Vaccines
[Preprint] Serological responses to COVID-19 booster vaccine in England.
26 Nov, 2021 | 08:34h | UTCSerological responses to COVID-19 booster vaccine in England – medRxiv
Commentary from the author on Twitter (thread – click for more)
1/ Our preprint on #SARSCoV2 antibody responses in UK adults receiving a #COVID19 vaccine booster with the Pfizer vaccine at least 6 months after primary immunisation with Pfizer or AZ vaccine, which was given at an extended interval (8-12 wks) … ?
— Shamez Ladhani (@ShamezLadhani) November 25, 2021
WHO Interim statement on COVID-19 vaccination for children and adolescents.
25 Nov, 2021 | 10:49h | UTCInterim statement on COVID-19 vaccination for children and adolescents – World Health Organization
Perspective: COVID-19 vaccine makers plan for annual boosters, but it’s not clear they’ll be needed.
25 Nov, 2021 | 10:43h | UTCCOVID-19 Vaccine Makers Plan for Annual Boosters, but It’s Not Clear They’ll Be Needed – JAMA
Do vaccines protect against long COVID? What the data say – “Vaccines reduce the risk of developing COVID-19 — but studies disagree on their protective effect against long COVID”.
25 Nov, 2021 | 10:41h | UTCDo vaccines protect against long COVID? What the data say – Nature
Related:
EuGMS Guidance: Management of post-acute COVID-19 patients in geriatric rehabilitation.
Addressing Post-COVID Symptoms: A Guide for Primary Care Physicians.
Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.
Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.
WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).
Characterizing long COVID: a living systematic review.
Long Covid – The illness narratives.
New guidelines to help doctors manage long COVID patients published.
M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)
Commentary on Twitter
Vaccines reduce the risk of long COVID by lowering the chances of contracting COVID-19. But studies suggest that vaccination might only halve the risk of long COVID, or have no effect on it at all, in a breakthrough infection. Read the @Nature report. https://t.co/MEkzXyO7hD
— Nature Portfolio (@NaturePortfolio) November 25, 2021
Promoting COVID-19 vaccine acceptance: recommendations from the Lancet Commission on Vaccine Refusal, Acceptance, and Demand in the USA.
24 Nov, 2021 | 08:47h | UTCRelated: WHO Guidance for improving acceptance and uptake of COVID-19 vaccines
[Preprint] Systematic Review: Duration of Effectiveness of Vaccines Against SARS-CoV-2 Infection and COVID-19 Disease – “effectiveness against COVID-19 severe disease remained high (>70%) in most studies in the six months after full vaccination, although it did decrease some (on average, 8-10 percentage points) between one and six months after full vaccination”.
23 Nov, 2021 | 08:57h | UTCRelated:
Correlation of SARS-CoV-2-breakthrough infections to time-from-vaccine.
China’s COVID vaccines have been crucial — now immunity is waning.
Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.
COVID vaccine effects wane over time but still prevent death and severe illness.
Perspective | What we actually know about waning immunity.
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Studies: COVID vaccine protection waning against infection but not hospitalization.
Systematic Review: Vaccines for preventing rotavirus diarrhea.
24 Nov, 2021 | 08:20h | UTCVaccines for preventing rotavirus diarrhoea: vaccines in use – Cochrane Library
Commentary: Vaccines for preventing rotavirus diarrhoea: an updated Cochrane review – Cochrane Library
Populational study in France did not show an increased incidence of acute myocardial infarction, stroke, and pulmonary embolism following the Pfizer vaccine.
23 Nov, 2021 | 08:51h | UTC
United States FDA clears COVID vaccine boosters for all adults over 18 – Pfizer & Moderna 6 months after second jab.
21 Nov, 2021 | 23:17h | UTCSee also:
FDA expands emergency authorization for Covid-19 booster shots to all adults – STAT
FDA, CDC advisors approve COVID boosters for all US adults – CIDRAP
FDA Approves Both Pfizer, Moderna Boosters for All Adults – HealthDay
No, vaccinated people are not ‘just as infectious’ as unvaccinated people if they get COVID.
