Infectious Diseases (all articles)

Antibiotics may be an Alternative First-line Treatment for Uncomplicated Appendicitis

7 Feb, 2019 | 14:55h | UTC

Antibiotics may be an alternative first-line treatment for uncomplicated appendicitis – NIHR Signal (free)

Original Study: Randomized Trial: Antibiotic Therapy Alone Seems Reasonable for Uncomplicated Appendicitis (link to abstract, other studies, commentaries and a guideline on the subject)

Guideline: Acute Exacerbation of Bronchiectasis (Non-cystic Fibrosis)

7 Feb, 2019 | 01:07h | UTC

Bronchiectasis (non-cystic fibrosis), acute exacerbation: antimicrobial prescribing – National Institute for Health and Care Excellence (free)

Study: Scaling Up Prevention and Treatment Towards the Elimination of Hepatitis C

6 Feb, 2019 | 00:40h | UTC

Scaling up prevention and treatment towards the elimination of hepatitis C: a global mathematical model – The Lancet (free)

Commentaries: How feasible is the global elimination of HCV infection? – The Lancet (free) AND HCV Elimination Is Possible, First Estimates Suggest – Medscape (free registration required) AND Major progress against hep C by 2030 is possible, but will need vast improvements in screening, prevention, treatment – MedicalXpress (free) AND Big Gains Against Hep C Possible With Big Investment – U.S. News (free)

Related Commentary on Twitter

Major progress against #hepatitisC by 2030 is possible, but will need vast improvements in screening, prevention and treatment: finding from a global mathematical model https://t.co/aMUS2hard1 pic.twitter.com/ZNhhbwJDr1

— The Lancet (@TheLancet) January 28, 2019

2019 ACIP Adult Immunization Schedule

5 Feb, 2019 | 00:39h | UTC

International Consensus Guidelines for the Optimal Use of the Polymyxins

4 Feb, 2019 | 23:45h | UTC

International Consensus Guidelines for the Optimal Use of the Polymyxins – Pharmacotherapy (free)

Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti‐infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP).

Randomized Trial: Oral versus Intravenous Antibiotics for Bone and Joint Infection

30 Jan, 2019 | 23:56h | UTC

Oral versus Intravenous Antibiotics for Bone and Joint Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Related Trial: Partial Oral vs. Intravenous Antibiotic Treatment of Endocarditis (link to abstract and commentaries)

Commentary: Oral antibiotics may work for some ortho, heart infections – CIDRAP (free)

Related Commentary on Twitter

In this trial, 1054 participants with complex orthopedic infections were assigned to receive either oral or intravenous antibiotics for the first 6 weeks of treatment. At 1 year, oral therapy was noninferior to intravenous therapy.

— NEJM (@NEJM) January 30, 2019

British Guideline for the Management of Neisseria Gonorrhoeae

30 Jan, 2019 | 00:51h | UTC

British Association for Sexual Health and HIV national guideline for the management of infection with Neisseria gonorrhoeae (2019) (free PDF)

Commentary: UK Gonorrhea Guideline Guards Against Antibiotic Resistance – MD Magazine (free)

Study: Human Papillomavirus Vaccine Effectiveness and Herd Protection in Young Women

29 Jan, 2019 | 00:00h | UTC

Human Papillomavirus Vaccine Effectiveness and Herd Protection in Young Women – Pediatrics (free)

Commentaries: Three Important Findings From a Study on HPV “Real World” Effectiveness – Pediatrics (free) AND HPV vaccine effective against infection and for herd immunity – 2 Minute Medicine (free)

Related Perspective on Herd Immunity: The Herd to the Rescue: How an Invisible Shield Can Keep us Healthy (free)

Study: Cost-effectiveness of Urine-based Tuberculosis Screening in Hospitalized Patients with HIV

28 Jan, 2019 | 23:58h | UTC

Cost-effectiveness of urine-based tuberculosis screening in hospitalised patients with HIV in Africa: a microsimulation modelling study – The Lancet Global Health (free)

Commentaries: Costs of tuberculosis screening among inpatients with HIV – The Lancet Global Health (free) AND Using urine testing to diagnose TB in patients with HIV can save lives and be cost-effective – London School of Hygiene & Tropical Medicine (free)

WHO Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo

27 Jan, 2019 | 19:01h | UTC

Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Commentary: Ebola spreads to high-risk area of Congo: WHO – Reuters (free)

Related: DRC Ebola Total Hits 699 Amid More Resistance, Insecurity (free commentaries)

Observational Study: Mortality with Oral Step-Down vs Continued IV Therapy in Enterobacteriaceae Bacteremia

