Genetics
Randomized Controled Trial: Genotype-Guided Warfarin Dosing on Clinical Events and Anticoagulation Control
27 Sep, 2017 | 14:02h | UTCEffect of Genotype-Guided Warfarin Dosing on Clinical Events and Anticoagulation Control Among Patients Undergoing Hip or Knee Arthroplasty: The GIFT Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Genotyping Reduces Adverse Events with Warfarin – Cardiobrief (free) AND Genotype-Guided Warfarin Dosing Reduces Adverse Events After Hip, Knee Arthroplasty – Physician’s First Watch (free)
Review: Sickle Cell Disease
24 Sep, 2017 | 00:15h | UTCSickle Cell Disease – Gene Reviews (free)
Systematic Review: Molecular testing for Lynch syndrome in people with colorectal cancer
18 Sep, 2017 | 13:54h | UTC
Review: Heritable pulmonary hypertension
16 Sep, 2017 | 17:54h | UTCHeritable pulmonary hypertension: from bench to bedside – European Respiratory Review (free)
Free Online Course: Genomics: Decoding the Universal Language of Life
11 Sep, 2017 | 01:02h | UTCStarts Today! Free Online Course: Genomics: Decoding the Universal Language of Life – University of Illinois at Urbana-Champaign and Coursera
FDA approval brings first gene therapy to the United States
3 Sep, 2017 | 21:19h | UTCFDA News Release: FDA approval brings first gene therapy to the United States (free)
Commentaries: A $475,000 cancer drug: Wall Street sees ‘bargain’; patients see ‘completely broken’ system – HealthNewsReview (free) FDA Approves First CAR-T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia – National Institutes of Health (free) AND FDA Approves First Gene-Altering Leukemia Treatment, Costing $475.000 – New York Times (10 articles per month are free) AND The FDA Approves a Landmark Cancer Drug – The Atlantic (free)
“…is a cancer therapy that represents several things at once: a game-changing way to treat cancer through genetic engineering, a novel paradigm for the biotech business, and the latest turn in the debate over just how astronomically expensive a life-saving therapy can be”. (from The Atlantic)
Review: Familial Cancers of Head and Neck Region
26 Aug, 2017 | 15:46h | UTCFamilial Cancers of Head and Neck Region – Journal of Clinical & Diagnostic Research (free)
Study: Genetic counseling works as well over the phone as in person
26 Aug, 2017 | 15:34h | UTCGenetic counseling works as well over the phone as in person, study finds – STAT (free)
Related commentary: Telemedicine OK for Genetic Testing and Counseling – MedPage Today (free registration required)
Guideline: Management of Inherited Polyposis Syndromes
22 Aug, 2017 | 12:59h | UTC
Pig genome editing with goal of providing organs for transplant
16 Aug, 2017 | 18:04h | UTCInactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9 – Science (link to abstract – $ for full-text)
Commentaries: Birth of CRISPR’d pigs advances hopes for turning swine into organ donos – STAT (free) AND Gene editing to remove viruses brings transplant organs from pigs a step closer – The Guardian (free) AND Gene Editing Spurs Hope for Transplanting Pig Organs Into Humans – New York Times (10 articles per month are free) AND Gene editing brings pig organ transplant closer – NHS Choices (free) AND Scientists edit pig genome with goal of human organ transplants – CNN (free text and video)
Gene Editing Using CRISPR: Why the Excitement?
