Covid-19
Modeling study: Delaying second doses of Pfizer-BioNTech and Moderna mRNA vaccines could reduce deaths by up to 20% under certain conditions.
17 May, 2021 | 08:51h | UTCCommentaries: Expert reaction to study looking at the public health impact of delaying the second dose of the Pfizer-BioNTech and Moderna COVID-19 vaccines – Science Media Centre AND Delaying second Covid vaccine doses can save lives, study finds – The Guardian AND Delaying second COVID vaccine dose may prevent deaths under certain conditions – The BMJ
The pandemic surge at home is threatening an Indian vaccinemaker’s bid to protect the world.
17 May, 2021 | 08:42h | UTC
#ACC21 – [Not published yet] RCT: DARE-19: Dapagliflozin is safe, but did not significantly improve outcomes among high-risk patients hospitalized with COVID-19.
17 May, 2021 | 08:49h | UTC
Commentaries on Twitter
DARE-19 trial #ACC21 @ACCinTouch
Dapa did not reduce clinical endpoints in #COVID19, but excellent safety profile
🎯 Do not discontinue SGLT2i in 🏥 for #COVID19
Full slideset available in 👇https://t.co/RPi5mpPbbN pic.twitter.com/B9VQdSSAFu
— Enrique Santas (@SantasEnrique) May 16, 2021
DARE-19 findings presented at #ACC21 show #dapagliflozin didn’t significantly ⬇️ risk of organ failure or death or improve recovery in patients hospitalized w/ #COVID19. However, data suggest the SGLT2 inhibitor was well tolerated in acutely ill patients. https://t.co/YjYxbuc952 pic.twitter.com/J4PqwvGpLJ
— American College of Cardiology (@ACCinTouch) May 16, 2021
‘It’s not over yet’: Uncertain protection from Covid vaccines leaves cancer patients in limbo.
17 May, 2021 | 08:45h | UTC‘It’s not over yet’: Uncertain protection from Covid vaccines leaves cancer patients in limbo – STAT
India’s COVID-19 crisis: a call for international action.
17 May, 2021 | 08:43h | UTCIndia’s COVID-19 crisis: a call for international action – The Lancet
Commentary on Twitter (thread – click for more)
The team @IndiaCOVIDSOS and others call for international action for India’s COVID-19 crisis in their Lancet paper.https://t.co/T7RvexuMJP@paimadhu @PrakashLab @KrutikaKuppalli @BhramarBioStat @spkalantri @cspramesh pic.twitter.com/QkuYv2QEb6
— Raj Kumar Manna (@rajphys) May 14, 2021
Setting the record straight: There is no ‘Covid heart’.
17 May, 2021 | 08:47h | UTCSetting the record straight: There is no ‘Covid heart’ – STAT
Commentary on Twitter
Why the issue of Covid-19 induced cardiac problems was massively overblown and why screening low-risk patients with MRI and other fancy tests is neither necessary nor wise. https://t.co/HkJFOJ6oeM
— Raffaele Rasoini (@RasoiniR) May 14, 2021
WHO: Wealthy nations urged to delay youth Covid vaccines, donate to solidarity scheme
17 May, 2021 | 08:40h | UTCCommentaries: Vaccinate vulnerable global poor before children in rich countries, WHO says – The Guardian AND Covid: Delay child vaccinations and share jabs with Covax, says WHO – BBC
Cohort study of 12,306 pediatric COVID-19 patients finds only 16.5% presented with typical respiratory symptoms (cough, dyspnea). 13.9% had GI symptoms, 8.1% had dermatological symptoms (rash), 4.8% had neurological (headache), and 18.8% had other non-specific symptoms (fever, malaise, myalgia, arthralgia and disturbances of smell or taste).
14 May, 2021 | 08:48h | UTCCommentary: COVID-19: Majority of infected children may not show typical symptoms – Nature Publishing Group
Commentary on Twitter
A retrospective cohort study of 12,306 pediatric COVID-19 patients
📍5% require hospitalization
📍18% of these require critical care
📍4% of these require ventilation
https://t.co/X6MTdS8D1i— RJ MacDonald MD 🚴♂️🏄🏻🎾 (@Kidsdoc1Rick) May 13, 2021
Perspective | New SARS-CoV-2 Variants — Clinical, Public Health, and Vaccine Implications.
14 May, 2021 | 08:43h | UTC
Perspective | The Covid-19 Infodemic — Applying the Epidemiologic Model to Counter Misinformation.
14 May, 2021 | 08:44h | UTCCommentary: Treating the COVID-19 ‘infodemic’ as an epidemic – University of Pennsylvania
RCT: Mixing 2 different Covid vaccines is associated with increased risk of side effects.
14 May, 2021 | 08:46h | UTCHeterologous prime-boost COVID-19 vaccination: initial reactogenicity data – The Lancet
Commentaries: More side effects noted after using 2 different COVID vaccines – CIDRAP AND Covid vaccines: Mixing increases reports of mild side-effects – BBC
Perspective | Vaccines seem to work well against coronavirus variants. It’s also complicated.
14 May, 2021 | 08:41h | UTCVaccines seem to work well against coronavirus variants. It’s also complicated – STAT
CDC says fully vaccinated Americans can go indoors and outdoors without masks.
14 May, 2021 | 08:38h | UTCCDC Guidance: Interim Public Health Recommendations for Fully Vaccinated People – Centers for Disease Control and Prevention
Commentaries: CDC backtracks, saying fully vaccinated people can go maskless indoors – STAT AND Fully Vaccinated People Can Stop Wearing Masks Indoors And Outdoors, CDC Says – NPR AND CDC: No masks needed for COVID-vaccinated Americans – CIDRAP
Editorial: Vaccinating children against SARS-CoV-2 – “Hard to justify right now for most children in most countries”.
