Infectious Diseases (all articles)
British Guidelines on the Use of HIV Pre–exposure Prophylaxis (PrEP)
19 Mar, 2019 | 02:54h | UTCBHIVA/BASHH guidelines on the use of HIV pre–exposure prophylaxis (PrEP) 2018 – HIV Medicine (free)
Related guidelines: WHO implementation tool for pre-exposure prophylaxis of HIV infection – World Health Organization (free) AND Draft Recommendation Statement: Prevention of Human Immunodeficiency Virus (HIV) Infection: Pre-Exposure Prophylaxis – U.S. Preventive Services Task Force (free) AND Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis – Canadian Medical Association Journal (free) AND Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine HIV pre-exposure prophylaxis: clinical guidelines. Update April 2018 – Journal of Virus Eradication (free) AND Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update: a Clinical Practice Guideline (free)
Randomized Trial: An Environmental Cleaning Bundle and Health-care-associated Infections in Hospitals
17 Mar, 2019 | 18:54h | UTCAn environmental cleaning bundle and health-care-associated infections in hospitals (REACH): a multicentre, randomised trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Commentary: Hospital cleaning trial cuts infections – Queensland University of Technology (free)
Randomized Trial: Chlorhexidine vs. Routine Bathing to Prevent Multidrug-resistant Organisms and All-cause Bloodstream Infections in General Medical and Surgical Units
17 Mar, 2019 | 18:53h | UTCChlorhexidine versus routine bathing to prevent multidrug-resistant organisms and all-cause bloodstream infections in general medical and surgical units (ABATE Infection trial): a cluster-randomised trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Results of Trial to Stem Hospital-Acquired Bacterial Infections Published – NIAID (free) Quick Take: Chlorhexidine Versus Routine Bathing to Prevent Multidrug-Resistant Organisms and All-Cause Bloodstream Infections in General Medical and Surgical Units (ABATE Infection Trial) – 2 Minute Medicine (free) AND Infection control technique may reduce infections in patients with catheters, drains – Rush University Medical Center (free)
“Decolonisation with universal chlorhexidine bathing and targeted mupirocin for MRSA carriers did not significantly reduce multidrug-resistant organisms in non-critical-care patients.”
Systematic Review: Value of Hospital Antimicrobial Stewardship Programs
17 Mar, 2019 | 18:12h | UTC
Randomized Trial: 9-month Treatment for Multi-drug Resistant TB is as Effective as 24-month Treatment
15 Mar, 2019 | 04:17h | UTCA Trial of a Shorter Regimen for Rifampin-Resistant Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: STREAM trial final results show 9-month treatment for multi-drug resistant TB is as effective as 24-month treatment – University College London (free) AND Trial data support shorter drug-resistant TB regimen – CIDRAP (free)
Randomized Trial: Ivermectin Mass Drug Administration for Control of Malaria
15 Mar, 2019 | 02:24h | UTCCommentaries: Advancing the repurposing of ivermectin for malaria – The Lancet (free) AND Mosquito-killing drug reduces malaria episodes by a fifth among children – expert comment – London School of Hygiene & Tropical Medicine (free)
Systematic Review: Treatment, Prevention and Public Health Management of Impetigo, Scabies, Crusted Scabies and Fungal Skin Infections in Endemic Populations
15 Mar, 2019 | 02:13h | UTC
Randomized Trial: One Month of Rifapentine plus Isoniazid vs. 9 months of Isoniazid Alone for Preventing Tuberculosis in HIV-infected Patients with Latent Tuberculosis Infection
14 Mar, 2019 | 01:06h | UTCOne Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis – New England Journal of Medicine (free for a limited period)
Editorial: Ending Tuberculosis through Prevention (free)
Commentary: Ultrashort TB Therapy Found Just As Effective as 6 Month Course – MedicalResearch.com (free)
Related Commentary on Twitter
Treatment of latent #tuberculosis infection is an important control measure, especially in patients coinfected with #HIV. In this international phase 3 trial, 1 month of isoniazid plus rifapentine was noninferior to the standard 9 months of isoniazid in HIV-infected patients.
— NEJM (@NEJM) March 13, 2019
A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery
14 Mar, 2019 | 01:00h | UTCA Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery – New England Journal of Medicine (free for a limited period)
Video Summary: Prophylactic Antibiotics before Miscarriage Surgery (free)
Commentaries: Research shines light on preventing infection after miscarriage – University of Birmingham (free) AND Antibiotics before miscarriage surgery not tied to fewer infections – CIDRAP (free)
Related Commentary on Twitter
Antibiotic prophylaxis before miscarriage surgery did not result in a significantly lower risk of pelvic infection, as defined by pragmatic broad criteria, than placebo. However, benefit was observed in a secondary analysis that defined pelvic infection by strict criteria.