15 Aug, 2017 | 21:08h | UTCViewpoint: Gene Editing Using CRISPR: Why the Excitement? – JAMA (free)
Genetic counseling works as well over the phone as in person, study finds
15 Aug, 2017 | 20:35h | UTCGenetic counseling works as well over the phone as in person, study finds – STAT (free)
Related commentary: Telemedicine OK for Genetic Testing and Counseling – MedPage Today (free registration required)
Gene-edited embryos are exciting, but the truly urgent conversations concern genomic medicine
15 Aug, 2017 | 19:34h | UTCCommit to talks on patient data and public health – Nature News (free)
“unlike gene-edited infants, which are still years away, genomic medicine is with us now” (RT @NatureNews see Tweet)
11 Organizations Urge Cautious but Proactive Approach to Gene Editing
11 Aug, 2017 | 15:50h | UTCPosition Statement: Human Germline Genome Editing – American Society of Human Genetics (free)
News Release: 11 Organizations Urge Cautious but Proactive Approach to Gene Editing
Commentaries: International Genetics Groups Call for Cautious Approach to Gene Editing – Physician’s First Watch (free)
Use of Molecular Tools to Identify Patients With Indolent Breast Cancers With Ultralow Risk
8 Aug, 2017 | 00:19h | UTCUse of Molecular Tools to Identify Patients With Indolent Breast Cancers With Ultralow Risk Over 2 Decades – JAMA Oncology (link to abstract – $ for full-text)
Commentaries: ‘Ultralow-Risk’ Breast Cancers Can Skip Endocrine Therapy – Medscape (free registration required) AND Tumor Test Helps Identify Which Breast Cancers Don’t Require Extra Treatment – NPR (free)
Simple guide to CRISPR
7 Aug, 2017 | 21:57h | UTCSimple guide to CRISPR, one of the biggest science stories of the decade – VOX (free) (RT @Students4BE see Tweet)
Genetic testing threatens the insurance industry
5 Aug, 2017 | 15:04h | UTCGenetic testing threatens the insurance industry – The Economist (a few articles per month are free)
“Insurers worry about adverse selection; the insured worry about discrimination”
Correction of a pathogenic gene mutation in human embryos
3 Aug, 2017 | 14:02h | UTCCorrection of a pathogenic gene mutation in human embryos – Nature (free)
Nature News & Views: Biotechnology: At the heart of gene edits in human embryos (free)
Commentaries: Embryo Gene-Editing Experiment Reignites Ethical Debate – Scientific American (free) AND Scientists successfully used CRISPR to fix a mutation that causes disease. This is huge – VOX (free) AND U.S. scientists edit genome of human embryo, but cast doubt on possibility of ‘designer babies’ – STAT (free) AND Human embryos edited to stop disease – BBC (free) AND In Breakthrough, Scientists Edit a Dangerous Mutation From Genes in Human Embryos – The New York Times (10 articles per month are free)
The genetic background of acromegaly
1 Aug, 2017 | 17:14h | UTCReview: The genetic background of acromegaly – Pituitary (free)
Diagnostic approaches for inherited hemolytic anemia in the genetic era
1 Aug, 2017 | 17:07h | UTCReview: Diagnostic approaches for inherited hemolytic anemia in the genetic era – Blood Research (free)
Human Genome Editing: Science, Ethics, and Governance
27 Jul, 2017 | 16:43h | UTCReport: Human Genome Editing: Science, Ethics, and Governance (2017) – The National Academies Press (free)
The trouble with genetic testing
23 Jul, 2017 | 23:29h | UTC‘We are all mutants now’: the trouble with genetic testing – The Guardian (free) (RT @EricTopol see Tweet)
Related: The uncertain future of genetic testing – Mosaic (free)
“With so many unknowns in our DNA, using genetics in medical testing doesn’t always bring the answers – sometimes it brings only doubt”.
Development and Validation of the PREMM5 Model for Comprehensive Risk Assessment of Lynch Syndrome
23 Jul, 2017 | 19:02h | UTCCommentary: PREMM5 Model for Comprehensive Risk Assessment of Lynch Syndrome – PracticeUpdate (free registration required)
The Uncertain Future of Genetic Testing
21 Jul, 2017 | 17:38h | UTCThe Uncertain Future of Genetic Testing – The Atlantic (free)
“Bringing genetics into medicine leads to more accuracy, better diagnosis, and personalized treatment—but for some, gene testing has only resulted in unanswered questions”.
Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development
18 Jul, 2017 | 22:56h | UTC