Infectious Diseases (all articles)
Therapeutics and COVID-19 | WHO guideline update advises Ivermectin should only be used to treat COVID-19 within clinical trials
1 Apr, 2021 | 04:02h | UTCSummary and Infographic: Drug treatments for covid-19: living systematic review and network meta-analysis – The BMJ
Original guideline: Therapeutics and COVID-19: living guideline – World Health Organization
News release: WHO advises that ivermectin only be used to treat COVID-19 within clinical trials – World Health Organization
Commentary: WHO joins Europe, Merck in recommending against ivermectin for COVID-19 – Reuters
Commentary on Twitter
?Our updated @WHO #LivingGuidance on #COVID19 now adding recommandation on #ivermectin to previous recs on #steroids #remdesivir #lopinavir #Hydroxychloroquine
?https://t.co/eV7BtVrvAf
?https://t.co/G3Eu18Vg0s#MichaelJacobs @Bram_Rochwerg @PerVandvik @diazjv @bmj_latest https://t.co/qdrBQIZK8e pic.twitter.com/s9TkO1afYs— Thomas Agoritsas, MD PhD (@ThomasAgoritsas) March 31, 2021
Consensus Document: Management of superficial and deep surgical site infection
1 Apr, 2021 | 03:33h | UTCRelated Guidelines: Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery AND Global guidelines on the prevention of surgical site infection – World Health Organization AND Surgical site infections: prevention and treatment – National Institute for Health and Care Excellence AND APSIC guidelines for the prevention of surgical site infections – Antimicrobial Resistance & Infection Control
M-A: Vitamin D supplementation to prevent acute respiratory infections
1 Apr, 2021 | 03:30h | UTCCommentaries: Vitamin D to prevent acute respiratory infections – The Lancet Diabetes & Endocrinology AND
Editorial | Vaccine certificates: does the end justify the means?
1 Apr, 2021 | 03:41h | UTCVaccine certificates: does the end justify the means? – The Lancet Microbe
Related: Covid-19 vaccine passports will harm sustainable development – The BMJ Opinion AND Covid-19 vaccine passports and vaccine hesitancy: freedom or control? – The BMJ Opinion AND “Vaccine Passport” Certification — Policy and Ethical Considerations – New England Journal of Medicine AND Interim position paper: considerations regarding proof of COVID-19 vaccination for international travellers – World Health Organization
WHO: Sinopharm, Sinovac COVID-19 vaccine data show efficacy
1 Apr, 2021 | 03:58h | UTCSinopharm, Sinovac COVID-19 vaccine data show efficacy: WHO – Reuters
Commentary on Twitter
WHO decision on Sinopharm & Sinovac vaccines coming in the next few weeks: signal from WHO at a press briefing that the decision may be positive https://t.co/HcbZnJ7WDE
— Hilda Bastian, PhD (@hildabast) March 31, 2021
AstraZeneca COVID vaccine 70% effective vs. B117 variant
1 Apr, 2021 | 03:55h | UTCAstraZeneca COVID vaccine 70% effective vs B117 variant – CIDRAP
Commentary on Twitter (thread – Click for more)
ASYMPTOMATIC & SYMPTOMATIC Efficacy of Oxford-AstraZeneca #COVID19 vaccine versus #B117 & non-B117 variants via 200k swabs in ~8500:?
