Internal Medicine
More data showing increased risk of hospitalization with SARS-CoV-2 delta variant.
6 Sep, 2021 | 11:12h | UTCHospitalisation associated with SARS-CoV-2 delta variant in Denmark – The Lancet Infectious Diseases
Podcast: The Best of Liver Tests.
7 Sep, 2021 | 10:29h | UTC#293 The Best of Liver Tests with Dr. Elliot Tapper – The Curbsiders
The resurgence of SARS-CoV-2 infection in a highly vaccinated health system workforce; vaccine effectiveness against infection was reduced from above 90% from March through June to 65% in July.
6 Sep, 2021 | 11:09h | UTCRelated:
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Commentary on Twitter (thread – click for more)
💥 NEW DATA💥
1/ "Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce" published today in @NEJM details ↓ in vaccine effectiveness against INFECTION among @UCSDHealth employees – from 95%+ in the spring to 65% in July
👉🏽 https://t.co/wMgjoLgJzS pic.twitter.com/lgOwlEqUQG
— Christopher A. Longhurst, MD (@CALonghurst) September 1, 2021
RCT: Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels.
6 Sep, 2021 | 11:11h | UTC
Commentary on Twitter
The SAVE-MORE phase 3 study demonstrates the efficacy of anakinra, an IL-1α/β inhibitor, in patients with COVID-19 and high serum levels of soluble plasminogen activator receptor, according to a @NatureMedicine paper. https://t.co/aM5teLMipK pic.twitter.com/bTVNqbBOcv
— Nature Portfolio (@NaturePortfolio) September 3, 2021
Large surveillance study finds severe adverse events after COVID-19 mRNA vaccination are rare.
6 Sep, 2021 | 11:02h | UTCSurveillance for Adverse Events After COVID-19 mRNA Vaccination – JAMA
Editorial: Safety Surveillance of COVID-19 mRNA Vaccines Through the Vaccine Safety Datalink – JAMA
Commentaries:
mRNA COVID vaccines not tied to serious side effects – CIDRAP
Researchers find no serious health effects linked to mRNA COVID-19 vaccines – News Medical
Commentary on Twitter
Concerned about the safety of mRNA vaccines? This study of 6.2 million people who got 11.8 million doses is immensely reassuring. https://t.co/nUIqTacl0g pic.twitter.com/JBvenRVrRc
— David Juurlink (@DavidJuurlink) September 4, 2021
Systematic review: evaluation of dietary patterns and all-cause mortality.
6 Sep, 2021 | 10:43h | UTCEvaluation of Dietary Patterns and All-Cause Mortality: A Systematic Review – JAMA Network Open
Commentary on Twitter (thread – click for more)
Great to see work focused on diet patterns (rather than single nutrient/foods)
Nutrient-dense diet patterns, regardless of pattern label/name (Med Diet, DASH, HEI, "plant-based"), were associated with significantly lower risk of death
Commonalities?👇https://t.co/yQxo4lNJNQ
— Stephan van Vliet (@vanvlietphd) September 1, 2021
Interactive infographic showing the effects of Delta: How coronavirus spreads through a population and how we can beat it.
6 Sep, 2021 | 10:59h | UTCHow coronavirus spreads through a population and how we can beat it – The Guardian
Differentiating central from peripheral causes of acute vertigo in an emergency setting with the HINTS, STANDING, and ABCD2 tests: A diagnostic cohort study.
6 Sep, 2021 | 10:36h | UTCDifferentiating central from peripheral causes of acute vertigo in an emergency setting with the HINTS, STANDING, and ABCD2 tests: A diagnostic cohort study – Academic Emergency Medicine (link to abstract – $ for full-text)
Commentary: Can We Detect Central Vertigo on Exam? – Journal Feed
M-A: Effect of monthly injections of naltrexone on alcohol consumption.
6 Sep, 2021 | 10:39h | UTCEffect of extended-release naltrexone on alcohol consumption: a systematic review and meta-analysis – Addiction (link to abstract – $ for full-text)
Double vaccination halves risk of Long COVID.
