Gynecology & Obstetrics (all articles)
RCT: Community pharmacies provision of a progestogen-only pill + invitation to a sexual and reproductive health clinic as a bridging contraception intervention for women receiving emergency contraception is associated with increased subsequent use of long-term effective contraception.
10 May, 2021 | 00:45h | UTC
Population-based cohort study suggests increased survival after breast conservation surgery + radiotherapy compared to mastectomy with or without radiotherapy in women with breast cancer.
10 May, 2021 | 00:42h | UTC
Commentary on Twitter
Women receiving breast-conserving surgery for #breastcancer fare better than those who take away the whole breast says a new study taking into account comorbidities and socioeconomic background. Superior survival rates support less extensive surgery https://t.co/JEXasP56Di
— JAMA Surgery (@JAMASurgery) May 5, 2021
RCT: Prophylactic closed incision negative pressure wound therapy reduces (difference close to statistical significance; P=0.06) the risk of surgical site infection in obese women undergoing cesarean section.
7 May, 2021 | 08:24h | UTC
WHO: New report sounds the alarm on global shortage of 900 000 midwives.
6 May, 2021 | 08:45h | UTCNew report sounds the alarm on global shortage of 900 000 midwives – World Health Organization
Report: The State of the World’s Midwifery 2021 – UN sexual and reproductive health agency
Commentary on Twitter (thread – click for more)
9⃣3⃣% of #midwives are women. But too many face persistent gender discrimination that prevents them from thriving professionally.
Gender transformative policies are key to change this! 👉https://t.co/qxkv16SVxp #MidwivesDay #IDM2021 pic.twitter.com/7aBBwvXFQa
— World Health Organization (WHO) (@WHO) May 5, 2021
Cohort study: Risk of developmental difficulties remains high among children born early
5 May, 2021 | 08:24h | UTCNeurodevelopmental outcomes at age 5 among children born preterm: EPIPAGE-2 cohort study – The BMJ
News release: Risk of developmental difficulties remains high among children born early – The BMJ
Commentary on Twitter
Children born preterm remain at high risk of developmental difficulties that can affect their behaviour and ability to learn, finds new research https://t.co/0A1aIQWWqk #BMJResearch
— The BMJ (@bmj_latest) May 2, 2021
RCT: Community-initiated kangaroo mother care reduced the risk of moderate-to-severe maternal postpartum depressive symptoms among mothers of low-birth-weight infants in low-income areas in India
5 May, 2021 | 08:21h | UTC
Commentary on Twitter
Skin to Skin care doesn’t only help babies; it also helps mothers!
Randomized trial of ~2k mothers from India found kangaroo care reduces postpartum depression #neoEBM #mentalhealth @JAMANetworkOpen https://t.co/6YqPQChKLe pic.twitter.com/DYAbU3Tsxu
— Abdul Razak (@DrAbdulRazak_MD) April 23, 2021
Study: Despite clinical practice guidelines recommending cervical cancer screening every 3 years or cotesting with HPV and cytologic testing every 5 years, many women get tested much more often
3 May, 2021 | 05:19h | UTC
The Lancet Series | Miscarriage matters
3 May, 2021 | 05:11h | UTCEditorial: Miscarriage: worldwide reform of care is needed
- Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss
- Sporadic miscarriage: evidence to provide effective care
- Recurrent miscarriage: evidence to accelerate action
RCT: Tranexamic acid for the prevention of blood loss after cesarean delivery – even though TA resulted in a significantly lower incidence of estimated blood loss, the clinical relevance of the findings was small
30 Apr, 2021 | 08:38h | UTC
Commentaries on Twitter
Another typically "positive" trial for TXA.
"the mean between-group difference was approximately 100 ml …. the clinical relevance of this narrow difference is questionable"
– No difference in RBC transfusions.
– 0.4% vs 0.1% VTE at 3 mos.— Ryan Radecki, MD MS (@emlitofnote) April 28, 2021
NEJM-Prevention of Blood Loss after Cesarean Delivery | tranexamic acid ➡️ significantly lower incidence of EBL greater than 1000 ml or RBC transfusion by day 2 than placebo, but did not result in a ⬇️ incidence of hemorrhage-related secondary outcomes https://t.co/ydF5HgHM0N
— Skeptical Scalpel (@Skepticscalpel) April 28, 2021
Cohort study: Association of maternal SARS-CoV-2 infection in pregnancy with neonatal outcomes – “although babies born of test-positive mothers are more likely to be born early, extremely few were infected with COVID-19”
30 Apr, 2021 | 08:17h | UTCAssociation of Maternal SARS-CoV-2 Infection in Pregnancy With Neonatal Outcomes – JAMA
News release: Low risk of infection in babies born to mothers with COVID-19 – Karolinska Institutet
Editorial: Understanding Risk for Newborns Born to SARS-CoV-2–Positive Mothers – JAMA
Commentary on Twitter
Maternal #SARSCoV2 infection in pregnancy was significantly associated with small increases in the absolute risk of respiratory disorders and some other neonatal morbidities https://t.co/ANkXkaxnwp
— JAMA (@JAMA_current) April 29, 2021
AHA Scientific Statement: Close monitoring for heart risk needed if breast, prostate cancer treatment includes hormonal therapies
29 Apr, 2021 | 08:33h | UTCNews release: Close monitoring for heart risk needed if breast, prostate cancer treatment includes hormones – American Heart Association
Top Things to Know: Impact of Hormonal Therapies for Treatment of Hormone-Dependent Cancers (Breast and Prostate) on the Cardiovascular System – American Heart Association
Commentaries: Hormonal Therapy for Breast and Prostate Cancer: Lessons and Opportunities – American Heart Association AND Hormonal Based Therapies in the Treatment of Breast and Prostate Cancer – balancing the risks! – American Heart Association AND Hormone Cancer Therapies Increase CV Risk: AHA Scientific Statement – TCTMD AND Closely Monitor Heart Health in Cancer Patients Who Get Hormonal Therapies: AHA – HealthDay
Pre-post study: A hospital quality improvement intervention significantly reduced the rates of cesarean delivery for nulliparous, term, singleton, vertex births
29 Apr, 2021 | 08:21h | UTCHospital Quality Improvement Interventions, Statewide Policy Initiatives, and Rates of Cesarean Delivery for Nulliparous, Term, Singleton, Vertex Births in California – JAMA (free for a limited period)
Editorial: Initiatives to Reduce Cesarean Delivery Rates for Low-risk First Births – JAMA
Commentary on Twitter (thread – click for more)
"Rates of cesarean delivery for NTSV births in California decreased [from 26% to 22.8%] in the setting of a coordinated hospital-level collaborative and statewide initiatives designed to support vaginal birth.
