Antibiotic Stewardship
Case-Control Study | Outpatient oral macrolide use is associated with increased risk of sensorineural hearing loss in children, adolescents, and young adults.
4 Aug, 2022 | 14:29h | UTCAssociation of Outpatient Oral Macrolide Use With Sensorineural Hearing Loss in Children, Adolescents, and Young Adults – JAMA Otolaryngology-Head & Neck Surgery (link to abstract – $ for full-text)
Commentary: Kids’ Hearing Loss Associated With Common Antibiotics — Children and teens with sensorineural hearing loss more often macrolide users – MedPage Today (free registration required)
M-A | Efficacy of Doxycycline for mild-to-moderate community-acquired pneumonia in adults.
4 Aug, 2022 | 14:17h | UTCEfficacy of Doxycycline for Mild-to-moderate Community-acquired Pneumonia in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials – Clinical Infectious Diseases (link to abstract – $ for full-text)
Commentary on Twitter
🆕⚡⚡Systematic Review and Meta-analysis of Randomized Controlled Trials @CIDJournal
Efficacy of Doxycycline for Mild-to-moderate CAP in Adults
The efficacy of doxycycline was comparable to macrolides or fluoroquinolones in mild-moderate CAP #IDTwitter https://t.co/L7UBBUc4Dm— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) July 29, 2022
M-A | The global burden of sore throat and group A Streptococcus pharyngitis.
4 Aug, 2022 | 13:33h | UTC
Cohort Study | Association of higher-dose fluoroquinolone therapy with serious adverse events in older adults with advanced chronic kidney disease.
3 Aug, 2022 | 14:22h | UTC
M-A | Global prevalence of non-tuberculous mycobacteria in adults with non-cystic fibrosis bronchiectasis 2006–2021.
3 Aug, 2022 | 14:04h | UTC
M-A | Perioperative care bundles for the prevention of surgical-site infections.
2 Aug, 2022 | 12:30h | UTC
RCT | Short vs. extended treatment with a carbapenem in patients with high-risk fever of unknown origin during neutropenia.
27 Jul, 2022 | 12:17h | UTCShort versus extended treatment with a carbapenem in patients with high-risk fever of unknown origin during neutropenia: a non-inferiority, open-label, multicentre, randomised trial – The Lancet Haematology (link to abstract – $ for full-text)
Commentary: Short-Course or Extended Antibiotics in Febrile Neutropenia? – Medscape (free registration required)
Commentary on Twitter
NEW online—Short-term is not inferior to extended carbapenem in patients with haematological malignancy and neutropenic fever of unknown origin, however, higher serious adverse events and mortality were noted in the short treatment group: the SHORT trial https://t.co/FOp1M3D6cL pic.twitter.com/6z5e8MSEgQ
— The Lancet Haematology (@TheLancetHaem) June 10, 2022
NICE Guideline | Pneumonia in adults: diagnosis and management.
26 Jul, 2022 | 13:37h | UTCPneumonia in adults: diagnosis and management – National Institute for Health and Care Excellence
Related Guidelines:
Pneumonia (community-acquired): antimicrobial prescribing
Pneumonia (hospital-acquired): antimicrobial prescribing
Systematic Review | Impact of early postoperative indwelling urinary catheter removal.
20 Jul, 2022 | 11:48h | UTC
Review | New antibiotics for hospital-acquired pneumonia and ventilator-associated pneumonia.
20 Jul, 2022 | 11:44h | UTC
RCT | Efficacy and safety of topical nitric oxide releasing Berdazimer gel in patients with molluscum contagiosum.
18 Jul, 2022 | 11:12h | UTC
Commentary on Twitter
This randomized, vehicle-controlled trial of molluscum contagiosum patients found the efficacy and safety of a once-daily application of berdazimer gel, 10.3% an experimental topical, nitric oxide-releasing medication. https://t.co/zKuA29BTPS
— JAMA Dermatology (@JAMADerm) July 13, 2022
M-A of RCTs | Efficacy and safety of potassium-competitive acid blockers versus proton pump inhibitors as Helicobacter pylori eradication therapy.
18 Jul, 2022 | 11:03h | UTC
M-A | Global trends in the proportion of Macrolide-resistant Mycoplasma pneumoniae infections.
18 Jul, 2022 | 10:50h | UTC
Commentary on Twitter
This meta-analysis found the proportion of Mycoplasma pneumoniae (MRMP) showed an increasing trend with regional difference. The proportion of MRMP was highest in the Western Pacific Regions. Strategies to prevent the spread of MRMP are urgently needed. https://t.co/78qmC9l9z1
— JAMA Network Open (@JAMANetworkOpen) July 11, 2022
Review | Invasive respiratory fungal infections in COVID-19 critically ill patients.