3 Sep, 2021 | 10:29h | UTCNews release: Double vaccination halves risk of Long COVID – King’s College London
Commentaries:
Largest study of its kind finds face masks reduce COVID-19 – University of California – Berkeley
Study: Vaccines slash long-haul COVID, hospital rates – CIDRAP
Vaccination reduces risk of long Covid, even when people are infected, U.K. study indicates – STAT
Being fully vaccinated reduces odds of long-term Covid-19 symptoms by half, UK study suggests – CNN
Coronavirus vaccines cut risk of long Covid, study finds – BBC
Related: M-A: More than 50 long-term effects of COVID-19.
Commentary on Twitter
NEW evidence on breakthrough infections indicates people who tested positive for #SARS-CoV-2 after 1 or 2 vaccine doses had significantly lower odds of severe disease, hospitalisation, or #LongCOVID than unvaccinated. https://t.co/MgHt7Ztqa0 @TheLancetInfDis pic.twitter.com/nt2b7jVrH9
— The Lancet (@TheLancet) September 1, 2021
WHO says it is monitoring a new Covid variant called ‘mu’.
3 Sep, 2021 | 10:21h | UTCWHO says it is monitoring a new Covid variant called ‘mu’ – CNBC
See also:
What’s the Mu variant? And will we keep seeing more concerning variants? – The Conversation
WHO monitoring new coronavirus variant named ‘Mu’ – France 24
New ‘mu’ coronavirus variant could escape vaccine-induced immunity, WHO says – LiveScience
WHO monitoring new coronavirus variant named Mu – The Guardian
[Preprint] Largest study of masks yet details their importance in fighting Covid-19.
3 Sep, 2021 | 10:30h | UTCLargest study of masks yet details their importance in fighting Covid-19 – NBC News
Original study: The Impact of Community Masking on COVID-19: A Cluster-Randomized Trial in Bangladesh – Innovations for Poverty Action
See also: A Study In Bangladesh Tripled The Rate Of Mask-Wearing. Can It Help In The U.S.? – NPR
Commentaries on Twitter (thread – click for more)
This is arguably the most important single piece of epidemiological research of the entire pandemic.
A MASSIVE randomized trial launched a pro-mask campaign in some Bangladeshi villages, but not others.
The result: masking villages got less COVID. https://t.co/8uKPXAvvnU
— Lyman Stone 石來民 🦬🦬🦬 (@lymanstoneky) September 1, 2021
(thread from the author – click for more)
Some misinterpretation of our #Bangladesh Mask RCT by those who don’t read research, which I’ll ignore, but also some parochial/racist reactions, which I must respond to https://t.co/FFeqz1zox5
— Mushfiq Mobarak (@mushfiq_econ) September 2, 2021
EU agency says to focus on vaccines first not booster shots.
3 Sep, 2021 | 10:34h | UTCEU agency says to focus on vaccines first not booster shots – Associated Press
See also: European officials say COVID-19 booster isn’t urgent – CIDRAP
Review: Cardiovascular care of older adults.
3 Sep, 2021 | 10:13h | UTCCardiovascular care of older adults – The BMJ
Musculoskeletal complications following critical illness: A scoping review.
3 Sep, 2021 | 10:07h | UTC
Commentary on Twitter
Very pleased that our scoping review on MSK complications following critical illness has been published – first paper from my PhD! @mawilliamsinOx @helendawes2 @matthewjrowland @ouh_therapies @MOReS_OBU #icurehab https://t.co/f6kHDtMzrj pic.twitter.com/bOm3YvLP5U
— Owen Gustafson (@OxfordICUPhysio) August 26, 2021
RCT: In patients with Immune Thrombocytopenia, the addition of Mycophenolate Mofetil to a standard glucocorticoid regimen reduced refractory or relapsed disease but was associated with decreased quality of life outcomes regarding physical function and fatigue.
3 Sep, 2021 | 10:15h | UTC
Position Paper: Diagnosis and management of heart failure in elderly patients from hospital admission to discharge.
3 Sep, 2021 | 10:11h | UTC
RCT: Baricitinib reduced mortality in hospitalized adults with COVID-19.