— NEJM (@NEJM) March 13, 2019
Special Issue: Infections in Solid Organ Transplantation Guidelines
14 Mar, 2019 | 00:35h | UTCInfections in Solid Organ Transplantation – Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice (free PDF articles)
– BK Polyomavirus in Solid Organ Transplantation
– Adenovirus in Solid Organ Transplant Recipients
– Mycobacterium tuberculosis Infections in Solid Organ Transplantation
– Nocardia Infections in Solid Organ Transplantation
– Urinary Tract Infections in Solid Organ Transplant Recipients
– Herpes Simplex Virus Infections in Solid Organ Transplantation
– RNA Respiratory Viral Infections in Solid Organ Transplant Recipients
– Interactions between Anti‐infective Agents and Immunosuppressants
– Travel Medicine, Transplant Tourism, and the Solid Organ Transplant Recipient
– Solid Organ Transplantation in the HIV‐Infected Patient
– Cytomegalovirus in Solid Organ Transplant Recipients
– Human Herpesvirus 6, 7 and 8 in Solid Organ Transplantation
– Strategies for Safe Living Following Solid Organ Transplantation
– Emerging Fungal Infections in Solid Organ Transplant Recipients
Italy Bans Unvaccinated Children From School
13 Mar, 2019 | 05:48h | UTCItaly bans unvaccinated children from school – BBC (free)
‘Test and Treat’ Reduces new HIV Infections by a Third
13 Mar, 2019 | 03:34h | UTCSee also: Largest ever HIV prevention study delivers sobering message – Science (free)
WHO Launches New Global Influenza Strategy
12 Mar, 2019 | 02:51h | UTCWHO launches new global influenza strategy – World Health Organization (free)
See Report: Global influenza strategy 2019-2030 – World Health Organization (free)
Commentaries: World must prepare for inevitable next flu pandemic, WHO says – Reuters (free) AND WHO launches strategy to fight ‘inevitable’ flu pandemics – MedicalXpress (free)
Meta-Analysis: Signs and Symptoms That Rule out Community-Acquired Pneumonia in Outpatient Adults
12 Mar, 2019 | 02:49h | UTCAdults with an acute respiratory infection who have normal vital signs (temperature < 37,8 / respiratory rate < 20 / heart rate < 100) and a normal pulmonary examination are very unlikely to have CAP.
WHO Guidelines for Malaria Vector Control
11 Mar, 2019 | 04:01h | UTCGuidelines for Malaria Vector Control – World Health Organization (free)
See also: Cochrane Infectious Disease Group works with WHO on latest guidelines for malaria vector control – Cochrane Library (free) AND Current vector control challenges in the fight against malaria in Brazil – Revista da Sociedade Brasileira de Medicine Tropical (free)
Study Confirms and Quantifies Zika-microcephaly Link
7 Mar, 2019 | 02:19h | UTCCommentaries: Study confirms and quantifies Zika-microcephaly link in Brazil – PLOS (free) AND Study highlights early pregnancy Zika microcephaly risk – CIDRAP (free)
Second Patient Free of HIV After Stem-cell Therapy
6 Mar, 2019 | 01:29h | UTCSecond patient free of HIV after stem-cell therapy – Nature News (free)
See also: Has a second person with HIV been cured? – Science (free) AND Expert reaction to HIV-1 remission in a second patient – Science Media Centre (free) AND Bone Marrow Transplant Renders Second Patient Free Of HIV – NPR (free) AND London patient might be second to be cured of HIV – CNN (free) AND H.I.V. Is Reported Cured in a Second Patient, a Milestone in the Global AIDS Epidemic – The New York Times (10 articles per month are free)
Guidelines for the Management of Clostridium Difficile Infection in Surgical Patients
6 Mar, 2019 | 01:35h | UTCRelated Guidelines: IDSA Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children (free) AND The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications (free) AND Guideline for the Management of Clostridium Difficile Infection in Children and Adolescents With Cancer and Pediatric Hematopoietic Stem-Cell Transplantation Recipients (free) AND Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children (free)
Pro/Con Debate: Contact Precautions for MRSA and VRE
6 Mar, 2019 | 01:17h | UTCCon: Things We Do For No Reason: Contact Precautions for MRSA and VRE – Journal of Hospital Medicine (free)
Study: Doctors are Prescribing Antibiotics for Longer than Guidelines Recommend
5 Mar, 2019 | 03:08h | UTCCommentaries: Doctors may be prescribing antibotics for longer than needed – The Conversation (free) AND UK primary care study finds overly long antibiotic courses – CIDRAP (free) AND Antibiotics courses often longer than guidelines – OnMedica (free)
Study: Impact of a Probiotic-based Hospital Sanitation on Antimicrobial Resistance and HAI-associated Antimicrobial Consumption and Costs
5 Mar, 2019 | 02:55h | UTCCommentaries: New sanitation system halves healthcare associated infections and cuts costs by 75 percent – Bocconi University (free) AND Study: Hospital sanitation system cuts infections by 52 percent – UPI (free)
Amazing results. Hopefully, a randomized trial will confirm these findings.
Nationwide Cohort Study Finds No Association Between MMR Vaccine and Autism
5 Mar, 2019 | 02:42h | UTCMeasles, Mumps, Rubella Vaccination and Autism: A Nationwide Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: It’s old news that vaccines don’t cause autism. But a major new study aims to refute skeptics again – STAT (free) AND Danish study finds no association between MMR vaccine and autism, even within high-risk subgroups – 2 Minute Medicine (free) AND A Large Study Provides More Evidence That MMR Vaccines Don’t Cause Autism – NPR (free)
UNICEF: Alarming Global Surge of Measles Cases a Growing Threat to Children
4 Mar, 2019 | 00:27h | UTCAlarming global surge of measles cases a growing threat to children – UNICEF (free)
Commentary: Measles cases at ‘alarmingly’ high levels around the world, UNICEF says – CNN (free)
Observational Study Suggests Delaying Antibiotics is Associated with Worse Outcomes in Elderly Patients with UTI
1 Mar, 2019 | 07:17h | UTCCommentaries: Early use of antibiotics in elderly patients with UTIs associated with reduced risk of sepsis – Imperial College London (free) AND Delaying antibiotics in elderly with UTI linked to higher sepsis, death rates – MDedge (free) AND Withholding antibiotics from over-65s may increases cases of deadly sepsis, study shows – The Telegraph (free)
WHO Publishes New Estimates on Congenital Syphilis
1 Mar, 2019 | 07:19h | UTCWHO publishes new estimates on congenital syphilis – World Health Organization (free)
Original Article: Global burden of maternal and congenital syphilis and associated adverse birth outcomes—Estimates for 2016 and progress since 2012 – PLOS One (free)