Symptomatic #B117➡️ 70%
Asymptomatic #B117➡️ 29%
Other variants symptomatic➡️ 81.5%
Other variants asymptomatic➡️ 70%https://t.co/qSWYlHKP0g pic.twitter.com/gS7P9MCpyz
— Eric Feigl-Ding (@DrEricDing) March 31, 2021
[Press release – not published yet] Pfizer-BioNTech vaccine 100% effective against Covid-19 in adolescents
1 Apr, 2021 | 03:52h | UTCPress release: Pfizer-BioNTech Announce Positive Topline Results Of Pivotal Covid-19 Vaccine Study In Adolescents
Commentaries: The Pfizer-BioNTech Vaccine Is Said to Be Powerfully Protective in Adolescents – The New York Times AND Covid: Children ‘well protected by Pfizer vaccine’ – BBC AND Pfizer Says COVID-19 Vaccine Shows ‘100% Efficacy’ In Adolescents – NPR AND Pfizer says its COVID-19 vaccine protects younger teens – Associated Press AND Pfizer and BioNTech say vaccine prevents Covid-19 in adolescents – STAT
Commentaries on Twitter
Press release for BNT-Pfizer vaccine efficacy in 2,260 adolescents aged 12 to 15: 0 Covid-19 among vaccinated, 18 in placebo group. Adverse reactions similar to those in 16 to 25 year-olds (no extra data: could be quite high, so eyes on that) https://t.co/mCoLmCtpgv
— Hilda Bastian, PhD (@hildabast) March 31, 2021
This is really terrific
In trial of 2260 adolescents 12-15 year of age, Pfizer vaccine highly effective at preventing infections
18 infections in placebo group
0 infections in vaccine group
Robust antibody response
No serious side-effects
Looking forward to @US_FDA review https://t.co/VymGXOVb5E
— Ashish K. Jha, MD, MPH (@ashishkjha) March 31, 2021
Post-covid syndrome in individuals admitted to hospital with covid-19: retrospective cohort study
1 Apr, 2021 | 03:43h | UTC
Commentary on Twitter
Follow-up of nearly 48,000 hospitalized patients with covid-19 shows a high rate of readmission, death, and multi-organ disease (heart, diabetes, kidney, lung) compared with matched controls https://t.co/dzxVYdugz2 @bmj_latest pic.twitter.com/hWBn5w2XQf
— Eric Topol (@EricTopol) April 1, 2021
Bill Gates: 5 things you should know about variants
1 Apr, 2021 | 03:49h | UTC5 things you should know about variants – GatesNotes
Commentary on Twitter
Here are five things you should know if you want to understand how variants are (and aren’t) complicating the pandemic. https://t.co/rANiDcZynJ
— Bill Gates (@BillGates) March 31, 2021
Despite Chile’s Speedy Covid-19 Vaccination Drive, Cases Soar
1 Apr, 2021 | 03:46h | UTCDespite Chile’s Speedy Covid-19 Vaccination Drive, Cases Soar – The New York Times (free registration may be required)
Commentary on Twitter (thread – click for more)
Hospital ICUs overwhelmed despite fast vaccinations—Chile ?? made a critical mistake—its government eased restrictions on travel, business and schools much too early, creating a false sense of confidence that pandemic was over. This always been my fear. ?https://t.co/6McpZjekxT pic.twitter.com/NbmKPiOpLI
— Eric Feigl-Ding (@DrEricDing) March 30, 2021
Opinion | “Vaccine Passport” Certification — Policy and Ethical Considerations
1 Apr, 2021 | 03:40h | UTCRelated: Covid-19 vaccine passports will harm sustainable development – The BMJ Opinion AND Covid-19 vaccine passports and vaccine hesitancy: freedom or control? – The BMJ Opinion AND Vaccine certificates: does the end justify the means? – The Lancet Microbe AND Interim position paper: considerations regarding proof of COVID-19 vaccination for international travellers – World Health Organization
Review and Algorithm: Tuberculosis and the Heart
31 Mar, 2021 | 03:07h | UTCTuberculosis and the Heart – Journal of the American Heart Association
Commentary on Twitter
Tuberculosis cardiac involvement is frequent. A systematic review and a new algorithm for CV TB is now available! https://t.co/QhzUCVWIxA @adribaran @JosePatricioLop @SIAC_cardio pic.twitter.com/AuotMOUjR0
— JAHA (@JAHA_AHA) March 29, 2021
Diagnosis and clinical management of hepatosplenic schistosomiasis: A scoping review of the literature
31 Mar, 2021 | 03:01h | UTC
Antibody evasion by the P.1 strain of SARS-CoV-2
31 Mar, 2021 | 03:36h | UTCAntibody evasion by the P.1 strain of SARS-CoV-2 – Cell
