Global & Public Health (all articles)
NICE COVID-19 Rapid Guideline: Dialysis Service Delivery
23 Mar, 2020 | 01:30h | UTCSee also: COVID-19: Updates for Nephrologists (free resources)
CDC Guidance: Preparing Long-term Care Facilities and Nursing Homes for COVID-19
24 Mar, 2020 | 11:28h | UTCRelated Guideline: Infection Prevention and Control guidance for Long-Term Care Facilities in the context of COVID-19 – World Health Organization (PDF)
Related Article: COVID-19 in a Long-Term Care Facility — King County, Washington, February 27–March 9, 2020 – CDC Morbidity and Mortality Weekly Report
Related Perspective: The Coronavirus’s Rampage Through a Suburban Nursing – The New York Times
CEBM Estimates Infection Rate Fatality (IFR) of COVID-19 at 0,20%
23 Mar, 2020 | 01:16h | UTCGlobal Covid-19 Case Fatality Rates – Centre for Evidence-Based Medicine, University of Oxford (free)
[Preprint] Randomized Trial: Favipiravir vs. Arbidol for COVID-19
23 Mar, 2020 | 01:18h | UTCFavipiravir versus Arbidol for COVID-19: A Randomized Clinical Trial – medRxiv
Infection Prevention and Control guidance for Long-Term Care Facilities in the context of COVID-19
23 Mar, 2020 | 01:34h | UTCRelated Study: COVID-19 in a Long-Term Care Facility — King County, Washington, February 27–March 9, 2020 – CDC Morbidity and Mortality Weekly Report (free)
“Introduction of COVID-19 into a long-term residential care facility in Washington resulted in cases among 81 residents, 34 staff members, and 14 visitors; 23 persons died” (from CDC)
IDSA Statement: COVID-19 Prioritization of Diagnostic Testing
20 Mar, 2020 | 11:01h | UTCCOVID-19 Prioritization of Diagnostic Testing – Infectious Diseases Society of America (free PDF)
Summary: IDSA Statement On COVID-19 Testing Recommendations – Infectious Diseases Society of America (free)
Editorial by John P.A. Ioannidis: COVID-19: The Harms of Exaggerated Information and Non‐evidence‐based Measures
23 Mar, 2020 | 01:08h | UTCRelated Opinion Piece: A fiasco in the making? As the coronavirus pandemic takes hold, we are making decisions without reliable data – STAT (free)
Rebuttal 1: We know enough now to act decisively against Covid-19. Social distancing is a good place to start – STAT (free)
Rebuttal 2: A Rebuttal to “A Fiasco in the Making?” – Hilda Bastian (Free)
New Preliminary Studies with Hydroxychloroquine:
20 Mar, 2020 | 10:57h | UTCThis was an open-label study with only 42 patients without patient-relevant endpoints. The 6 patients that received Hydroxychloroquine + Azithromycin achieved more efficient virus elimination than control patients.
New in Vitro Study: Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro – Cell Discovery (free)
Related Articles: In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) – Clinical Infectious Diseases (free PDF) AND New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? – International Journal of Antimicrobial Agents (free) AND A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19 – Journal of Critical Care (free) AND Of chloroquine and COVID-19 – Antiviral Research (free)
Meta-Analysis: The Risk of Tuberculosis in Children After Close Exposure
23 Mar, 2020 | 00:52h | UTCCommentary: Incidence of Tuberculosis High in Children Exposed to the Disease – Drugs.com (free)
CDC Guideline: Strategies for Optimizing the Supply of Facemasks
20 Mar, 2020 | 11:03h | UTCStrategies for Optimizing the Supply of Facemasks – Centers for Disease Control and Prevention (free)
Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the Coronavirus Disease 2019 (COVID-19) Pandemic
20 Mar, 2020 | 11:05h | UTCCommentary: CVD in the Setting of COVID-19: Considerations to Prepare Patients, Providers, Health Systems – American College of Cardiology (free)
Video: Coronavirus Update with Anthony Fauci, MD
19 Mar, 2020 | 11:04h | UTCCoronavirus Update with Anthony Fauci, MD – March 18, 2020 – JAMA (free)
Study: SARS-CoV-2 Infection in Children
19 Mar, 2020 | 10:59h | UTCSARS-CoV-2 Infection in Children – New England Journal of Medicine (free)
Related Articles: Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China – Peditrics (free) Detection of Covid-19 in Children in Early January 2020 in Wuhan, China – New England Journal of Medicine (free) AND Coronavirus Infections in Children Including COVID-19: An Overview of the Epidemiology, Clinical Features, Diagnosis, Treatment and Prevention Options in Children – The Pediatric Infectious Diseases Journal (free PDF) AND Characteristics of pediatric SARS-CoV-2 infection and potential evidence for persistent fecal viral shedding – Nature Medicine (free)
Randomized Trial: No Benefit from Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19
19 Mar, 2020 | 11:01h | UTCEditorial: Covid-19 — The Search for Effective Therapy (free)
See also: Interview with Dr. Eric Rubin and Dr. Lindsey Baden on new research on possible treatments for Covid-19 – New England Journal of Medicine (free)
Podcast: New Research on Possible Treatments for Covid-19
19 Mar, 2020 | 10:57h | UTC
Report: Impact of Non-pharmaceutical Interventions to Reduce COVID19 Mortality and Healthcare Demand
18 Mar, 2020 | 09:53h | UTCSummary: Report 9 – Imperial College London (free)
Commentaries: US, UK coronavirus strategies shifted following UK epidemiologists’ ominous report – CNN (free) AND New Analysis Suggests Months Of Social Distancing May Be Needed To Stop Virus – NPR (free)
“…in an unmitigated epidemic, we would predict approximately 510,000 deaths in GB and 2.2 million in the US, not accounting for the potential negative effects of health systems being overwhelmed on mortality.”
