Infectious Diseases (all articles)
AHA/ASA Guidance: Diagnosis and Management of Cerebral Venous Sinus Thrombosis with Vaccine-Induced Thrombotic Thrombocytopenia – “No heparin products in any dose should be given.”
30 Apr, 2021 | 08:25h | UTCNews release: Guidance on treatment for rare blood clots and low platelets related to COVID-19 vaccine – American Heart Association
Study with 6.9 million people in England shows severe Covid-19 in young people can mostly be explained by obesity – At a BMI of more than 23 kg/m2, there was a linear increase in risk of severe COVID-19
30 Apr, 2021 | 08:22h | UTCCommentaries: Severe COVID in young people can mostly be explained by obesity – new study – The Conversation AND Obesity studies highlight severe COVID outcomes, even in young adults – CIDRAP AND Expert reaction to study looking at a potential link between body weight and risk of severe COVID-19, especially for younger adults – Science Media Centre
Commentary on Twitter (thread – click for more)
NEW—Study of health records of nearly 7 million people in England found that the risk of worse outcomes from #COVID19 starts rising in people with a BMI above 23kg/m2—considered to be in the healthy range.
Read in @TheLancetEndo: https://t.co/5ibn3yb1xO 1/2 pic.twitter.com/4MwnGq95Sz
— The Lancet (@TheLancet) April 29, 2021
Debate: Should masks be worn outdoors?
30 Apr, 2021 | 08:21h | UTCShould masks be worn outdoors? – The BMJ
Commentaries: Experts debate on wearing masks outdoors – News Medical AND Do masks need to be worn outdoors? – Advanced Science News
Commentary on Twitter (thread – click for more)
Who do so many of us go off about outdoor masking?
Because if governments can show its people that it's taking #COVID19 seriously by focusing on outdoor masking while ignoring the living and working conditions driving so many infections, we'll get nowhere.#endpandemictheatre
— Stefan Baral (@sdbaral) April 29, 2021
Cohort study: Association of maternal SARS-CoV-2 infection in pregnancy with neonatal outcomes – “although babies born of test-positive mothers are more likely to be born early, extremely few were infected with COVID-19”
30 Apr, 2021 | 08:17h | UTCAssociation of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes – JAMA
News release: Low risk of infection in babies born to mothers with COVID-19 – Karolinska Institutet
Editorial: Understanding Risk for Newborns Born to SARS-CoV-2–Positive Mothers – JAMA
Commentary on Twitter
Maternal #SARSCoV2 infection in pregnancy was significantly associated with small increases in the absolute risk of respiratory disorders and some other neonatal morbidities https://t.co/ANkXkaxnwp
— JAMA (@JAMA_current) April 29, 2021
Household COVID-19 risk and in-person schooling – “While in-person schooling is associated with household COVID-19 risk, this risk can likely be controlled with properly implemented school-based mitigation measures”
30 Apr, 2021 | 08:19h | UTCHousehold COVID-19 risk and in-person schooling – Science
Commentary on Twitter
After analyzing responses from the #COVID19 Symptom Survey, @JustinLessler et al. find support for the idea that in-person schooling increases COVID-19 risk to household members; but also evidence that common mitigation measures can reduce this risk. https://t.co/DFtCoN0FEE pic.twitter.com/gxt7nkhdMb
— Science Magazine (@ScienceMagazine) April 29, 2021
Opinion | The world could be doing much more to help India: Countries can’t go it alone in tackling Covid-19
30 Apr, 2021 | 08:16h | UTCThe world could be doing much more to help India – Vox
See also: WHO provides update on India’s surging epidemic second wave and variant B.1.617 – Science Speaks: Global ID News AND People Are Talking About A ‘Double Mutant’ Variant In India. What Does That Mean? – NPR AND WHO says India COVID crisis could ‘happen anywhere’ – MedicalXpress AND India’s COVID-19 Crisis Is Spiraling Out of Control. It Didn’t Have to Be This Way – TIME
‘Unprecedented achievement’: who received the first billion COVID vaccinations?
30 Apr, 2021 | 08:14h | UTC‘Unprecedented achievement’: who received the first billion COVID vaccinations? – Nature
Opinion | SARS-CoV-2 elimination, not mitigation, creates best outcomes for health, the economy, and civil liberties
30 Apr, 2021 | 08:12h | UTC
Counterpoint: Commentary on Twitter (thread – click for more)
Fantasy commentary letter in Lancet (not a peer reviewed study)!