Commentary on Twitter (thread – Click for more)
An in-depth assessment of the P.1 (Brazil) variant
—less immune evasion than B.1.351 (South Africa) variant despite similar receptor binding domain mutations
—very good neutralization by mRNA vaccine via sera from vaccineshttps://t.co/2m0A1Pjs9O @CellCellPress today pic.twitter.com/uyV2eZdLQ9— Eric Topol (@EricTopol) March 30, 2021
Why indoor spaces are still prime COVID hotspots
31 Mar, 2021 | 03:35h | UTCWhy indoor spaces are still prime COVID hotspots – Nature
[Preprint] Single dose of AstraZeneca and Pfizer vaccines shows 62% efficacy for preventing disease and reduces viral load/transmissibility of SARS-CoV-2 in residents of Long-Term Care Facilities
31 Mar, 2021 | 03:38h | UTCCommentaries: Single dose of Pfizer and Oxford vaccines shows 60% efficacy in elderly care home residents – NewsMedical AND Care home residents gain 62% protection from single dose of COVID-19 vaccine – University College London
Commentary on Twitter (thread – click for more)
Good news! An updated study has found that ONE dose of either Pfizer’s OR AstraZeneca’s vaccine led to a 62% reduction in the risk of ANY infection and lower viral loads in those that were infected after 28 days. Long-Term Care Facility/High-Risk Setting.https://t.co/ajgoSOA4fj
— Mac n’ Chise ??? (@sailorrooscout) March 29, 2021
Transmissibility and transmission of respiratory viruses
31 Mar, 2021 | 03:33h | UTCTransmissibility and transmission of respiratory viruses – Nature Reviews Microbiology
What it will take to vaccinate the world against COVID-19
31 Mar, 2021 | 03:32h | UTCWhat it will take to vaccinate the world against COVID-19 – Nature
Opinion | Covid-19 vaccine passports will harm sustainable development
31 Mar, 2021 | 03:31h | UTCCovid-19 vaccine passports will harm sustainable development – The BMJ Opinion
“Where you are born can predict how freely you will be able to travel for opportunity, education, and leisure. Being a citizen of certain countries grants people access to nearly the entire globe, whereas others face challenges just to legally leave the borders of the country they live in”
Opinion | Covid-19 vaccine passports and vaccine hesitancy: freedom or control?
31 Mar, 2021 | 03:29h | UTCCovid-19 vaccine passports and vaccine hesitancy: freedom or control? – The BMJ Opinion
“Recent debates around “vaccine passports,” or formal/mandatory certification of vaccination, point towards a potential widening societal divide between those who are vaccinated and those who are not.”
WHO-convened global study of origins of SARS-CoV-2: China Part
31 Mar, 2021 | 03:25h | UTCWHO-convened global study of origins of SARS-CoV-2: China Part – World Health Organization
News release: WHO calls for further studies, data on origin of SARS-CoV-2 virus, reiterates that all hypotheses remain open
Commentaries: WHO report into COVID pandemic origins zeroes in on animal markets, not labs – Nature AND WHO Director-General’s remarks at the Member State Briefing on the report of the international team studying the origins of SARS-CoV-2 – World Health Organization
See also: WHO report: COVID likely 1st jumped into humans from animals
The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis
31 Mar, 2021 | 03:27h | UTC
All the Covid-19 vaccines prevent death and severe disease, and that’s what matters, experts say
31 Mar, 2021 | 03:28h | UTC
WHO report: COVID likely 1st jumped into humans from animals
30 Mar, 2021 | 03:29h | UTCWHO report: COVID likely 1st jumped into humans from animals – Associated Press
Commentaries: WHO report: Jump from animals most likely COVID-19 source – CIDRAP AND WHO, China Report Suggests COVID-19 Passed From Bats to Humans Through Another Animal – ContagionLive
Point-Counterpoint | Should healthcare providers receive treatment priority during a pandemic?
30 Mar, 2021 | 03:23h | UTCIntroducing Point-Counterpoint Perspectives in the Journal of Hospital Medicine
Counterpoint: Prioritizing Healthcare Workers for Scarce Critical Care Resources Is Impractical and Unjust – Journal of Hospital Medicine