Covid-19
Vaccine-induced immune thrombotic thrombocytopenia (VITT) – a novel clinico-pathological entity with heterogeneous clinical presentations.
2 Jul, 2021 | 11:39h | UTCCommentary: Blood clots related to AstraZeneca/Oxford vaccine can be mitigated with early detection – MedicalXpress
Delirium in COVID-19: can we make the unknowns knowns?
2 Jul, 2021 | 11:17h | UTCDelirium in COVID-19: can we make the unknowns knowns? – Intensive Care Medicine
Commentary on Twitter
Delirium in #COVID19 critical illness?
➡️high incidence likely due to microvascular disease & inflammatory mechanisms
⬇️standards of care ie strained resources
➡️key predictor of cognitive impairment/dementia post 🏥
➡️long-term post #ICU follow-up pivotal https://t.co/dC339XrfGm pic.twitter.com/nzyPCu16ap— Intensive Care Medicine (@yourICM) June 30, 2021
[Press release] J&J single-shot COVID-19 vaccine generates strong, persistent activity against the rapidly spreading Delta variant and other highly prevalent SARS-CoV-2 viral variants.
2 Jul, 2021 | 11:38h | UTCCommentary: J&J Covid Shot Neutralizes Delta Variant, Company Says – Bloomberg (a few articles per month are free)
COVID-19 vaccines reduce severity, length, viral load for those who still get infected.
1 Jul, 2021 | 09:57h | UTCOriginal study: Prevention and Attenuation of Covid-19 with the BNT162b2 and mRNA-1273 Vaccines – New England Journal of Medicine
Commentary on Twitter
The @CDCgov trial to rigorously assess mRNA vaccination suppression of covid infections as assessed with frequent NP swabs in nearly 4,000 participants
91% efficacy of blocking transmission of infection (2 doses); 40% reduction of viral load https://t.co/tI6LECbw42 pic.twitter.com/y85Vd9ih5A— Eric Topol (@EricTopol) June 30, 2021
RCT: Novavax vaccine conferred 89.7% protection against symptomatic SARS-CoV-2 infection and 100% protection against hospitalizations or deaths.
1 Jul, 2021 | 09:59h | UTCSafety and Efficacy of NVX-CoV2373 Covid-19 Vaccine – New England Journal of Medicine
Audio interview: Audio Interview: Another New Covid-19 Vaccine – New England Journal of Medicine
Related: Opinion | The mRNA vaccines are extraordinary, but Novavax is even better
Analysis: How long does covid-19 immunity last?
1 Jul, 2021 | 09:56h | UTCHow long does covid-19 immunity last? – The BMJ
The neurological manifestations of post-acute sequelae of SARS-CoV-2 infection.
1 Jul, 2021 | 09:55h | UTC
Systematic review: Border controls, restricted entry, quarantine essential for curbing COVID-19 and future pandemics.
1 Jul, 2021 | 09:53h | UTCNews release: Border controls, restricted entry, quarantine essential for curbing COVID-19 and future pandemics – British Medical Journal
Commentary: Strategies ID’d Than Can Interrupt Spread of Infectious Disease – HealthDay
Perspective | Why no one is sure if Delta is deadlier – “The variants are spreading faster, but they don’t necessarily have incentive to kill more often”.
1 Jul, 2021 | 09:52h | UTCWhy No One Is Sure If Delta Is Deadlier – The Atlantic
Long COVID or post-acute sequelae of COVID-19 (PASC): An overview of biological factors that may contribute to persistent symptoms.
30 Jun, 2021 | 10:24h | UTC
Case Series: Myocarditis following immunization with mRNA COVID-19 vaccines.
30 Jun, 2021 | 10:22h | UTCSee also: Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination – JAMA Cardiology
Editorials: Myocarditis Occurring After Immunization With mRNA-Based COVID-19 Vaccines AND Temporal Associations Between Immunization With the COVID-19 mRNA Vaccines and Myocarditis: The Vaccine Safety Surveillance System Is Working
Commentary: More Evidence Links Myocarditis to mRNA COVID-19 Vaccines – TCTMD
Commentary on Twitter
2 new reports of myocarditis after mRNA vaccination documenting its rare occurrence
23 males serving in the military among 2.8 million doses givenhttps://t.co/yPbYxkuSHi
4 cases in North Carolina, including a 70-year-old womanhttps://t.co/Iwj2Hx6O2U@JAMACardio pic.twitter.com/fv2JoOFAyt— Eric Topol (@EricTopol) June 29, 2021
Exclusive-WHO estimates COVID-19 boosters needed yearly for most vulnerable.
30 Jun, 2021 | 10:17h | UTCExclusive-WHO estimates COVID-19 boosters needed yearly for most vulnerable – Reuters
Related: CDC group says there isn’t enough data yet to recommend Covid booster shots – CNBC
Covid: Masks upgrade cuts infection risk, research finds.
30 Jun, 2021 | 10:16h | UTCCovid: Masks upgrade cuts infection risk, research finds – BBC
COVID-19 cut Brazilian life span almost 2 years in 2021.