15 Jul, 2022 | 12:58h | UTCInvasive Respiratory Fungal Infections in COVID-19 Critically Ill Patients – Journal of Fungi
M-A | The efficacy and tolerability of antibiotics in scrub typhus.
8 Jul, 2022 | 11:32h | UTC
M-A | Prenatal antibiotic exposure, asthma, and the atopic march.
8 Jul, 2022 | 11:31h | UTC
M-A | It is not safe to withhold antibiotic use in uncomplicated urinary tract infections in adult women.
7 Jul, 2022 | 12:47h | UTC
Commentary on Twitter (thread – click for more)
A really important analysis of previous trials!
1/ All short-term outcomes were worse for women given non-antibiotic strategies, including need for future antibiotics (number needed to harm=5!) https://t.co/iozelljFLk
— Annie Joseph (@ajosephnotts) July 2, 2022
RCT | Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis.
6 Jul, 2022 | 11:31h | UTCCommentary: Does Azithromycin antagonize the effect of inhaled tobramycin in cystic fibrosis? – Medical Dialogues
Commentary on Twitter
Original research: Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis: a randomised, controlled clinical trialhttps://t.co/z9dGX52dAe pic.twitter.com/tpiOqIIQjb
— ThoraxBMJ (@ThoraxBMJ) May 23, 2022
RCT | Single-dose, bioadhesive Clindamycin 2% gel for bacterial vaginosis.
5 Jul, 2022 | 11:56h | UTCCommentary:
Single-Dose Clindamycin Gel Highly Effective for Bacterial Vaginosis – JAMA
Single-Dose Clindamycin Gel Highly Effective for Bacterial Vaginosis in Women – Medical Dialogues
Commentary on Twitter
FREE: Single-Dose, Bioadhesive Clindamycin 2% Gel for Bacterial Vaginosis: A Randomized Controlled Trial #obgyn https://t.co/ofIXGiFXbL pic.twitter.com/0nQigeCFP5
— The Green Journal (@greenjrnl) May 27, 2022
RCT | CT vs. [18F]FDG-PET-CT for persistent or recurrent neutropenic fever in high-risk patients.
4 Jul, 2022 | 12:21h | UTC[18F]FDG-PET-CT compared with CT for persistent or recurrent neutropenic fever in high-risk patients (PIPPIN): a multicentre, open-label, phase 3, randomised, controlled trial – The Lancet Haematology (link to abstract – $ for full-text)
Commentary on Twitter
NEW research: [18F]FDG-PET-CT resulted in more frequent antimicrobial rationalisation than CT in patients w/ haem diseases & persistent/recurrent high-risk neutropenic fever after chemotherapy. Results of the ph3 RCT PIPPIN #radonc #hemonc https://t.co/isOPFZVVpY pic.twitter.com/PVd8yFy7Ck
— The Lancet Haematology (@TheLancetHaem) June 29, 2022
M-A | Antibiotics for preventing recurrent urinary tract infection.
4 Jul, 2022 | 12:17h | UTCBrief Review | Ventilator-associated pneumonia.
4 Jul, 2022 | 12:15h | UTCVentilator-associated pneumonia – Intensive Care Medicine (if the link is paywalled, try this one in PMC)
Commentary on Twitter
VAP, main challenges & lessons learned
➡️ epidemiology: surveillance & data from LMICs
➡️ pathophysiology
➡️ prevention bundle
➡️ gold standard for diagnosis & microbiology
➡️ treatment: appropriate/timely ABTs
➡️ MDR pathogens
➡️ #COVID19: VAP's back
📎 https://t.co/oYblI6OGLK pic.twitter.com/qXWcABsU0H— Intensive Care Medicine (@yourICM) July 1, 2022
Brief Review: Update on prevention of intra-vascular accesses complications.
30 Jun, 2022 | 10:38h | UTCUpdate on prevention of intra-vascular accesses complications – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Update on intra-vascular accesses complications
🎯 choice
🗝 key measures to prevent CRBSI
Most of times CVL essential in #ICU but deescalation to PVL to be promoted. ⬆️ occlusions/thrombosis w midline/PICCS, CRBSI similar to CVL; interesting out ICU.
🖇 https://t.co/XVxJDkOL4i pic.twitter.com/iIQNEXctoe— Intensive Care Medicine (@yourICM) June 30, 2022
Guideline: Differential diagnosis of acute and chronic redness of the lower legs.
29 Jun, 2022 | 11:42h | UTC
RCT: Two-day vs. seven-day course of levofloxacin in acute COPD exacerbation.
28 Jun, 2022 | 11:19h | UTCCommentary: Antibiotics in COPD Exacerbations – 2 days vs 7 days – RebelEM