 08:54h | UTC

Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials – The BMJ

Commentary: Do statins cause muscle symptom side effects? – The BMJ Opinion AND Study: Muscle Symptoms Didn’t Differ Between Statin and Placebo Periods – NEJM Journal Watch

Related study: #AHA20 – In patients who had discontinued statins because of side effects, a N-of-1 trial of a statin, placebo, or no treatment found that side effects often attributed to statins were the same for those taking a placebo (study and commentaries)

 

Consensus statement on the prevention of opioid‐related harm in adult surgical patients

25 Feb, 2021 | 08:41h | UTC

An international multidisciplinary consensus statement on the prevention of opioid‐related harm in adult surgical patients – Anaesthesia

Commentary: Stopping opioid-related addiction, harm and accidents after surgery – AAGBI

 

Commentary on Twitter

 

RCT: Effect of high-dose subcutaneous Semaglutide vs. placebo in adults with overweight or obesity

25 Feb, 2021 | 08:52h | UTC

Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial – JAMA

Commentary: Semaglutide paired with intensive behavioral therapy showed triple weight loss vs placebo – University of Pennsylvania School of Medicine

Related study: Once-weekly, high-dose semaglutide is effective for improving overweight or obesity among non-diabetic adults – New England Journal of Medicine (study and commentary)

 

Commentary on Twitter

 

Cohort study: High glycemic index diets are linked to increased risk of cardiovascular disease and death

25 Feb, 2021 | 08:49h | UTC

Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality – New England Journal of Medicine

Commentaries: Study finds diet high in poor quality carbohydrates increases heart disease and death – McMaster University AND High Glycemic Index Diets Linked to CVD and Mortality – TCTMD

 

RCT: Effect of telephone cognitive behavioral therapy for insomnia in older adults with osteoarthritis pain

25 Feb, 2021 | 08:29h | UTC

Effect of Telephone Cognitive Behavioral Therapy for Insomnia in Older Adults With Osteoarthritis Pain: A Randomized Clinical Trial – JAMA Internal Medicine

Commentary: Effective treatment for insomnia delivered in a few short phone calls – University of Washington

 

People with SARS-CoV-2 antibodies may have a low risk of future infection

25 Feb, 2021 | 09:04h | UTC

Association of SARS-CoV-2 Seropositive Antibody Test With Risk of Future Infection – JAMA Internal Medicine

Editorial: How to Advise Persons Who Are Antibody Positive for SARS-CoV-2 About Future Infection Risk

Commentaries: Covid-19 antibodies may protect against reinfection later, study suggests – CNN AND NCI study finds that people with SARS-CoV-2 antibodies may have a low risk of future infection – National Cancer Institute

 

Perspective: Coronavirus reinfection will soon become our reality

25 Feb, 2021 | 08:59h | UTC

Coronavirus reinfection will soon become our reality – The Atlantic (a few articles per month are free)

 

Position Paper: Management of drug-induced liver injury

25 Feb, 2021 | 08:27h | UTC

Drug-induced liver injury: A management position paper from the Latin American Association for Study of the liver – Annals of Hepatology

 

Sepsis treatment: Another trial shows no benefit from the combination of Vitamin C, Thiamine, and Hydrocortisone

24 Feb, 2021 | 02:25h | UTC

Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Hydrocortisone, Vitamin C, and Thiamine for Treatment of Sepsis: Making Evidence Matter

Related: The VITAMINS Randomized Clinical Trial: Vitamin C, Hydrocortisone, and Thiamine Not beneficial for Patients with Sepsis (study and commentaries)

 

Commentary on Twitter

 

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