30 Jun, 2021 | 10:19h | UTCCOVID-19 cut Brazilian life span almost 2 years in 2021 – CIDRAP
Original Study: Reduction in life expectancy in Brazil after COVID-19 – Nature Medicine
Pulmonary embolism in patients with COVID-19: incidence, risk factors, clinical characteristics, and outcome.
30 Jun, 2021 | 10:13h | UTC
Consensus Statement: The role of lung ultrasound in COVID-19 disease.
30 Jun, 2021 | 10:12h | UTCThe role of lung ultrasound in COVID-19 disease – Insights into Imaging
Should I get my second AstraZeneca dose? Yes, it almost doubles your protection against Delta.
30 Jun, 2021 | 10:11h | UTCRelated: Effectiveness of COVID-19 vaccines against the B.1.617.2 variant – medRxiv
IHME COVID-19 model has been updated for over 200 world locations.
29 Jun, 2021 | 10:13h | UTCCOVID-19 Projections – Institute for Health Metrics and Evaluation
Video: Insights from IHME’s latest COVID-19 model update
Commentary on Twitter
📣 NEW ✨ Our COVID-19 model has been updated for over 200 world locations 🌎 🌍 🌏 📊 (https://t.co/5biAggRz1T)
📺 Full video: https://t.co/wLGeAiiYhy
📄 PDFs with explanations of country-specific projections: https://t.co/9KQxWwhQqx pic.twitter.com/8sSEzyXEf8— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) June 27, 2021
Phase 1/2 RCT: CoronaVac is well tolerated and safe and induces strong humoral responses in children and adolescents aged 3–17 years.
29 Jun, 2021 | 10:09h | UTCInvited commentary: COVID-19 vaccines for children younger than 12 years: are we ready? – The Lancet Infectious Diseases
Commentary on Twitter
NEW—A phase 1/2 clinical trial of #CoronaVac in 550 children and adolescents aged 3-17 years in China suggests two doses of the vaccine are safe and generate a strong antibody response. Read in @TheLancetInfDis: https://t.co/eXSagRu1Cs pic.twitter.com/fOKNLUjNwc
— The Lancet (@TheLancet) June 28, 2021
SARS-CoV-2 mRNA vaccines induce persistent human germinal center responses, suggesting immunity will be long-lasting.
29 Jun, 2021 | 10:03h | UTCSARS-CoV-2 mRNA vaccines induce persistent human germinal centre responses – Nature
Commentaries: Immune response to FDA-approved vaccines is strong and potentially long-lasting – News Medical
Commentary on Twitter (thread – click for more)
Just published @nature
A bonus factor after covid vaccination: germinal center factories for durable, antigen-specific, B cells and plasmoblasts induced by mRNA vaccination, as determined by lymph node aspirates from vaccinees https://t.co/5eR0gDSWHq
@TheBcellArtist @WUSTLmed pic.twitter.com/C5xPSrh5Gw— Eric Topol (@EricTopol) June 28, 2021
Case report: Thrombosis with Thrombocytopenia After the Messenger RNA–1273 Vaccine.
29 Jun, 2021 | 10:07h | UTCThrombosis With Thrombocytopenia After the Messenger RNA–1273 Vaccine – Annals of Internal Medicine
[Preprint] 3rd AstraZeneca shot gives strong immunity.
29 Jun, 2021 | 10:01h | UTCStudy: 3rd AstraZeneca shot gives strong immunity – Reuters
Original Study (preprint): Tolerability and Immunogenicity After a Late Second Dose or a Third Dose of ChAdOx1 nCoV-19 (AZD1222) – SSRN/The Lancet
Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials – “IVM did not reduce all-cause mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease”.
29 Jun, 2021 | 10:00h | UTC
The COVID pandemic’s lingering impact on clinical trials – “Medical researchers are beginning to shift their focus away from COVID-19 — but the pandemic could continue to affect studies focused on other diseases.”
29 Jun, 2021 | 09:57h | UTCThe COVID pandemic’s lingering impact on clinical trials – Nature
Phase 2 RCT: Immunogenicity and reactogenicity of a Pfizer-BioNTech booster in patients that have received a single dose of AstraZeneca vaccine – “BNT162b2 (Pfizer) given as a second dose in individuals prime vaccinated with ChAdOx1-S (AstraZeneca) induced a robust immune response, with an acceptable and manageable reactogenicity profile”.
28 Jun, 2021 | 10:01h | UTCCommentaries: Heterologous vaccine regimens against COVID-19 – The Lancet AND
Commentary on Twitter (thread – click for more)
NEW #COVID19 research—Phase 2 trial by @borobia_am, @antoniojcarcas
et al. reports BNT162b2 given as a 2nd dose in individuals prime vaccinated with ChAdOx1-S induced a robust immune response, with an acceptable and manageable reactogenicity profile. Read https://t.co/muL0XQxdjG. pic.twitter.com/BxPlXB8EF7— The Lancet (@TheLancet) June 26, 2021


