Gynecology & Obstetrics (all articles)
Asherman’s Syndrome: Current Perspectives on Diagnosis and Management
4 Apr, 2019 | 22:42h | UTC
Management of Hypertension in the Obese Pregnant Patient
4 Apr, 2019 | 22:40h | UTCManagement of Hypertension in the Obese Pregnant Patient – Current Hypertension Reports (free)
Study: Reduction in Preinvasive Cervical Disease after HPV Immunization
4 Apr, 2019 | 22:19h | UTCEditorial: The remarkable impact of bivalent HPV vaccine in Scotland (free)
Commentaries: Tim Palmer: Bivalent HPV vaccine in Scotland is having a considerable and sustained effect – The BMJ Opinion (free) AND HPV Vaccination Program Brings Lower Rates of Cervical Disease in Scotland – NEJM Journal Watch (free) AND HPV programme linked to dramatic fall in cervical disease – OnMedica (free)
Randomized Trial: Metformin to Treat Pregnant Women with Polycystic Ovary Syndrome
4 Apr, 2019 | 22:11h | UTCUse of metformin to treat pregnant women with polycystic ovary syndrome (PregMet2): a randomised, double-blind, placebo-controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentary: Well-known drug has less risk for preterm delivery in PCOS – Norwegian University of Science and Technology (free)
Meta-analysis: Antibiotic Therapy for Pelvic Inflammatory Disease
4 Apr, 2019 | 12:04h | UTC
NICE Guideline: Urinary Incontinence and Pelvic Organ Prolapse in Women
3 Apr, 2019 | 01:09h | UTC
Guideline: Valproate Use in Women and Girls Of Childbearing Years
1 Apr, 2019 | 02:06h | UTCValproate Use In Women and Girls Of Childbearing Years (free PDF)
News Release: Thirteen UK healthcare bodies launch ‘pragmatic’ guidance on valproate use – Royal College of General Practitioners (free)
Commentary: New guidance on valproate use in women – OnMedica (free)
Meta-Analysis: Mortality and Complications Associated with Cesarean Section in Low and Middle-income Countries
1 Apr, 2019 | 01:53h | UTCMaternal and perinatal mortality and complications associated with caesarean section in low-income and middle-income countries: a systematic review and meta-analysis – The Lancet (free registration required)
Commentaries: Death rates from caesarean section far higher in developing countries, finds major global study – Queen Mary, University of London (free) AND C-section death rates highest in low-income countries – OnMedica (free)
Randomized Trial: Treatments for Hormone Receptor–Positive Metastatic Brest Cancer Compared
28 Mar, 2019 | 07:32h | UTCOverall Survival with Fulvestrant plus Anastrozole in Metastatic Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Gain in Survival with Fulvestrant plus Anastrozole in Metastatic Breast Cancer – MedicalResearch.com (free) AND Fulvestrant plus anastrozole extends lives of women with advanced HR+ breast cancer – SWOG (free)
Pregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism
27 Mar, 2019 | 06:14h | UTCPregnancy-Adapted YEARS Algorithm for Diagnosis of Suspected Pulmonary Embolism – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: YEARS algorithm adaptation for pregnant women helped avoid CT scans for suspected PE – ACP Hospitalist (free) AND Pregnancy-adapted algorithm avoids diagnostic imaging for PE – MedicalXpress (free) AND PE in Pregnancy & YEARS Protocol – Emergency Medicine Literature of Note (free)
Evidence Review: Tranexamic Acid (TXA) for Everything that Bleeds?
27 Mar, 2019 | 05:56h | UTCTranexamic Acid (TXA) for Everything that Bleeds? – REBEL EM (free)
Related: Meta-analysis – Tranexamic acid: is it about time? (free study and commentaries) AND Randomized Controlled Trial: Tranexamic Acid for Hyperacute Primary Intracerebral Hemorrhage (free) AND Systematic Review: Tranexamic Acid for Patients with Epistaxis (free) AND Systematic Review: Antifibrinolytic drugs for treating primary postpartum haemorrhage (free) AND WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage (free) AND Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (free) AND Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial (landmark trial on the subject)
Cohort Study: Night Work and Risk of Miscarriage
27 Mar, 2019 | 05:37h | UTCCommentaries: Link Between Night Shift Work and Miscarriage – MedicalResearch.com (free) AND Miscarriage risk linked with night shift work – OnMedica (free) AND Night shift work linked to a higher risk of miscarriage – Reuters (free) AND Expert reaction to night shifts and miscarriage – Science Media Centre (free)
IDSA Guideline for the Management of Asymptomatic Bacteriuria
22 Mar, 2019 | 07:36h | UTCCommentaries: Bacteria in urine doesn’t always indicate infection – Infectious Diseases Society of America (free) AND Most Urinary Bacteria Do Not Require Antibiotics – MedicalResearch.com (free)
Observational Study Suggests the Benefits of Ultrasonography as an Adjunct to Screening Mammography May Not Outweigh Associated Harms
22 Mar, 2019 | 06:55h | UTCPerformance of Screening Ultrasonography as an Adjunct to Screening Mammography in Women Across the Spectrum of Breast Cancer Risk – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Breast Screening: Adding Ultrasonography Doesn’t Seem Worth Associated Harms – NEJM Journal Watch (free) AND Does supplemental whole-breast ultrasound provide significant value? – Radiology Business (free)
Mesh Implants for Women: Scandal or Standard of Care?
