Gynecology & Obstetrics (all articles)
Circulating tumor DNA and late recurrence in high-risk hormone receptor–positive, human epidermal growth factor receptor 2–negative breast cancer.
13 Jun, 2022 | 07:35h | UTCCommentary: Tumor DNA Assay Portends Metastatic Breast Cancer Recurrence Months in Advance — First evidence for patients in late adjuvant setting, years after initial diagnosis – MedPage Today (free registration required)
Commentary on Twitter
103 women in long-term remission from high-risk HR+/HER2- breast cancer had customized monitoring of recurrence based on ctDNA seq for tumour-associated mut. Among 8 pts MRD+ pts, 6 developed distant recurrence at a median 12.4 mo after ctDNA positivity https://t.co/aX1ruLCSbb
— NatureRevClinOncol (@NatRevClinOncol) June 9, 2022
Cohort Study: Neurodevelopmental outcomes at 1 year in infants of mothers who tested positive for SARS-CoV-2 during pregnancy.
10 Jun, 2022 | 12:14h | UTCCommentaries:
Commentary on Twitter
This cohort study of #SARSCoV2 exposure in utero found preliminary evidence that maternal SARS-CoV-2 may be associated with neurodevelopmental sequelae in some offspring. https://t.co/dYdoJbNOdl
— JAMA Network Open (@JAMANetworkOpen) June 9, 2022
Systematic review: educational interventions to improve the menstrual health of young adolescent girls.
10 Jun, 2022 | 10:59h | UTC
[News release – not published yet] Women not being routinely informed that a common anesthetic may lessen contraception effectiveness, doctors warn.
9 Jun, 2022 | 11:31h | UTCCommentary: Women in UK ‘seldom’ told drug used in surgery can impede contraception – The Guardian
Screening every five years safe for women who test negative for HPV, study confirms.
9 Jun, 2022 | 11:26h | UTCNews Release: Screening every five years safe for women who test negative for HPV, study confirms – King’s College London
Editorial: HPV screening for cervical cancer is reaching maturity – The BMJ
Related WHO Guidance:
News release: New recommendations for screening and treatment to prevent cervical cancer – World Health Organization
Related USPSTF Guidance: Screening for Cervical Cancer: US Preventive Services Task Force Recommendation Statement – JAMA
Migraine history tied to higher risk for adverse pregnancy outcomes.
9 Jun, 2022 | 10:49h | UTCMigraine History Tied to Higher Risk for Adverse Pregnancy Outcomes – HealthDay
Cohort Study: Long-term quality of life in patients with breast cancer after breast conservation vs mastectomy and reconstruction.
9 Jun, 2022 | 10:30h | UTCLong-term Quality of Life in Patients With Breast Cancer After Breast Conservation vs Mastectomy and Reconstruction – JAMA Surgery (link to abstract – $ for full-text)
Commentaries:
Long-Term QOL Examined for Surgical Choices in Breast Cancer – HealthDay
Commentary on Twitter
Survey of #breastcancer survivors after treatment found:
1. Breast satisfaction and physical well-being similar with lumpectomy+rads or mastectomy+reconstruction (no rads)
2. Psychosocial well-being and sexual well-being better with lumpectomy+rads https://t.co/tPh9Pt4gYx— JAMA Surgery (@JAMASurgery) April 14, 2022
Cohort Study: Intrauterine device-related uterine perforation incidence and risk.
6 Jun, 2022 | 10:59h | UTCIntrauterine device-related uterine perforation incidence and risk (APEX-IUD): a large multisite cohort study – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
Although the risk for uterine perforation with IUD insertion 4 days to 6 weeks or less postpartum is nearly 7x that of insertion non-postpartum, perforation remains an incredibly rare event for all clinical time pointshttps://t.co/DPqgLAh1Dx
— The Lancet (@TheLancet) June 3, 2022
Cohort Study: Pregnancy outcomes in young women with youth-onset type 2 diabetes.
3 Jun, 2022 | 12:00h | UTC
Commentary on Twitter
Type 2 diabetes in youth is a severe disease.
Among 260 pregnancies reported in the TODAY study, 2/3rds with complications:
👉25% pregnancy loss
👉33% preterm birth
👉35% hypertension
👉27% large infantsNew prevention/treatment desperately neededhttps://t.co/SaMXAy4Xjz
— Dr. David Ludwig (@davidludwigmd) June 2, 2022
Cohort Study: Association of SARS-CoV-2 infection during pregnancy with maternal and perinatal outcomes.
3 Jun, 2022 | 11:55h | UTCAssociation of SARS-CoV-2 Infection During Pregnancy With Maternal and Perinatal Outcomes – JAMA
Guideline: Ultrasound in labor.
3 Jun, 2022 | 11:34h | UTC
Maternal vaccination: a review of current evidence and recommendations.
3 Jun, 2022 | 11:40h | UTC
Commentary on Twitter
AJOG Expert Review: Maternal vaccination: a review of current evidence and recommendations – Placental transfer of IgG antibodies from maternal to fetal circulation https://t.co/yd3DQpwSoD pic.twitter.com/obicClLhzC
— AJOG (@AJOG_thegray) April 1, 2022
Brief Review: Medication for early pregnancy termination.
