Hematology (all articles)
Series from the Lancet journals: Hematological malignancies in older people.
6 Oct, 2021 | 08:47h | UTCHomepage: Haematological malignancies in older people – The Lancet Haematology
Commentary: Living longer and better with haematological malignancies: a promise for older adults too? (free registration required)
A comprehensive approach to therapy of haematological malignancies in older patients (free registration required)
Frailty assessment in the care of older people with haematological malignancies
Haematopoietic stem-cell transplantation in older adults: geriatric assessment, donor considerations, and optimisation of care (free registration required)
RCT: Another study shows convalescent plasma does not improve outcomes in critically ill patients with Covid-19.
5 Oct, 2021 | 10:06h | UTCRelated:
M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.
RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.
Vaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance.
3 Oct, 2021 | 22:59h | UTCVaccine induced immune thrombocytopenia and thrombosis: summary of NICE guidance – The BMJ
Original Guidance: NICE COVID-19 rapid guideline: vaccine-induced immune thrombocytopenia and thrombosis.
Related:
Clinical features of vaccine-induced immune thrombocytopenia and thrombosis.
Vaccine-induced immune thrombotic thrombocytopenia: what we know and do not know.
Very rare cases of thrombosis with thrombocytopenia syndrome (TTS) after AstraZeneca vaccine: a global safety database analysis – the estimated rate of TTS after the first dose was 8.1 per million vaccinees; after the second dose, the estimated rate was 2.3 per million vaccinees. (several articles and resources on the subject)
Systematic Review: Does testing for cancer in people with unprovoked blood clots in the legs and lungs reduce cancer- and blood clot-related death and illness?
3 Oct, 2021 | 22:33h | UTCOriginal article: Effect of testing for cancer on cancer‐ or venous thromboembolism (VTE)‐related mortality and morbidity in people with unprovoked VTE – Cochrane Library
Another meta-analysis suggests standard-dose prophylactic anticoagulation is the best option for patients hospitalized with Covid-19.
1 Oct, 2021 | 10:35h | UTC
AGA Clinical Practice Guideline on the Management of Coagulation Disorders in Patients With Cirrhosis.
29 Sep, 2021 | 10:07h | UTCSee also: AGA Technical Review on Coagulation in Cirrhosis – Gastroenterology
Podcast: Neutropenic Fever.
28 Sep, 2021 | 08:52h | UTC#288 LIVE! Neutropenic Fever featuring Dr. Susan Seo – The Curbsiders
Evaluating the Cost-effectiveness of Prehospital Plasma Transfusion in Unstable Trauma Patients: A Secondary Analysis of the PAMPer Trial.
26 Sep, 2021 | 21:54h | UTCEvaluating the Cost-effectiveness of Prehospital Plasma Transfusion in Unstable Trauma Patients: A Secondary Analysis of the PAMPer Trial – JAMA Surgery (free for a limited period)
Commentaries:
CHEERS to You on a Well-done Cost-effectiveness Analysis of Prehospital Plasma for Helicopter Resuscitation of Patients With Traumatic Shock – JAMA Surgery (free for a limited period)
Prehospital Plasma: A Cheap, Effective Way to Save Trauma Patients’ Lives? – BreakingMed
Commentary on Twitter
A cost-effectiveness analysis of the pragmatic, randomized, multicenter PAMPer trial reveals thawed plasma administration for trauma patients in hemorrhagic shock during air medical transport is life-saving and cost-effective https://t.co/WDCoJctZox
— JAMA Surgery (@JAMASurgery) September 24, 2021
M-A: Safety and efficacy of different prophylactic anticoagulation dosing regimens in critically and non-critically ill patients with COVID-19 – According to this analysis, standard-dose prophylactic anticoagulation should be the standard of care for hospitalized patients with COVID-19 who do not have an indication for therapeutic anticoagulation, irrespective of disease severity.
21 Sep, 2021 | 09:54h | UTC
Commentary on Twitter (thread – click for more)
Safety and efficacy of different prophylactic anticoagulation dosing regimens in critically and non-critically ill patients with #COVID-19: A systematic review and meta-analysis of randomized controlled trials https://t.co/Gkdfp9vn75 @ESC_Journals @escardio @ESCardioNews #COVID19
— Luis Ortega Paz (@Ortega_Paz) September 15, 2021
Review: Transfusion-related acute lung injury in the perioperative patient.
21 Sep, 2021 | 08:56h | UTCTransfusion-related Acute Lung Injury in the Perioperative Patient – Anesthesiology
RCT: Rivaroxaban does not have an impact on disease progression and symptoms resolution in high-risk adults with mild COVID-19.
17 Sep, 2021 | 10:19h | UTC
Review | Thrombophilia testing in the era of direct oral anticoagulants.
17 Sep, 2021 | 09:53h | UTCThrombophilia testing in the era of direct oral anticoagulants – Clinical Medicine Journal
Case series: Vaccine-induced thrombocytopenia with severe headache may precede cerebral venous sinus thrombosis by several days – patients with severe headache 5 to 20 days after adenovirus vector vaccination against Covid-19 should undergo immediate testing for thrombocytopenia and d-dimer levels and, if available, testing for anti–PF4–heparin IgG antibodies.