It's an unreasonable proposition for most countries like the UK to achieve elimination + constraints of reality negates claimed economic and liberty benefits if attempted…
— Devan Sinha (@DevanSinha) April 29, 2021
COVID-19 ‘brain fog’ inspires search for causes and treatments
30 Apr, 2021 | 08:13h | UTCCOVID-19 ‘brain fog’ inspires search for causes and treatments – Science (a few articles per month are free)
Study in England showed one dose of COVID-19 vaccine can cut household transmission by up to half – This protection is on top of the reduced risk of a vaccinated person developing symptomatic infection, which is around 60 to 65% after the first dose
29 Apr, 2021 | 08:44h | UTCNews release: One dose of COVID-19 vaccine can cut household transmission by up to half – Public Health England
Original study (preprint): Impact of vaccination on household transmission of SARS-COV-2 in England – Public Health England
Commentaries: Covid-19: One dose of vaccine cuts risk of passing on infection by as much as 50%, research shows – The BMJ AND Covid: One dose of vaccine halves transmission – study – BBC
Opinion | A global pandemic treaty should aim for deep prevention
30 Apr, 2021 | 08:11h | UTCA global pandemic treaty should aim for deep prevention – The Lancet
Review: COVID-19-associated coagulopathy and antithrombotic agents – In non-critically ill hospitalized patients, therapeutic dose anticoagulation may improve clinical outcomes. In critically ill patients, this same treatment does not improve outcomes, and prophylactic dose anticoagulation is recommended
29 Apr, 2021 | 08:46h | UTCRelated: Full-dose Heparin best for moderate COVID-19 regardless of D-dimer — Data released from ACTIV-4a, ATTACC, and REMAP-CAP trials AND RCT: Intermediate-dose enoxaparin (1 mg/kg/d) not better than standard-dose prophylactic anticoagulation in patients with Covid-19 admitted to the intensive care unit
Commentary on Twitter
🆕💥💥State of the Art Review Article @TheLancetHaem by @MiddeldorpS
COVID-19-associated coagulopathy
Excellent explanation for the pathophysiology and great summary for the major RCTs and clinical guidelines https://t.co/NxP06KP2Hm pic.twitter.com/qHzyDsUZpt— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) April 28, 2021
India’s surge leads to further global COVID rise as role of variants probed
29 Apr, 2021 | 08:41h | UTCIndia’s surge leads to further global COVID rise as role of variants probed – CIDRAP
See also: India Blames a Virus Variant as Its Covid-19 Crisis Deepens – The New York Times (free registration required) AND Why the COVID-19 Variants Spreading in India Are a Global Concern – TIME
Commentary on Twitter (thread – click for more)
Variant? “The current 🇮🇳 wave of #COVID19 has a different clinical behavior. It’s affecting young adults. It’s affecting families. It’s a new thing altogether. Two-month-old babies are getting infected.” Also many reports of reinfections/breakthroughs.🧵https://t.co/qve23lduGb pic.twitter.com/FFIBaFsh0J
— Eric Feigl-Ding (@DrEricDing) April 28, 2021
Brazilian regulatory authorities decide not to approve the Gamaleya vaccine
29 Apr, 2021 | 08:38h | UTCBrazil Rejects the Gamaleya Vaccine – Science Translational Medicine
See also: Russia’s Sputnik V developers reject Brazil’s criticisms – Reuters
CDC Study: Pfizer-BioNTech and Moderna vaccines reduce Covid-19 hospitalization risk by 64% after the first dose and 94% after the second dose among adults aged ≥65 years
29 Apr, 2021 | 08:42h | UTCCommentaries: Pfizer/Moderna Vaccine Protection: 64% at First Dose, 94% at Second – HealthDay AND Pfizer and Moderna vaccines reduce Covid-19 hospitalization risk by 94% among older adults, CDC study says – CNN
Commentary on Twitter
New @CDCMMWR has good news: mRNA COVID-19 vaccines (Pfizer-BioNTech, Moderna) reduced the risk of #COVID19-related hospitalization by 94% among fully vaccinated people 65+. CDC recommends getting a COVID-19 vaccine to prevent severe COVID-19 illness: https://t.co/W4SFuV6wQp. pic.twitter.com/Jf4ph2rl4s
— CDC (@CDCgov) April 28, 2021