2 Sep, 2021 | 10:17h | UTCCommentaries:
Commentaries on Twitter
NEW—Baricitinib did not improve the composite primary endpoint of progression to NIV,
high-flow O2, IMV, or death; however, it did reduce 28-day all-cause mortality by 38·2% vs placebo (HR 0·57 [95% CI 0·41–0·78])Read the COV-BARRIER study: https://t.co/QrU6GW0XcQ#ISICEM2021
— The Lancet Respiratory Medicine (@LancetRespirMed) September 1, 2021
(thread – click for more)
1/🧵💥 NEW COVID THERAPY SAVES LIVES
Adding baricitinib to steroids will save 1,000s of hospitalized #COVID pts. Our @LancetRespirMed COV-Barrier study is FREE.
I explain👇why it’s such a great #Pandemic discovery story: a new way to ⬇️ COVID19 deaths.https://t.co/8I5BlwyT2R pic.twitter.com/6KcfQrljqC
— WesElyMD (@WesElyMD) September 1, 2021
Review | COVID-19 and immune-mediated inflammatory diseases: effect of disease and treatment on COVID-19 outcomes and vaccine responses.
2 Sep, 2021 | 10:06h | UTC
Commentary on Twitter
NEW REVIEW—COVID-19 and immune-mediated inflammatory diseases
Filippo Fagni and colleagues @UniFAU review the effect of disease and treatment on #COVID19 outcomes and #vaccine responseshttps://t.co/ue8XnDF1sM #LancetRheumatology @KorayTascilar pic.twitter.com/Yrk4SmeSbE
— The Lancet Rheumatology (@TheLancetRheum) August 27, 2021
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
2 Sep, 2021 | 10:05h | UTCWaning of BNT162b2 vaccine protection against SARS-CoV-2 infection in Qatar – medRxiv
Related:
Studies: COVID vaccine protection waning against infection but not hospitalization.
Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.
Commentary on Twitter (thread – click for more)
The evidence of mRNA vaccine effectiveness (VE) waning grows: large Qatar experience shows substantial 5 month attrition for symptomatic infection VE below 50% and, to a lesser extent, vs hospitalization and deathhttps://t.co/4lIG68Bxm0 pic.twitter.com/rnyo0Si3RP
— Eric Topol (@EricTopol) August 27, 2021
Scientific Statement: Coronavirus Disease-2019 and Heart Failure.
2 Sep, 2021 | 10:08h | UTC
Commentary on Twitter
Released today: Coronavirus Disease-2019 and Heart Failure: A Scientific Statement from @HFSA, published in @JCardFail. @dranulala @ankeetbhatt @EricAdler17 @BhadeliaMD @AshishCorrea @ersied727 @heartofthemater @AndrewJSauer @NMHheartdoc @scottdsolomon https://t.co/fyWab32ruU pic.twitter.com/8pNY60I6gD
— HFSA (@HFSA) September 1, 2021
RCT: Ketamine administration in patients with acute painful sickle cell crisis was effective for pain control and reduced the cumulative morphine dose in the emergency department.
2 Sep, 2021 | 08:11h | UTCKetamine Administration for Acute Painful Sickle Cell Crisis: A Randomized Controlled Trial – Academic Emergency Medicine (link to abstract – $ for full-text)
[Preprint] Pfizer vaccine booster dose protection: A nationwide study from Israel – “Twelve days or more after the booster dose we found an 11.4-fold decrease in the relative risk of confirmed infection, and a >10-fold decrease in the relative risk of severe illness”.
1 Sep, 2021 | 09:59h | UTCBNT162b2 vaccine booster dose protection: A nationwide study from Israel – medRxiv
Why is a third COVID-19 vaccine dose important for people who are immunocompromised?
1 Sep, 2021 | 09:57h | UTCRelated:
RCT: third dose of Moderna mRNA vaccine increases immunity in transplant recipients.
COVID-19 patients at higher risk of blood clots after surgery, study shows.
1 Sep, 2021 | 09:54h | UTCCOVID-19 patients at higher risk of blood clots after surgery, study shows – CIDRAP
Original study: SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study – Anaesthesia
Related:
ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.
Position statement: Perioperative management of post-COVID-19 surgical patients.
Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery