Geriatrics
Randomized trial: Among women with urinary incontinence, biofeedback-mediated intensive pelvic floor training does not provide additional benefit to basic pelvic floor muscle training
15 Dec, 2020 | 01:23h | UTC
NICE Guideline: Osteoarthritis care and management
13 Dec, 2020 | 23:19h | UTCOsteoarthritis: care and management – National Institute for Health and Care Excellence
Randomized trial: No benefit and potential harm from Vitamin D at doses of 1000 IU/d or higher compared with 200 IU/d in older persons with elevated fall risk
9 Dec, 2020 | 08:13h | UTCCommentaries: Study Finds No Benefit, Possible Harm to Seniors’ Fall Risks with Higher Doses of Vitamin D – Johns Hopkins Medicine AND Does High-Dose Vitamin D Actually Heighten Fall Risk? – Physician’s Weekly
Commentary on Twitter (thread – click for more)
https://twitter.com/ErinMichos/status/1336091776994537472
Cohort study: In the general population, both low and high levels of LDL cholesterol were associated with an increased risk of all-cause mortality
9 Dec, 2020 | 08:11h | UTC
Commentary on Twitter
Studies on the association between LDL-C levels and the risk of all cause mortality have provided conflicting results. This new study investigates the association between levels of LDL-C and the risk of all cause and cause specific mortalityhttps://t.co/phsKXIgPfq
— The BMJ (@bmj_latest) December 8, 2020
Could COVID delirium bring on dementia?
4 Dec, 2020 | 08:11h | UTCCould COVID delirium bring on dementia? – Nature
CDC panel moves health workers, nursing home residents to front of COVID vaccine line
2 Dec, 2020 | 07:26h | UTCCDC panel moves health workers, nursing home residents to front of COVID vaccine line – CIDRAP
Cohort study: Higher dose Z-drug use in dementia is associated with increased fracture and stroke risks, similar or greater to that for higher dose benzodiazepines
1 Dec, 2020 | 08:25h | UTCCommentary: The danger of Z-drugs for dementia patients – University of Exeter
Long Covid: Comprehensive health assessment three months after recovery from acute COVID-19 revealed problems in several health domains in a substantial number of patients
27 Nov, 2020 | 08:33h | UTC
Phase 2 trial of Oxford COVID-19 vaccine finds it is safe and provokes immune response in young as well as in older adults
20 Nov, 2020 | 08:50h | UTCCommentaries: Covid: Oxford vaccine shows ‘encouraging’ immune response in older adults – BBC AND Age and frailty in COVID-19 vaccine development – The Lancet AND Expert reaction to phase 2 trial safety and immunogenicity data from the Oxford COVID-19 vaccine trial including in healthy older adults – Science Media Centre AND Phase 2 trial of Oxford COVID-19 vaccine in healthy older adults finds it is safe and provokes immune response – The Lancet
Commentary on Twitter
NEW—UK’s #COVID19 vaccine shows similar safety and immunogenicity results in healthy older adults (aged 56 years & over) to those seen in adults aged 18-55 years: finding from a single-blind, randomised, controlled, phase 2 trial https://t.co/OKDSySPwfK pic.twitter.com/JyXRk5ZzPT
— The Lancet (@TheLancet) November 19, 2020
Older adults with COVID-19 commonly present to the ED with delirium
20 Nov, 2020 | 08:46h | UTCDelirium in Older Patients With COVID-19 Presenting to the Emergency Department – JAMA Network Open
Commentaries: Delirium could signal Covid-19 infection in older adults, study finds – STAT AND Delirium fairly common in older COVID-19 patients – CIDRAP AND Delirium is first symptom for many elderly COVID-19 patients – UPI
Commentary on Twitter
In older ED patients w/ COVID-19 only 56% had a fever, 51% SOB & 50% cough. 28% had delirium & one third of delirious pts lacked typical symptoms. In the ED delirium may the only symptom of #COVID19. @sharon_inouye @ACEPNow @GeriatricEDNews @AGEM_SAEM @JAMANetworkOpen pic.twitter.com/MxjSTx3Ffi
— Maura Kennedy (@MauraKennedyMD) November 19, 2020
CDC Report: 9% readmitted after Covid-19 hospitalization. Risk factors were age ≥65 y, chronic medical conditions, recent hospitalization before Covid-19, and discharge to a skilled nursing facility or with home health care
17 Nov, 2020 | 09:46h | UTCCommentary: 9 percent readmitted after index COVID-19 hospitalization – MedicalXpress AND One in 11 coronavirus patients discharged from a hospital is readmitted within two months, suggesting long-lasting effects of the infection, CDC report warns – Daily Mail
Commentary on Twitter
A new @CDCMMWR finds 9% of the more than 100,000 patients discharged after being hospitalized for #COVID19 were readmitted to the same hospital within 2 months. Learn more: https://t.co/s96NXLxQUE. pic.twitter.com/ugJq9f1gHP
— CDC (@CDCgov) November 9, 2020
Sleep problems in dementia: Despite many drugs being widely prescribed, systematic review finds lack of evidence and no randomized controlled trials to guide decisions about drug treatment
17 Nov, 2020 | 09:29h | UTCPharmacotherapies for sleep disturbances in dementia – Cochrane Library
Long Covid: Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection
13 Nov, 2020 | 09:27h | UTCCommentary: Half of recovered COVID-19 patients report lingering fatigue – CIDRAP
Long Covid: 2 months after being hospitalized for Covid-19, many patients persisted symptomatic and did not resume normal activities
13 Nov, 2020 | 09:28h | UTCSixty-Day Outcomes Among Patients Hospitalized With COVID-19 – Annals of Internal Medicine
Commentary on Twitter
New Mich. hospital data: Of people admitted with COVID, 70% were alive and home 60 days later.