21 Nov, 2021 | 23:05h | UTC
[Not published yet] Single-dose HPV vaccine highly effective, researchers say – “Results of randomized controlled trial in Kenya bring new energy to eliminate cervical cancer worldwide”.
21 Nov, 2021 | 22:56h | UTCRelated:
Three-year follow-up of 2-dose versus 3-dose HPV vaccine
CDC: 92% of Human Papillomavirus–Attributable Cancers can be Targeted by HPV Vaccination
Meta-Analysis: Population-level Impact of HPV Vaccination Programs
Editorial: COVID-19 vaccines for children – “Although it is true that most children experience asymptomatic or mild disease, some will get quite sick, and a small number will die. It’s why children are vaccinated against influenza, meningitis, chickenpox, and hepatitis”.
19 Nov, 2021 | 10:57h | UTCCOVID-19 vaccines for children – Science
Related: Review: Should children under 12 years of age be vaccinated against COVID-19?
Commentary on Twitter
"Although it is true that most children experience asymptomatic or mild COVID disease, some will get quite sick, and a small number will die.
It’s why children are vaccinated against influenza, meningitis, chickenpox, and hepatitis" @DrPaulOffit et al.https://t.co/mvXHXdiYha
— Madhu Pai, MD, PhD (@paimadhu) November 18, 2021
Correlation of SARS-CoV-2-breakthrough infections to time-from-vaccine.
19 Nov, 2021 | 10:47h | UTCCorrelation of SARS-CoV-2-breakthrough infections to time-from-vaccine – Nature Communications
Commentary: Long-term effectiveness of Pfizer/BioNTech two-dose regimen mRNA vaccine – News Medical
China’s COVID vaccines have been crucial — now immunity is waning.
Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.
COVID vaccine effects wane over time but still prevent death and severe illness.
Perspective | What we actually know about waning immunity.
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Studies: COVID vaccine protection waning against infection but not hospitalization.
Commentary on Twitter
A paper in @NatureComms presents preliminary evidence of Pfizer-BioNTech COVID-19 vaccine waning, with a higher incidence of breakthrough infection in people who received their second dose early in 2021 compared to later in the year. https://t.co/QJ7sPZIDuC pic.twitter.com/Gwkj0ugz57
— Nature Portfolio (@NaturePortfolio) November 18, 2021
Opinion: With 128 Covid vaccines in clinical development, we don’t know if the approved/authorized ones are the best ones.
19 Nov, 2021 | 10:45h | UTC
Perspective | The Future of SARS-CoV-2 Vaccination — Lessons from Influenza.
19 Nov, 2021 | 10:49h | UTCThe Future of SARS-CoV-2 Vaccination — Lessons from Influenza – New England Journal of Medicine
Review: Should children under 12 years of age be vaccinated against COVID-19?
18 Nov, 2021 | 08:56h | UTCShould children be vaccinated against COVID-19? – Archives of Disease in Childhood
Commentary from the author on Twitter (thread – click for more)
Should #children be vaccinated against #COVID19?
Our review outlines the points to consider in weighing up whether all healthy children under 12y should be vaccinated against COVID-19.https://t.co/JtoOr2TZoq#medpeds #IDTwitter #PaedsID #tweetiatrician #paediatrics
?1/n pic.twitter.com/g4UGu3pMsE
— Nigel Curtis (@nigeltwitt) November 6, 2021
Covid: Children in UK told to delay jab for 12 weeks after infection.
18 Nov, 2021 | 08:54h | UTCCovid: Children told to delay jab for 12 weeks after infection – BBC
Original Report: Joint Committee on Vaccination and Immunisation (JCVI) advice on COVID-19 vaccination in people aged 16 to 17 years: 15 November 2021
The big questions about Covid-19 booster shots – “From the why to the who, we still need a lot of answers about booster shots”.