Ethics Commission Position Statement: Admission criteria and management of critical care patients in a pandemic context – “Age cannot be used as the sole criterion for admission nor denial of access to ICU settings”
29 Apr, 2021 | 08:36h | UTC
China May Become World’s Biggest Vaccine Supplier As India Defaults On Global Deliveries
29 Apr, 2021 | 08:39h | UTC
Review: Systemic and organ-specific immune-related manifestations of COVID-19 – over 70 different systemic and organ-specific immune-related disorders have been reported
28 Apr, 2021 | 08:42h | UTCSystemic and organ-specific immune-related manifestations of COVID-19 – Nature Reviews Rheumatology
CDC says fully vaccinated Americans can go outside without masks – but masks still needed in crowds
28 Apr, 2021 | 08:44h | UTCCDC Guidance: Choosing Safer Activities – Centers for Disease Control and Prevention
Commentaries: CDC: If You’re Vaccinated, You Don’t Need To Mask Outdoors (Unless You’re In A Crowd) – NPR AND CDC: Fully vaccinated Americans can go maskless outdoors – CIDRAP
Commentary on Twitter (thread – click for more)
If you are fully vaccinated against #COVID19, you can start doing many things that you had stopped doing because of the pandemic. If you haven’t been vaccinated yet, get a vaccine as soon as you can. See full details: https://t.co/s5kXwg65fB pic.twitter.com/fvhehUiiCi
— CDC (@CDCgov) April 27, 2021
Socioeconomic status determines COVID-19 incidence and related mortality in Santiago, Chile
28 Apr, 2021 | 08:41h | UTC
Commentary on Twitter
An analysis of #COVID19 incidence and mortality in Santiago, Chile, highlights major consequences of healthcare disparities in a highly segregated city, showing that these inequalities disproportionately affected younger people @OxfordStats @HarvardChanSPH https://t.co/8f2Q2PdqBj pic.twitter.com/Ip1cikxvi7
— Science Magazine (@ScienceMagazine) April 27, 2021
Covid-19 in India: Cases, deaths and oxygen supply
28 Apr, 2021 | 08:40h | UTCCovid-19 in India: Cases, deaths and oxygen supply – BBC
See also: In Covid’s grip, India gasps for air: ‘If there is an apocalypse, this has to be one’ – STAT
How the UK found the first effective Covid-19 treatment — and saved a million lives (about the RECOVERY trial and the effects of Dexamethasone)
28 Apr, 2021 | 08:36h | UTCHow the UK found the first effective Covid-19 treatment — and saved a million lives – Vox
Related: Covid-19: The Inside Story of the RECOVERY Trial AND Covid: The London bus trip that saved maybe a million lives – BBC
Scientists say the rush to do Covid research led to a whole lot of waste
28 Apr, 2021 | 08:34h | UTCScientists Say The Rush To Do COVID Research Led To A Whole Lot Of Waste – NPR
Original Article: How COVID-19 has fundamentally changed clinical research in global health – The Lancet Global Health
Related: Data Show Panic and Disorganization Dominate the Study of Covid-19 Drugs (other commentaries on the subject)
See also: The Lancet Series: Clinical Trials in Global Health
Commentary on Twitter (thread – click for more)
Quantity > quality? The magnitude of #COVID19 research of questionable methodological quality reveals an urgent need to optimise clinical trial research—but how?
A new @LancetGH Series discusses challenges and solutions. Read https://t.co/z4SluR3yuh 1/5 pic.twitter.com/94RRVT0qhF
— The Lancet (@TheLancet) April 16, 2021
Tracking the Evolution of a ‘Variant of Concern’ in Brazil – “P.1 may be 1.7 to 2.4 times more transmissible than earlier variants”
28 Apr, 2021 | 08:38h | UTCTracking the Evolution of a ‘Variant of Concern’ in Brazil – NIH Director’s Blog
Related: Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil – Science
Overview of SARS-CoV-2 infection in adults living with HIV – Low CD4 cell counts, or untreated HIV infection is associated a more severe clinical course
28 Apr, 2021 | 08:32h | UTCOverview of SARS-CoV-2 infection in adults living with HIV – The Lancet HIV
Commentary on Twitter
New Review: Overview of SARS-CoV-2 infection in adults living with HIV: https://t.co/xXTntfIYPF pic.twitter.com/6w6MUSbo3n
— The Lancet HIV (@TheLancetHIV) April 27, 2021