Of those who'd been working, 40% either lost their job or were still too sick to work.
It's not just the deaths; it's the health and economic damage. https://t.co/wMGkJw5KSF pic.twitter.com/8EbHktTxRX
— Atul Gawande (@Atul_Gawande) November 12, 2020
Older age and frailty are frequently associated with atypical and unspecific COVID-19 presentations, including functional decline, acute mental change, and hypotension
12 Nov, 2020 | 09:22h | UTC
Commentary on Twitter
DIVERGENT: age, #frailty, and presentations of #COVID19
Typical symptoms were uncommon in frail and older
patients; they were more likely to experience functional decline and key features of delirium. #geriatrics @geronsociety @OxfordJournals #gerontolhttps://t.co/jRhwvacsVm pic.twitter.com/9zhHZjsSoy— Marlon Aliberti (@marlon_aliberti) November 5, 2020
Randomized trial: vitamin D, omega-3 fatty acids, or a strength-training exercise program do not improve clinical outcomes in older adults
11 Nov, 2020 | 09:11h | UTCEffect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial – JAMA (free for a limited period)
[Not published yet – presented at #ACR20] Randomized trial: Methotrexate improves function in people with knee osteoarthritis after 3 months
9 Nov, 2020 | 01:19h | UTC
[Abstract Only] Large randomized trial fails to show benefit from a multifactorial prevention strategy to prevent falls and fractures in older people
6 Nov, 2020 | 09:48h | UTCScreening and Intervention to Prevent Falls and Fractures in Older People – New England Journal of Medicine (link to abstract – $ for full-text)
Related study: A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries – New England Journal of Medicine
[Abstract Only] More than a third of older adults are prescribed potentially inappropriate drugs, study finds
6 Nov, 2020 | 09:42h | UTCOriginal study: Potentially Inappropriate Medications Are Associated with Increased Healthcare Utilization and Costs – Journal of the American Geriatrics Society (link to abstract – $ for full-text)
Study provides new estimates of breast cancer risks associated with different hormone replacement therapy preparations
30 Oct, 2020 | 01:04h | UTCCommentaries: Study provides new estimates of breast cancer risks associated with HRT – University of Oxford AND New estimates of breast cancer risks associated with HRT – The BMJ AND HRT: Breast Ca Risk Tied to Hormone Type, Duration of Tx – Physician’s Weekly
Narrative systematic review: Benefits of medication charts provided at transitions of care
25 Oct, 2020 | 23:29h | UTC
Meta-analysis: Evidence-based prevention of Alzheimer’s disease
20 Oct, 2020 | 01:21h | UTCCommentaries: Biggest risk factors identified to try and prevent Alzheimer’s disease – BMJ AND Systematic review finds ten lifestyle factors that clearly impact the probability of developing Alzheimer’s disease (AD) – Sharp Brains
Commentary on Twitter
Evidence-based #prevention of #Alzheimers disease https://t.co/XOMiEoMlmI via @JNNP_BMJ #dementia @perryd43 @PennilessScribe @u3Y4BDE @SanWren @lfkraus @the_scholar1 @ktanimara @drsharwood @TargetLatino @LilithResists @Joseph_Santoro @liftdupbyangels @mrtom101 @SteveDitchfield pic.twitter.com/T5hqbzmIwi
— Ian Kremer (@LEAD_Coalition) July 24, 2020
[Preprint] Multi-organ impairment in low-risk individuals with long COVID
18 Oct, 2020 | 23:18h | UTCMulti-organ impairment in low-risk individuals with long COVID – medRxiv
Related study (preprint): Persistent symptoms after Covid-19: qualitative study of 114 long Covid patients and draft quality criteria for services – medRxiv
Commentary on Twitter
"In a young, low-risk population with ongoing symptoms, almost 70% of individuals have impairment in 1 or more organs 4 months after initial symptoms of #SARSCoV2 infection" #LongCovid https://t.co/gPnDtacI1J by @amibanerjee1 and colleagues
via @ahandvanish<-🙏 pic.twitter.com/7mKEsQgq5l— Eric Topol (@EricTopol) October 17, 2020
NIHR dynamic review of the evidence around ongoing Covid19 symptoms (often called Long Covid)
18 Oct, 2020 | 23:14h | UTCA dynamic review of the evidence around ongoing Covid19 symptoms (often called Long Covid) – National Institute for Health Research
News Release: Living with COVID: NIHR publishes dynamic themed review into ‘ongoing COVID’
Commentaries: Coronavirus: ‘Long Covid could be four different syndromes’ – BBC AND Long covid could be four different syndromes, review suggests – The BMJ AND ‘Long COVID’ may affect multiple parts of body and mind, doctors say – Reuters
Randomized trial: Effectiveness of pelvic floor muscle training with and without electromyographic biofeedback for urinary incontinence in women
18 Oct, 2020 | 23:06h | UTCCommentary: For Urinary Incontinence, No Need to Add Biofeedback to Pelvic Floor Exercises – NEJM Journal Watch
Commentary on Twitter
This RCT did not find a statistically significant or clinically important difference in severity of urinary incontinence between women randomised to electromyographic biofeedback plus pelvic floor muscle training or to pelvic floor muscle training alonehttps://t.co/z8nxLplT57
— The BMJ (@bmj_latest) October 17, 2020