17 Nov, 2021 | 08:48h | UTCThe big questions about Covid-19 booster shots – Vox
Commentary on Twitter
1/ Thoughtful piece by @voxdotcom's @germanrlopez on COVID vaccine boosters.
In good company with @ashishkjha @DrPaulOffit @MonicaGandhi9 @jenkatesdc.https://t.co/pOwZLkmJHn pic.twitter.com/ZAD7AOj0Vz
— Céline Gounder, MD, ScM, FIDSA (@celinegounder) November 12, 2021
Review: Vaccine-induced immune thrombotic thrombocytopenia.
16 Nov, 2021 | 08:46h | UTCVaccine-induced immune thrombotic thrombocytopenia – The Lancet Haematology
Related:
Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance.
Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.
Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.
Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)
Commentary on Twitter
NEW Viewpoint by @Erik_Klok_MD, @MPaiMD, Menno Huisman & @ProfMakris discussing the epidemiology, pathophysiology, and optimal diagnostic and therapeutic management of vaccine-induced immune thrombotic thrombocytopenia #VITT #COVID19Vaccine https://t.co/FI4NynwzEn pic.twitter.com/9PbjaioA2T
— The Lancet Haematology (@TheLancetHaem) November 12, 2021
Covid: Austria introduces lockdown for unvaccinated.
16 Nov, 2021 | 08:43h | UTCCovid: Austria introduces lockdown for unvaccinated – BBC
See also: Austria orders nationwide lockdown for the unvaccinated – Associated Press
Covid-19: global vaccine production is a mess and shortages are down to more than just hoarding.
16 Nov, 2021 | 08:42h | UTC
Commentary on Twitter
Seventy countries have yet to vaccinate 10% of their populations for covid-19. What is holding up the process?
Includes a #BMJInfographic that shows whether countries producing vaccines are able to vaccinate more of their populationshttps://t.co/9Z9BtzJKR9 pic.twitter.com/zfUfSgZQtC
— The BMJ (@bmj_latest) November 2, 2021
[Preprint] Risk of severe COVID-19 is rare among fully vaccinated individuals in England.
14 Nov, 2021 | 20:10h | UTCCommentary: Risk of severe COVID-19 is rare among fully vaccinated individuals in England – News Medical
Phase 4 RCT: Concomitant administration of COVID-19 vaccines (AstraZeneca or Pfizer) with seasonal influenza vaccines in adults is safe and preserves antibody responses to both vaccines.
14 Nov, 2021 | 20:14h | UTC
Large populational study finds prior SARS-CoV-2 infection reduces the risk of breakthrough infection following mRNA vaccination.
14 Nov, 2021 | 20:12h | UTCCommentaries:
Vaccine plus previous infection may offer enhanced COVID-19 protection – CIDRAP
Commentary on Twitter
Study found prior #SARSCoV2 infection was associated with lower risk for breakthrough infection among persons receiving the SARS-CoV-2 mRNA vaccines; however, the observational study design precludes direct comparison of infection risk btwn the 2 vaccines https://t.co/1RLuKSGPjy
— JAMA (@JAMA_current) November 1, 2021
Populational study in Qatar showed the effectiveness against SARS-CoV-2 Delta-induced severe, critical or fatal disease was 93.4% for the Pfizer vaccine and 96.1% for Moderna.
14 Nov, 2021 | 20:11h | UTC
Commentary on Twitter
A study in @NatureMedicine shows that mRNA COVID-19 vaccines are highly effective at preventing severe outcomes and death caused by the SARS-CoV-2 Delta variant in Qatar despite substantially lower effectiveness at blocking infection. https://t.co/V09Ma583fy pic.twitter.com/QG2HaDsrCo
— Nature Portfolio (@NaturePortfolio) November 4, 2021