Covid-19
Here’s what’s known about the coronavirus variants.
10 May, 2021 | 01:12h | UTCHere’s what’s known about the coronavirus variants – CNN
Viewpoint | Precision Medicine for COVID-19: Phenotype Anarchy or Promise Realized?
10 May, 2021 | 01:09h | UTCPrecision Medicine for COVID-19: Phenotype Anarchy or Promise Realized? – JAMA
Editorial: India’s COVID-19 emergency.
10 May, 2021 | 01:09h | UTCIndia’s COVID-19 emergency – The Lancet
Related: Editorial: ovid-19: India’s crisis is everyone’s crisis – The BMJ AND India’s worsening Covid crisis could spiral into a problem for the world – CNBC AND Is India’s coronavirus death ‘paradox’ vanishing? – Science
Perspective | Flu Has Disappeared Worldwide during the COVID Pandemic: “The public health measures that slow the spread of the novel coronavirus work really well on influenza”.
10 May, 2021 | 01:08h | UTCFlu Has Disappeared Worldwide during the COVID Pandemic – Scientific American
One third of patients hospitalized with COVID-19 have lung changes after a year
7 May, 2021 | 08:37h | UTCCommentaries: One third of patients hospitalized with COVID-19 have lung changes after a year – University of Southampton AND An integrated understanding of long-term sequelae after acute COVID-19 – The Lancet Respiratory Medicine
Cohort study: Arterial events, venous thromboembolism, thrombocytopenia, and bleeding after vaccination with Oxford-AstraZeneca ChAdOx1-S. 11 excess venous thromboembolic events per 100 000 vaccinations; 2.5 excess cerebral venous thrombosis per 100 000 vaccinations.
7 May, 2021 | 08:33h | UTCEditorial: Thromboembolism and the Oxford-AstraZeneca vaccine – The BMJ
Commentaries: Thrombosis and bleeding after the Oxford-AstraZeneca covid-19 vaccination – The BMJ Opinion AND Putting risks into context: covid-19 vaccines and blood clots – The BMJ Opinion AND Expert reaction to study from Denmark and Norway looking at rare blood clots after the Oxford-AstraZeneca vaccine – Science Media Centre
Commentary on Twitter
NEW research sheds more light on rate of rare blood clots after Oxford-AstraZeneca vaccine
Rate of adverse events low; benefits of the vaccine still outweigh risks in most situations, say researchershttps://t.co/LslgvzWlWi @Pottegard
— The BMJ (@bmj_latest) May 6, 2021
Opinion | Covid-19: Sputnik vaccine rockets, thanks to Lancet boost
7 May, 2021 | 08:31h | UTCCovid-19: Sputnik vaccine rockets, thanks to Lancet boost – The BMJ
Commentary on Twitter
Journals risk being used in place of regulators when they publish studies of novel vaccines that have not yet been authorised by a major regulator @DoctorChrisVT unpicks the story of the Sputnik V vaccine https://t.co/lYf7l0lXcy
— The BMJ (@bmj_latest) May 6, 2021
COVID-19 has caused 6.9 million deaths globally, more than double what official reports show
7 May, 2021 | 08:35h | UTCReport: Estimation of total mortality due to COVID-19 – Institute for Health Metrics and Evaluation
Commentaries: New analysis finds global Covid death toll is double official estimates – STAT AND Global COVID-19 death toll more than double official estimates – IHME – Reuters
The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity
7 May, 2021 | 08:30h | UTC
Commentary on Twitter
We forget that covid-19 is a new disease, never having been seen until late 2019, w/ different features than any prior illness. A truly outstanding review today on its pathophysiology https://t.co/8gx2w8r1xf @LancetRespirMed @osuchm and colleagues pic.twitter.com/WGIfI2nb9B
— Eric Topol (@EricTopol) May 6, 2021
In shock move, US backs waiving patents on COVID vaccines. “The development from the Biden administration draws cheers from public health researchers and ire from drugmakers.”
6 May, 2021 | 09:10h | UTCIn shock move, US backs waiving patents on COVID vaccines – Nature
See also: U.S. will back proposal to waive intellectual property rights and boost Covid-19 vaccine production – STAT AND Statement from the Executive Director of UNAIDS, Winnie Byanyima on the decision by the United States of America to support the TRIPS waiver for COVID-19 vaccines – UNAIDS AND WHO Director-General commends United States decision to support temporary waiver on intellectual property rights for COVID-19 vaccines – World Health Organization
Commentary on Twitter
These extraordinary times and circumstances of call for extraordinary measures.
The US supports the waiver of IP protections on COVID-19 vaccines to help end the pandemic and we’ll actively participate in @WTO negotiations to make that happen. pic.twitter.com/96ERlboZS8
— Ambassador Katherine Tai (@AmbassadorTai) May 5, 2021
Cohort study shows inadequate antibody response to mRNA SARS-CoV-2 vaccine among kidney transplant recipients.