Study: Aerosol and Surface Stability of SARS-CoV-2
18 Mar, 2020 | 09:50h | UTCCommentaries: New coronavirus stable for hours on surfaces – NIH News Releases (free) AND How Long Will Coronavirus Live on Surfaces or in the Air Around You? – The New York Times (10 articles per month are free) AND New coronavirus can persist in air for hours and on surfaces for days: study – Reuters (free)
Randomized, Phase 2 Trial: Safety and Immunogenicity of a Tetravalent Dengue Vaccine in Children Aged 2–17 Years
18 Mar, 2020 | 09:47h | UTCSafety and immunogenicity of a tetravalent dengue vaccine in children aged 2–17 years: a randomised, placebo-controlled, phase 2 trial – The Lancet (link to abstract – $ for full-text)
[Abstract Only] Study: Consequences of Measles Undervaccination
18 Mar, 2020 | 09:49h | UTCConsequences of Undervaccination – Measles Outbreak, New York City, 2018-2019 – New England Journal of Medicine (link to abstract – $ for full-text)
Epidemiological Characteristics of 2143 Pediatric Patients With 2019 Coronavirus Disease in China
17 Mar, 2020 | 08:45h | UTCCommentary: Children with COVID-19 Impacted Less Severely Than Adults: Study – American Academy of Pediatrics (free)
‘A Ticking Time Bomb’: Scientists Worry About Coronavirus Spread in Africa
17 Mar, 2020 | 08:48h | UTC‘A ticking time bomb’: Scientists worry about coronavirus spread in Africa – Science (free)
Related: Managing COVID-19 in Low- and Middle-Income Countries – JAMA (free) AND Inside the Efforts to Prepare African Countries for COVID-19 – TIME (free) AND Looming threat of COVID-19 infection in Africa: act collectively, and fast – The Lancet (free) AND Is the Africa prepared for tackling the COVID-19 (SARS-CoV-2) epidemic? – lessons from past outbreaks, ongoing pan-African public health efforts, and implications for the future – International Journal of Infectious Diseases (free PDF)
COVID-19: Undocumented Infections are the Infection Source for 79% of Documented Cases
17 Mar, 2020 | 08:51h | UTCCommentaries: 80% of COVID-19 spreads from people who don’t know they are sick – UPI (free) AND Coronavirus Is Hiding in Plain Sight – The New York Times (10 articles per month are free)
Related: COVID-19: Who Is Infectious? – Forbes (free) AND Infected people without symptoms might be driving the spread of coronavirus more than we realized – CNN (free)
Interim Guidance: Clinical Management of Severe Acute Respiratory Infection When Novel Coronavirus (nCoV) Infection is Suspected
16 Mar, 2020 | 08:01h | UTCRelated: Severe SARS-CoV-2 Infections: Practical Considerations and Management Strategy for Intensivists (free studies and reviews)
Related Commentary on Twitter
Updated #COVID19 clinical guidance covers:
🔹Early case recognition
🔹Guidance for care of children, pregnant women, adults & older people
🔹Managing cases
🔹Infection prevention & control
🔹Sample collection & an update on investigational therapeutics
👉https://t.co/ZVaiu2C19V pic.twitter.com/yyOzIbtbEO— World Health Organization (WHO) (@WHO) March 15, 2020
Critical Care Utilization for the COVID-19 Outbreak in Lombardy, Italy: Early Experience and Forecast During an Emergency Response
16 Mar, 2020 | 07:55h | UTCRelated Video: Coronavirus in Italy – Report From The Front Lines – JAMA (free)
Study: Characteristics of Pediatric SARS-CoV-2 Infection and Potential Evidence for Persistent Fecal Viral Shedding
16 Mar, 2020 | 07:50h | UTCCommentaries: How Does The Coronavirus Affect Kids? What We Know So Far About COVID-19 In Children – Forbes (free) AND Coronavirus study finds children with COVID-19 show milder symptom pattern – Reuters (free)
“Children infected with the #COVID19 outbreak coronavirus, SARS-CoV-2, show mild symptoms but prolonged shedding of viral RNA in feces, suggesting that the fecal–oral route might play a role in virus transmission #CORONAVIRUS” (via @NatureMedicine see Tweet)