16 Sep, 2021 | 10:14h | UTCVaccine-Induced Thrombocytopenia with Severe Headache – New England Journal of Medicine
Commentary on Twitter
Experience with 11 patients suggests that elements of VITT (severe headache, elevated d-dimer levels, and positivity for anti-PF4 antibodies) after ChAdOx1 nCoV-19 vaccination may precede VITT. #Covid19Vaccines #COVID19 #SARSCoV2 #IDTwitter https://t.co/mzBgjJIE6l pic.twitter.com/wGqb1gKFXk
— NEJM (@NEJM) September 15, 2021
State of the Art Review: Eosinophils in Health and Disease.
16 Sep, 2021 | 09:59h | UTCEosinophils in Health and Disease: A State-of-the-Art Review – Mayo Clinic Proceedings
Review: Is there an optimal antiplatelet strategy after gastrointestinal bleeding in patients with coronary artery disease?
16 Sep, 2021 | 09:57h | UTC
M-A: Study shows significant risk of major bleeding during extended oral anticoagulant therapy for first unprovoked venous thromboembolism.
14 Sep, 2021 | 08:55h | UTCLong-Term Risk for Major Bleeding During Extended Oral Anticoagulant Therapy for First Unprovoked Venous Thromboembolism: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries:
Long-term Anticoagulation After Unprovoked VTE: New Insights – TCTMD
Extended Anticoagulation Tied to Major Bleeding Risk – HealthDay
Commentary on Twitter
? Delighted to share the MAJESTIC Study providing best available estimates for major bleeding risk during extended #anticoagulation of up to 5 years in patients with unprovoked #VTE (& clinically important subgroups), now published in @AnnalsofIM!https://t.co/Ri2EvZvffq pic.twitter.com/3jvN8mTKSi
— Faizan Khan (@FaizanK91) September 13, 2021
Guidelines for the management of iron deficiency anemia in adults.
12 Sep, 2021 | 21:48h | UTC
RCT: Convalescent plasma does not improve outcomes and may be harmful to hospitalized patients with COVID-19.
10 Sep, 2021 | 05:37h | UTCNews release: Major study finds convalescent plasma doesn’t help seriously ill COVID-19 patients – McMaster University
Related:
M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.
RECOVERY Trial: No benefit from convalescent plasma in patients admitted to hospital with COVID-19.
Commentary on Twitter
A randomized trial in patients hospitalized with COVID-19 showed no benefit and potentially increased harm associated with the use of convalescent plasma, according to a @NatureMedicine paper. https://t.co/7JFhEXLmbA pic.twitter.com/Q3e50Q0I7T
— Nature Portfolio (@NaturePortfolio) September 9, 2021
Drug-drug interactions with direct oral anticoagulants: practical recommendations for clinicians.
10 Sep, 2021 | 04:59h | UTC
Supplement: Current Issues in Venous Thromboembolism.
7 Sep, 2021 | 21:36h | UTCHomepage: Current Issues in Venous Thromboembolism – Postgraduate Medicine
Editorial: Current issues in venous thromboembolism
A review of upper extremity deep vein thrombosis
Outpatient treatment of emergency department patients diagnosed with venous thromboembolism
Venous thromboembolism prophylaxis in high-risk orthopedic and cancer surgery
Prophylaxis and treatment of COVID-19 related venous thromboembolism
Challenges in the diagnostic approach of suspected pulmonary embolism in COVID-19 patients
Post-hospital discharge venous thromboembolism prophylaxis in medically ill patients
Radiologic mimics of pulmonary embolism
A comprehensive review of DOACs for cancer associated VTE prophylaxis or treatment
RCT: In patients with Immune Thrombocytopenia, the addition of Mycophenolate Mofetil to a standard glucocorticoid regimen reduced refractory or relapsed disease but was associated with decreased quality of life outcomes regarding physical function and fatigue.
3 Sep, 2021 | 10:15h | UTC
Systematic review: In individuals with hemophilia A or B, there is evidence from RCTs that prophylaxis with clotting factor concentrates, as compared to on‐demand treatment, may reduce bleeding frequency.
2 Sep, 2021 | 08:17h | UTC
RCT: Ketamine administration in patients with acute painful sickle cell crisis was effective for pain control and reduced the cumulative morphine dose in the emergency department.
2 Sep, 2021 | 08:11h | UTCKetamine Administration for Acute Painful Sickle Cell Crisis: A Randomized Controlled Trial – Academic Emergency Medicine (link to abstract – $ for full-text)
COVID-19 patients at higher risk of blood clots after surgery, study shows.
1 Sep, 2021 | 09:54h | UTCCOVID-19 patients at higher risk of blood clots after surgery, study shows – CIDRAP
Original study: SARS-CoV-2 infection and venous thromboembolism after surgery: an international prospective cohort study – Anaesthesia
Related:
ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.
Position statement: Perioperative management of post-COVID-19 surgical patients.
Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery
Study finds increased risk of gastrointestinal bleeding following concomitant treatment with oral glucocorticoids in patients on non-vitamin K oral anticoagulants.
20 Aug, 2021 | 08:45h | UTCGastrointestinal bleeding risk following concomitant treatment with oral glucocorticoids in patients on non-vitamin K oral anticoagulants – Heart (link to abstract – $ for full-text)
Commentary on Twitter
In this @Heart_BMJ #Afib sdy @AndersHolt6 et al. found a X2 ⬆️ risk of GI bleeding w/ NOAC?+oral glucocorticoids⚪ vs NOAC alone ?
Authors recommend ☝️ close monitoring ? or other risk ? mitigation when co-prescribing
? https://t.co/CgtgmvnD29#CardioTwitter #cardiology pic.twitter.com/95eCOWxozK
— Copenhagen Cardiovascular Research Center (@CopCard) August 15, 2021