6 May, 2021 | 09:01h | UTC
Commentary on Twitter
https://twitter.com/hildabast/status/1390097665451462656
Observational study in Israel: Pfizer-BioNTech is 95.3% effective against SARS-CoV-2 infection.
6 May, 2021 | 09:04h | UTCCommentaries: Expert reaction to Israel nation-wide study looking at Pfizer vaccine effectiveness – Science Media Centre AND Covid-19: Two doses of Pfizer vaccine are “highly effective” against infection, hospital admission, and death, study finds – The BMJ
Observational study in Qatar: Pfizer–BioNTech Covid vaccine is 89.5% effective against B.1.1.7 variant and 75.0% effective against B.1.351 variant. Vaccine effectiveness against severe, critical, or fatal disease with any SARS-CoV-2 variant was very high, at 97.4%.
6 May, 2021 | 09:06h | UTC
Commentary on Twitter
https://twitter.com/DrEricDing/status/1390107362485211136
RCT: Novavax vaccine is 49.4% effective against B.1.351 SARS-CoV-2 variant.
6 May, 2021 | 09:08h | UTC
Organ transplant recipients remain vulnerable to Covid-19 even after second vaccine dose.
6 May, 2021 | 09:03h | UTCOriginal Study: Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients – JAMA
[Press release – not published yet] Moderna announces positive initial booster data against SARS-CoV-2 variants of concern.
6 May, 2021 | 08:57h | UTCModerna Announces Positive Initial Booster Data Against SARS-CoV-2 Variants of Concern – Moderna
Commentary: We just got our first evidence that Moderna’s coronavirus booster shot works to fight variants – Insider
Commentaries on Twitter
Moderna announces that a single dose of their #COVID19 booster shot provides a strong immunologic response to the variant first identified in South Africa (B.1.351) & Brazil (P.1).
This was also well tolerated.
Press release: https://t.co/q46Wx27BzI pic.twitter.com/16JpxrM4Vq
— Isaac Bogoch (@BogochIsaac) May 5, 2021
Great news
💥Single booster dose of 50 µg of mRNA-1273 or mRNA-1273.351 increased neutralizing titers against SARS-CoV-2 and two variants of concern (B.1.351, P.1)in previously vaccinated clinical trial participants💥 https://t.co/rzhDsgxEDh— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) May 6, 2021
Perspective | How many COVID deaths are acceptable in a post-pandemic world? “Even after mass vaccinations, some hospitalizations and deaths from the coronavirus are inevitable — but opinions differ on how many is too many for a return to relative normality.”
6 May, 2021 | 08:59h | UTCHow many COVID deaths are acceptable in a post-pandemic world? – Nature
[Preprint] SARS-CoV-2 antibodies remain detectable 12 months after infection and antibody magnitude is associated with age and COVID-19 severity
5 May, 2021 | 08:40h | UTCCommentary: SARS-CoV-2 antibodies are detectable up to a year after infection, finds study – News Medical
Commentary on Twitter
https://twitter.com/hildabast/status/1388963453134532609
COVID has pushed medical research into remote trials, benefiting patients and scientists
5 May, 2021 | 08:38h | UTC
Covax: How will Covid vaccines be shared around the world?
5 May, 2021 | 08:35h | UTCCovax: How will Covid vaccines be shared around the world? – BBC
Related: WHO chief – The world can bring the global COVID-19 pandemic under control in the coming months provided it distributes the necessary resources fairly AND A year in the COVID-19 vaccine scheme COVAX
China’s COVID vaccines are going global — but questions remain
5 May, 2021 | 08:32h | UTCChina’s COVID vaccines are going global — but questions remain – Nature
What’s the future of vaccines linked to rare clotting disorders? Science breaks down the latest
5 May, 2021 | 08:37h | UTC
Perspective | We may never achieve long-term global herd immunity for COVID. But if we’re all vaccinated, we’ll be safe from the worst
5 May, 2021 | 08:33h | UTCSee also: Reaching ‘Herd Immunity’ Is Unlikely in the U.S., Experts Now Believe – The New York Times (free registration required) AND We May Never Get to Herd Immunity – Think Global Health
M-A: Prone positioning of nonintubated patients with Covid-19 improve oxygenation variables without any reported serious adverse events – randomized trials with patient-relevant outcomes such as the need for intubation or mortality rates are required
4 May, 2021 | 08:52h | UTCProne Positioning of Nonintubated Patients With Coronavirus Disease 2019—A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)
Prior SARS-CoV-2 infection boosts response to variants after first vaccine dose
4 May, 2021 | 08:51h | UTCOriginal study: Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose – Science
Commentary on Twitter (thread – click for more)
Just published @ScienceMagazine
"After one dose, individuals with *prior infection* showed enhanced T cell immunity, antibody secreting memory B cell response to spike and neutralizing antibodies effective against B.1.1.7 and B.1.351." 👍https://t.co/7cCVM6iqdP pic.twitter.com/GiC43bjwZZ— Eric Topol (@EricTopol) April 30, 2021