"The rest of the US had no change."https://t.co/jwKkQZ4nix @cmqcc
— Ben Harder #BlackLivesMatter (@benharder) April 27, 2021
M-A: Effectiveness of intrapartum fetal surveillance to improve maternal and neonatal outcomes – “none of the newer surveillance methods seem to significantly reduce emergency cesarean deliveries in labor or neonatal morbidity compared with using simple intermittent auscultation of the fetal heart”
28 Apr, 2021 | 08:08h | UTC
M-A: Lidocaine lubricant jelly does not reduce pain perception during female urethral catheterization
27 Apr, 2021 | 09:11h | UTCLidocaine lubricant jelly does not reduce pain perception during female urethral catheterization: A systematic review with meta‐analysis and trial sequential analysis – The International Journal of Clinical Practice (link to abstract – $ for full-text)
Systematic Review: Dopamine agonists for preventing ovarian hyperstimulation syndrome
27 Apr, 2021 | 09:08h | UTCDopamine agonists for preventing ovarian hyperstimulation syndrome – Cochrane Library
RCT: Intracytoplasmic sperm injection vs. conventional in-vitro fertilization in couples with infertility in whom the male partner has normal total sperm count and motility – no difference in livebirth rates between the strategies
25 Apr, 2021 | 21:14h | UTCIntracytoplasmic sperm injection versus conventional in-vitro fertilisation in couples with infertility in whom the male partner has normal total sperm count and motility: an open-label, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
🔴New RCT in @TheLancet
⭐In couples with infertility + normal total sperm count and motility ➡️ ICSI did not improve the livebirth rate compared with conventional IVF.
No excuses left to do ICSI for all.
Full text ⬇️https://t.co/6FYX7TeDRN— Rita Vassena (@RitaVassena) April 23, 2021
RCT: Metformin vs. insulin in gestational diabetes – metformin was associated better glycemic control, lower risk of hypoglycemia, and less maternal weight gain
25 Apr, 2021 | 21:03h | UTCMeDiGes Study. Metformin versus insulin in gestational diabetes: Glycemic control, and obstetrical and perinatal outcomes. Randomized prospective trial. – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)
Related: Randomized trial tests metformin in women with type 2 diabetes in pregnancy AND Neonatal, infant, and childhood growth following metformin versus insulin treatment for gestational diabetes: A systematic review and meta-analysis – PLOS Medicine AND Case-Control Study: Metformin Exposure in First Trimester of Pregnancy is Not Associated with Congenital Anomalies
RCT: Induction of Labor at Term with Vaginal Misoprostol or a PGE2 Pessary – little difference in outcomes, the clinical risk-benefit ratio justifies the use of both drugs
25 Apr, 2021 | 20:59h | UTCInduction of Labor at Term With Vaginal Misoprostol or a PGE2 Pessary: a Noninferiority RCT – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)
Guideline: Prevention of Positioning Injuries During Gynecologic Surgery
25 Apr, 2021 | 20:50h | UTC
RCT: No benefit from immune checkpoint inhibitors in newly diagnosed stage III or IV ovarian cancer
25 Apr, 2021 | 20:57h | UTC
Guideline: Diagnosis and Treatment of Endometriosis
25 Apr, 2021 | 20:46h | UTC
Recommendations on the Management of Maternal Hepatitis B, C and D Infection in Pregnancy
25 Apr, 2021 | 20:44h | UTC
Guideline: Vulvovaginal Candidosis (Excluding Mucocutaneous Candidosis)
25 Apr, 2021 | 20:47h | UTC
Covid-19: More data on the increased risks to pregnant women and their newborn infants
23 Apr, 2021 | 08:44h | UTCEditorial: COVID-19 in Pregnant Women and Their Newborn Infants
Commentaries: Pregnant women with COVID-19 face high mortality rate – University of Washington School of Medicine AND Covid-19 raises risks for expectant mothers and babies, study says – CNN
Commentary on Twitter
18 country study in >2000 pregnant women with and without #COVID19 shows higher complication and death rates in symptomatic, but not asymptomatic, women with COVID-19. Their babies were at greater risk of neonatal complications, mainly due to preterm birth https://t.co/mRl8OOIMsz
— JAMA Pediatrics (@JAMAPediatrics) April 22, 2021
Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons
22 Apr, 2021 | 08:49h | UTCAudio Interview: Covid-19 Vaccines and Pregnancy — A Conversation with CDC Director Rochelle Walensky – New England Journal of Medicine
Commentaries: No evidence that Pfizer or Moderna vaccines are unsafe during pregnancy, a preliminary study says. – The New York Times AND Preliminary data show no safety concerns for pregnant women receiving COVID-19 vaccines – AAP News AND Messenger RNA COVID vaccines likely safe for pregnant women: Study – ABC News