27 Jan, 2019 | 18:36h | UTC

Association of 30-Day Mortality With Oral Step-Down vs Continued Intravenous Therapy in Patients Hospitalized With Enterobacteriaceae Bacteremia – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Switch to oral antibiotics in bacteremia not tied to worse outcomes – CIDRAP (free)

Cohort Study: Prior Dengue Virus Infection May Protect Against Zika

24 Jan, 2019 | 17:05h | UTC

Prior dengue virus infection and risk of Zika: A pediatric cohort in Nicaragua – PLOS Medicine (free)

Commentaries: Prior dengue in kids may protect against Zika symptoms – CIDRAP (free) AND Dengue immunity may be protective against symptomatic Zika, study finds – NIH News Releases (free) AND Children who had a dengue infection could be protected from symptomatic Zika – University of Michigan (free)

Systematic Review: Early Discontinuation of Antibiotics for Febrile Neutropenia vs. Continuation Until Neutropenia Resolution in People with Cancer

24 Jan, 2019 | 00:17h | UTC

Early discontinuation of antibiotics for febrile neutropenia versus continuation until neutropenia resolution in people with cancer – Cochrane Library (free)

Summary: Stopping antibiotic therapy early versus continuing until normal neutrophil count in people with cancer with fever and low neutrophil counts – Cochrane Library (free)

The Herd to the Rescue: How an Invisible Shield Can Keep us Healthy

23 Jan, 2019 | 14:25h | UTC

The herd to the rescue: How an invisible shield can keep us healthy – STAT (free)

Related: Case Report: Fatal Measles Case Highlights Importance of Herd Immunity in Protecting the Vulnerable (free case report and commentary)

DRC Ebola Total Hits 699 Amid More Resistance, Insecurity

22 Jan, 2019 | 22:42h | UTC

DRC Ebola total hits 699 amid more resistance, insecurity – CIDRAP (free)

NYT Editorial: How to Inoculate Against Anti-Vaxxers

21 Jan, 2019 | 23:58h | UTC

How to Inoculate Against Anti-Vaxxers – The New York Times (10 articles per month are free)

New Single-Dose Drug to Prevent Relapse of Plasmodium vivax Malaria

21 Jan, 2019 | 14:18h | UTC

Single-Dose Tafenoquine to Prevent Relapse of Plasmodium vivax Malaria – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: New one-dose drug prevents malaria relapse, studies show – CIDRAP (free)

New Concepts in Diagnostics for Invasive Mycoses: Non-Culture-Based Methodologies

21 Jan, 2019 | 14:28h | UTC

New Concepts in Diagnostics for Invasive Mycoses: Non-Culture-Based Methodologies – Journal of Fungi (free PDF)

This article belongs to the Special Issue Fungal Infections in Immunocompromised Hosts (free articles)

WHO: Global Antimicrobial Resistance Surveillance System (GLASS) Report

21 Jan, 2019 | 10:20h | UTC

Global antimicrobial resistance surveillance system (GLASS) report: Early implementation 2017-2018 – World Health Organization (free PDF)

Study: Appropriateness of Outpatient Antibiotic Prescribing

18 Jan, 2019 | 01:01h | UTC

Appropriateness of outpatient antibiotic prescribing among privately insured US patients: ICD-10-CM based cross sectional study – The BMJ (free)

Commentaries: Nearly a fourth of outpatient antibiotics unneeded, study finds – CIDRAP (free) AND Nearly a quarter of antibiotic prescriptions for children and adults may be unnecessary – University of Michigan (free)

Ebola Has Gotten So Bad, It’s Normal

18 Jan, 2019 | 00:58h | UTC

Ebola Has Gotten So Bad, It’s Normal – Foreign Policy (free)

Guideline: Adult Outpatients with Acute Cough Due to Suspected Pneumonia or Influenza

16 Jan, 2019 | 00:56h | UTC

Adult Outpatients With Acute Cough Due to Suspected Pneumonia or Influenza – CHEST Guideline and Expert Panel Report (free)

See other recently published CHEST guidelines on the management of cough in specific populations: Classification of Cough as a Symptom in Adults and Management Algorithms (free) AND Clinically Diagnosing Pertussis-associated Cough in Adults and Children (free) AND Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold (free) AND Cough Due to TB and Other Chronic Infections (free) AND Chronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND Cough in the athlete (free) AND Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND Treatment of Unexplained Chronic Cough (free) AND Use of Management Pathways or Algorithms in Children With Chronic Cough (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis (free)

Summary: Antiamoebic drugs for treating amoebic colitis – Cochrane Library (free)