3 Jun, 2022 | 11:06h | UTCMedication for Early Pregnancy Termination – JAMA (free for a limited period)
Note: Abortion is not legalized in Brazil and other countries.
RCT: Efficacy of bariatric surgery in treating women with obesity and polycystic ovary syndrome.
3 Jun, 2022 | 11:05h | UTC
A systematic review of the guidelines on venous thromboembolism prophylaxis in gynecologic oncology.
3 Jun, 2022 | 10:48h | UTC
Cohort Study: Evaluation of adverse pregnancy outcomes in physicians compared with nonphysicians.
3 Jun, 2022 | 10:43h | UTC
Commentary on Twitter
In this cohort study, associations between physician occupation and pregnancy complications were likely mediated by maternal age rather than the nature of the occupation. @mccusimano @enenbee @AndreaSimpsonMD https://t.co/awy77QzzoZ
— JAMA Network Open (@JAMANetworkOpen) May 23, 2022
Guidelines on stroke in women: management of menopause, pregnancy and postpartum.
2 Jun, 2022 | 11:27h | UTC
Phase 2 RCT: Efficacy of epigallocatechin-3-gallate in preventing dermatitis in patients with breast cancer receiving postoperative radiotherapy.
2 Jun, 2022 | 10:34h | UTCEfficacy of Epigallocatechin-3-Gallate in Preventing Dermatitis in Patients With Breast Cancer Receiving Postoperative Radiotherapy: A Double-Blind, Placebo-Controlled, Phase 2 Randomized Clinical Trial – JAMA Dermatology (free for a limited period)
Visual Abstract: Efficacy of Epigallocatechin-3-Gallate on Dermatitis in Patients With Breast Cancer Receiving Postoperative Radiotherapy
Essential components of postnatal care – a systematic literature review and development of signal functions to guide monitoring and evaluation.
2 Jun, 2022 | 10:29h | UTC
M-A: Association between benign ovarian tumors and ovarian cancer risk.
2 Jun, 2022 | 10:18h | UTC
Cohort Study: Association of prenatal exposure to antiseizure medication with risk of autism and intellectual disability.
1 Jun, 2022 | 11:44h | UTCAuthor Interview: Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability – JAMA
Commentaries:
Prenatal Exposure to Certain Antiseizure Meds Linked to Autism – HealthDay
Related:
Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs – Neurology (link to abstract – $ for full-text)
Educational attainment of children born to mothers with epilepsy – Journal of Neurology, Neurosurgery, and Psychiatry (link to abstract – $ for full-text)
Commentary on Twitter
Nordic study of 4.5 million children found an association between prenatal exposure to topiramate and valproate and child intellectual disability and #autism. https://t.co/UH2THznPiV
— JAMA Neurology (@JAMANeuro) May 31, 2022
Global, regional, and national incidence and mortality of neonatal preterm birth, 1990-2019.
1 Jun, 2022 | 11:15h | UTCCommentary: Global Incidence of Neonatal Preterm Birth Decreasing Overall – HealthDay
Commentary on Twitter
Data from the Global Burden of Disease study found preterm birth remains a crucial issue in children worldwide and discovery research into the underlying mechanisms of neonatal preterm birth and the development of innovative interventions are urgent. https://t.co/ajOK4FUlHf
— JAMA Pediatrics (@JAMAPediatrics) May 31, 2022
Interventions for heavy menstrual bleeding; overview of Cochrane reviews and network meta‐analysis.
1 Jun, 2022 | 11:09h | UTC
Commentary on Twitter (thread – click for more)
1) Hot off the press!
"Interventions for heavy menstrual bleeding; overview of Cochrane reviews and network meta‐analysis"#Evidence suggests levonorgestrel‐releasing intrauterine system (LNG‐IUS) is the best first‐line treatment for reducing menstrual blood loss;
— Cochrane Gynaecology & Fertility (@CochraneCGF) May 31, 2022
Systematic Review: Cleavage‐stage versus blastocyst‐stage embryo transfer in assisted reproductive technology.
1 Jun, 2022 | 11:02h | UTC
Commentary on Twitter
Transferring fresh embryos at the blastocyst stage (day 5 to 6) may increase live births compared to transfer at cleavage stage (day 2 to 3). We are uncertain if blastocyst‐stage transfer increases multiple pregnancy or miscarriage @CochraneLibrary https://t.co/O5CrUPTpet pic.twitter.com/YNdrwCIkmt
— Cochrane Gynaecology & Fertility (@CochraneCGF) May 25, 2022
Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomized controlled trials.
31 May, 2022 | 11:50h | UTCRelated Study: Reducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial – The Lancet AND Commentary: Expensive antiseptics and sutures do not reduce the risk of surgical infections – National Institute for Health and Care Research
Commentary from one of the authors on Twitter (thread – click for more)
1. Today: our @TheLancetInfDis meta-analysis based on @FalconRct – triclosan sutures and alcoholic skin prep to reduce surgical site infection.
Link to open access PDF:https://t.co/cj7yFdbNpB pic.twitter.com/VkKRaxCAtm
— Aneel Bhangu (@aneelbhangu) May 27, 2022