Vaccines
J&J Covid-19 vaccination is associated with increased risk of cerebral venous sinus thrombosis.
2 Nov, 2021 | 03:02h | UTCCommentary: Cerebral Venous Sinus Thrombosis Rate Up After Ad26.COV2.S Shot – HealthDay
Study shows increased risk of Guillain-Barré syndrome following vaccination with recombinant zoster vaccine – “an attributable risk of 3 cases per million RZV (Shingrix) doses”.
2 Nov, 2021 | 02:45h | UTCRisk of Guillain-Barré Syndrome Following Recombinant Zoster Vaccine in Medicare Beneficiaries – JAMA Internal Medicine (free for a limited period)
Observational study suggests a third dose of the Pfizer COVID-19 vaccine can prevent severe COVID-19-related outcomes, compared with only two doses received at least 5 months before.
31 Oct, 2021 | 20:14h | UTCInvited Commentary: Boosters appear effective, but are they always needed? – The Lancet
Commentaries on Twitter
Nice analysis of boosters in @TheLancet Fri.: https://t.co/KqXInFa3a9
But I want to highlight one number:
Risk of severe disease w no booster & no coexisting conditions = 1 in 32,000 (3 per 100k).
If you have no other medical problems, this is not an urgent priority. pic.twitter.com/Qwcwsf6LIY
— David Dowdy (@davidwdowdy) October 31, 2021
Study in Israel suggests third dose of BNT162b2 mRNA vaccine effective in protecting individuals against severe COVID-19-related outcomes, compared with receiving only two doses at least 5 months before. https://t.co/g3vFqVFZLI pic.twitter.com/HfbBAPY8qP
— The Lancet (@TheLancet) October 31, 2021
Adding to the body of data for booster shot effectiveness, a new @TheLancet report of over 728,000 people w/ 3 shots vs >728,000 matched controls (2 shots):
93% reduction of Covid hospitalizationshttps://t.co/cVpANpnkHs pic.twitter.com/LlBwWi2Vtw— Eric Topol (@EricTopol) October 30, 2021
CDC Study: COVID-19 vaccine associated with 5 times the protection of ‘natural immunity’.
31 Oct, 2021 | 20:09h | UTCCommentaries:
COVID-19 vaccine gives 5 times the protection of ‘natural immunity,’ data show – CIDRAP
COVID shots more protective than past infection, study shows – Associated Press
Commentary on Twitter
⚠️BREAKING—REINFECTION & NATURAL IMMUNITY—new CDC study in hospitalized adults finds: unvaccinated people with prior #COVID19 infection recently were **5 times more likely** to be reinfected / get breakthrough versus people recently fully vaccinated! 🧵 https://t.co/VGmWPmm5lE pic.twitter.com/mlt5fJ3643
— Eric Feigl-Ding (@DrEricDing) October 29, 2021
Opinion | Is Moderna really better than Pfizer—or is it just a higher dose?
31 Oct, 2021 | 20:06h | UTCIs Moderna Really Better Than Pfizer—Or Is It Just a Higher Dose? – The Atlantic
Commentary on Twitter
Nice piece @theatlantic explores question of: Does Moderna give better protection than Pfizer, which gives better protection than J&J (the data would say yes to both)? And – if so – is it simply a matter of the relative doses? https://t.co/Bqav2pNNi7
— Bob Wachter (@Bob_Wachter) October 30, 2021
The effectiveness of the AstraZeneca vaccine in older adults during SARS-CoV-2 Gamma variant circulation in São Paulo was 77.9% against symptomatic Covid-19, 87.6% against hospitalization, and 93.6% against death.
29 Oct, 2021 | 10:25h | UTC
Commentary on Twitter (thread – click for more)
https://twitter.com/MHitchingsEpi/status/1453779176826105857
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern.
29 Oct, 2021 | 10:16h | UTCmRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern – Science
Commentary from the author on Twitter (thread – click for more)
Antibodies come and go, but memory cells are forever (maybe not forever, but at least 6 months). Our latest in @ScienceMagazine: https://t.co/YHHBMrMsTA
How long does immune memory last after #mRNA vax? Is it effective vs. variants? What about “boosted” responses?
