Covid-19
Systematic review and meta-analysis of observational studies suggest low-dose aspirin may be of benefit for patients with Covid-19 – the finds require further investigation in randomized studies.
20 May, 2021 | 08:54h | UTC
One year after hospital discharge due to SARS-CoV-2 Infection, the prevalence of long-term cough, chest pain, dyspnea, and fatigue was 2.5%, 6.5%, 23.3%, and 61.2%, respectively
20 May, 2021 | 08:57h | UTCPrevalence of Post-COVID-19 Cough One Year After SARS-CoV-2 Infection: A Multicenter Study – Lung
COVID vaccines: the danger of journals being seen as substitute regulators – “the peer-review process is not adequate to evaluate a new vaccine in the way that a regulator can”.
20 May, 2021 | 08:51h | UTCCOVID vaccines: the danger of journals being seen as substitute regulators – The Conversation
Related: Covid-19: Sputnik vaccine rockets, thanks to Lancet boost
Characteristics associated with Multisystem Inflammatory Syndrome among adults with SARS-CoV-2 infection
20 May, 2021 | 08:52h | UTCCommentary: COVID-related inflammatory syndrome looks different in adults – CIDRAP
[Preprint] RECOVERY Trial: Colchicine does not improve outcomes in patients admitted to hospital with COVID-19.
19 May, 2021 | 08:51h | UTC
Commentary on Twitter (thread – click for more)
RECOVERY pre-print: Colchicine
11340 patients hospitalised with COVID-19
Randomised to colchicine vs usual care
No significant improvement in:
– 28-day mortality
– discharge alive at 28 days
– progression to invasive mechanical ventilation or deathhttps://t.co/mEtYq2qwkL pic.twitter.com/B0MNJWDi6e— Martin Landray (@MartinLandray) May 18, 2021
Perspective | Covid-19: What should we do about B.1.617.2? A classic case of decision making under uncertainty.
19 May, 2021 | 08:48h | UTC
SARS-CoV-2 infects human pancreatic β-cells and elicits β-cell impairment.
19 May, 2021 | 08:49h | UTCSARS-CoV-2 infects human pancreatic β-cells and elicits β-cell impairment – Cell Metabolism
Commentary on Twitter
A new report reinforces the capability for #SARSCoV2 to infect and kill pancreatic β-islet cells, affect insulin secretion https://t.co/4tpIVNpjTf @Cell_Metabolism #diabetes @StanfordMed @stanfordimmuno @UCSF and collaborators pic.twitter.com/dG027CXS5e
— Eric Topol (@EricTopol) May 18, 2021
WHO Solidarity trial to restart with focus on drugs that act on immune responses caused by Covid-19.
19 May, 2021 | 08:47h | UTCInternational COVID-19 trial to restart with focus on immune responses – Nature
Opinion | Vaccinating children before poor morally wrong, Oxford scientist says.
19 May, 2021 | 08:44h | UTCVaccinating children before poor morally wrong, Oxford scientist says – BBC
Related: WHO: Wealthy nations urged to delay youth Covid vaccines, donate to solidarity scheme AND Editorial: Vaccinating children against SARS-CoV-2 – “Hard to justify right now for most children in most countries”. AND Opinion | American Kids Can Wait – “The U.S. should delay shots for children until global vaccine-manufacturing capacity significantly expands and the crisis in India subsides”.
Former CDC director: Direct Covid-19 vaccines to where they’re needed most.
19 May, 2021 | 08:42h | UTCFormer CDC director: Direct Covid-19 vaccines to where they’re needed most – CNN
Commentary on Twitter
Vaccine inequity is a serious problem ethically and epidemiologically. Read my latest at @CNN on why we must direct Covid vaccines to where they’re needed the most. https://t.co/2CD5xzI00h
— Dr. Tom Frieden (@DrTomFrieden) May 17, 2021
Review: Testing at scale during the COVID-19 pandemic.
19 May, 2021 | 08:45h | UTCTesting at scale during the COVID-19 pandemic – Nature Reviews Immunology
Commentary on Twitter
🆕💥 @NatureRevGenet
Testing at scale during the COVID-19 pandemic
💥Changes in modes of testing across a generalized COVID-19 infectious course💥
✨Excellent Figure ✨ https://t.co/sUZjRr1gQR pic.twitter.com/ZiOXCw7en2— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) May 10, 2021
M-A: Encephalitis as Neurological Complication of COVID‐19.
19 May, 2021 | 08:41h | UTC
ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections.
19 May, 2021 | 08:37h | UTC
Commentary on Twitter
📢New ACG Clinical Guideline on Prevention, Diagnosis & Treatment of C. difficile Infections
Focus on clinical challenges – diagnostic issues in diarrhea, distinguishing C. diff colonization from active infection + eval/mgmt of CDI in IBD
Full guideline: https://t.co/QTCzeLB9Ri pic.twitter.com/mqZUN4r4jA
— AJG – The American Journal of Gastroenterology (@AmJGastro) May 18, 2021
[Preprint] Practice Changing RCT: Therapeutic-dose anticoagulation with heparin (LMWH or unfractionated heparin) improves outcomes in non-critically ill patients with Covid-19 – the superiority of therapeutic-dose anticoagulation was seen in both high and low D-dimer groups.