21 Mar, 2019 | 07:01h | UTCPerspective: Mesh Implants for Women: Scandal or Standard of Care? – JAMA (free for a limited period)
Related Commentary on Twitter
Urogyne mesh implants have been called the “biggest medical scandal” since thalidomide and the “gold standard” treatment for stress urinary incontinence. These divergent views illustrate the complexity of the ongoing debate over their safety and efficacy. https://t.co/Yg0MiWjmp8
— JAMA (@JAMA_current) March 20, 2019
Meta-Analysis: Pharmacologic and Nonpharmacologic Treatments for Urinary Incontinence in Women
20 Mar, 2019 | 03:11h | UTCPharmacologic and Nonpharmacologic Treatments for Urinary Incontinence in Women: A Systematic Review and Network Meta-analysis of Clinical Outcomes – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Behavioral therapy appears more effective than pharmacologic therapy for urinary incontinence outcomes – ACP Internist (free) AND For Urinary Incontinence, Behavioral Therapies Outperform Meds – NEJM Journal Watch (free)
Systematic Review: Multiple‐Micronutrient Supplementation for Women During Pregnancy
19 Mar, 2019 | 03:18h | UTCMultiple‐micronutrient supplementation for women during pregnancy – Cochrane Library (free)
Summary: Vitamin and mineral supplements for women during pregnancy – Cochrane Library (free)
British Guidelines for the Management of HIV in Pregnancy and Postpartum
19 Mar, 2019 | 02:59h | UTC
Meta-Analysis: Mode of Delivery and Preterm Birth in Subsequent Births
17 Mar, 2019 | 18:21h | UTC“A previous cesarean section could increase the risk of preterm birth in subsequent pregnancies”
Consensus Statement: Prevention and Treatment of Postpartum Hemorrhage
15 Mar, 2019 | 02:59h | UTC
Study: Conceiving Within a Year of Stillbirth Does Not Increase Risks for Next Pregnancy
14 Mar, 2019 | 01:59h | UTCAssociation between interpregnancy interval and adverse birth outcomes in women with a previous stillbirth: an international cohort study – The Lancet (link to abstract – $ for full-text)
Commentaries: Conceiving within a year of stillbirth does not increase risks for next pregnancy – The Lancet (free) AND No added health risks for pregnancy within a year of a stillbirth – Reuters (free) AND Quick pregnancy safe after stillbirth, study finds – BBC News (free)
A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery
14 Mar, 2019 | 01:00h | UTCA Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery – New England Journal of Medicine (free for a limited period)
Video Summary: Prophylactic Antibiotics before Miscarriage Surgery (free)
Commentaries: Research shines light on preventing infection after miscarriage – University of Birmingham (free) AND Antibiotics before miscarriage surgery not tied to fewer infections – CIDRAP (free)
Related Commentary on Twitter
Antibiotic prophylaxis before miscarriage surgery did not result in a significantly lower risk of pelvic infection, as defined by pragmatic broad criteria, than placebo. However, benefit was observed in a secondary analysis that defined pelvic infection by strict criteria.
— NEJM (@NEJM) March 13, 2019
Guidelines for the Evaluation and Treatment of Perimenopausal Depression
11 Mar, 2019 | 12:02h | UTC
MRI in Pregnancy: Indications and Practical Considerations
11 Mar, 2019 | 11:53h | UTCMRI in pregnancy: Indications and practical considerations – Journal of Magnetic Resonance Imaging (free)
Observational Study Suggests Postmenopausal Hormone Therapy is Linked to a Small Risk of Alzheimer’s Disease
11 Mar, 2019 | 03:33h | UTCEditorial: Menopausal hormone therapy and cognition (free)
Commentaries: Systemic Hormone Therapy Tied to Small Increase in Alzheimer’s Risk – NEJM Journal Watch (free) AND ‘Small’ increase in risk of Alzheimer’s disease with HRT use, study suggests – NHS Choices (free)
“The findings of this case-control study, with the modest effect sizes and substantial potential for bias, will not change how I counsel patients regarding benefits and risks of HT.” (from Journal Watch)
“Evidence is reassuring for women needing a few years’ treatment for menopausal symptoms” (from Editorial)