Full 🧵⬇️… pic.twitter.com/oZ5BxLuVdw
— Rishi Goel (@rishirajgoel) October 14, 2021
What COVID vaccines for young kids could mean for the pandemic.
28 Oct, 2021 | 10:15h | UTCWhat COVID vaccines for young kids could mean for the pandemic – Nature
Related: FDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children ages 5 to 11.
FDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children ages 5 to 11.
27 Oct, 2021 | 01:48h | UTCFDA advisory panel recommends Pfizer Covid-19 vaccine be authorized for children – STAT
See also:
Tracking the FDA advisory panel meeting on Covid-19 vaccines for kids – STAT
FDA advisory panel recommends Pfizer vaccine for kids ages 5 to 11 – NPR
Mix-and-match COVID vaccines ace the effectiveness test – “No need for brand loyalty”.
27 Oct, 2021 | 01:42h | UTCMix-and-match COVID vaccines ace the effectiveness test – Nature
Related:
Should You Mix and Match Your Booster Shot?
A primer on what we know about mixing and matching Covid vaccines.
Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.
RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Heterologous AstraZeneca/Pfizer vaccination seems to be associated with increased effectiveness against Covid-19 compared to homologous Pfizer/Pfizer vaccination.
27 Oct, 2021 | 01:44h | UTCImmunogenicity and efficacy of heterologous ChadOx1/BNT162b2 vaccination – Nature
Related:
Should You Mix and Match Your Booster Shot?
A primer on what we know about mixing and matching Covid vaccines.
Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.
RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Commentary on Twitter
A dose of the AstraZeneca COVID-19 vaccine followed by a dose of the Pfizer/BioNTech vaccine confers better protection against SARS-CoV-2 infection than two doses of the Pfizer vaccine, according to a study in healthcare workers published in @Nature. https://t.co/6hIVkiOLQ1 pic.twitter.com/AmsyVUMpoj
— Nature Portfolio (@NaturePortfolio) October 26, 2021
[Press release – not published yet] Moderna says its COVID vaccine produced a strong antibody response for kids 6 to 11.
26 Oct, 2021 | 02:06h | UTCPress release: Moderna Announces Positive Top Line Data from Phase 2/3 Study of COVID-19 Vaccine in Children 6 to 11 Years of Age
Commentary: Moderna says new data supports its COVID vaccine for kids 6 to 11 – NPR
What It Means To Be Fully Vaccinated.
26 Oct, 2021 | 01:57h | UTCWhat It Means To Be Fully Vaccinated – Think Global Health
Half doses, third doses, kids’ doses: Covid vaccine delivery goes next-level difficult.
24 Oct, 2021 | 23:52h | UTCHalf doses, third doses, kids’ doses: Covid vaccine delivery goes next-level difficult – STAT
AstraZeneca vaccination not linked to reduced fertility rates and adverse birth outcomes.
24 Oct, 2021 | 23:58h | UTCFertility rates and birth outcomes after ChAdOx1 nCoV-19 (AZD1222) vaccination – The Lancet
Related:
Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.
CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
Commentary on Twitter
New research letter: Fertility rates and birth outcomes after ChAdOx1 nCoV-19 (AZD1222) vaccination. Authors analysed pregnancies occurring in four ongoing clinical trials in the UK, Brazil, and South Africa. https://t.co/hDM1olKts9@OxfordVacGroup | #COVID19 #AstraZeneca pic.twitter.com/m5qvWhPcph
— The Lancet (@TheLancet) October 23, 2021
Coronavirus: Chinese residents start receiving vaccine boosters.
24 Oct, 2021 | 23:51h | UTCCoronavirus: Chinese residents start receiving vaccine boosters – South China Morning Post
[Press release – not published yet] A phase 3 trial with more than 10,000 participants showed a booster dose of the Pfizer/BioNTech vaccine had an efficacy of 95.6% against disease; there were 5 cases in the booster group and 109 cases in the non-boosted group, not classified according to severity.