18 May, 2021 | 08:04h | UTCTherapeutic Anticoagulation in Non-Critically Ill Patients with Covid-19 – medRxiv
Commentary on Twitter
Final results of the mpRCT now on preprint server. In non-critically ill patients with COVID-19 (n=2219), therapeutic-dose anticoagulation with heparins increases survival to hospital discharge with reduced use of organ support. https://t.co/TkhGs5qow5
— Ryan Zarychanski (@RZarychanski) May 17, 2021
#ACC21 – [Not published yet] RCT: Among hospitalized patients with Covid-19 and elevated D-Dimer, therapeutic anticoagulation with Rivaroxaban 20 mg was not associated with improved outcomes and resulted in increased major bleeding.
18 May, 2021 | 08:01h | UTCAntiCoagulaTIon cOroNavirus – ACTION – American College of Cardiology
Commentary: ACTION: Full-Dose Rivaroxaban Doesn’t Help in Hospitalized COVID-19 – TCTMD
More flexible storage conditions for BioNTech/Pfizer’s COVID-19 vaccine. – “This change extends the approved storage period of the unopened thawed vial at 2-8°C (i.e. in a normal fridge after taking out of deep-freeze conditions) from five days to one month”.
18 May, 2021 | 07:59h | UTCMore flexible storage conditions for BioNTech/Pfizer’s COVID-19 vaccine – European Medicines Agency
Commentary: EU Regulator Backs Month-Long Storage of Pfizer COVID-19 Vaccine in Fridges – U.S. News/Reuters
Commentary on Twitter
EMA has changed the recommended storage conditions for Pfizer vaccine. Instead of 5 days the thawed, unopened vials can now be stored in a normal fridge for a month. 👏 https://t.co/MVkDJRQn4b
— Kai Kupferschmidt (@kakape) May 17, 2021
COVID vaccines can block variant hitting Asia, lab study finds – “Assays using live SARS-CoV-2 offer hope that the vaccines made by Pfizer and Moderna will protect against a viral strain first seen in India”.
18 May, 2021 | 07:56h | UTCCOVID vaccines can block variant hitting Asia, lab study finds – Nature
See also: Pfizer, Moderna vaccines effective against Indian variants: study – MedicalXpress
Commentary on Twitter
Pfizer & Moderna mRNA vaccines are effective against multiple SARSCoV2 variants, including the B.1.617 & B.1.618, 2 variants underlying the surge in India. The research, while not yet peer-reviewed, was conducted at NYU School of Medicine in New York City https://t.co/3ziRhk8f4t pic.twitter.com/VzYQKWqyQF
— delthia ricks 🔬 (@DelthiaRicks) May 17, 2021
SARS-CoV-2 antibody-positivity protects against reinfection for at least seven months with 95% efficacy.
18 May, 2021 | 07:52h | UTC
M-A: Incidence and mortality of COVID‐19‐associated pulmonary aspergillosis – The incidence and mortality in the ICU were estimated to be 10.2% and 54.9%, respectively.
18 May, 2021 | 07:50h | UTC
Cohort study finds racial minorities face more severe COVID-19 outcomes.
18 May, 2021 | 07:44h | UTCRacial minorities face more severe COVID-19 outcomes – CIDRAP
Priorities for COVID-19 research response and preparedness in low-resource settings.
18 May, 2021 | 07:46h | UTCPriorities for COVID-19 research response and preparedness in low-resource settings – The Lancet
Analysis: Where are we with drug treatments for covid-19?
18 May, 2021 | 07:47h | UTCWhere are we with drug treatments for covid-19? – The BMJ
RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.
17 May, 2021 | 08:56h | UTCInvited commentary: Convalescent plasma in patients hospitalised with COVID-19
Commentaries on Twitter
Convalescent plasma:
Yet another example of
Don’t guess, don’t gamble
Randomize… and learn
I’ve heard it said that it was deemed “too difficult” to do a randomised controlled trial. Really? If that’s the case, we must (and can) fix that problem. Pts deserve better. https://t.co/zxIiK5U63v
— Martin Landray (@MartinLandray) May 15, 2021
NEW #COVID19 research—In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Read https://t.co/7Sbe8V9THp. #RECOVERY #RECOVERYtrial pic.twitter.com/D0OLZKxZc4
— The Lancet (@TheLancet) May 16, 2021
[Preprint] Delaying second Pfizer vaccine dose to 12 weeks increases specific antibody response 3.5-fold in people over 80 years of age.
17 May, 2021 | 08:53h | UTCCommentaries: Delaying a COVID vaccine’s second dose boosts immune response – Nature AND Delaying Second Pfizer COVID-19 Vaccine Dose Increases Antibody Response Threefold In Over-80s, Study Finds – Health Policy Watch AND Delay in giving second jabs of Pfizer vaccine improves immunity – The Guardian AND Expert reaction to preprint looking at the immune response in older people after vaccination the Pfizer-BioNTech COVID-19 vaccine with either a 3-week or a 12-week dosing schedule – Science Media Centre
Disease surveillance for the COVID-19 era: time for bold changes.
17 May, 2021 | 08:54h | UTCDisease surveillance for the COVID-19 era: time for bold changes – The Lancet
Commentary on Twitter
https://twitter.com/Chikwe_I/status/1393544947970760707