14 May, 2021 | 08:39h | UTCVaccinating children against SARS-CoV-2 – The BMJ
Related: Pfizer COVID-19 shot expanded to US children as young as 12.
What is mucormycosis, the fungal infection affecting COVID patients in India?
14 May, 2021 | 08:35h | UTCWhat is mucormycosis, the fungal infection affecting COVID patients in India? – The Conversation
Related: What Is ‘Black Fungus’? And Why Is It Spreading Among India’s COVID Patients? – NPR AND Mucormycosis: The ‘black fungus’ maiming Covid patients in India
Review: How to interpret and use COVID-19 serology and immunology tests.
14 May, 2021 | 08:36h | UTC
[Preprint] The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries.
14 May, 2021 | 08:34h | UTCThe Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries – The Lancet
Report | COVID-19: Make it the Last Pandemic
13 May, 2021 | 06:09h | UTCCOVID-19: Make it the Last Pandemic – Independent Panel for Pandemic Preparedness and Response
Commentaries: Report of the Independent Panel for Pandemic Preparedness and Response: making COVID-19 the last pandemic – The Lancet AND WHO ‘needs more powers’ says independent panel co-chair Helen Clark – Devex AND COVID-19 Was ‘A Preventable Disaster,’ WHO-Ordered Report Says – NPR AND How the world failed to curb COVID – Nature AND Panel suggests WHO should have more power to stop pandemics – Associated Press AND ‘A toxic cocktail:’ Panel delivers harsh verdict on the world’s failure to prepare for pandemic – Science AND Covid: Serious failures in WHO and global response, report finds – BBC AND Covid pandemic should serve as ‘Chernobyl moment’ for global health reform, international experts say – STAT
Commentary on Twitter
For the past 8 months, @TheIndPanel has been examining the state of #pandemic preparedness and responses to #COVID19. In a new report, they describe 13 key events that shaped its course, and outline recommendations to make this the #LastPandemic. Read https://t.co/KrcBTFEZ3J. pic.twitter.com/exH80QZ9Xl
— The Lancet (@TheLancet) May 12, 2021
[Not published yet] Observational study in Indonesia finds China’s Sinovac COVID-19 vaccine (CoronaVac) was 98% effective at preventing death and 96% effective at preventing hospitalization in healthcare workers
13 May, 2021 | 06:07h | UTCIndonesia study finds China’s Sinovac COVID-19 vaccine effective in medical staff – Reuters
[Preprint] Observational study finds single-dose Johnson & Johnson vaccine is 76.7% effective in preventing SARS-CoV-2 infection
13 May, 2021 | 06:06h | UTCReal-World Effectiveness of Ad26.COV2.S Adenoviral Vector Vaccine for COVID-19 – The Lancet
Commentary on Twitter
One of the first studies to assess real-world effectiveness of the J&J 1-dose vaccine, matches Phase 3 clinical trial, at 77%https://t.co/3YgcML9YSh @MayoClinic @MayoClinicHS preprint pic.twitter.com/XOjQlUaHK2
— Eric Topol (@EricTopol) May 11, 2021
Perspective | How covid-19 revealed the scandal of medical oxygen supplies worldwide
13 May, 2021 | 06:02h | UTCHow covid-19 revealed the scandal of medical oxygen supplies worldwide – Nature
Opinion | American Kids Can Wait – “The U.S. should delay shots for children until global vaccine-manufacturing capacity significantly expands and the crisis in India subsides”.
13 May, 2021 | 06:04h | UTCAmerican Kids Can Wait – The Atlantic
Commentary on Twitter
Now in the Atlantic, @TracyBethHoeg @MonicaGandhi9 and I argue that we ought to vaccinate OLDER people around the globe before we vaccinate children in high income nations. It is in OUR best interest to do sohttps://t.co/B0O8xj4fo1
— Vinay Prasad MD MPH (@VPrasadMDMPH) May 12, 2021
Perspective | How COVID broke the evidence pipeline
13 May, 2021 | 06:01h | UTCHow COVID broke the evidence pipeline – Nature
Editorial: Evidence-based medicine: how COVID can drive positive change – Nature
Related: Scientists say the rush to do Covid research led to a whole lot of waste
Commentary on Twitter
The weak pursuit of evidence-based medicine during the pandemic.
Thankfully, the #RECOVERY and #SOLIDARITY collaborative trial groups led the way in rapidly accumulating pivotal data asking the right questions with large sample size https://t.co/aSAhQvq5dz @hcpearson @nature pic.twitter.com/iM956krq0Q— Eric Topol (@EricTopol) May 12, 2021
Eight out of ten people hospitalized with COVID-19 develop neurological problems – the most common self-reported symptoms included headache (37%) and anosmia or ageusia (26%).
12 May, 2021 | 08:55h | UTC
Pfizer COVID-19 shot expanded to US children as young as 12.
12 May, 2021 | 08:53h | UTCPfizer COVID-19 shot expanded to US children as young as 12 – Associated Press
Counterpoint: Covid vaccines for children should not get emergency use authorization – The BMJ Opinion
Commentaries: Covid-19: FDA authorises Pfizer vaccine for children 12-15 – The BMJ AND Expert reaction to U.S. FDA authorising Pfizer-BioNTech COVID-19 vaccine for emergency use in adolescents – Science Media Centre