22 Oct, 2021 | 10:34h | UTC
Commentaries on Twitter
This will presumably mean everyone gets boosters early next year. That’s great, because they do work. Except it’s likely to be boosters for rich countries at the expense of primary vaccination for poorer countries. You won’t stop the pandemic when half the world is unvaccinated https://t.co/F31DMSI2zf
— Niall Conroy (@NICU_doc_salone) October 21, 2021
The 1st randomized trial of a booster (3rd) shot in 10,000 people, placebo-controlled, shows 95.6% efficacy, with 5 cases (Pfizer vaccine) vs 109 in placebo group, Delta variant, broad benefit across age groups https://t.co/TQpF35d8Jk pic.twitter.com/3RkqvXNfsU
— Eric Topol (@EricTopol) October 21, 2021
Pfizer vaccine showed estimated effectiveness of 93% against symptomatic SARS-CoV-2 Delta variant infection in adolescents.
21 Oct, 2021 | 10:17h | UTC
Commentary on Twitter
The remarkably high effectiveness (VE) of vaccination for teens vs the Delta variant in over 94,000 vaccinees and 94,000 matched controls: 93% VE vs symptomatic infection (95% CI 88,97) https://t.co/wwoXlw7PH9@NEJM pic.twitter.com/8m3fJ7avc5
— Eric Topol (@EricTopol) October 20, 2021
A case-controlled study showed Covid-19 vaccination during early pregnancy was not associated with increased risk of first-trimester miscarriage.
21 Oct, 2021 | 10:14h | UTCRelated:
Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.
CDC Guidance: Pregnant people should be vaccinated against COVID-19.
Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.
FDA authorizes booster doses of Moderna and Johnson & Johnson vaccines, says mix and match OK.
21 Oct, 2021 | 10:09h | UTCFDA authorizes booster doses of Moderna and Johnson & Johnson vaccines, says mix and match OK – CNN
See also:
FDA OKs mixing COVID vaccines; backs Moderna, J&J boosters – Associated Press
FDA OKs Moderna, J&J boosters, along with ‘mix and match’ approach – NBC News
CDC Study: Pfizer vaccine showed 93% effectiveness against Covid-19 hospitalization among children aged 12-18 years.
20 Oct, 2021 | 10:31h | UTC
Commentary on Twitter (thread – click for more)
Vaccination reduced the risk of hospitalization among 12–18-year-olds by 93%, according to a new CDC study. No vaccinated adolescents died or were admitted to the ICU.
— Dr. Tom Frieden (@DrTomFrieden) October 19, 2021
Cohort Study: The effectiveness of heterologous AstraZeneca (AZ)/mRNA prime-boost vaccination was more significant (68%) compared to the effectiveness of homologous AZ/AZ vaccination (50%) against symptomatic Covid-19 infection in Sweden.
20 Oct, 2021 | 10:27h | UTCCommentary: High effectiveness of mix-and-match COVID-19 vaccines – UMEA University
Related:
A primer on what we know about mixing and matching Covid vaccines.
Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.
RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
Commentary on Twitter
Study from Sweden assessing heterogenous vaccination in 3,445,061 individuals who received AZ as the first dose and either #pfizer, #moderna, or #AZ as second dose showed the following vaccine effectiveness:
AZ/Pfizer- 67%
AZ/Moderna- 79%
AZ/AZ- 50%https://t.co/UN0pey2kJ2— Yan Leyfman, MD (@YLeyfman) October 19, 2021
Should You Mix and Match Your Booster Shot?
20 Oct, 2021 | 10:25h | UTCShould You Mix and Match Your Booster Shot? – The Atlantic
Related:
A primer on what we know about mixing and matching Covid vaccines.
Another study shows increased immune response with heterologous Oxford-AstraZeneca/mRNA vaccination.
RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
[Preprint] Observational study in Brazil showed the J&J vaccine adjusted effectiveness was 50.9% against any symptomatic Covid-19, 72.9% for hospitalization, 92.5% for ICU admission, 88.7% for mechanical ventilation, and 90.5% for death.
20 Oct, 2021 | 10:24h | UTC
China’s COVID vaccines have been crucial — now immunity is waning.
19 Oct, 2021 | 09:53h | UTCChina’s COVID vaccines have been crucial — now immunity is waning – Nature
Related:
Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.
COVID vaccine effects wane over time but still prevent death and severe illness.
Perspective | What we actually know about waning immunity.
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Studies: COVID vaccine protection waning against infection but not hospitalization.